| Chain sequence(s) |
A: GLPALNPEPALLSTDEYVTPTDLLLYAETDLLTETGHPTKDIVVNGKVVVPRVSAYQWKVYRLTLPDPNTLPLPSADFVDPSTERLIWRLLAFKIERFGPLGKGTYGHANFNAFGDIDNPTEYQHETEDDTVAYSWRPKYLQQYIIGDRPPLGKYTALAEPAPGLPPGAIPPLKTVTTVIEDGDMADIGFGAKDFAALEPTKDDVPDIILDTTTKVVDYAGMRAEPTGRRMFTYDKYEKSYSSKTLRRDGPDLIPLPAAPPPSPLYVPPPPTSPYAVLPSTDIFTIPDQGEITEEDELFNKPVYITKTEGLNNAILWHNQLYVTVVDNSRDEIETIRTRVSTPKENVYDPSNYVTSKRYTREYKLSLILQLCRIPLTPETLALLRRIDPRILVDAKLPFVPPVERPDPLAGKKFKEIDLTNKLSTELEKSELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.2026 | |
| 2 | L | A | 1.4675 | |
| 3 | P | A | 0.5542 | |
| 4 | A | A | 0.5428 | |
| 5 | L | A | 0.8401 | |
| 6 | N | A | -1.1694 | |
| 7 | P | A | -1.4132 | |
| 8 | E | A | -2.1735 | |
| 9 | P | A | -1.1525 | |
| 10 | A | A | -0.2441 | |
| 11 | L | A | 0.3765 | |
| 12 | L | A | 0.4466 | |
| 13 | S | A | -0.4426 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.6628 | |
| 16 | E | A | -2.4157 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -1.0245 | |
| 20 | P | A | -1.0040 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6847 | |
| 23 | L | A | -0.5779 | |
| 24 | L | A | -0.2206 | |
| 25 | L | A | 0.0000 | |
| 26 | Y | A | -0.4913 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.8282 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3949 | |
| 31 | L | A | 0.1805 | |
| 32 | L | A | -0.0353 | |
| 33 | T | A | -0.1619 | |
| 34 | E | A | -0.3878 | |
| 35 | T | A | -0.4416 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.4854 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.5205 | |
| 40 | K | A | -2.0809 | |
| 41 | D | A | -0.8777 | |
| 42 | I | A | 1.2249 | |
| 43 | V | A | 2.2316 | |
| 44 | V | A | 1.7352 | |
| 45 | N | A | -0.5044 | |
| 46 | G | A | -0.3436 | |
| 47 | K | A | -0.1427 | |
| 48 | V | A | 1.8845 | |
| 49 | V | A | 2.4371 | |
| 50 | V | A | 1.1069 | |
| 51 | P | A | -0.1858 | |
| 52 | R | A | -1.1748 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | -0.4260 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | Y | A | 0.0000 | |
| 62 | R | A | -1.5371 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2830 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.8675 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.0427 | |
| 70 | T | A | -0.4060 | |
| 71 | L | A | -0.0869 | |
| 72 | P | A | -0.0675 | |
| 73 | L | A | 0.0387 | |
| 74 | P | A | -0.2571 | |
| 75 | S | A | -0.5932 | |
| 76 | A | A | -0.9553 | |
| 77 | D | A | -1.9929 | |
| 78 | F | A | -0.9832 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -2.0935 | |
| 81 | P | A | -1.4616 | |
| 82 | S | A | -0.9349 | |
| 83 | T | A | -0.9024 | |
| 84 | E | A | -1.2003 | |
| 85 | R | A | -1.2370 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.2497 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.1908 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | E | A | -0.5855 | |
| 97 | R | A | 0.0000 | |
| 98 | F | A | 0.4216 | |
| 99 | G | A | -0.3432 | |
| 100 | P | A | -0.3717 | |
| 101 | L | A | -0.2806 | |
| 102 | G | A | 0.0000 | |
| 103 | K | A | -1.4429 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.6760 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.7352 | |
| 108 | H | A | -0.9235 | |
| 109 | A | A | -0.4988 | |
| 110 | N | A | -1.5532 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0396 | |
| 113 | A | A | -0.1565 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.4611 | |
| 117 | I | A | -0.6165 | |
| 118 | D | A | -2.1373 | |
| 119 | N | A | -2.3860 | |
| 120 | P | A | -1.7844 | |
| 121 | T | A | -1.5853 | |
| 122 | E | A | -2.3076 | |
| 123 | Y | A | -1.1332 | |
| 124 | Q | A | -1.8245 | |
| 125 | H | A | -1.7490 | |
| 126 | E | A | -2.6116 | |
| 127 | T | A | -2.5881 | |
| 128 | E | A | -3.0801 | |
| 129 | D | A | -3.1439 | |
| 130 | D | A | -2.1053 | |
| 131 | T | A | -1.0176 | |
| 132 | V | A | 0.3081 | |
| 133 | A | A | 0.1977 | |
| 134 | Y | A | 0.1877 | |
| 135 | S | A | -0.2528 | |
| 136 | W | A | 0.0000 | |
| 137 | R | A | -0.8180 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Y | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | Q | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.4369 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | 0.0624 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.4481 | |
| 155 | Y | A | -0.4966 | |
| 156 | T | A | -0.1951 | |
| 157 | A | A | 0.0000 | |
| 158 | L | A | 0.3771 | |
| 159 | A | A | -0.5101 | |
| 160 | E | A | -1.7744 | |
| 161 | P | A | -0.6013 | |
| 162 | A | A | -0.5913 | |
| 163 | P | A | -0.5697 | |
| 164 | G | A | -0.3513 | |
| 165 | L | A | 0.4007 | |
| 166 | P | A | -0.0495 | |
| 167 | P | A | -0.2269 | |
| 168 | G | A | 0.2048 | |
| 169 | A | A | 1.0139 | |
| 170 | I | A | 2.2846 | |
| 171 | P | A | 0.9544 | |
| 172 | P | A | 0.6165 | |
| 173 | L | A | 1.0803 | |
| 174 | K | A | -0.6448 | |
| 175 | T | A | -0.3511 | |
| 176 | V | A | -0.1404 | |
| 177 | T | A | -0.2262 | |
| 178 | T | A | -0.0459 | |
| 179 | V | A | -0.4098 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.3271 | |
| 182 | D | A | -1.3812 | |
| 183 | G | A | -0.9575 | |
| 184 | D | A | -0.8295 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.1259 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2624 | |
| 190 | F | A | -0.0805 | |
| 191 | G | A | -0.2337 | |
| 192 | A | A | -0.3117 | |
| 193 | K | A | -0.5639 | |
| 194 | D | A | -0.5880 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.1552 | |
| 197 | A | A | -0.3864 | |
| 198 | L | A | -0.0230 | |
| 199 | E | A | 0.0000 | |
| 200 | P | A | -0.9925 | |
| 201 | T | A | -1.1043 | |
| 202 | K | A | -2.5495 | |
| 203 | D | A | -1.6874 | |
| 204 | D | A | -1.2134 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.9257 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.7125 | |
| 211 | D | A | -2.1321 | |
| 212 | T | A | -1.1025 | |
| 213 | T | A | -0.7326 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.4482 | |
| 217 | V | A | 0.0000 | |
| 218 | D | A | -0.3585 | |
| 219 | Y | A | -0.4086 | |
| 220 | A | A | -0.6308 | |
| 221 | G | A | -0.8559 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -2.3886 | |
| 224 | A | A | -1.1090 | |
| 225 | E | A | -1.0214 | |
| 226 | P | A | -0.4292 | |
| 227 | T | A | -0.2005 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.7576 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.6683 | |
| 234 | Y | A | -0.4715 | |
| 235 | D | A | -1.0161 | |
| 236 | K | A | -1.2467 | |
| 237 | Y | A | -0.9103 | |
| 238 | E | A | -1.2518 | |
| 239 | K | A | -1.0028 | |
| 240 | S | A | -0.2525 | |
| 241 | Y | A | 0.5402 | |
| 242 | S | A | 0.1376 | |
| 243 | S | A | -0.4519 | |
| 244 | K | A | -1.0879 | |
| 245 | T | A | -0.4847 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | -0.0281 | |
| 248 | R | A | -0.7319 | |
| 249 | D | A | -1.6014 | |
| 250 | G | A | -0.9922 | |
| 251 | P | A | -0.0461 | |
| 252 | D | A | 0.7742 | |
| 253 | L | A | 2.5412 | |
| 254 | I | A | 2.6220 | |
| 255 | P | A | 1.3311 | |
| 256 | L | A | 1.4576 | |
| 257 | P | A | 0.7139 | |
| 258 | A | A | 0.4914 | |
| 259 | A | A | 0.3285 | |
| 260 | P | A | -0.2080 | |
| 261 | P | A | 0.0526 | |
| 262 | P | A | 0.0837 | |
| 263 | S | A | 0.6206 | |
| 264 | P | A | 0.7416 | |
| 265 | L | A | 1.9322 | |
| 266 | Y | A | 1.7668 | |
| 267 | V | A | 1.9499 | |
| 268 | P | A | 1.1964 | |
| 269 | P | A | 0.6619 | |
| 270 | P | A | -0.1164 | |
| 271 | P | A | -0.0718 | |
| 272 | T | A | -0.0125 | |
| 273 | S | A | 0.2801 | |
| 274 | P | A | 0.4397 | |
| 275 | Y | A | 1.4324 | |
| 276 | A | A | 1.2770 | |
| 277 | V | A | 1.9986 | |
| 278 | L | A | 1.5586 | |
| 279 | P | A | 0.0734 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | 0.4632 | |
| 282 | D | A | -0.0828 | |
| 283 | I | A | 1.5590 | |
| 284 | F | A | 0.8318 | |
| 285 | T | A | 0.4054 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | Q | A | 0.0000 | |
| 290 | G | A | -0.9618 | |
| 291 | E | A | -1.7995 | |
| 292 | I | A | -1.5068 | |
| 293 | T | A | -1.9443 | |
| 294 | E | A | -2.7996 | |
| 295 | E | A | -2.9650 | |
| 296 | D | A | -2.0382 | |
| 297 | E | A | -1.8030 | |
| 298 | L | A | -1.2308 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.2779 | |
| 301 | K | A | -1.8606 | |
| 302 | P | A | -0.9478 | |
| 303 | V | A | 0.1501 | |
| 304 | Y | A | 0.2825 | |
| 305 | I | A | -0.0573 | |
| 306 | T | A | -0.6481 | |
| 307 | K | A | -2.1475 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.4723 | |
| 310 | G | A | -1.5135 | |
| 311 | L | A | -0.3316 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | A | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7580 | |
| 319 | N | A | -0.6967 | |
| 320 | Q | A | -0.6499 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | D | A | 0.0000 | |
| 332 | E | A | -1.8316 | |
| 333 | I | A | -1.4954 | |
| 334 | E | A | -2.1457 | |
| 335 | T | A | -1.3560 | |
| 336 | I | A | -0.4193 | |
| 337 | R | A | -1.4218 | |
| 338 | T | A | -0.6464 | |
| 339 | R | A | -1.0617 | |
| 340 | V | A | 0.9762 | |
| 341 | S | A | 0.0408 | |
| 342 | T | A | -0.8188 | |
| 343 | P | A | -1.3720 | |
| 344 | K | A | -2.3877 | |
| 345 | E | A | -2.5807 | |
| 346 | N | A | -1.4823 | |
| 347 | V | A | 0.6396 | |
| 348 | Y | A | 0.9161 | |
| 349 | D | A | -0.1964 | |
| 350 | P | A | -0.2990 | |
| 351 | S | A | -0.0455 | |
| 352 | N | A | -0.3120 | |
| 353 | Y | A | 0.2643 | |
| 354 | V | A | 1.0221 | |
| 355 | T | A | -0.2613 | |
| 356 | S | A | -0.7318 | |
| 357 | K | A | -1.7251 | |
| 358 | R | A | -1.4207 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.7166 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.1268 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.5802 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.4086 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -0.8776 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7593 | |
| 376 | L | A | -0.4514 | |
| 377 | T | A | -0.6903 | |
| 378 | P | A | -1.0313 | |
| 379 | E | A | -1.8436 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.0028 | |
| 382 | A | A | -1.3740 | |
| 383 | L | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | R | A | -2.2406 | |
| 386 | R | A | -1.7668 | |
| 387 | I | A | -0.7764 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.4578 | |
| 390 | R | A | -1.3943 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.1775 | |
| 394 | D | A | -2.0344 | |
| 395 | A | A | -1.5565 | |
| 396 | K | A | -1.8902 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.3051 | |
| 399 | F | A | 1.6576 | |
| 400 | V | A | 0.8106 | |
| 401 | P | A | 0.3396 | |
| 402 | P | A | -0.3434 | |
| 403 | V | A | 0.2955 | |
| 404 | E | A | -2.1274 | |
| 405 | R | A | -2.4156 | |
| 406 | P | A | -1.7284 | |
| 407 | D | A | -1.7285 | |
| 408 | P | A | -1.0418 | |
| 409 | L | A | 0.0000 | |
| 410 | A | A | -1.0489 | |
| 411 | G | A | -1.3949 | |
| 412 | K | A | -2.0673 | |
| 413 | K | A | -2.7341 | |
| 414 | F | A | -1.9066 | |
| 415 | K | A | -1.9779 | |
| 416 | E | A | -2.7210 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.6712 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.4249 | |
| 421 | N | A | -1.8600 | |
| 422 | K | A | -1.7107 | |
| 423 | L | A | -0.5759 | |
| 424 | S | A | -0.6984 | |
| 425 | T | A | -0.7070 | |
| 426 | E | A | -1.8826 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.3293 | |
| 429 | K | A | -3.3194 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.4593 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.9462 | |
| 435 | E | A | -1.9682 | |
| 436 | Y | A | -0.9295 | |
| 437 | L | A | -0.4535 | |
| 438 | N | A | -1.8535 | |
| 439 | R | A | -2.1752 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine