| Chain sequence(s) |
A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:15)
[INFO] Main: Simulation completed successfully. (00:02:18)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.6925 | |
| 2 | A | A | -0.3660 | |
| 3 | E | A | -2.0495 | |
| 4 | P | A | -2.4585 | |
| 5 | R | A | -3.1994 | |
| 6 | Q | A | -2.9152 | |
| 7 | E | A | -2.1599 | |
| 8 | F | A | 0.2977 | |
| 9 | E | A | -0.5781 | |
| 10 | V | A | 0.9690 | |
| 11 | M | A | 0.2737 | |
| 12 | E | A | -2.0881 | |
| 13 | D | A | -2.7124 | |
| 14 | H | A | -2.1961 | |
| 15 | A | A | -1.2366 | |
| 16 | G | A | -0.6316 | |
| 17 | T | A | 0.2408 | |
| 18 | Y | A | 1.3207 | |
| 19 | G | A | 0.6363 | |
| 20 | L | A | 0.7332 | |
| 21 | G | A | -1.4801 | |
| 22 | D | A | -3.2153 | |
| 23 | R | A | -4.0718 | |
| 24 | K | A | -4.2793 | |
| 25 | D | A | -4.0271 | |
| 26 | Q | A | -2.9987 | |
| 27 | G | A | -1.7166 | |
| 28 | G | A | -0.2076 | |
| 29 | Y | A | 1.1327 | |
| 30 | T | A | 0.5969 | |
| 31 | M | A | 0.3759 | |
| 32 | H | A | -1.5393 | |
| 33 | Q | A | -2.7908 | |
| 34 | D | A | -3.4735 | |
| 35 | Q | A | -3.6496 | |
| 36 | E | A | -3.5219 | |
| 37 | G | A | -2.5563 | |
| 38 | D | A | -2.9970 | |
| 39 | T | A | -1.8982 | |
| 40 | D | A | -2.2909 | |
| 41 | A | A | -0.7452 | |
| 42 | G | A | -0.4349 | |
| 43 | L | A | 0.1001 | |
| 44 | K | A | -2.0677 | |
| 45 | E | A | -2.5765 | |
| 46 | S | A | -1.2417 | |
| 47 | P | A | -0.2327 | |
| 48 | L | A | 0.7129 | |
| 49 | Q | A | -0.4915 | |
| 50 | T | A | -0.4640 | |
| 51 | P | A | -0.9404 | |
| 52 | T | A | -1.4590 | |
| 53 | E | A | -3.0374 | |
| 54 | D | A | -3.0967 | |
| 55 | G | A | -2.2549 | |
| 56 | S | A | -2.2849 | |
| 57 | E | A | -2.9568 | |
| 58 | E | A | -2.9793 | |
| 59 | P | A | -1.9322 | |
| 60 | G | A | -1.4394 | |
| 61 | S | A | -1.3784 | |
| 62 | E | A | -2.0956 | |
| 63 | T | A | -1.5684 | |
| 64 | S | A | -1.4846 | |
| 65 | D | A | -2.2807 | |
| 66 | A | A | -1.7232 | |
| 67 | K | A | -2.2180 | |
| 68 | S | A | -1.1488 | |
| 69 | T | A | -0.7031 | |
| 70 | P | A | -0.3561 | |
| 71 | T | A | -0.6098 | |
| 72 | A | A | -1.3122 | |
| 73 | E | A | -2.2554 | |
| 74 | D | A | -1.8053 | |
| 75 | V | A | 0.4588 | |
| 76 | T | A | 0.2151 | |
| 77 | A | A | 0.6204 | |
| 78 | P | A | 0.9090 | |
| 79 | L | A | 1.9095 | |
| 80 | V | A | 1.1557 | |
| 81 | D | A | -1.4167 | |
| 82 | E | A | -2.5121 | |
| 83 | G | A | -1.7343 | |
| 84 | A | A | -0.7920 | |
| 85 | P | A | -0.9136 | |
| 86 | G | A | -1.6337 | |
| 87 | K | A | -2.5519 | |
| 88 | Q | A | -2.0664 | |
| 89 | A | A | -0.9689 | |
| 90 | A | A | -0.3867 | |
| 91 | A | A | -0.5216 | |
| 92 | Q | A | -1.4617 | |
| 93 | P | A | -1.3029 | |
| 94 | H | A | -1.7772 | |
| 95 | T | A | -1.1931 | |
| 96 | E | A | -1.1903 | |
| 97 | I | A | 0.6515 | |
| 98 | P | A | -0.5408 | |
| 99 | E | A | -1.7897 | |
| 100 | G | A | -1.4600 | |
| 101 | T | A | -0.6871 | |
| 102 | T | A | -0.5806 | |
| 103 | A | A | -1.4357 | |
| 104 | E | A | -2.8192 | |
| 105 | E | A | -2.8974 | |
| 106 | A | A | -0.9897 | |
| 107 | G | A | -0.1433 | |
| 108 | I | A | 1.1388 | |
| 109 | G | A | -0.5243 | |
| 110 | D | A | -1.6845 | |
| 111 | T | A | -1.0408 | |
| 112 | P | A | -0.6349 | |
| 113 | S | A | -0.4367 | |
| 114 | L | A | -0.2110 | |
| 115 | E | A | -2.4556 | |
| 116 | D | A | -3.1264 | |
| 117 | E | A | -2.9283 | |
| 118 | A | A | -1.5961 | |
| 119 | A | A | -0.9517 | |
| 120 | G | A | -0.5637 | |
| 121 | H | A | -0.3344 | |
| 122 | V | A | 0.8576 | |
| 123 | T | A | -0.0018 | |
| 124 | Q | A | -1.1612 | |
| 125 | A | A | -1.1157 | |
| 126 | R | A | -1.1939 | |
| 127 | M | A | 1.0856 | |
| 128 | V | A | 1.5059 | |
| 129 | S | A | -0.1174 | |
| 130 | K | A | -1.9022 | |
| 131 | S | A | -2.4296 | |
| 132 | K | A | -3.2497 | |
| 133 | D | A | -3.0261 | |
| 134 | G | A | -2.0282 | |
| 135 | T | A | -0.9518 | |
| 136 | G | A | -1.0951 | |
| 137 | S | A | -1.7146 | |
| 138 | D | A | -3.2990 | |
| 139 | D | A | -3.9712 | |
| 140 | K | A | -3.8212 | |
| 141 | K | A | -3.4022 | |
| 142 | A | A | -2.2549 | |
| 143 | K | A | -2.3111 | |
| 144 | G | A | -1.9404 | |
| 145 | A | A | -1.5896 | |
| 146 | D | A | -2.4323 | |
| 147 | G | A | -2.2076 | |
| 148 | K | A | -2.7185 | |
| 149 | T | A | -1.5473 | |
| 150 | K | A | -1.1652 | |
| 151 | I | A | 1.1988 | |
| 152 | A | A | 0.6120 | |
| 153 | T | A | -0.1949 | |
| 154 | P | A | -1.2684 | |
| 155 | R | A | -2.2001 | |
| 156 | G | A | -1.3797 | |
| 157 | A | A | -0.5513 | |
| 158 | A | A | -0.1770 | |
| 159 | P | A | -0.4538 | |
| 160 | P | A | -0.8694 | |
| 161 | G | A | -1.6530 | |
| 162 | Q | A | -2.4023 | |
| 163 | K | A | -2.9004 | |
| 164 | G | A | -2.2969 | |
| 165 | Q | A | -2.1022 | |
| 166 | A | A | -1.2862 | |
| 167 | N | A | -1.4728 | |
| 168 | A | A | -0.9819 | |
| 169 | T | A | -0.8208 | |
| 170 | R | A | -0.9559 | |
| 171 | I | A | 0.9966 | |
| 172 | P | A | -0.0251 | |
| 173 | A | A | -0.4262 | |
| 174 | K | A | -1.8162 | |
| 175 | T | A | -1.0712 | |
| 176 | P | A | -0.8219 | |
| 177 | P | A | -0.4417 | |
| 178 | A | A | -0.6197 | |
| 179 | P | A | -1.1233 | |
| 180 | K | A | -1.9004 | |
| 181 | T | A | -1.1425 | |
| 182 | P | A | -0.8598 | |
| 183 | P | A | -0.5523 | |
| 184 | S | A | -0.5956 | |
| 185 | S | A | -1.0706 | |
| 186 | G | A | -1.6978 | |
| 187 | E | A | -2.3040 | |
| 188 | P | A | -1.7223 | |
| 189 | P | A | -1.6550 | |
| 190 | K | A | -2.0991 | |
| 191 | S | A | -1.9221 | |
| 192 | G | A | -2.2865 | |
| 193 | D | A | -3.1281 | |
| 194 | R | A | -2.9590 | |
| 195 | S | A | -1.6876 | |
| 196 | G | A | -0.6390 | |
| 197 | Y | A | 0.6647 | |
| 198 | S | A | 0.0957 | |
| 199 | S | A | -0.2965 | |
| 200 | P | A | -0.5237 | |
| 201 | G | A | -0.9012 | |
| 202 | S | A | -0.7716 | |
| 203 | P | A | -0.7724 | |
| 204 | G | A | -0.8505 | |
| 205 | T | A | -0.6650 | |
| 206 | P | A | -0.9006 | |
| 207 | G | A | -1.1816 | |
| 208 | S | A | -1.4570 | |
| 209 | R | A | -2.6005 | |
| 210 | S | A | -2.1040 | |
| 211 | R | A | -2.4602 | |
| 212 | T | A | -1.2078 | |
| 213 | P | A | -0.5439 | |
| 214 | S | A | 0.3557 | |
| 215 | L | A | 1.2539 | |
| 216 | P | A | 0.3623 | |
| 217 | T | A | -0.1059 | |
| 218 | P | A | -0.5048 | |
| 219 | P | A | -0.8148 | |
| 220 | T | A | -1.6278 | |
| 221 | R | A | -2.8780 | |
| 222 | E | A | -3.2315 | |
| 223 | P | A | -2.5492 | |
| 224 | K | A | -2.6239 | |
| 225 | K | A | -1.5064 | |
| 226 | V | A | 1.1916 | |
| 227 | A | A | 1.5420 | |
| 228 | V | A | 2.4488 | |
| 229 | V | A | 1.8926 | |
| 230 | R | A | -0.6834 | |
| 231 | T | A | -0.7066 | |
| 232 | P | A | -1.1895 | |
| 233 | P | A | -1.6129 | |
| 234 | K | A | -2.0799 | |
| 235 | S | A | -1.3507 | |
| 236 | P | A | -0.8978 | |
| 237 | S | A | -0.9331 | |
| 238 | S | A | -0.8715 | |
| 239 | A | A | -1.2868 | |
| 240 | K | A | -2.2197 | |
| 241 | S | A | -1.6319 | |
| 242 | R | A | -2.0709 | |
| 243 | L | A | -0.2708 | |
| 244 | Q | A | -1.0470 | |
| 245 | T | A | -0.1652 | |
| 246 | A | A | 0.2482 | |
| 247 | P | A | 0.5622 | |
| 248 | V | A | 1.7837 | |
| 249 | P | A | 0.7087 | |
| 250 | M | A | 1.0373 | |
| 251 | P | A | -0.1727 | |
| 252 | D | A | -1.4671 | |
| 253 | L | A | -0.1059 | |
| 254 | K | A | -1.9394 | |
| 255 | N | A | -1.6201 | |
| 256 | V | A | -0.1804 | |
| 257 | K | A | -1.4635 | |
| 258 | S | A | -1.0699 | |
| 259 | K | A | -1.2044 | |
| 260 | I | A | 0.3840 | |
| 261 | G | A | -0.8367 | |
| 262 | S | A | -0.6280 | |
| 263 | T | A | -1.1939 | |
| 264 | E | A | -2.2697 | |
| 265 | N | A | -2.2270 | |
| 266 | L | A | -0.9539 | |
| 267 | K | A | -2.5121 | |
| 268 | H | A | -2.2879 | |
| 269 | Q | A | -2.2168 | |
| 270 | P | A | -1.7482 | |
| 271 | G | A | -1.6539 | |
| 272 | G | A | -1.3298 | |
| 273 | G | A | -1.3071 | |
| 274 | K | A | -1.3387 | |
| 275 | V | A | 0.9269 | |
| 276 | Q | A | 0.7407 | |
| 277 | I | A | 2.7287 | |
| 278 | V | A | 2.8088 | |
| 279 | Y | A | 1.8917 | |
| 280 | K | A | -0.2623 | |
| 281 | P | A | 0.0950 | |
| 282 | V | A | 0.9255 | |
| 283 | D | A | -0.5558 | |
| 284 | L | A | 1.0891 | |
| 285 | S | A | -0.1084 | |
| 286 | K | A | -0.7925 | |
| 287 | V | A | 0.8703 | |
| 288 | T | A | 0.0837 | |
| 289 | S | A | -0.6236 | |
| 290 | K | A | -1.3962 | |
| 291 | C | A | -0.2511 | |
| 292 | G | A | -0.3414 | |
| 293 | S | A | 0.2022 | |
| 294 | L | A | 1.2711 | |
| 295 | G | A | -0.1335 | |
| 296 | N | A | -0.7244 | |
| 297 | I | A | 0.6257 | |
| 298 | H | A | -1.4570 | |
| 299 | H | A | -2.1845 | |
| 300 | K | A | -2.4917 | |
| 301 | P | A | -1.8799 | |
| 302 | G | A | -1.6969 | |
| 303 | G | A | -1.3006 | |
| 304 | G | A | -1.1372 | |
| 305 | Q | A | -1.0470 | |
| 306 | V | A | 0.3916 | |
| 307 | E | A | -0.9766 | |
| 308 | V | A | 0.1370 | |
| 309 | K | A | -1.9385 | |
| 310 | S | A | -1.9024 | |
| 311 | E | A | -2.7738 | |
| 312 | K | A | -2.3022 | |
| 313 | L | A | -0.3528 | |
| 314 | D | A | -1.6552 | |
| 315 | F | A | -0.1903 | |
| 316 | K | A | -2.2055 | |
| 317 | D | A | -2.9863 | |
| 318 | R | A | -2.3648 | |
| 319 | V | A | -0.5411 | |
| 320 | Q | A | -1.4350 | |
| 321 | S | A | -0.8246 | |
| 322 | K | A | -1.0915 | |
| 323 | I | A | 0.9013 | |
| 324 | G | A | -0.1288 | |
| 325 | S | A | 0.2369 | |
| 326 | L | A | 0.9340 | |
| 327 | D | A | -1.4053 | |
| 328 | N | A | -0.8962 | |
| 329 | I | A | 1.2823 | |
| 330 | T | A | 0.3692 | |
| 331 | H | A | -0.3227 | |
| 332 | V | A | 1.1045 | |
| 333 | P | A | -0.1010 | |
| 334 | G | A | -0.7983 | |
| 335 | G | A | -1.3377 | |
| 336 | G | A | -2.2160 | |
| 337 | N | A | -2.7408 | |
| 338 | K | A | -3.0396 | |
| 339 | K | A | -2.4945 | |
| 340 | I | A | -0.4164 | |
| 341 | E | A | -2.0190 | |
| 342 | T | A | -1.3787 | |
| 343 | H | A | -1.6703 | |
| 344 | K | A | -1.4321 | |
| 345 | L | A | 0.7335 | |
| 346 | T | A | -0.0474 | |
| 347 | F | A | 0.1530 | |
| 348 | R | A | -2.1987 | |
| 349 | E | A | -3.0621 | |
| 350 | N | A | -2.4993 | |
| 351 | A | A | -1.9563 | |
| 352 | K | A | -2.8124 | |
| 353 | A | A | -1.9577 | |
| 354 | K | A | -2.8606 | |
| 355 | T | A | -2.3546 | |
| 356 | D | A | -2.8614 | |
| 357 | H | A | -2.5733 | |
| 358 | G | A | -1.8060 | |
| 359 | A | A | -0.7739 | |
| 360 | E | A | -0.3641 | |
| 361 | I | A | 2.1010 | |
| 362 | V | A | 2.3401 | |
| 363 | Y | A | 1.5993 | |
| 364 | K | A | -0.2086 | |
| 365 | S | A | 0.1380 | |
| 366 | P | A | 0.7037 | |
| 367 | V | A | 2.1174 | |
| 368 | V | A | 2.0913 | |
| 369 | S | A | 0.4240 | |
| 370 | G | A | -0.8353 | |
| 371 | D | A | -1.9621 | |
| 372 | T | A | -1.4909 | |
| 373 | S | A | -1.4720 | |
| 374 | P | A | -1.4928 | |
| 375 | R | A | -2.1394 | |
| 376 | H | A | -1.4316 | |
| 377 | L | A | 0.3820 | |
| 378 | S | A | 0.0004 | |
| 379 | N | A | -0.3721 | |
| 380 | V | A | 1.1387 | |
| 381 | S | A | 0.1603 | |
| 382 | S | A | -0.2703 | |
| 383 | T | A | -0.0460 | |
| 384 | G | A | -0.3583 | |
| 385 | S | A | 0.1100 | |
| 386 | I | A | 1.4575 | |
| 387 | D | A | -0.1472 | |
| 388 | M | A | 1.0675 | |
| 389 | V | A | 1.0108 | |
| 390 | D | A | -0.9366 | |
| 391 | S | A | -0.6652 | |
| 392 | P | A | -0.4924 | |
| 393 | Q | A | -0.4739 | |
| 394 | L | A | 0.7275 | |
| 395 | A | A | -0.1466 | |
| 396 | T | A | -0.1334 | |
| 397 | L | A | 0.9936 | |
| 398 | A | A | 0.1508 | |
| 399 | D | A | -1.3740 | |
| 400 | E | A | -1.0571 | |
| 401 | V | A | 0.6921 | |
| 402 | S | A | -0.4040 | |
| 403 | A | A | -0.8555 | |
| 404 | S | A | -0.6409 | |
| 405 | L | A | 0.0609 | |
| 406 | A | A | -0.5329 | |
| 407 | K | A | -1.7421 | |
| 408 | Q | A | -1.5192 | |
| 409 | G | A | -0.6212 | |
| 410 | L | A | 0.9126 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine