Project name: 6df94cbe2ad2f8a

Chain sequence(s)	A: EVQLVESGGGLVQPGGSLKLSCAASGFTFSTYAMNWVRQAPGKGLEWVGRIRSKYNNYATYYADSVKDRFTISRDDSKNTLYLQMNSLRAEDTAVYYCVRHGNFGNSYVSWFAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPWTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVL
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	No
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       runJob:   FoldX not utilized. Treating input pdb file as it was already optimized.    (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:01)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:02)

• Minimal score value: -3.125
• Maximal score value: 1.7985
• Average score: -0.4338
• Total score value: -108.0053

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
10	E	A	-2.0074
11	V	A	-1.4271
12	Q	A	-1.1935
13	L	A	0.0000
14	V	A	0.9919
15	E	A	0.0000
16	S	A	-0.2561
17	G	A	-0.8396
18	G	A	-0.3605
19	G	A	0.5583
20	L	A	1.5638
21	V	A	0.2686
22	Q	A	-1.2016
23	P	A	-1.5782
24	G	A	-1.5399
25	G	A	-1.2443
26	S	A	-1.2333
27	L	A	-0.6650
28	K	A	-1.5358
29	L	A	0.0000
30	S	A	-0.3449
31	C	A	0.0000
32	A	A	-0.2939
33	A	A	-0.6856
34	S	A	-1.1009
35	G	A	-1.1847
36	F	A	-0.3007
37	T	A	-0.0123
38	F	A	0.0000
39	S	A	-0.8175
40	T	A	-0.0336
41	Y	A	-0.0313
42	A	A	0.0000
43	M	A	0.0000
44	N	A	0.0000
45	W	A	0.0000
46	V	A	0.0000
47	R	A	0.0000
48	Q	A	-0.4214
49	A	A	0.0000
50	P	A	-0.5217
51	G	A	-0.8258
52	K	A	-1.1074
53	G	A	-0.5898
54	L	A	-0.1525
55	E	A	-0.1866
56	W	A	0.0000
57	V	A	0.0000
58	G	A	0.0000
59	R	A	-0.1053
60	I	A	0.0000
61	R	A	-0.9300
62	S	A	-1.1689
63	K	A	-1.8838
64	Y	A	-0.4704
65	N	A	-1.6568
66	N	A	-1.8286
67	Y	A	-0.9874
68	A	A	-0.6717
69	T	A	-0.2003
70	Y	A	-0.1086
71	Y	A	-0.8074
72	A	A	-1.3814
73	D	A	-2.8386
74	S	A	0.0000
75	V	A	0.0000
76	K	A	-3.1250
77	D	A	-3.0355
78	R	A	-2.1125
79	F	A	0.0000
80	T	A	-0.9627
81	I	A	0.0000
82	S	A	-0.2920
83	R	A	-1.0134
84	D	A	-1.4764
85	D	A	-1.8320
86	S	A	-1.5963
87	K	A	-2.4097
88	N	A	-1.8380
89	T	A	-1.0836
90	L	A	0.0000
91	Y	A	-0.3654
92	L	A	0.0000
93	Q	A	-0.9927
94	M	A	0.0000
95	N	A	-1.6377
96	S	A	-1.5509
97	L	A	0.0000
98	R	A	-1.8001
99	A	A	-0.5674
100	E	A	0.0000
101	D	A	0.0000
102	T	A	0.0000
103	A	A	0.0000
104	V	A	-0.0020
105	Y	A	0.0000
106	Y	A	0.0000
107	C	A	0.0000
108	V	A	0.1364
109	R	A	-0.0714
110	H	A	0.0000
111	G	A	0.0000
112	N	A	0.0000
113	F	A	0.7292
114	G	A	-0.4689
115	N	A	-1.3095
116	S	A	-0.0815
117	Y	A	1.0524
118	V	A	1.7985
119	S	A	0.0000
120	W	A	0.1172
121	F	A	0.0000
122	A	A	-0.3964
123	Y	A	0.3422
124	W	A	1.1157
125	G	A	0.0914
126	Q	A	-0.1552
127	G	A	-0.2018
128	T	A	0.0000
129	L	A	1.2617
130	V	A	0.0000
131	T	A	0.6661
132	V	A	1.2519
133	S	A	0.0841
134	S	A	-0.3896
135	G	A	-0.8880
136	G	A	-1.1272
137	G	A	-1.3237
138	G	A	-1.4540
139	S	A	-1.4493
140	G	A	-1.5364
141	G	A	-1.7091
142	G	A	-1.5358
143	G	A	-1.6694
144	S	A	-1.2279
145	G	A	-1.2859
146	G	A	-1.1756
147	G	A	-1.3031
148	G	A	-1.5171
149	S	A	-1.5507
150	Q	A	-1.4484
151	T	A	0.1021
152	V	A	1.1407
153	V	A	0.0000
154	T	A	-0.4155
155	Q	A	0.0000
156	E	A	-0.8664
157	P	A	-0.8064
158	S	A	-0.6265
159	L	A	0.0145
160	T	A	0.3088
161	V	A	0.3496
162	S	A	0.0760
163	P	A	-0.5954
164	G	A	-0.9311
165	G	A	-0.6557
166	T	A	-0.4451
167	V	A	0.0000
168	T	A	0.0861
169	L	A	0.0000
170	T	A	-0.3161
171	C	A	0.0000
172	R	A	-1.5585
173	S	A	0.0000
174	S	A	-0.3017
175	T	A	-0.4076
176	G	A	-0.6973
177	A	A	-0.4437
178	V	A	0.0000
179	T	A	0.1263
180	T	A	-0.0618
181	S	A	-0.0686
182	N	A	0.1601
183	Y	A	0.5332
184	A	A	0.0000
185	N	A	-0.2949
186	W	A	0.0000
187	V	A	-0.3326
188	Q	A	0.0000
189	Q	A	-1.3141
190	K	A	-1.5576
191	P	A	-1.1251
192	G	A	-1.1711
193	Q	A	-1.2497
194	A	A	-0.8691
195	P	A	-0.9141
196	R	A	-1.1897
197	G	A	0.0000
198	L	A	0.0000
199	I	A	0.0000
200	G	A	0.0000
201	G	A	-0.3628
202	T	A	0.0000
203	N	A	-1.6620
204	K	A	-1.5073
205	R	A	-1.4392
206	A	A	0.0000
207	P	A	0.5338
208	W	A	0.8298
209	T	A	0.0000
210	P	A	-0.0091
211	A	A	-0.1905
212	R	A	-0.4726
213	F	A	0.0000
214	S	A	-0.9059
215	G	A	-0.7486
216	S	A	0.0391
217	L	A	0.8613
218	L	A	1.4344
219	G	A	0.0825
220	G	A	-0.2328
221	K	A	-0.4560
222	A	A	0.0000
223	A	A	0.0000
224	L	A	0.0000
225	T	A	-0.2331
226	L	A	0.0000
227	S	A	-0.6113
228	G	A	-0.7995
229	V	A	0.0000
230	Q	A	-1.3227
231	P	A	-1.1315
232	E	A	-1.8611
233	D	A	0.0000
234	E	A	-1.4742
235	A	A	0.0000
236	E	A	-1.4080
237	Y	A	0.0000
238	Y	A	0.0000
239	C	A	0.0000
240	A	A	0.0000
241	L	A	0.0000
242	W	A	0.3870
243	Y	A	0.1855
244	S	A	-0.3696
245	N	A	-0.4505
246	L	A	0.3997
247	W	A	0.5139
248	V	A	0.7885
249	F	A	0.5851
250	G	A	0.0000
251	G	A	-0.4909
252	G	A	-0.7203
253	T	A	0.0000
254	K	A	-1.2109
255	L	A	0.0000
256	T	A	-0.1827
257	V	A	0.2317
258	L	A	1.3654