Project name: 6c264c57043fb22

Chain sequence(s)	H: QVQLVQSGPGVVQPSQSLSITCTVSGLSLTGVGVHWIRQPPGKGLEWLGTIWSDGNTNYNGSLKSRVTISVDTSKNQFSLNLRSVTAADTAVYYCARHATSATSHSYLDPFDYWGQGTLVTVSS; L: EIVLTQSPGTLSLSPGERATLSCRASQSVTSTYLAWHQQKPGQAPRLLIYGASSRATGIPDRFSGSGSEADFTLTINRLEPEDFAVYYCQQYATSPWTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:09)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:11)

• Minimal score value: -3.3724
• Maximal score value: 1.6282
• Average score: -0.5859
• Total score value: -135.9267

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.4745
2	V	H	-0.8611
3	Q	H	-1.1498
4	L	H	0.0000
5	V	H	0.6938
6	Q	H	0.0000
7	S	H	-0.3056
8	G	H	-0.1857
9	P	H	0.2476
11	G	H	0.7862
12	V	H	1.4712
13	V	H	0.0000
14	Q	H	-1.0834
15	P	H	-1.0444
16	S	H	-1.2908
17	Q	H	-1.7827
18	S	H	-1.5385
19	L	H	0.0000
20	S	H	-0.6678
21	I	H	0.0000
22	T	H	-0.1086
23	C	H	0.0000
24	T	H	-0.3773
25	V	H	0.0000
26	S	H	-0.7075
27	G	H	-0.9661
28	L	H	-0.3981
29	S	H	-0.3319
30	L	H	0.0000
35	T	H	-0.7528
36	G	H	-0.7314
37	V	H	0.0000
38	G	H	0.0000
39	V	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	I	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5643
45	P	H	-0.6707
46	P	H	-0.8063
47	G	H	-1.4533
48	K	H	-2.3696
49	G	H	-1.5579
50	L	H	0.0000
51	E	H	-0.8410
52	W	H	0.0000
53	L	H	0.0000
54	G	H	0.0000
55	T	H	0.0000
56	I	H	0.0000
57	W	H	-0.9863
58	S	H	-1.3450
59	D	H	-2.2962
63	G	H	-1.7241
64	N	H	-1.9580
65	T	H	-1.1092
66	N	H	-1.0035
67	Y	H	-0.8740
68	N	H	-1.0918
69	G	H	-1.5142
70	S	H	-1.0307
71	L	H	0.0000
72	K	H	-2.2002
74	S	H	-1.4621
75	R	H	-1.4633
76	V	H	0.0000
77	T	H	-0.8065
78	I	H	0.0000
79	S	H	-0.4093
80	V	H	-0.8028
81	D	H	-1.3179
82	T	H	-1.3608
83	S	H	-1.3387
84	K	H	-2.2076
85	N	H	-1.4980
86	Q	H	-1.0926
87	F	H	0.0000
88	S	H	-0.3556
89	L	H	0.0000
90	N	H	-0.8252
91	L	H	0.0000
92	R	H	-1.7193
93	S	H	-1.4226
94	V	H	0.0000
95	T	H	-0.5597
96	A	H	-0.1510
97	A	H	0.0333
98	D	H	0.0000
99	T	H	0.4528
100	A	H	0.0000
101	V	H	0.7283
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.2136
107	H	H	0.0000
108	A	H	-0.0636
109	T	H	0.0630
110	S	H	-0.0291
111	A	H	-0.0958
111A	T	H	-0.2311
111B	S	H	-0.5495
112C	H	H	-0.8742
112B	S	H	-0.2673
112A	Y	H	0.6274
112	L	H	0.0000
113	D	H	-0.0067
114	P	H	0.0000
115	F	H	0.0000
116	D	H	-0.3945
117	Y	H	-0.1244
118	W	H	-0.2800
119	G	H	0.0000
120	Q	H	-1.0236
121	G	H	0.0000
122	T	H	0.5362
123	L	H	1.6282
124	V	H	0.0000
125	T	H	0.7476
126	V	H	0.0000
127	S	H	-0.1741
128	S	H	-0.4193
1	E	L	-1.6699
2	I	L	0.0000
3	V	L	0.5876
4	L	L	0.0000
5	T	L	-0.8439
6	Q	L	0.0000
7	S	L	-0.9501
8	P	L	-0.5633
9	G	L	-0.9417
10	T	L	-0.6643
11	L	L	-0.2123
12	S	L	-0.1693
13	L	L	-0.7685
14	S	L	-1.1541
15	P	L	-1.5471
16	G	L	-2.3288
17	E	L	-3.1223
18	R	L	-3.3724
19	A	L	0.0000
20	T	L	-0.7851
21	L	L	0.0000
22	S	L	-0.9739
23	C	L	0.0000
24	R	L	-2.6061
25	A	L	0.0000
26	S	L	-1.2293
27	Q	L	-2.0389
28	S	L	-1.9766
29	V	L	0.0000
30	T	L	-0.7722
36	S	L	-0.7633
37	T	L	0.1082
38	Y	L	0.2996
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	H	L	0.0000
43	Q	L	-0.8365
44	Q	L	0.0000
45	K	L	-1.3659
46	P	L	-0.9285
47	G	L	-1.3431
48	Q	L	-2.0979
49	A	L	-1.4109
50	P	L	0.0000
51	R	L	-1.9023
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.0801
56	G	L	-0.1188
57	A	L	0.0000
65	S	L	-0.5762
66	S	L	-0.5610
67	R	L	-1.2319
68	A	L	0.0000
69	T	L	-0.5231
70	G	L	-0.8590
71	I	L	0.0000
72	P	L	-1.2869
74	D	L	-2.2814
75	R	L	-2.1533
76	F	L	0.0000
77	S	L	-0.9991
78	G	L	-0.4680
79	S	L	-0.6868
80	G	L	-1.4331
83	S	L	-1.8589
84	E	L	-2.8696
85	A	L	-2.5782
86	D	L	-2.7210
87	F	L	0.0000
88	T	L	-0.8060
89	L	L	0.0000
90	T	L	-0.9682
91	I	L	0.0000
92	N	L	-3.0042
93	R	L	-3.2857
94	L	L	0.0000
95	E	L	-1.6165
96	P	L	-0.9500
97	E	L	-1.8082
98	D	L	0.0000
99	F	L	-0.2953
100	A	L	0.0000
101	V	L	-0.2681
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	A	L	0.0945
109	T	L	-0.4026
114	S	L	-0.6319
115	P	L	-0.8020
116	W	L	0.0000
117	T	L	-0.1706
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.4469
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.9861
124	V	L	0.0000
125	E	L	-0.1787
126	I	L	0.8827
127	K	L	-0.9749