| Chain sequence(s) |
A: GPLPLNPAPELVSTDEYVTPTDLLYIAETDLITLVGHPTSDIVVDGKVVVPRVSATQWKVFKLTLPDPNTLPLPSPDFLDPSTEIAIWRLLAFKIGLGGPLGTGSYGHANFNALGDVDNPTEPLHEGADDTVNYSWTPVRLQMFIVGDEPPLGVYTAPAPPAPGLPPGAVPPTTKVSTTLEHGDAADIGFGARDYKALLPRKDDVPDIIRDTVTKRPDLAGMRAEPTGRRMFTYDRSESSSSSKTLRRSGPDLLPLPALPPPSLLFTRPPPSSPYAVPPSTNLFTIPNQGSITPSDLLFNRPYFFDKAEGKNNFILWHNQLYVTIVDNSRSEIETITTQCCTPPINVYDPSCYVTSQRYREEYKLSLIVQLCKIPLTPETLALLSRIDPRILVDARLPFIPPVEREDPLAGKKFLEIDLTNKLSSNLSESELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2090 | |
| 2 | P | A | 0.4111 | |
| 3 | L | A | 1.3967 | |
| 4 | P | A | 0.7077 | |
| 5 | L | A | 1.1427 | |
| 6 | N | A | -0.5014 | |
| 7 | P | A | -0.7789 | |
| 8 | A | A | -0.8048 | |
| 9 | P | A | -1.5584 | |
| 10 | E | A | -1.8533 | |
| 11 | L | A | -0.8242 | |
| 12 | V | A | -0.8394 | |
| 13 | S | A | -1.4647 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.9448 | |
| 16 | E | A | -2.6788 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.9332 | |
| 20 | P | A | -0.9725 | |
| 21 | T | A | -0.9198 | |
| 22 | D | A | -1.6302 | |
| 23 | L | A | -0.4934 | |
| 24 | L | A | -0.1378 | |
| 25 | Y | A | -0.0515 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.1129 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.4020 | |
| 31 | L | A | 0.2469 | |
| 32 | I | A | 0.1844 | |
| 33 | T | A | -0.0584 | |
| 34 | L | A | 0.0502 | |
| 35 | V | A | 0.1496 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.9029 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.7037 | |
| 40 | S | A | -0.5017 | |
| 41 | D | A | -0.0417 | |
| 42 | I | A | 1.7557 | |
| 43 | V | A | 2.4075 | |
| 44 | V | A | 1.6438 | |
| 45 | D | A | -0.9589 | |
| 46 | G | A | -0.5332 | |
| 47 | K | A | -0.2137 | |
| 48 | V | A | 2.0902 | |
| 49 | V | A | 2.5058 | |
| 50 | V | A | 1.5944 | |
| 51 | P | A | 0.4744 | |
| 52 | R | A | -0.3384 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | T | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.1984 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1722 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.8216 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.0076 | |
| 70 | T | A | -0.3599 | |
| 71 | L | A | -0.0509 | |
| 72 | P | A | -0.0864 | |
| 73 | L | A | -0.0134 | |
| 74 | P | A | -0.2969 | |
| 75 | S | A | -0.7003 | |
| 76 | P | A | -1.2232 | |
| 77 | D | A | -2.0701 | |
| 78 | F | A | -0.9537 | |
| 79 | L | A | 0.0000 | |
| 80 | D | A | -1.9740 | |
| 81 | P | A | -1.5656 | |
| 82 | S | A | -0.9036 | |
| 83 | T | A | -0.8402 | |
| 84 | E | A | -1.1252 | |
| 85 | I | A | 0.0000 | |
| 86 | A | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.2934 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.1412 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -0.9432 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -0.8116 | |
| 97 | L | A | -0.5947 | |
| 98 | G | A | -0.7104 | |
| 99 | G | A | -1.0904 | |
| 100 | P | A | -0.5259 | |
| 101 | L | A | -0.0156 | |
| 102 | G | A | -0.5129 | |
| 103 | T | A | -0.6345 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.4824 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.8122 | |
| 108 | H | A | -1.2939 | |
| 109 | A | A | -1.0965 | |
| 110 | N | A | -2.0142 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | -0.4907 | |
| 115 | G | A | -1.0497 | |
| 116 | D | A | -1.4371 | |
| 117 | V | A | -1.2386 | |
| 118 | D | A | -2.6709 | |
| 119 | N | A | -2.6102 | |
| 120 | P | A | -1.8985 | |
| 121 | T | A | -1.5850 | |
| 122 | E | A | -2.2102 | |
| 123 | P | A | -1.0114 | |
| 124 | L | A | -1.0276 | |
| 125 | H | A | -1.7851 | |
| 126 | E | A | -2.7330 | |
| 127 | G | A | -2.1214 | |
| 128 | A | A | -1.4615 | |
| 129 | D | A | -2.3911 | |
| 130 | D | A | -1.8426 | |
| 131 | T | A | -1.1035 | |
| 132 | V | A | -0.5160 | |
| 133 | N | A | -1.2309 | |
| 134 | Y | A | -0.5320 | |
| 135 | S | A | -0.4401 | |
| 136 | W | A | 0.0000 | |
| 137 | T | A | -0.3332 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | -0.4667 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | M | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.3698 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.1129 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | -0.5257 | |
| 155 | Y | A | -0.7769 | |
| 156 | T | A | -0.7866 | |
| 157 | A | A | -0.7571 | |
| 158 | P | A | -0.3466 | |
| 159 | A | A | -0.5184 | |
| 160 | P | A | -0.4732 | |
| 161 | P | A | -0.2413 | |
| 162 | A | A | -0.2500 | |
| 163 | P | A | -0.3971 | |
| 164 | G | A | -0.3749 | |
| 165 | L | A | 0.3366 | |
| 166 | P | A | -0.0876 | |
| 167 | P | A | -0.2563 | |
| 168 | G | A | 0.1702 | |
| 169 | A | A | 1.0132 | |
| 170 | V | A | 1.9814 | |
| 171 | P | A | 0.6116 | |
| 172 | P | A | 0.1031 | |
| 173 | T | A | -0.4123 | |
| 174 | T | A | -0.9586 | |
| 175 | K | A | -1.5495 | |
| 176 | V | A | -0.5045 | |
| 177 | S | A | -0.3918 | |
| 178 | T | A | -0.0337 | |
| 179 | T | A | -0.3763 | |
| 180 | L | A | 0.0000 | |
| 181 | E | A | -1.1392 | |
| 182 | H | A | -1.2346 | |
| 183 | G | A | -0.7526 | |
| 184 | D | A | -0.7603 | |
| 185 | A | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2376 | |
| 190 | F | A | -0.0154 | |
| 191 | G | A | -0.4617 | |
| 192 | A | A | -0.7866 | |
| 193 | R | A | -1.1097 | |
| 194 | D | A | -1.0337 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -2.6839 | |
| 197 | A | A | -1.1507 | |
| 198 | L | A | -0.3035 | |
| 199 | L | A | -1.3778 | |
| 200 | P | A | -1.6784 | |
| 201 | R | A | -2.2731 | |
| 202 | K | A | -3.2610 | |
| 203 | D | A | -1.9492 | |
| 204 | D | A | -1.3973 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.6700 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -2.3979 | |
| 211 | D | A | -2.4258 | |
| 212 | T | A | -1.2800 | |
| 213 | V | A | -0.5215 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | R | A | -1.4890 | |
| 217 | P | A | -0.7085 | |
| 218 | D | A | -0.7238 | |
| 219 | L | A | -0.6960 | |
| 220 | A | A | -0.7323 | |
| 221 | G | A | -0.8031 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -2.4754 | |
| 224 | A | A | -1.3285 | |
| 225 | E | A | -1.2384 | |
| 226 | P | A | -0.9708 | |
| 227 | T | A | -0.7147 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.6763 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.9550 | |
| 234 | Y | A | -0.6602 | |
| 235 | D | A | -1.2596 | |
| 236 | R | A | -2.3514 | |
| 237 | S | A | -1.8957 | |
| 238 | E | A | -2.0413 | |
| 239 | S | A | -1.0346 | |
| 240 | S | A | -0.9187 | |
| 241 | S | A | -0.7786 | |
| 242 | S | A | -0.8668 | |
| 243 | S | A | -1.1614 | |
| 244 | K | A | -1.8303 | |
| 245 | T | A | -0.9341 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5252 | |
| 249 | S | A | -1.1926 | |
| 250 | G | A | -0.7569 | |
| 251 | P | A | -0.4387 | |
| 252 | D | A | 0.0631 | |
| 253 | L | A | 2.0488 | |
| 254 | L | A | 2.4107 | |
| 255 | P | A | 1.1488 | |
| 256 | L | A | 1.4917 | |
| 257 | P | A | 0.5783 | |
| 258 | A | A | 0.7657 | |
| 259 | L | A | 1.5085 | |
| 260 | P | A | 1.0178 | |
| 261 | P | A | 0.6263 | |
| 262 | P | A | 0.4439 | |
| 263 | S | A | 0.5231 | |
| 264 | L | A | 2.0258 | |
| 265 | L | A | 1.7087 | |
| 266 | F | A | 0.9542 | |
| 267 | T | A | -0.2677 | |
| 268 | R | A | -1.3897 | |
| 269 | P | A | -0.5839 | |
| 270 | P | A | -0.5856 | |
| 271 | P | A | -0.3533 | |
| 272 | S | A | -0.3147 | |
| 273 | S | A | 0.0404 | |
| 274 | P | A | 0.1520 | |
| 275 | Y | A | 1.0951 | |
| 276 | A | A | 0.6856 | |
| 277 | V | A | 1.5573 | |
| 278 | P | A | 0.6547 | |
| 279 | P | A | -0.1986 | |
| 280 | S | A | -0.2054 | |
| 281 | T | A | -0.3941 | |
| 282 | N | A | -0.5429 | |
| 283 | L | A | 1.1101 | |
| 284 | F | A | 0.5397 | |
| 285 | T | A | -0.2693 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | N | A | -0.9131 | |
| 289 | Q | A | 0.0000 | |
| 290 | G | A | -0.6216 | |
| 291 | S | A | -0.4081 | |
| 292 | I | A | -0.0421 | |
| 293 | T | A | -0.3182 | |
| 294 | P | A | -0.4560 | |
| 295 | S | A | -0.6987 | |
| 296 | D | A | -1.1469 | |
| 297 | L | A | -0.7280 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3430 | |
| 301 | R | A | -1.2171 | |
| 302 | P | A | -0.7569 | |
| 303 | Y | A | -0.0376 | |
| 304 | F | A | -0.2264 | |
| 305 | F | A | -0.8129 | |
| 306 | D | A | -2.3762 | |
| 307 | K | A | -3.1765 | |
| 308 | A | A | 0.0000 | |
| 309 | E | A | -2.7844 | |
| 310 | G | A | -2.1683 | |
| 311 | K | A | -1.7768 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | F | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.5668 | |
| 319 | N | A | -0.6021 | |
| 320 | Q | A | -0.6012 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.8146 | |
| 331 | S | A | 0.0000 | |
| 332 | E | A | -2.2451 | |
| 333 | I | A | -1.6565 | |
| 334 | E | A | -1.9355 | |
| 335 | T | A | -0.5978 | |
| 336 | I | A | 0.8715 | |
| 337 | T | A | 0.8737 | |
| 338 | T | A | 0.8919 | |
| 339 | Q | A | 0.4137 | |
| 340 | C | A | 1.0693 | |
| 341 | C | A | 0.5317 | |
| 342 | T | A | 0.0062 | |
| 343 | P | A | -0.3330 | |
| 344 | P | A | -0.1467 | |
| 345 | I | A | 0.4688 | |
| 346 | N | A | -0.0490 | |
| 347 | V | A | 1.7119 | |
| 348 | Y | A | 1.5906 | |
| 349 | D | A | 0.1483 | |
| 350 | P | A | 0.1533 | |
| 351 | S | A | 0.1538 | |
| 352 | C | A | 0.0000 | |
| 353 | Y | A | 1.3532 | |
| 354 | V | A | 2.0989 | |
| 355 | T | A | 0.9796 | |
| 356 | S | A | 0.1438 | |
| 357 | Q | A | -0.8562 | |
| 358 | R | A | -1.2819 | |
| 359 | Y | A | 0.0000 | |
| 360 | R | A | -1.9336 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.5127 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -1.2820 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3593 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.6561 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6764 | |
| 376 | L | A | -0.5442 | |
| 377 | T | A | -0.6814 | |
| 378 | P | A | -0.9983 | |
| 379 | E | A | -1.8183 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.4620 | |
| 382 | A | A | -0.7521 | |
| 383 | L | A | -0.8623 | |
| 384 | L | A | 0.0000 | |
| 385 | S | A | -0.5429 | |
| 386 | R | A | -1.2862 | |
| 387 | I | A | -0.4127 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -0.6444 | |
| 390 | R | A | -1.0306 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -0.1655 | |
| 393 | V | A | -0.4805 | |
| 394 | D | A | -1.2960 | |
| 395 | A | A | -1.3031 | |
| 396 | R | A | -1.7245 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.2172 | |
| 399 | F | A | 1.7155 | |
| 400 | I | A | 1.0185 | |
| 401 | P | A | 0.3373 | |
| 402 | P | A | -0.2209 | |
| 403 | V | A | 0.0379 | |
| 404 | E | A | -2.3750 | |
| 405 | R | A | -3.4458 | |
| 406 | E | A | -3.2526 | |
| 407 | D | A | -2.2129 | |
| 408 | P | A | -1.2690 | |
| 409 | L | A | -0.8942 | |
| 410 | A | A | -1.1223 | |
| 411 | G | A | -1.2743 | |
| 412 | K | A | -1.8722 | |
| 413 | K | A | -2.4990 | |
| 414 | F | A | -1.4426 | |
| 415 | L | A | -1.1589 | |
| 416 | E | A | -2.2416 | |
| 417 | I | A | -1.6310 | |
| 418 | D | A | -2.4212 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.3667 | |
| 421 | N | A | -1.8140 | |
| 422 | K | A | -1.6893 | |
| 423 | L | A | -0.5890 | |
| 424 | S | A | -0.7991 | |
| 425 | S | A | -0.5734 | |
| 426 | N | A | -1.4721 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -2.1924 | |
| 429 | E | A | -2.8967 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.8826 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.1480 | |
| 435 | E | A | -2.2007 | |
| 436 | Y | A | -1.0068 | |
| 437 | L | A | -0.3833 | |
| 438 | N | A | -2.0252 | |
| 439 | R | A | -2.1932 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine