| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFSDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGSVGHPLFNKLGDTENPTAPQHEGADVRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRAGPEGHPLPAGPPPSPLYTPPPPSSPYAVPPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPKINVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9424 | |
| 2 | L | A | 1.9639 | |
| 3 | P | A | 0.6540 | |
| 4 | P | A | 0.3725 | |
| 5 | T | A | 0.1223 | |
| 6 | T | A | 0.1323 | |
| 7 | P | A | 0.1718 | |
| 8 | V | A | 1.2410 | |
| 9 | A | A | 0.0934 | |
| 10 | K | A | -1.0050 | |
| 11 | V | A | -0.1289 | |
| 12 | Q | A | -1.3924 | |
| 13 | S | A | -1.5528 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4428 | |
| 16 | E | A | -2.4501 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4545 | |
| 20 | P | A | 0.1242 | |
| 21 | T | A | 0.1827 | |
| 22 | S | A | -0.0913 | |
| 23 | L | A | 0.1300 | |
| 24 | F | A | -0.0166 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.3019 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9056 | |
| 31 | R | A | -2.6862 | |
| 32 | L | A | -0.8018 | |
| 33 | L | A | 1.1494 | |
| 34 | T | A | 1.3471 | |
| 35 | V | A | 1.7762 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | 0.1777 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | 0.1418 | |
| 40 | S | A | -0.1005 | |
| 41 | D | A | 0.0559 | |
| 42 | I | A | 1.8178 | |
| 43 | V | A | 2.5064 | |
| 44 | V | A | 1.7165 | |
| 45 | N | A | -0.5214 | |
| 46 | G | A | -0.3314 | |
| 47 | K | A | -0.0986 | |
| 48 | V | A | 2.2353 | |
| 49 | L | A | 2.5688 | |
| 50 | V | A | 1.6878 | |
| 51 | P | A | 0.6447 | |
| 52 | K | A | -0.1255 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1281 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3919 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2702 | |
| 70 | K | A | -1.7898 | |
| 71 | F | A | -0.6387 | |
| 72 | A | A | -0.5709 | |
| 73 | L | A | -0.8563 | |
| 74 | P | A | -1.2033 | |
| 75 | Q | A | -2.5098 | |
| 76 | K | A | -3.1116 | |
| 77 | D | A | -2.9972 | |
| 78 | F | A | -1.6583 | |
| 79 | Y | A | -1.9020 | |
| 80 | D | A | -2.7028 | |
| 81 | P | A | -2.3716 | |
| 82 | E | A | -3.0577 | |
| 83 | K | A | -3.3989 | |
| 84 | E | A | -2.4667 | |
| 85 | R | A | -1.3033 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6594 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9733 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3640 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6984 | |
| 99 | G | A | -0.5394 | |
| 100 | P | A | -0.3994 | |
| 101 | L | A | 0.0520 | |
| 102 | G | A | -0.1654 | |
| 103 | K | A | -0.5502 | |
| 104 | G | A | -0.4553 | |
| 105 | S | A | -0.5390 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1039 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4150 | |
| 110 | L | A | 0.4017 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9481 | |
| 113 | K | A | -0.3697 | |
| 114 | L | A | -1.1446 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.0366 | |
| 117 | T | A | -0.8232 | |
| 118 | E | A | -1.8034 | |
| 119 | N | A | -1.9449 | |
| 120 | P | A | -1.4260 | |
| 121 | T | A | -0.7812 | |
| 122 | A | A | -0.5998 | |
| 123 | P | A | -0.7491 | |
| 124 | Q | A | -1.5443 | |
| 125 | H | A | -2.2472 | |
| 126 | E | A | -2.9127 | |
| 127 | G | A | -2.1889 | |
| 128 | A | A | -1.4574 | |
| 129 | D | A | -2.1651 | |
| 130 | V | A | -1.4303 | |
| 131 | R | A | -0.7303 | |
| 132 | V | A | 0.4427 | |
| 133 | A | A | 0.4510 | |
| 134 | F | A | 0.2815 | |
| 135 | S | A | -0.1117 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6192 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5647 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2153 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1158 | |
| 157 | D | A | 0.2772 | |
| 158 | I | A | 0.8148 | |
| 159 | A | A | 0.1060 | |
| 160 | E | A | -1.4875 | |
| 161 | P | A | -0.2300 | |
| 162 | C | A | 0.1902 | |
| 163 | P | A | -0.1632 | |
| 164 | G | A | -0.0623 | |
| 165 | L | A | 0.6210 | |
| 166 | P | A | -0.0969 | |
| 167 | P | A | -0.3318 | |
| 168 | G | A | -0.4169 | |
| 169 | A | A | -0.0158 | |
| 170 | C | A | 0.7429 | |
| 171 | P | A | 0.5528 | |
| 172 | P | A | 0.8141 | |
| 173 | I | A | 2.0449 | |
| 174 | Q | A | 0.8508 | |
| 175 | L | A | 1.4476 | |
| 176 | V | A | 0.8251 | |
| 177 | N | A | -0.3149 | |
| 178 | S | A | 0.0160 | |
| 179 | V | A | 0.4239 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3866 | |
| 182 | D | A | 0.0923 | |
| 183 | G | A | -0.1506 | |
| 184 | D | A | -0.5389 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1314 | |
| 190 | F | A | 0.0631 | |
| 191 | G | A | -0.1026 | |
| 192 | N | A | -0.2664 | |
| 193 | M | A | -0.1339 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3812 | |
| 197 | E | A | -2.5995 | |
| 198 | L | A | -1.2131 | |
| 199 | Q | A | -2.5409 | |
| 200 | Q | A | -3.3116 | |
| 201 | D | A | -3.5929 | |
| 202 | R | A | -3.3314 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.4416 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3586 | |
| 211 | S | A | -1.7156 | |
| 212 | T | A | -1.4376 | |
| 213 | R | A | -2.0970 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1616 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3471 | |
| 220 | L | A | 0.6139 | |
| 221 | K | A | -1.0904 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8080 | |
| 224 | N | A | -1.4853 | |
| 225 | E | A | -1.2289 | |
| 226 | A | A | -0.5961 | |
| 227 | Y | A | -0.3660 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6527 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0736 | |
| 234 | F | A | 0.2544 | |
| 235 | G | A | -0.8326 | |
| 236 | R | A | -2.6229 | |
| 237 | R | A | -2.9089 | |
| 238 | E | A | -2.1315 | |
| 239 | Q | A | -0.1670 | |
| 240 | V | A | 1.4514 | |
| 241 | Y | A | 1.2340 | |
| 242 | A | A | 0.1737 | |
| 243 | R | A | -1.2043 | |
| 244 | H | A | -0.9937 | |
| 245 | F | A | 0.0832 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5538 | |
| 249 | A | A | -1.3005 | |
| 250 | G | A | -1.3240 | |
| 251 | P | A | -1.1708 | |
| 252 | E | A | -1.3902 | |
| 253 | G | A | -1.2960 | |
| 254 | H | A | -1.4726 | |
| 255 | P | A | -1.0055 | |
| 256 | L | A | 0.1630 | |
| 257 | P | A | -0.0237 | |
| 258 | A | A | 0.0673 | |
| 259 | G | A | -0.1798 | |
| 260 | P | A | -0.5898 | |
| 261 | P | A | -0.4446 | |
| 262 | P | A | -0.3421 | |
| 263 | S | A | 0.1112 | |
| 264 | P | A | 0.3817 | |
| 265 | L | A | 1.5249 | |
| 266 | Y | A | 0.9040 | |
| 267 | T | A | 0.1013 | |
| 268 | P | A | 0.1766 | |
| 269 | P | A | 0.1185 | |
| 270 | P | A | -0.4051 | |
| 271 | P | A | -0.1508 | |
| 272 | S | A | -0.3461 | |
| 273 | S | A | 0.1491 | |
| 274 | P | A | 0.1741 | |
| 275 | Y | A | 1.1907 | |
| 276 | A | A | 0.9861 | |
| 277 | V | A | 1.9426 | |
| 278 | P | A | 1.0419 | |
| 279 | P | A | -0.2204 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.4331 | |
| 282 | D | A | -0.9628 | |
| 283 | Y | A | 0.8761 | |
| 284 | F | A | 0.6873 | |
| 285 | G | A | 0.2229 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8842 | |
| 291 | L | A | 1.6172 | |
| 292 | V | A | 0.6490 | |
| 293 | S | A | -0.1665 | |
| 294 | S | A | -0.9651 | |
| 295 | D | A | -1.8424 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1206 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6460 | |
| 301 | R | A | -1.8642 | |
| 302 | P | A | -0.9615 | |
| 303 | F | A | -0.2043 | |
| 304 | W | A | -0.5704 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0872 | |
| 307 | R | A | -2.8394 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2690 | |
| 310 | G | A | -1.2262 | |
| 311 | N | A | -1.2732 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7932 | |
| 319 | N | A | -0.9196 | |
| 320 | E | A | -1.0303 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3214 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0648 | |
| 333 | N | A | 0.5376 | |
| 334 | F | A | 1.7355 | |
| 335 | T | A | 0.8628 | |
| 336 | I | A | 0.4441 | |
| 337 | S | A | -0.8087 | |
| 338 | Q | A | -1.4440 | |
| 339 | Q | A | -1.0075 | |
| 340 | L | A | 0.7057 | |
| 341 | C | A | 0.1819 | |
| 342 | T | A | -0.2469 | |
| 343 | P | A | -0.9370 | |
| 344 | K | A | -1.4898 | |
| 345 | I | A | -0.0965 | |
| 346 | N | A | -0.3999 | |
| 347 | V | A | 1.5244 | |
| 348 | Y | A | 1.5764 | |
| 349 | D | A | 0.0967 | |
| 350 | P | A | -0.3322 | |
| 351 | S | A | -0.2641 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5608 | |
| 354 | K | A | -1.6362 | |
| 355 | N | A | -1.6887 | |
| 356 | Y | A | -0.1040 | |
| 357 | L | A | 0.6257 | |
| 358 | R | A | 0.9370 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3726 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0869 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0546 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6927 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3056 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3091 | |
| 376 | L | A | -1.7032 | |
| 377 | D | A | -1.9779 | |
| 378 | P | A | -1.0312 | |
| 379 | G | A | -1.0098 | |
| 380 | V | A | -0.9284 | |
| 381 | L | A | -0.5233 | |
| 382 | A | A | -0.6483 | |
| 383 | H | A | -0.7963 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3956 | |
| 386 | T | A | -0.5400 | |
| 387 | M | A | -0.2906 | |
| 388 | N | A | -0.8606 | |
| 389 | P | A | -1.2327 | |
| 390 | T | A | -1.4259 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4254 | |
| 393 | E | A | -2.7547 | |
| 394 | N | A | -2.3387 | |
| 395 | W | A | -1.3648 | |
| 396 | N | A | -1.1402 | |
| 397 | L | A | -0.1868 | |
| 398 | G | A | 0.5035 | |
| 399 | F | A | 2.4039 | |
| 400 | V | A | 1.8112 | |
| 401 | P | A | 0.0409 | |
| 402 | P | A | -1.8419 | |
| 403 | K | A | -3.3023 | |
| 404 | E | A | -3.7563 | |
| 405 | R | A | -3.8626 | |
| 406 | E | A | -3.7630 | |
| 407 | D | A | -2.8505 | |
| 408 | P | A | -1.7533 | |
| 409 | Y | A | -0.9863 | |
| 410 | K | A | -2.1139 | |
| 411 | G | A | -0.6358 | |
| 412 | L | A | 0.6710 | |
| 413 | I | A | 1.5897 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3836 | |
| 416 | E | A | -1.6704 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9463 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0620 | |
| 421 | E | A | -2.7985 | |
| 422 | R | A | -2.6686 | |
| 423 | F | A | -1.2920 | |
| 424 | S | A | -1.4639 | |
| 425 | Q | A | -1.8304 | |
| 426 | D | A | -2.8873 | |
| 427 | L | A | -1.9810 | |
| 428 | D | A | -2.7788 | |
| 429 | Q | A | -2.6166 | |
| 430 | F | A | -1.4252 | |
| 431 | A | A | -0.8983 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5812 | |
| 435 | K | A | -0.7174 | |
| 436 | F | A | 0.1385 | |
| 437 | L | A | 1.0260 | |
| 438 | Y | A | 0.8208 | |
| 439 | Q | A | -0.2786 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine