| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKFGDTENPTEVQHCGDDDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFFRRCGPEGHPLPDAPPPSPLYVPPPPTSPYAVRPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPEENVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9492 | |
| 2 | L | A | 1.9739 | |
| 3 | P | A | 0.6514 | |
| 4 | P | A | 0.3570 | |
| 5 | T | A | 0.1137 | |
| 6 | T | A | 0.1301 | |
| 7 | P | A | 0.1755 | |
| 8 | V | A | 1.2195 | |
| 9 | A | A | 0.0246 | |
| 10 | K | A | -1.1645 | |
| 11 | V | A | -0.4167 | |
| 12 | Q | A | -1.5420 | |
| 13 | S | A | -1.6202 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4326 | |
| 16 | E | A | -2.4476 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4552 | |
| 20 | P | A | 0.1036 | |
| 21 | T | A | 0.1146 | |
| 22 | S | A | -0.1694 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.0959 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2784 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8746 | |
| 31 | R | A | -2.6445 | |
| 32 | L | A | -0.7712 | |
| 33 | L | A | 1.2295 | |
| 34 | T | A | 1.4749 | |
| 35 | V | A | 2.0224 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2438 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6708 | |
| 40 | E | A | -1.7525 | |
| 41 | D | A | -0.9834 | |
| 42 | I | A | 0.8364 | |
| 43 | V | A | 1.0205 | |
| 44 | K | A | -1.1711 | |
| 45 | N | A | -1.9221 | |
| 46 | G | A | -1.2153 | |
| 47 | K | A | -0.9286 | |
| 48 | V | A | 1.4998 | |
| 49 | V | A | 2.0714 | |
| 50 | V | A | 1.2933 | |
| 51 | P | A | 0.4697 | |
| 52 | K | A | -0.6653 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1303 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4618 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2672 | |
| 70 | K | A | -1.8118 | |
| 71 | F | A | -0.6675 | |
| 72 | A | A | -0.5799 | |
| 73 | L | A | -0.9392 | |
| 74 | P | A | -1.2636 | |
| 75 | Q | A | -2.4795 | |
| 76 | K | A | -3.0951 | |
| 77 | D | A | -2.9933 | |
| 78 | F | A | -1.6488 | |
| 79 | Y | A | -1.9201 | |
| 80 | D | A | -2.7603 | |
| 81 | P | A | -2.3602 | |
| 82 | E | A | -3.0749 | |
| 83 | K | A | -3.4450 | |
| 84 | E | A | -2.5084 | |
| 85 | R | A | -1.3176 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6463 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9451 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3090 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7396 | |
| 99 | G | A | -0.5400 | |
| 100 | P | A | -0.4215 | |
| 101 | L | A | 0.0124 | |
| 102 | G | A | -0.2016 | |
| 103 | K | A | -0.5758 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4278 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1499 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4159 | |
| 110 | L | A | 0.2545 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2131 | |
| 113 | K | A | -0.5699 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.9320 | |
| 117 | T | A | -1.3917 | |
| 118 | E | A | -2.7719 | |
| 119 | N | A | -2.6799 | |
| 120 | P | A | -2.1314 | |
| 121 | T | A | -1.6704 | |
| 122 | E | A | -2.1415 | |
| 123 | V | A | -0.5191 | |
| 124 | Q | A | -1.1032 | |
| 125 | H | A | -0.8733 | |
| 126 | C | A | -1.3509 | |
| 127 | G | A | -2.2758 | |
| 128 | D | A | -3.0487 | |
| 129 | D | A | -3.0941 | |
| 130 | D | A | -2.2685 | |
| 131 | R | A | -1.4479 | |
| 132 | V | A | 0.1468 | |
| 133 | A | A | 0.4317 | |
| 134 | F | A | 0.2804 | |
| 135 | S | A | -0.0602 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.5019 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5566 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2523 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1385 | |
| 157 | D | A | 0.3224 | |
| 158 | L | A | 0.8260 | |
| 159 | A | A | 0.1744 | |
| 160 | E | A | -1.4541 | |
| 161 | P | A | -0.2422 | |
| 162 | C | A | 0.1700 | |
| 163 | P | A | -0.1808 | |
| 164 | G | A | -0.0929 | |
| 165 | L | A | 0.5602 | |
| 166 | P | A | -0.1309 | |
| 167 | P | A | -0.3490 | |
| 168 | G | A | -0.4536 | |
| 169 | A | A | -0.0334 | |
| 170 | C | A | 0.6517 | |
| 171 | P | A | 0.5136 | |
| 172 | P | A | 0.6765 | |
| 173 | I | A | 1.9669 | |
| 174 | Q | A | 0.8359 | |
| 175 | L | A | 1.4896 | |
| 176 | V | A | 0.8437 | |
| 177 | N | A | -0.3603 | |
| 178 | S | A | -0.0028 | |
| 179 | V | A | 0.3738 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3636 | |
| 182 | D | A | 0.0765 | |
| 183 | G | A | -0.1628 | |
| 184 | D | A | -0.5813 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4738 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1063 | |
| 190 | F | A | 0.0240 | |
| 191 | G | A | -0.1575 | |
| 192 | N | A | -0.3277 | |
| 193 | M | A | -0.1626 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4226 | |
| 197 | E | A | -2.6287 | |
| 198 | L | A | -1.2466 | |
| 199 | Q | A | -2.5679 | |
| 200 | Q | A | -3.3477 | |
| 201 | D | A | -3.6118 | |
| 202 | R | A | -3.3522 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1552 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3821 | |
| 211 | S | A | -1.9173 | |
| 212 | T | A | -1.4717 | |
| 213 | R | A | -2.1648 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2164 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2616 | |
| 220 | L | A | 0.4482 | |
| 221 | K | A | -1.4166 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9983 | |
| 224 | N | A | -1.7286 | |
| 225 | E | A | -1.3476 | |
| 226 | A | A | -0.6769 | |
| 227 | Y | A | -0.4597 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7243 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1320 | |
| 234 | F | A | 0.0496 | |
| 235 | G | A | -0.9295 | |
| 236 | R | A | -2.7050 | |
| 237 | R | A | -2.9956 | |
| 238 | E | A | -2.1323 | |
| 239 | Q | A | -0.1193 | |
| 240 | V | A | 1.5703 | |
| 241 | Y | A | 1.2556 | |
| 242 | A | A | 0.1527 | |
| 243 | R | A | -1.3638 | |
| 244 | H | A | -1.2660 | |
| 245 | F | A | -0.3336 | |
| 246 | F | A | 0.0000 | |
| 247 | R | A | -0.3766 | |
| 248 | R | A | -0.7945 | |
| 249 | C | A | -1.2061 | |
| 250 | G | A | -1.1921 | |
| 251 | P | A | -0.9581 | |
| 252 | E | A | -1.3606 | |
| 253 | G | A | -1.2851 | |
| 254 | H | A | -1.4620 | |
| 255 | P | A | -1.3156 | |
| 256 | L | A | -0.3355 | |
| 257 | P | A | -0.8814 | |
| 258 | D | A | -1.7227 | |
| 259 | A | A | -0.6219 | |
| 260 | P | A | -0.6795 | |
| 261 | P | A | -0.2010 | |
| 262 | P | A | 0.0437 | |
| 263 | S | A | 0.2623 | |
| 264 | P | A | 0.7023 | |
| 265 | L | A | 1.8668 | |
| 266 | Y | A | 1.5081 | |
| 267 | V | A | 1.7378 | |
| 268 | P | A | 0.5695 | |
| 269 | P | A | 0.5413 | |
| 270 | P | A | -0.1216 | |
| 271 | P | A | -0.0721 | |
| 272 | T | A | -0.0118 | |
| 273 | S | A | 0.2212 | |
| 274 | P | A | 0.2581 | |
| 275 | Y | A | 1.2282 | |
| 276 | A | A | 0.9979 | |
| 277 | V | A | 1.6672 | |
| 278 | R | A | 0.5944 | |
| 279 | P | A | -0.1041 | |
| 280 | P | A | 0.0000 | |
| 281 | T | A | -0.4700 | |
| 282 | D | A | -0.9430 | |
| 283 | Y | A | 0.8081 | |
| 284 | F | A | 0.6517 | |
| 285 | G | A | 0.0841 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9654 | |
| 291 | L | A | 1.6616 | |
| 292 | V | A | 0.6772 | |
| 293 | S | A | -0.1507 | |
| 294 | S | A | -0.9699 | |
| 295 | D | A | -1.8395 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1402 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6244 | |
| 301 | R | A | -1.8348 | |
| 302 | P | A | -0.9401 | |
| 303 | F | A | -0.1651 | |
| 304 | W | A | -0.5050 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0804 | |
| 307 | R | A | -2.9273 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7846 | |
| 310 | G | A | -1.4346 | |
| 311 | N | A | -1.4143 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9149 | |
| 319 | N | A | -0.9979 | |
| 320 | E | A | -1.0529 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3313 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1330 | |
| 333 | N | A | 0.4158 | |
| 334 | F | A | 1.4419 | |
| 335 | T | A | 0.7371 | |
| 336 | I | A | 0.3892 | |
| 337 | S | A | -1.0478 | |
| 338 | Q | A | -1.9074 | |
| 339 | Q | A | -1.6463 | |
| 340 | L | A | 0.2129 | |
| 341 | S | A | -0.2798 | |
| 342 | T | A | -0.8255 | |
| 343 | P | A | -1.3406 | |
| 344 | E | A | -2.5089 | |
| 345 | E | A | -2.6636 | |
| 346 | N | A | -1.5100 | |
| 347 | V | A | 0.5880 | |
| 348 | Y | A | 0.8838 | |
| 349 | D | A | -0.2276 | |
| 350 | P | A | -0.6766 | |
| 351 | S | A | -0.5827 | |
| 352 | N | A | -0.6996 | |
| 353 | F | A | -1.1268 | |
| 354 | K | A | -1.9992 | |
| 355 | N | A | -1.8143 | |
| 356 | Y | A | -0.1350 | |
| 357 | L | A | 0.5613 | |
| 358 | R | A | 0.9007 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4784 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | 0.0028 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9285 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6637 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2812 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3276 | |
| 376 | L | A | -1.7608 | |
| 377 | D | A | -2.0469 | |
| 378 | P | A | -1.0708 | |
| 379 | G | A | -1.0264 | |
| 380 | V | A | -0.9356 | |
| 381 | L | A | -0.5452 | |
| 382 | A | A | -0.6650 | |
| 383 | H | A | -0.8515 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4006 | |
| 386 | T | A | -0.5774 | |
| 387 | M | A | -0.3346 | |
| 388 | N | A | -0.8758 | |
| 389 | P | A | -1.2685 | |
| 390 | T | A | -1.5425 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5215 | |
| 393 | E | A | -2.9176 | |
| 394 | N | A | -2.6569 | |
| 395 | W | A | -1.5105 | |
| 396 | N | A | -1.1926 | |
| 397 | L | A | -0.2547 | |
| 398 | G | A | 0.5260 | |
| 399 | F | A | 2.4150 | |
| 400 | V | A | 1.8396 | |
| 401 | P | A | 0.0535 | |
| 402 | P | A | -1.8788 | |
| 403 | K | A | -3.4600 | |
| 404 | E | A | -3.9596 | |
| 405 | R | A | -4.3389 | |
| 406 | E | A | -3.9642 | |
| 407 | D | A | -2.9502 | |
| 408 | P | A | -1.8075 | |
| 409 | Y | A | -0.9918 | |
| 410 | K | A | -2.0986 | |
| 411 | G | A | -0.6412 | |
| 412 | L | A | 0.6583 | |
| 413 | I | A | 1.5774 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3960 | |
| 416 | E | A | -1.6631 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9363 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0735 | |
| 421 | E | A | -2.7972 | |
| 422 | R | A | -2.5980 | |
| 423 | F | A | -1.3052 | |
| 424 | S | A | -1.4618 | |
| 425 | Q | A | -1.7343 | |
| 426 | D | A | -2.8881 | |
| 427 | L | A | -1.9990 | |
| 428 | D | A | -2.7972 | |
| 429 | Q | A | -2.6178 | |
| 430 | F | A | -1.4457 | |
| 431 | A | A | -0.9106 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6025 | |
| 435 | K | A | -0.7420 | |
| 436 | F | A | 0.1436 | |
| 437 | L | A | 1.0249 | |
| 438 | Y | A | 0.8198 | |
| 439 | Q | A | -0.2725 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine