| Chain sequence(s) |
A: TPLSGTQELHFSEDNYEKLLTPVDGLSPLGAGEDGMDAWYITSSNPSHASRTKLRINSDIMISAGHGGAGDNNDGNSCGGNGGDSITGSDLSIINQGMILGGSGGSGADHNGDGGEAVTGDNLFIINGEIISGGHGGDSYSDSDGGNGGDAVTGVNLPIINKGTISGGNGGNNYGEGDGGNGGDAITGSSLSVINKGTFAGGNGGAAYGYGYDGYGGNAITGDNLSVINNGAILGGNGGHWGDAINGSNMTIANSGYIISGKEDDGTQNVAGNAIHITGGNNSLILHEGSVITGDVQVNNS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:02)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | T | A | -0.1576 | |
| 2 | P | A | -0.4118 | |
| 3 | L | A | 0.0677 | |
| 4 | S | A | -0.6669 | |
| 5 | G | A | -0.7309 | |
| 6 | T | A | -0.5672 | |
| 7 | Q | A | -0.7839 | |
| 8 | E | A | -1.8198 | |
| 9 | L | A | -1.1589 | |
| 10 | H | A | -1.5096 | |
| 11 | F | A | 0.0000 | |
| 12 | S | A | -2.2543 | |
| 13 | E | A | -3.1887 | |
| 14 | D | A | -3.3675 | |
| 15 | N | A | -3.3437 | |
| 16 | Y | A | -2.3798 | |
| 17 | E | A | -2.6866 | |
| 18 | K | A | -1.5274 | |
| 19 | L | A | -0.1255 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.2284 | |
| 22 | P | A | -0.2339 | |
| 23 | V | A | 0.0000 | |
| 24 | D | A | -1.7527 | |
| 25 | G | A | -0.9568 | |
| 26 | L | A | 0.0000 | |
| 27 | S | A | -0.9186 | |
| 28 | P | A | -0.3529 | |
| 29 | L | A | 0.8986 | |
| 30 | G | A | -0.2082 | |
| 31 | A | A | -1.2055 | |
| 32 | G | A | -1.7538 | |
| 33 | E | A | -2.3473 | |
| 34 | D | A | -2.9061 | |
| 35 | G | A | -1.5665 | |
| 36 | M | A | -0.6078 | |
| 37 | D | A | -0.6660 | |
| 38 | A | A | 0.0000 | |
| 39 | W | A | 0.0000 | |
| 40 | Y | A | -0.1996 | |
| 41 | I | A | 0.0000 | |
| 42 | T | A | -0.7298 | |
| 43 | S | A | -1.0569 | |
| 44 | S | A | -1.1995 | |
| 45 | N | A | -1.3233 | |
| 46 | P | A | -0.9603 | |
| 47 | S | A | -0.9291 | |
| 48 | H | A | -1.3663 | |
| 49 | A | A | -1.0244 | |
| 50 | S | A | -1.0209 | |
| 51 | R | A | -2.0634 | |
| 52 | T | A | 0.0000 | |
| 53 | K | A | -1.7169 | |
| 54 | L | A | 0.0000 | |
| 55 | R | A | -1.1331 | |
| 56 | I | A | 0.0000 | |
| 57 | N | A | -1.5502 | |
| 58 | S | A | -1.6930 | |
| 59 | D | A | -1.9577 | |
| 60 | I | A | -0.7049 | |
| 61 | M | A | 0.2418 | |
| 62 | I | A | 0.0000 | |
| 63 | S | A | -0.0698 | |
| 64 | A | A | 0.0000 | |
| 65 | G | A | 0.0000 | |
| 66 | H | A | -1.6950 | |
| 67 | G | A | -1.8646 | |
| 68 | G | A | -1.3059 | |
| 69 | A | A | -0.9774 | |
| 70 | G | A | -2.1504 | |
| 71 | D | A | -2.6363 | |
| 72 | N | A | -3.3000 | |
| 73 | N | A | -3.3286 | |
| 74 | D | A | -3.5640 | |
| 75 | G | A | -2.9595 | |
| 76 | N | A | -3.1049 | |
| 77 | S | A | 0.0000 | |
| 78 | C | A | -1.9775 | |
| 79 | G | A | -1.9370 | |
| 80 | G | A | 0.0000 | |
| 81 | N | A | -2.4343 | |
| 82 | G | A | -1.9028 | |
| 83 | G | A | 0.0000 | |
| 84 | D | A | -0.5296 | |
| 85 | S | A | 0.0000 | |
| 86 | I | A | 0.0000 | |
| 87 | T | A | -0.2962 | |
| 88 | G | A | -0.1818 | |
| 89 | S | A | -0.5393 | |
| 90 | D | A | -1.1797 | |
| 91 | L | A | 0.0000 | |
| 92 | S | A | 0.0000 | |
| 93 | I | A | 0.0000 | |
| 94 | I | A | 0.0543 | |
| 95 | N | A | 0.0000 | |
| 96 | Q | A | -1.6027 | |
| 97 | G | A | 0.0000 | |
| 98 | M | A | 0.1073 | |
| 99 | I | A | 0.0000 | |
| 100 | L | A | 0.3700 | |
| 101 | G | A | 0.0000 | |
| 102 | G | A | 0.0000 | |
| 103 | S | A | -1.4028 | |
| 104 | G | A | -1.8495 | |
| 105 | G | A | 0.0000 | |
| 106 | S | A | -0.7959 | |
| 107 | G | A | -1.4565 | |
| 108 | A | A | -1.9600 | |
| 109 | D | A | -3.1111 | |
| 110 | H | A | -2.6606 | |
| 111 | N | A | -1.8112 | |
| 112 | G | A | 0.0000 | |
| 113 | D | A | -2.1830 | |
| 114 | G | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | E | A | -0.8828 | |
| 117 | A | A | 0.0000 | |
| 118 | V | A | 0.0000 | |
| 119 | T | A | -0.2521 | |
| 120 | G | A | -0.5605 | |
| 121 | D | A | -0.9369 | |
| 122 | N | A | -0.9423 | |
| 123 | L | A | 0.0000 | |
| 124 | F | A | 0.5375 | |
| 125 | I | A | 0.0000 | |
| 126 | I | A | 0.4181 | |
| 127 | N | A | 0.0000 | |
| 128 | G | A | -1.3439 | |
| 129 | E | A | -1.2256 | |
| 130 | I | A | 0.1675 | |
| 131 | I | A | 0.0000 | |
| 132 | S | A | 0.0060 | |
| 133 | G | A | 0.0000 | |
| 134 | G | A | 0.0000 | |
| 135 | H | A | -1.6516 | |
| 136 | G | A | -1.6285 | |
| 137 | G | A | 0.0000 | |
| 138 | D | A | -0.8090 | |
| 139 | S | A | 0.0000 | |
| 140 | Y | A | 0.3251 | |
| 141 | S | A | -1.5760 | |
| 142 | D | A | -3.1092 | |
| 143 | S | A | -2.8780 | |
| 144 | D | A | -3.1889 | |
| 145 | G | A | 0.0000 | |
| 146 | G | A | 0.0000 | |
| 147 | N | A | -1.8397 | |
| 148 | G | A | 0.0000 | |
| 149 | G | A | 0.0000 | |
| 150 | D | A | -0.8056 | |
| 151 | A | A | 0.0000 | |
| 152 | V | A | 0.0000 | |
| 153 | T | A | -0.2791 | |
| 154 | G | A | -0.1812 | |
| 155 | V | A | 0.1280 | |
| 156 | N | A | -0.7665 | |
| 157 | L | A | 0.0000 | |
| 158 | P | A | 0.3356 | |
| 159 | I | A | 0.0000 | |
| 160 | I | A | 0.5763 | |
| 161 | N | A | 0.0000 | |
| 162 | K | A | -2.4348 | |
| 163 | G | A | -1.4303 | |
| 164 | T | A | -0.6207 | |
| 165 | I | A | 0.0000 | |
| 166 | S | A | -0.1009 | |
| 167 | G | A | 0.0000 | |
| 168 | G | A | 0.0000 | |
| 169 | N | A | -1.4627 | |
| 170 | G | A | 0.0000 | |
| 171 | G | A | 0.0000 | |
| 172 | N | A | -0.5841 | |
| 173 | N | A | 0.0000 | |
| 174 | Y | A | 0.7814 | |
| 175 | G | A | -0.6296 | |
| 176 | E | A | -1.9835 | |
| 177 | G | A | 0.0000 | |
| 178 | D | A | -1.3065 | |
| 179 | G | A | 0.0000 | |
| 180 | G | A | 0.0000 | |
| 181 | N | A | -1.3887 | |
| 182 | G | A | -0.9859 | |
| 183 | G | A | 0.0000 | |
| 184 | D | A | -0.6858 | |
| 185 | A | A | 0.0000 | |
| 186 | I | A | 0.0000 | |
| 187 | T | A | -0.1786 | |
| 188 | G | A | -0.3186 | |
| 189 | S | A | -0.5598 | |
| 190 | S | A | -0.9269 | |
| 191 | L | A | 0.0000 | |
| 192 | S | A | 0.0365 | |
| 193 | V | A | 0.0000 | |
| 194 | I | A | 0.7405 | |
| 195 | N | A | 0.0000 | |
| 196 | K | A | -2.3340 | |
| 197 | G | A | -1.8441 | |
| 198 | T | A | -0.6941 | |
| 199 | F | A | 0.0000 | |
| 200 | A | A | -0.0177 | |
| 201 | G | A | 0.0000 | |
| 202 | G | A | 0.0000 | |
| 203 | N | A | -1.5994 | |
| 204 | G | A | -1.0975 | |
| 205 | G | A | 0.0000 | |
| 206 | A | A | -0.0808 | |
| 207 | A | A | 0.3389 | |
| 208 | Y | A | 1.5139 | |
| 209 | G | A | 0.4312 | |
| 210 | Y | A | 0.7497 | |
| 211 | G | A | -0.0394 | |
| 212 | Y | A | 0.6759 | |
| 213 | D | A | -0.6490 | |
| 214 | G | A | 0.0000 | |
| 215 | Y | A | 0.1026 | |
| 216 | G | A | 0.0000 | |
| 217 | G | A | 0.0000 | |
| 218 | N | A | -0.2581 | |
| 219 | A | A | 0.0000 | |
| 220 | I | A | 0.0000 | |
| 221 | T | A | -0.3846 | |
| 222 | G | A | -0.6930 | |
| 223 | D | A | -1.4071 | |
| 224 | N | A | -2.1774 | |
| 225 | L | A | 0.0000 | |
| 226 | S | A | -0.2563 | |
| 227 | V | A | 0.0000 | |
| 228 | I | A | 1.3655 | |
| 229 | N | A | 0.0000 | |
| 230 | N | A | -1.3649 | |
| 231 | G | A | -0.9493 | |
| 232 | A | A | 0.1730 | |
| 233 | I | A | 0.0000 | |
| 234 | L | A | 0.6931 | |
| 235 | G | A | -0.3125 | |
| 236 | G | A | 0.0000 | |
| 237 | N | A | -1.8211 | |
| 238 | G | A | 0.0000 | |
| 239 | G | A | -1.4077 | |
| 240 | H | A | -1.0024 | |
| 241 | W | A | -0.8162 | |
| 242 | G | A | 0.0000 | |
| 243 | D | A | 0.0000 | |
| 244 | A | A | 0.0000 | |
| 245 | I | A | 0.0000 | |
| 246 | N | A | -0.4859 | |
| 247 | G | A | 0.0000 | |
| 248 | S | A | -1.3257 | |
| 249 | N | A | -2.1459 | |
| 250 | M | A | 0.0000 | |
| 251 | T | A | -0.1893 | |
| 252 | I | A | 0.0000 | |
| 253 | A | A | 1.2976 | |
| 254 | N | A | 0.0000 | |
| 255 | S | A | -0.4831 | |
| 256 | G | A | 0.0000 | |
| 257 | Y | A | 1.5198 | |
| 258 | I | A | 0.0000 | |
| 259 | I | A | 0.7728 | |
| 260 | S | A | 0.0000 | |
| 261 | G | A | 0.0000 | |
| 262 | K | A | -2.8390 | |
| 263 | E | A | -2.9226 | |
| 264 | D | A | -3.6635 | |
| 265 | D | A | -3.4419 | |
| 266 | G | A | -2.5631 | |
| 267 | T | A | -2.2358 | |
| 268 | Q | A | -2.5847 | |
| 269 | N | A | -1.9489 | |
| 270 | V | A | -1.0923 | |
| 271 | A | A | -0.9574 | |
| 272 | G | A | 0.0000 | |
| 273 | N | A | -0.7827 | |
| 274 | A | A | 0.0000 | |
| 275 | I | A | 0.0000 | |
| 276 | H | A | -0.0690 | |
| 277 | I | A | -0.0519 | |
| 278 | T | A | -0.4840 | |
| 279 | G | A | -0.9779 | |
| 280 | G | A | -1.7453 | |
| 281 | N | A | -2.1561 | |
| 282 | N | A | -1.2732 | |
| 283 | S | A | 0.0467 | |
| 284 | L | A | 1.3727 | |
| 285 | I | A | 2.1043 | |
| 286 | L | A | 1.4536 | |
| 287 | H | A | -0.9379 | |
| 288 | E | A | -2.1169 | |
| 289 | G | A | -1.1044 | |
| 290 | S | A | 0.1059 | |
| 291 | V | A | 1.2745 | |
| 292 | I | A | 1.3245 | |
| 293 | T | A | 0.5466 | |
| 294 | G | A | -0.6016 | |
| 295 | D | A | -1.0935 | |
| 296 | V | A | 0.4189 | |
| 297 | Q | A | -0.1046 | |
| 298 | V | A | 0.8717 | |
| 299 | N | A | -0.4170 | |
| 300 | N | A | -1.3375 | |
| 301 | S | A | -0.9535 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine