Project name: 6cb998ef2a487f0

Chain sequence(s)	H: EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSGISGSGGFTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKPPRGYNYGPFDYWGQGTLVTVSS; L: SYVLTQPPSVSVAPGQTARITCGGNNIGSKSVHWYQQKPGQAPVLVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDSSSDHVVFGGGTKLTVL
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:28)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:30)

• Minimal score value: -3.0156
• Maximal score value: 1.7077
• Average score: -0.5281
• Total score value: -120.9358

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0378
2	V	H	-1.0461
3	Q	H	-1.1365
4	L	H	0.0000
5	L	H	0.4011
6	E	H	0.0000
7	S	H	-0.0996
8	G	H	-0.5193
9	G	H	0.2711
11	G	H	0.8295
12	L	H	1.4137
13	V	H	-0.0205
14	Q	H	-1.3328
15	P	H	-1.6281
16	G	H	-1.4239
17	G	H	-0.9915
18	S	H	-1.0101
19	L	H	-0.5046
20	R	H	-1.1083
21	L	H	0.0000
22	S	H	-0.2339
23	C	H	0.0000
24	A	H	-0.2945
25	A	H	0.0000
26	S	H	-1.0188
27	G	H	-1.1924
28	F	H	-0.4807
29	T	H	-0.2530
30	F	H	0.0000
35	S	H	-0.8097
36	S	H	-0.3712
37	Y	H	-0.0967
38	A	H	0.1570
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6067
45	A	H	-1.0092
46	P	H	-0.7984
47	G	H	-1.4845
48	K	H	-2.2639
49	G	H	-1.4918
50	L	H	0.0000
51	E	H	-0.8493
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	G	H	0.0000
56	I	H	0.0000
57	S	H	0.4555
58	G	H	-0.1369
59	S	H	-0.3163
62	G	H	-0.1018
63	G	H	0.2963
64	F	H	1.6368
65	T	H	0.8677
66	Y	H	0.0747
67	Y	H	-0.9803
68	A	H	0.0000
69	D	H	-2.5016
70	S	H	-1.7521
71	V	H	0.0000
72	K	H	-2.5995
74	G	H	-1.7236
75	R	H	-1.4136
76	F	H	0.0000
77	T	H	-0.6586
78	I	H	0.0000
79	S	H	-0.1695
80	R	H	-0.9416
81	D	H	-1.4942
82	N	H	-1.7306
83	S	H	-1.5716
84	K	H	-2.3480
85	N	H	-1.6989
86	T	H	-0.9967
87	L	H	0.0000
88	Y	H	-0.2725
89	L	H	0.0000
90	Q	H	-0.7066
91	M	H	0.0000
92	N	H	-1.1733
93	S	H	-1.2450
94	L	H	0.0000
95	R	H	-2.2829
96	A	H	-1.6984
97	E	H	-2.2327
98	D	H	0.0000
99	T	H	-0.3455
100	A	H	0.0000
101	V	H	0.8171
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	K	H	0.0000
107	P	H	0.0000
108	P	H	-0.2416
109	R	H	-0.6081
110	G	H	-0.1128
111	Y	H	1.1036
112A	N	H	0.5994
112	Y	H	1.1753
113	G	H	0.3458
114	P	H	0.0000
115	F	H	0.0000
116	D	H	0.3085
117	Y	H	0.8343
118	W	H	0.5070
119	G	H	0.0000
120	Q	H	-1.2773
121	G	H	-0.2445
122	T	H	0.5304
123	L	H	1.7077
124	V	H	0.0000
125	T	H	0.3637
126	V	H	0.0000
127	S	H	-0.6754
128	S	H	-0.5558
1	S	L	0.1525
2	Y	L	0.6948
3	V	L	1.5582
4	L	L	0.0000
5	T	L	-0.0205
6	Q	L	-0.3384
7	P	L	-0.5203
8	P	L	-0.7868
9	S	L	-0.7170
11	V	L	-0.5571
12	S	L	-0.0369
13	V	L	0.0703
14	A	L	-0.1789
15	P	L	-1.1801
16	G	L	-2.2356
17	Q	L	-2.3539
18	T	L	-1.8736
19	A	L	0.0000
20	R	L	-1.9564
21	I	L	0.0000
22	T	L	-0.6274
23	C	L	0.0000
24	G	L	-0.8702
25	G	L	-1.1955
26	N	L	-2.2135
27	N	L	-2.8267
28	I	L	0.0000
29	G	L	-1.9671
36	S	L	-1.3632
37	K	L	-0.9300
38	S	L	-0.5188
39	V	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.1711
44	Q	L	0.0000
45	K	L	-1.3294
46	P	L	-1.2935
47	G	L	-1.4304
48	Q	L	-1.7125
49	A	L	-0.6743
50	P	L	0.0000
51	V	L	1.5018
52	L	L	0.0000
53	V	L	0.0000
54	V	L	0.0000
55	Y	L	-0.8923
56	D	L	-1.1066
57	D	L	-1.3234
65	S	L	-1.4230
66	D	L	-1.9736
67	R	L	-1.6657
68	P	L	-0.6002
69	S	L	-0.6676
70	G	L	-0.7432
71	I	L	-0.5906
72	P	L	-1.1901
74	E	L	-2.2562
75	R	L	-1.7255
76	F	L	0.0000
77	S	L	-1.2260
78	G	L	0.0000
79	S	L	-0.8804
80	N	L	-1.3135
83	S	L	-1.4410
84	G	L	-2.0453
85	N	L	-2.6589
86	T	L	-1.5062
87	A	L	0.0000
88	T	L	-0.7719
89	L	L	0.0000
90	T	L	-1.1013
91	I	L	0.0000
92	S	L	-2.1507
93	R	L	-3.0156
94	V	L	0.0000
95	E	L	-2.4319
96	A	L	-0.9290
97	G	L	-1.2074
98	D	L	0.0000
99	E	L	-1.4072
100	A	L	0.0000
101	D	L	-1.4170
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	V	L	0.0000
107	W	L	0.1805
108	D	L	0.0000
109	S	L	-0.4241
110	S	L	-0.5047
113	S	L	-0.5345
114	D	L	-0.6333
115	H	L	-0.5277
116	V	L	0.0000
117	V	L	0.5069
118	F	L	0.3337
119	G	L	0.0000
120	G	L	-0.7645
121	G	L	-1.0583
122	T	L	0.0000
123	K	L	-1.4010
124	L	L	0.0000
125	T	L	-0.0078
126	V	L	0.2111
127	L	L	1.4761