| Chain sequence(s) |
A: GAPPVDPAPPLLPTSAYVTPTDLLYYAETDLITKRGHPTKDIIENGKVVKPRVSAYDFKVFKLTLPDPNTMPLPSADFLDPSTEIRIWQLRALKIGVFGPLGKGSYGHKNYNALGDVTNPTEPVKETEDDTQDLSWEPVLRQEYVVGNEPPIGKYTAPAAPAPGLPPGALPPLKTVSTLIEDGDVADIGFGARDFAALEPEKDEVPDIILNTTTKVLDYDGMRAEPYGDRMFDYDSYEKSKSVKKLVRDGPDLIPLPDSPPPSTEYVEPPPSSPDYVRPSTDYFDIPDSGEIKEEDLLFNKPLFFEKAAGLNNFVLWHNRLYVTVLDNRRAEIKTIRTQISTPEDNVYDESNYVTSEEYEEEYKLELIVQLCIIPLTPEILAEIRRRDPRILTEANLPDIPPVERPDPYAGKKFHEIDLTDKLSSDLEKSELGRQYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.5451 | |
| 2 | A | A | -0.0716 | |
| 3 | P | A | -0.2599 | |
| 4 | P | A | -0.1026 | |
| 5 | V | A | 0.6856 | |
| 6 | D | A | -1.1980 | |
| 7 | P | A | -0.7739 | |
| 8 | A | A | -0.3869 | |
| 9 | P | A | -0.5289 | |
| 10 | P | A | -0.1397 | |
| 11 | L | A | 0.2714 | |
| 12 | L | A | 0.3119 | |
| 13 | P | A | 0.2200 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -0.3808 | |
| 16 | A | A | 0.0319 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.1347 | |
| 20 | P | A | -0.6018 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6888 | |
| 23 | L | A | -0.6293 | |
| 24 | L | A | -0.3390 | |
| 25 | Y | A | 0.0000 | |
| 26 | Y | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.2952 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3500 | |
| 31 | L | A | 0.5157 | |
| 32 | I | A | 0.1716 | |
| 33 | T | A | -0.5922 | |
| 34 | K | A | -1.5863 | |
| 35 | R | A | -2.4888 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.9142 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.4845 | |
| 40 | K | A | -2.1185 | |
| 41 | D | A | -1.2113 | |
| 42 | I | A | 0.4067 | |
| 43 | I | A | 0.8588 | |
| 44 | E | A | -1.3892 | |
| 45 | N | A | -1.9794 | |
| 46 | G | A | -1.2793 | |
| 47 | K | A | -1.1265 | |
| 48 | V | A | 1.0405 | |
| 49 | V | A | 1.3770 | |
| 50 | K | A | -0.0800 | |
| 51 | P | A | -0.7609 | |
| 52 | R | A | -1.6870 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.4767 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.7293 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.7090 | |
| 70 | T | A | -0.4043 | |
| 71 | M | A | -0.0918 | |
| 72 | P | A | -0.1486 | |
| 73 | L | A | 0.0057 | |
| 74 | P | A | -0.3235 | |
| 75 | S | A | -0.4874 | |
| 76 | A | A | -0.6525 | |
| 77 | D | A | -1.4704 | |
| 78 | F | A | -0.2322 | |
| 79 | L | A | -0.1682 | |
| 80 | D | A | -1.1977 | |
| 81 | P | A | -0.9236 | |
| 82 | S | A | -0.9413 | |
| 83 | T | A | -0.5973 | |
| 84 | E | A | -0.5056 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6534 | |
| 92 | A | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | K | A | -0.9786 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.5480 | |
| 99 | G | A | -0.3356 | |
| 100 | P | A | -0.3713 | |
| 101 | L | A | -0.3980 | |
| 102 | G | A | -0.9088 | |
| 103 | K | A | -1.3475 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.7325 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.3470 | |
| 108 | H | A | 0.0000 | |
| 109 | K | A | -3.2812 | |
| 110 | N | A | -3.2004 | |
| 111 | Y | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -1.1008 | |
| 116 | D | A | -1.9668 | |
| 117 | V | A | -1.1963 | |
| 118 | T | A | -1.4715 | |
| 119 | N | A | -2.0179 | |
| 120 | P | A | -1.6800 | |
| 121 | T | A | -1.4744 | |
| 122 | E | A | -2.4475 | |
| 123 | P | A | -1.3704 | |
| 124 | V | A | -1.3770 | |
| 125 | K | A | -2.2911 | |
| 126 | E | A | -2.5352 | |
| 127 | T | A | -2.5487 | |
| 128 | E | A | -3.0471 | |
| 129 | D | A | -3.2395 | |
| 130 | D | A | -2.4650 | |
| 131 | T | A | -2.3522 | |
| 132 | Q | A | -2.5274 | |
| 133 | D | A | -3.1219 | |
| 134 | L | A | -1.6265 | |
| 135 | S | A | -1.1049 | |
| 136 | W | A | 0.0000 | |
| 137 | E | A | -0.6242 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | R | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | N | A | 0.0000 | |
| 149 | E | A | -0.5418 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | -0.0824 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.4603 | |
| 155 | Y | A | -0.6621 | |
| 156 | T | A | -0.5343 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | 0.1515 | |
| 159 | A | A | -0.0915 | |
| 160 | A | A | -0.1236 | |
| 161 | P | A | 0.1237 | |
| 162 | A | A | -0.1254 | |
| 163 | P | A | -0.3216 | |
| 164 | G | A | -0.3254 | |
| 165 | L | A | 0.4114 | |
| 166 | P | A | -0.0731 | |
| 167 | P | A | -0.2700 | |
| 168 | G | A | 0.1062 | |
| 169 | A | A | 1.0001 | |
| 170 | L | A | 1.8569 | |
| 171 | P | A | 0.8026 | |
| 172 | P | A | 0.4884 | |
| 173 | L | A | 0.6890 | |
| 174 | K | A | -0.8741 | |
| 175 | T | A | -0.6006 | |
| 176 | V | A | -0.3459 | |
| 177 | S | A | -0.3480 | |
| 178 | T | A | -0.0455 | |
| 179 | L | A | -0.2883 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.2919 | |
| 182 | D | A | -1.4659 | |
| 183 | G | A | -0.9697 | |
| 184 | D | A | -0.7669 | |
| 185 | V | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2932 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.7907 | |
| 190 | F | A | -0.4471 | |
| 191 | G | A | -0.4387 | |
| 192 | A | A | -0.5433 | |
| 193 | R | A | -0.8100 | |
| 194 | D | A | -0.6757 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.0680 | |
| 197 | A | A | -0.4101 | |
| 198 | L | A | -0.1493 | |
| 199 | E | A | 0.0000 | |
| 200 | P | A | -1.7887 | |
| 201 | E | A | -2.8162 | |
| 202 | K | A | -3.1461 | |
| 203 | D | A | -2.5381 | |
| 204 | E | A | -1.7370 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.9406 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.1852 | |
| 211 | N | A | -1.5923 | |
| 212 | T | A | -0.8350 | |
| 213 | T | A | -0.5668 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.0212 | |
| 217 | L | A | 0.0000 | |
| 218 | D | A | -0.9176 | |
| 219 | Y | A | -1.1899 | |
| 220 | D | A | -2.3816 | |
| 221 | G | A | -1.6701 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -2.3734 | |
| 224 | A | A | -1.4454 | |
| 225 | E | A | -1.1813 | |
| 226 | P | A | -0.4895 | |
| 227 | Y | A | -0.1250 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.6893 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.7701 | |
| 234 | Y | A | -0.2758 | |
| 235 | D | A | -0.7159 | |
| 236 | S | A | -0.6768 | |
| 237 | Y | A | -1.0001 | |
| 238 | E | A | -2.1411 | |
| 239 | K | A | -2.1760 | |
| 240 | S | A | -1.8316 | |
| 241 | K | A | -1.9161 | |
| 242 | S | A | -1.0512 | |
| 243 | V | A | 0.0670 | |
| 244 | K | A | -1.7057 | |
| 245 | K | A | -1.8604 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | D | A | -1.7744 | |
| 250 | G | A | -0.9393 | |
| 251 | P | A | -0.3946 | |
| 252 | D | A | 0.0738 | |
| 253 | L | A | 2.0801 | |
| 254 | I | A | 2.2807 | |
| 255 | P | A | 0.6445 | |
| 256 | L | A | 0.1756 | |
| 257 | P | A | -0.8938 | |
| 258 | D | A | -1.7903 | |
| 259 | S | A | -1.3071 | |
| 260 | P | A | -1.1238 | |
| 261 | P | A | -0.8141 | |
| 262 | P | A | -0.9021 | |
| 263 | S | A | -0.6295 | |
| 264 | T | A | -0.8096 | |
| 265 | E | A | -1.4987 | |
| 266 | Y | A | 0.0788 | |
| 267 | V | A | 0.6140 | |
| 268 | E | A | -1.1466 | |
| 269 | P | A | -0.4143 | |
| 270 | P | A | -0.6337 | |
| 271 | P | A | -0.8945 | |
| 272 | S | A | -0.6432 | |
| 273 | S | A | -0.4487 | |
| 274 | P | A | -0.6589 | |
| 275 | D | A | -1.1122 | |
| 276 | Y | A | 0.5022 | |
| 277 | V | A | 1.0763 | |
| 278 | R | A | -0.2168 | |
| 279 | P | A | -0.5676 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.8239 | |
| 282 | D | A | -1.1255 | |
| 283 | Y | A | -0.0830 | |
| 284 | F | A | -0.7925 | |
| 285 | D | A | -1.9077 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.2358 | |
| 289 | S | A | 0.0000 | |
| 290 | G | A | 0.0000 | |
| 291 | E | A | -2.4427 | |
| 292 | I | A | -1.8328 | |
| 293 | K | A | -2.8168 | |
| 294 | E | A | -3.3043 | |
| 295 | E | A | -3.1322 | |
| 296 | D | A | -2.2158 | |
| 297 | L | A | -1.4411 | |
| 298 | L | A | -0.8119 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1454 | |
| 301 | K | A | -1.5953 | |
| 302 | P | A | -0.9401 | |
| 303 | L | A | -0.3005 | |
| 304 | F | A | -0.4596 | |
| 305 | F | A | 0.0000 | |
| 306 | E | A | -2.6011 | |
| 307 | K | A | -2.6775 | |
| 308 | A | A | 0.0000 | |
| 309 | A | A | -0.6748 | |
| 310 | G | A | -0.6851 | |
| 311 | L | A | 0.1657 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -0.9830 | |
| 314 | F | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7828 | |
| 319 | N | A | -0.7113 | |
| 320 | R | A | -0.8981 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | R | A | 0.0000 | |
| 330 | R | A | -0.6233 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.0774 | |
| 333 | I | A | -1.4958 | |
| 334 | K | A | -1.9852 | |
| 335 | T | A | -1.1266 | |
| 336 | I | A | -0.1569 | |
| 337 | R | A | -0.8077 | |
| 338 | T | A | 0.0327 | |
| 339 | Q | A | -0.1988 | |
| 340 | I | A | 1.6675 | |
| 341 | S | A | 0.3576 | |
| 342 | T | A | -0.5595 | |
| 343 | P | A | -1.3915 | |
| 344 | E | A | -2.5894 | |
| 345 | D | A | -2.5407 | |
| 346 | N | A | -1.7037 | |
| 347 | V | A | 0.3482 | |
| 348 | Y | A | 0.3151 | |
| 349 | D | A | -1.4852 | |
| 350 | E | A | -2.0176 | |
| 351 | S | A | -0.8191 | |
| 352 | N | A | 0.0000 | |
| 353 | Y | A | 0.1757 | |
| 354 | V | A | 1.0350 | |
| 355 | T | A | -0.1561 | |
| 356 | S | A | -0.4551 | |
| 357 | E | A | -1.2941 | |
| 358 | E | A | -1.6987 | |
| 359 | Y | A | 0.0000 | |
| 360 | E | A | -1.7712 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.3062 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.5221 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | -1.0952 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.4005 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | I | A | 0.2785 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.4558 | |
| 376 | L | A | -0.3097 | |
| 377 | T | A | -0.6672 | |
| 378 | P | A | -1.0261 | |
| 379 | E | A | -1.8067 | |
| 380 | I | A | 0.0000 | |
| 381 | L | A | -0.9300 | |
| 382 | A | A | -1.3065 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | R | A | -2.0602 | |
| 386 | R | A | -1.6570 | |
| 387 | R | A | -1.1922 | |
| 388 | D | A | -1.1962 | |
| 389 | P | A | -1.5565 | |
| 390 | R | A | -1.5644 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | T | A | -1.3916 | |
| 394 | E | A | -1.6212 | |
| 395 | A | A | -1.3442 | |
| 396 | N | A | -1.9602 | |
| 397 | L | A | -1.3982 | |
| 398 | P | A | -1.3715 | |
| 399 | D | A | -2.0144 | |
| 400 | I | A | -1.0795 | |
| 401 | P | A | -0.8989 | |
| 402 | P | A | -1.2988 | |
| 403 | V | A | -1.1487 | |
| 404 | E | A | -2.7025 | |
| 405 | R | A | -2.9507 | |
| 406 | P | A | -1.8749 | |
| 407 | D | A | -1.4849 | |
| 408 | P | A | -0.9814 | |
| 409 | Y | A | -0.8292 | |
| 410 | A | A | -0.9392 | |
| 411 | G | A | -1.3590 | |
| 412 | K | A | -1.9976 | |
| 413 | K | A | -2.6816 | |
| 414 | F | A | -1.7701 | |
| 415 | H | A | -1.6641 | |
| 416 | E | A | -2.5561 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.7151 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6563 | |
| 421 | D | A | -2.3691 | |
| 422 | K | A | -2.0523 | |
| 423 | L | A | -0.8827 | |
| 424 | S | A | -0.9713 | |
| 425 | S | A | -0.8661 | |
| 426 | D | A | -1.9962 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.6328 | |
| 429 | K | A | -3.4965 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.8849 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.6072 | |
| 435 | Q | A | -2.1918 | |
| 436 | Y | A | -1.2780 | |
| 437 | L | A | -0.8273 | |
| 438 | N | A | -2.0809 | |
| 439 | R | A | -2.2593 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine