Project name: 6e46ff206059329

Chain sequence(s)	P: GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLS
Selected Chain(s)	P
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with P chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:56)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:57)

• Minimal score value: -3.4483
• Maximal score value: 1.7568
• Average score: -0.6221
• Total score value: -161.1365

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
244	G	P	-0.5192
245	C	P	0.0125
246	G	P	-0.4081
247	E	P	-0.9503
248	L	P	0.0000
249	V	P	1.2128
250	W	P	0.6281
251	V	P	0.0000
252	G	P	-1.3743
253	E	P	-2.0470
254	P	P	-0.8589
255	L	P	0.6764
256	T	P	0.1891
257	L	P	-0.0227
258	R	P	-1.7909
259	T	P	0.0000
260	A	P	-0.6037
261	E	P	-0.7297
262	T	P	0.1599
263	I	P	1.2862
264	T	P	0.1837
265	G	P	-0.7350
266	K	P	-2.0489
267	Y	P	-0.9913
268	G	P	-0.5896
269	V	P	0.0000
270	W	P	0.0549
271	M	P	0.0000
272	R	P	0.0000
273	D	P	0.0000
274	P	P	0.0000
275	K	P	-1.1454
276	P	P	-0.6704
277	T	P	0.1336
278	Y	P	1.0774
279	P	P	0.5157
280	Y	P	-0.3931
281	T	P	-1.0461
282	Q	P	-2.0512
283	E	P	-1.6730
284	T	P	0.0000
285	T	P	0.0000
286	W	P	0.0000
287	R	P	0.0000
288	I	P	0.0000
289	D	P	-0.5868
290	T	P	-0.6984
291	V	P	0.1533
292	G	P	-0.4886
293	T	P	-0.9010
294	D	P	-1.7420
295	V	P	0.0000
296	R	P	-0.8565
297	Q	P	0.0211
298	V	P	0.0000
299	F	P	0.0000
300	E	P	-0.8789
301	Y	P	0.0000
302	D	P	-1.8552
303	L	P	-0.4535
304	I	P	-0.2903
305	S	P	-0.5536
306	Q	P	-0.4295
307	F	P	0.0000
308	M	P	0.0000
309	Q	P	-1.1203
310	G	P	0.0000
311	Y	P	0.5389
312	P	P	0.0675
313	S	P	0.0000
314	K	P	-1.1646
315	V	P	0.5025
316	H	P	0.2688
317	I	P	1.0394
318	L	P	0.0000
319	P	P	-0.7062
320	R	P	-1.3908
321	P	P	-1.2445
322	L	P	0.0000
323	E	P	-2.5648
324	S	P	-1.3845
325	T	P	-0.6344
326	G	P	-0.2852
327	A	P	-0.0009
328	V	P	0.0000
329	V	P	0.0000
330	Y	P	0.0000
331	S	P	-0.5019
332	G	P	-0.2710
333	S	P	0.0000
334	L	P	0.0000
335	Y	P	0.0000
336	F	P	0.0000
337	Q	P	0.0000
338	G	P	-1.6960
339	A	P	-1.7594
340	E	P	-2.4710
341	S	P	-1.8917
342	R	P	-2.4105
343	T	P	-2.3349
344	V	P	0.0000
345	I	P	0.0000
346	R	P	-1.3901
347	Y	P	0.0000
348	E	P	-1.3066
349	L	P	-1.2362
350	N	P	-1.9004
351	T	P	-1.6436
352	E	P	-2.1821
353	T	P	-1.1417
354	V	P	-0.6847
355	K	P	-2.0046
356	A	P	-2.1096
357	E	P	-2.8133
358	K	P	-3.1102
359	E	P	-3.1751
360	I	P	0.0000
361	P	P	-1.0872
362	G	P	-1.1414
363	A	P	-1.4142
364	G	P	-1.3512
365	Y	P	-1.1022
366	H	P	-1.0876
367	G	P	-0.1092
368	Q	P	-0.3376
369	F	P	1.5817
370	P	P	1.2531
371	Y	P	1.7568
372	S	P	1.0537
373	W	P	1.0960
374	G	P	-0.5944
375	G	P	-1.1777
376	Y	P	-1.0030
377	T	P	-1.3106
378	D	P	-1.2241
379	I	P	0.0000
380	D	P	-0.7985
381	L	P	0.0000
382	A	P	0.0000
383	V	P	-0.2571
384	D	P	-0.6948
385	E	P	-1.4022
386	A	P	-0.6979
387	G	P	-0.8322
388	L	P	0.0000
389	W	P	0.0000
390	V	P	0.0000
391	I	P	0.0000
392	Y	P	0.0000
393	S	P	0.0000
394	T	P	-2.5056
395	D	P	-3.4483
396	E	P	-3.1733
397	A	P	-2.8995
398	K	P	-3.4356
399	G	P	0.0000
400	A	P	0.0000
401	I	P	0.0000
402	V	P	0.0000
403	L	P	0.0000
404	S	P	0.0000
405	K	P	-1.4553
406	L	P	0.0000
407	N	P	-2.0893
408	P	P	-1.7643
409	E	P	-2.9540
410	N	P	-3.1148
411	L	P	0.0000
412	E	P	-3.0117
413	L	P	-1.4198
414	E	P	-1.8540
415	Q	P	-1.8455
416	T	P	-1.1575
417	W	P	-0.9962
418	E	P	-1.8120
419	T	P	0.0000
420	N	P	-1.9835
421	I	P	-1.4425
422	R	P	-2.4995
423	K	P	0.0000
424	Q	P	-1.3287
425	S	P	-0.9559
426	V	P	-0.5855
427	A	P	-0.2054
428	N	P	-0.4029
429	A	P	-0.1690
430	F	P	0.0000
431	I	P	0.0000
432	I	P	0.0000
433	C	P	0.0160
434	G	P	-0.2472
435	T	P	0.0000
436	L	P	0.0000
437	Y	P	0.0000
438	T	P	0.0000
439	V	P	0.0000
440	S	P	-0.2097
441	S	P	-0.5343
442	Y	P	-0.6930
443	T	P	-0.3791
444	S	P	-0.6050
445	A	P	-1.0715
446	D	P	-1.6819
447	A	P	0.0000
448	T	P	-0.3136
449	V	P	0.0000
450	N	P	0.3431
451	F	P	0.9412
452	A	P	0.1144
453	Y	P	0.0000
454	D	P	-0.4424
455	T	P	-0.5899
456	G	P	-0.4125
457	T	P	-0.0743
458	G	P	-0.3489
459	I	P	0.3321
460	S	P	-0.1150
461	K	P	-1.0317
462	T	P	-0.1939
463	L	P	0.5196
464	T	P	0.3944
465	I	P	0.0000
466	P	P	-0.7739
467	F	P	0.0000
468	K	P	-2.7388
469	N	P	-2.1654
470	R	P	-2.3321
471	Y	P	-0.5865
472	K	P	-1.7623
473	Y	P	0.0000
474	S	P	-0.6931
475	S	P	-0.1100
476	M	P	0.0965
477	I	P	-0.0168
478	D	P	-0.3636
479	Y	P	0.0000
480	N	P	0.0000
481	P	P	0.0000
482	L	P	-1.4851
483	E	P	-2.2948
484	K	P	-1.8081
485	K	P	-1.6159
486	L	P	0.0000
487	F	P	0.0000
488	A	P	0.0000
489	W	P	-0.3760
490	D	P	-1.2790
491	N	P	-1.3073
492	L	P	-0.3853
493	N	P	-0.7110
494	M	P	-0.1165
495	V	P	0.0000
496	T	P	0.0000
497	Y	P	0.0000
498	D	P	-1.9313
499	I	P	0.0000
500	K	P	-0.7777
501	L	P	0.1971
502	S	P	0.0670