| Chain sequence(s) |
A: SFNFCLPNLSFRSSCSSRPCVPSSCCGTTLPGACNIPANVGSCNWFCEGSFDGNEKETMQFLNDRLASYLEKVRQLERENAELESRILERSQQQEPLVCPNYQSYFRTIEELQQKILCAKSENARLVVQIDNAKLAADDFRTKYETELGLRQLVESDINGLRRILDELTLCKSDLEAQVESLKEELICLKSNHEEEVNTLRSQLGDRLNVEVDAAPTVDLNRVLNETRAQYEALVETNRRDVEEWYIRQTEELNKQVVSSSEQLQSCQTEIIELRRTVNALEVELQAQHNLRDSLENTLTETEARYSCQLNQVQSLISNVESQLAEIRGDLERQNQEYQVLLDVRARLECEINTYRGLLDSEDCKLPCNPCATTNACGKTITPCISSPCAPAAPCTPCVPRSRCGPCNSYVR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:04)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:04)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:04)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:04)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:04)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:09:55)
[INFO] Main: Simulation completed successfully. (00:10:00)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | 0.6281 | |
| 2 | F | A | 1.7760 | |
| 3 | N | A | 0.9224 | |
| 4 | F | A | 2.4863 | |
| 5 | C | A | 2.0888 | |
| 6 | L | A | 1.9924 | |
| 7 | P | A | 0.6259 | |
| 8 | N | A | -0.0268 | |
| 9 | L | A | 1.2092 | |
| 10 | S | A | 0.5902 | |
| 11 | F | A | 1.1109 | |
| 12 | R | A | -0.8480 | |
| 13 | S | A | -0.5691 | |
| 14 | S | A | -0.3071 | |
| 15 | C | A | 0.0074 | |
| 16 | S | A | -0.4920 | |
| 17 | S | A | -1.0262 | |
| 18 | R | A | -1.6355 | |
| 19 | P | A | -0.4634 | |
| 20 | C | A | 0.8760 | |
| 21 | V | A | 1.6378 | |
| 22 | P | A | 0.6746 | |
| 23 | S | A | 0.3667 | |
| 24 | S | A | 0.3316 | |
| 25 | C | A | 0.7681 | |
| 26 | C | A | 0.7537 | |
| 27 | G | A | 0.1899 | |
| 28 | T | A | 0.3223 | |
| 29 | T | A | 0.4884 | |
| 30 | L | A | 1.2087 | |
| 31 | P | A | 0.3369 | |
| 32 | G | A | -0.1357 | |
| 33 | A | A | 0.2335 | |
| 34 | C | A | 0.4948 | |
| 35 | N | A | -0.0454 | |
| 36 | I | A | 1.3311 | |
| 37 | P | A | 0.3439 | |
| 38 | A | A | 0.1685 | |
| 39 | N | A | -0.3609 | |
| 40 | V | A | 0.9481 | |
| 41 | G | A | -0.0261 | |
| 42 | S | A | 0.0405 | |
| 43 | C | A | 0.6423 | |
| 44 | N | A | 0.0770 | |
| 45 | W | A | 1.6372 | |
| 46 | F | A | 2.1681 | |
| 47 | C | A | 0.7737 | |
| 48 | E | A | -1.1216 | |
| 49 | G | A | -0.6032 | |
| 50 | S | A | -0.3587 | |
| 51 | F | A | 0.3960 | |
| 52 | D | A | -1.8249 | |
| 53 | G | A | -2.2730 | |
| 54 | N | A | -3.5120 | |
| 55 | E | A | -3.7758 | |
| 56 | K | A | -3.7911 | |
| 57 | E | A | -3.3566 | |
| 58 | T | A | -1.9407 | |
| 59 | M | A | -1.5411 | |
| 60 | Q | A | -2.1780 | |
| 61 | F | A | -0.1817 | |
| 62 | L | A | -0.1728 | |
| 63 | N | A | -1.4243 | |
| 64 | D | A | -1.7307 | |
| 65 | R | A | -1.1627 | |
| 66 | L | A | 0.1720 | |
| 67 | A | A | -0.4179 | |
| 68 | S | A | -1.0062 | |
| 69 | Y | A | 0.2098 | |
| 70 | L | A | 0.0648 | |
| 71 | E | A | -2.1990 | |
| 72 | K | A | -2.0347 | |
| 73 | V | A | -1.1577 | |
| 74 | R | A | -3.4589 | |
| 75 | Q | A | -3.1580 | |
| 76 | L | A | -2.6694 | |
| 77 | E | A | -4.1851 | |
| 78 | R | A | -4.5699 | |
| 79 | E | A | -3.8961 | |
| 80 | N | A | -3.8205 | |
| 81 | A | A | -3.0434 | |
| 82 | E | A | -2.9519 | |
| 83 | L | A | -1.5291 | |
| 84 | E | A | -2.2998 | |
| 85 | S | A | -1.8589 | |
| 86 | R | A | -2.1965 | |
| 87 | I | A | -0.6005 | |
| 88 | L | A | -0.8486 | |
| 89 | E | A | -3.1315 | |
| 90 | R | A | -3.7383 | |
| 91 | S | A | -2.6244 | |
| 92 | Q | A | -3.4603 | |
| 93 | Q | A | -3.7698 | |
| 94 | Q | A | -3.4498 | |
| 95 | E | A | -2.7528 | |
| 96 | P | A | -0.5564 | |
| 97 | L | A | 1.3286 | |
| 98 | V | A | 1.7371 | |
| 99 | C | A | 0.9983 | |
| 100 | P | A | 0.1693 | |
| 101 | N | A | -0.2654 | |
| 102 | Y | A | 1.2490 | |
| 103 | Q | A | 0.4583 | |
| 104 | S | A | -0.0182 | |
| 105 | Y | A | 1.1172 | |
| 106 | F | A | 0.8651 | |
| 107 | R | A | -1.4721 | |
| 108 | T | A | -0.5940 | |
| 109 | I | A | -0.3539 | |
| 110 | E | A | -2.6331 | |
| 111 | E | A | -2.7204 | |
| 112 | L | A | -0.6617 | |
| 113 | Q | A | -1.6520 | |
| 114 | Q | A | -2.2041 | |
| 115 | K | A | -1.8408 | |
| 116 | I | A | -0.5363 | |
| 117 | L | A | -0.2432 | |
| 118 | C | A | -0.5705 | |
| 119 | A | A | -1.7087 | |
| 120 | K | A | -2.3547 | |
| 121 | S | A | -1.7614 | |
| 122 | E | A | -2.3955 | |
| 123 | N | A | -2.0190 | |
| 124 | A | A | -0.9853 | |
| 125 | R | A | -1.4373 | |
| 126 | L | A | 0.3996 | |
| 127 | V | A | 1.6177 | |
| 128 | V | A | 0.8954 | |
| 129 | Q | A | -0.2774 | |
| 130 | I | A | 0.5500 | |
| 131 | D | A | -0.7803 | |
| 132 | N | A | -1.3060 | |
| 133 | A | A | -1.2760 | |
| 134 | K | A | -2.0531 | |
| 135 | L | A | -1.0441 | |
| 136 | A | A | -1.1373 | |
| 137 | A | A | -1.8442 | |
| 138 | D | A | -2.8404 | |
| 139 | D | A | -2.5843 | |
| 140 | F | A | -0.8687 | |
| 141 | R | A | -2.7519 | |
| 142 | T | A | -2.6858 | |
| 143 | K | A | -2.7594 | |
| 144 | Y | A | -1.3873 | |
| 145 | E | A | -2.6311 | |
| 146 | T | A | -2.0041 | |
| 147 | E | A | -2.4466 | |
| 148 | L | A | -1.2755 | |
| 149 | G | A | -1.0697 | |
| 150 | L | A | -0.0090 | |
| 151 | R | A | -2.2072 | |
| 152 | Q | A | -1.6613 | |
| 153 | L | A | 0.0807 | |
| 154 | V | A | -0.4227 | |
| 155 | E | A | -2.0337 | |
| 156 | S | A | -1.5463 | |
| 157 | D | A | -1.9952 | |
| 158 | I | A | -0.6663 | |
| 159 | N | A | -1.5519 | |
| 160 | G | A | -1.0212 | |
| 161 | L | A | -0.1769 | |
| 162 | R | A | -1.9269 | |
| 163 | R | A | -2.2524 | |
| 164 | I | A | 0.5773 | |
| 165 | L | A | 0.5708 | |
| 166 | D | A | -1.6675 | |
| 167 | E | A | -1.2212 | |
| 168 | L | A | 0.3206 | |
| 169 | T | A | -0.1842 | |
| 170 | L | A | 0.3611 | |
| 171 | C | A | -0.3177 | |
| 172 | K | A | -1.9470 | |
| 173 | S | A | -1.4701 | |
| 174 | D | A | -1.8170 | |
| 175 | L | A | -1.1582 | |
| 176 | E | A | -2.3878 | |
| 177 | A | A | -1.9396 | |
| 178 | Q | A | -1.6016 | |
| 179 | V | A | -0.4224 | |
| 180 | E | A | -2.3727 | |
| 181 | S | A | -1.5678 | |
| 182 | L | A | -0.2212 | |
| 183 | K | A | -1.5604 | |
| 184 | E | A | -2.1177 | |
| 185 | E | A | -1.6006 | |
| 186 | L | A | 0.1291 | |
| 187 | I | A | 0.7292 | |
| 188 | C | A | 0.0519 | |
| 189 | L | A | -0.0356 | |
| 190 | K | A | -2.1305 | |
| 191 | S | A | -2.0262 | |
| 192 | N | A | -2.9834 | |
| 193 | H | A | -3.5803 | |
| 194 | E | A | -4.0602 | |
| 195 | E | A | -4.3754 | |
| 196 | E | A | -3.5841 | |
| 197 | V | A | -1.4983 | |
| 198 | N | A | -2.2591 | |
| 199 | T | A | -1.5317 | |
| 200 | L | A | -0.0948 | |
| 201 | R | A | -1.8693 | |
| 202 | S | A | -1.7419 | |
| 203 | Q | A | -1.6458 | |
| 204 | L | A | -0.7048 | |
| 205 | G | A | -1.8226 | |
| 206 | D | A | -2.9244 | |
| 207 | R | A | -2.0584 | |
| 208 | L | A | 0.1498 | |
| 209 | N | A | -0.5751 | |
| 210 | V | A | 0.7225 | |
| 211 | E | A | -0.6235 | |
| 212 | V | A | 0.4989 | |
| 213 | D | A | -1.1559 | |
| 214 | A | A | -0.5703 | |
| 215 | A | A | -0.0138 | |
| 216 | P | A | -0.2272 | |
| 217 | T | A | 0.3963 | |
| 218 | V | A | 0.9423 | |
| 219 | D | A | -0.9579 | |
| 220 | L | A | 0.1000 | |
| 221 | N | A | -1.8637 | |
| 222 | R | A | -2.7497 | |
| 223 | V | A | -0.9545 | |
| 224 | L | A | -1.5750 | |
| 225 | N | A | -2.9832 | |
| 226 | E | A | -3.2782 | |
| 227 | T | A | -2.3787 | |
| 228 | R | A | -3.0264 | |
| 229 | A | A | -2.0309 | |
| 230 | Q | A | -1.6234 | |
| 231 | Y | A | -0.2725 | |
| 232 | E | A | -1.4760 | |
| 233 | A | A | -0.5045 | |
| 234 | L | A | 0.4013 | |
| 235 | V | A | 0.3122 | |
| 236 | E | A | -1.1825 | |
| 237 | T | A | -1.5858 | |
| 238 | N | A | -2.5736 | |
| 239 | R | A | -2.9824 | |
| 240 | R | A | -3.6359 | |
| 241 | D | A | -2.9204 | |
| 242 | V | A | -0.8372 | |
| 243 | E | A | -1.9911 | |
| 244 | E | A | -2.1623 | |
| 245 | W | A | -0.1294 | |
| 246 | Y | A | 0.5177 | |
| 247 | I | A | 0.0405 | |
| 248 | R | A | -1.9716 | |
| 249 | Q | A | -1.7156 | |
| 250 | T | A | -1.6460 | |
| 251 | E | A | -3.0949 | |
| 252 | E | A | -2.8550 | |
| 253 | L | A | -1.2606 | |
| 254 | N | A | -2.2165 | |
| 255 | K | A | -2.4003 | |
| 256 | Q | A | -1.4442 | |
| 257 | V | A | 0.4809 | |
| 258 | V | A | 0.6890 | |
| 259 | S | A | -0.6710 | |
| 260 | S | A | -0.5809 | |
| 261 | S | A | -0.4935 | |
| 262 | E | A | -1.9562 | |
| 263 | Q | A | -1.4723 | |
| 264 | L | A | -0.4346 | |
| 265 | Q | A | -1.9162 | |
| 266 | S | A | -1.4972 | |
| 267 | C | A | -0.7712 | |
| 268 | Q | A | -1.0471 | |
| 269 | T | A | -1.0776 | |
| 270 | E | A | -1.7491 | |
| 271 | I | A | -0.2695 | |
| 272 | I | A | -0.3250 | |
| 273 | E | A | -2.2187 | |
| 274 | L | A | -0.9582 | |
| 275 | R | A | -2.2061 | |
| 276 | R | A | -2.9173 | |
| 277 | T | A | -1.1030 | |
| 278 | V | A | -1.0005 | |
| 279 | N | A | -2.0362 | |
| 280 | A | A | -0.7157 | |
| 281 | L | A | -0.2350 | |
| 282 | E | A | -1.4369 | |
| 283 | V | A | -0.1012 | |
| 284 | E | A | -1.5344 | |
| 285 | L | A | -0.8553 | |
| 286 | Q | A | -1.8852 | |
| 287 | A | A | -1.7222 | |
| 288 | Q | A | -2.3486 | |
| 289 | H | A | -2.7887 | |
| 290 | N | A | -2.9586 | |
| 291 | L | A | -1.5251 | |
| 292 | R | A | -3.4556 | |
| 293 | D | A | -3.5922 | |
| 294 | S | A | -1.9412 | |
| 295 | L | A | -1.0671 | |
| 296 | E | A | -2.6566 | |
| 297 | N | A | -2.5093 | |
| 298 | T | A | -1.2960 | |
| 299 | L | A | -0.5581 | |
| 300 | T | A | -1.4920 | |
| 301 | E | A | -2.2455 | |
| 302 | T | A | -1.6755 | |
| 303 | E | A | -2.1746 | |
| 304 | A | A | -1.5054 | |
| 305 | R | A | -1.9480 | |
| 306 | Y | A | -0.6512 | |
| 307 | S | A | -0.8655 | |
| 308 | C | A | -0.7604 | |
| 309 | Q | A | -1.3043 | |
| 310 | L | A | -0.2805 | |
| 311 | N | A | -1.1900 | |
| 312 | Q | A | -0.9215 | |
| 313 | V | A | 0.0090 | |
| 314 | Q | A | -0.8989 | |
| 315 | S | A | -0.4646 | |
| 316 | L | A | 1.0562 | |
| 317 | I | A | 0.7853 | |
| 318 | S | A | -0.2908 | |
| 319 | N | A | -0.5919 | |
| 320 | V | A | 0.5500 | |
| 321 | E | A | -1.3279 | |
| 322 | S | A | -1.3997 | |
| 323 | Q | A | -1.5129 | |
| 324 | L | A | -1.0143 | |
| 325 | A | A | -1.5864 | |
| 326 | E | A | -2.4545 | |
| 327 | I | A | -1.2980 | |
| 328 | R | A | -2.7092 | |
| 329 | G | A | -2.8467 | |
| 330 | D | A | -2.9420 | |
| 331 | L | A | -2.4736 | |
| 332 | E | A | -4.2416 | |
| 333 | R | A | -4.6274 | |
| 334 | Q | A | -3.9480 | |
| 335 | N | A | -3.5228 | |
| 336 | Q | A | -3.4192 | |
| 337 | E | A | -2.8060 | |
| 338 | Y | A | -0.7397 | |
| 339 | Q | A | -1.0667 | |
| 340 | V | A | 0.4194 | |
| 341 | L | A | 0.4927 | |
| 342 | L | A | 0.0963 | |
| 343 | D | A | -1.1119 | |
| 344 | V | A | 0.1443 | |
| 345 | R | A | -1.6886 | |
| 346 | A | A | -1.5446 | |
| 347 | R | A | -2.2711 | |
| 348 | L | A | -1.0744 | |
| 349 | E | A | -2.3490 | |
| 350 | C | A | -1.4404 | |
| 351 | E | A | -2.0869 | |
| 352 | I | A | -0.7210 | |
| 353 | N | A | -1.6046 | |
| 354 | T | A | -0.5418 | |
| 355 | Y | A | 0.2689 | |
| 356 | R | A | -1.5478 | |
| 357 | G | A | -1.2740 | |
| 358 | L | A | -0.0262 | |
| 359 | L | A | -0.9532 | |
| 360 | D | A | -2.6727 | |
| 361 | S | A | -1.8662 | |
| 362 | E | A | -2.7517 | |
| 363 | D | A | -2.6904 | |
| 364 | C | A | -1.4048 | |
| 365 | K | A | -1.9996 | |
| 366 | L | A | -0.0481 | |
| 367 | P | A | -0.0671 | |
| 368 | C | A | 0.2728 | |
| 369 | N | A | -0.7298 | |
| 370 | P | A | -0.3372 | |
| 371 | C | A | 0.3936 | |
| 372 | A | A | 0.0215 | |
| 373 | T | A | -0.2299 | |
| 374 | T | A | -0.5785 | |
| 375 | N | A | -1.1696 | |
| 376 | A | A | -0.5159 | |
| 377 | C | A | -0.1658 | |
| 378 | G | A | -0.8631 | |
| 379 | K | A | -1.2906 | |
| 380 | T | A | -0.0866 | |
| 381 | I | A | 1.4978 | |
| 382 | T | A | 1.0116 | |
| 383 | P | A | 1.0342 | |
| 384 | C | A | 1.7423 | |
| 385 | I | A | 2.1053 | |
| 386 | S | A | 0.8474 | |
| 387 | S | A | 0.3572 | |
| 388 | P | A | 0.1566 | |
| 389 | C | A | 0.5045 | |
| 390 | A | A | 0.2213 | |
| 391 | P | A | -0.0686 | |
| 392 | A | A | 0.0999 | |
| 393 | A | A | 0.0752 | |
| 394 | P | A | 0.0683 | |
| 395 | C | A | 0.6257 | |
| 396 | T | A | 0.4944 | |
| 397 | P | A | 0.6194 | |
| 398 | C | A | 1.2349 | |
| 399 | V | A | 1.4515 | |
| 400 | P | A | -0.3917 | |
| 401 | R | A | -1.8454 | |
| 402 | S | A | -1.7514 | |
| 403 | R | A | -2.1711 | |
| 404 | C | A | -0.6363 | |
| 405 | G | A | -0.7479 | |
| 406 | P | A | -0.5222 | |
| 407 | C | A | 0.0689 | |
| 408 | N | A | -0.5963 | |
| 409 | S | A | 0.2531 | |
| 410 | Y | A | 1.3776 | |
| 411 | V | A | 1.3232 | |
| 412 | R | A | -0.6897 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine