| Chain sequence(s) |
A: GPAAGAPGPALRSTDEYVEPTDLYYIAETDLLTETGHPTADIVVNGKVVLPRVSAYQWRVFLLKLPDPNKMPLPSEDFINPETEILIWRLLAFKIHVGGPLGEGTYGHPNFNALGDVDNPTAPVHETADVTQALSWRPVRRQEYIIGDRPPTGKYTARAPPAPGLPPGAIPPLTTVSTIIEHGDMADIGFGARDYAALLPNKDDVPDLIRDTTTKVVDYDGMAAEPYGRRMFTRDRLESSEAIKTLRRAGPEAVPLPDSPPPPLLYTKPPPWSPLAVLPSTDLFTLPDRGEITESDLLFNRPFFLEKTAGKNNGVLWHNRLYVTVLDNSRATIEELTTKISTPAENVYDPSNYVTSRRFTREYRLSLIVQLCKIPLTPETLAELARLDPRILVDANLPDIPPVERADPLAGLRFIEIDLTDRFSSELEKSDLGREFLNK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.5635 | |
| 2 | P | A | -0.5018 | |
| 3 | A | A | -0.2869 | |
| 4 | A | A | -0.2914 | |
| 5 | G | A | -0.5629 | |
| 6 | A | A | -0.4094 | |
| 7 | P | A | -0.6042 | |
| 8 | G | A | -0.6904 | |
| 9 | P | A | -0.4722 | |
| 10 | A | A | -0.1862 | |
| 11 | L | A | -0.2496 | |
| 12 | R | A | -1.2969 | |
| 13 | S | A | -1.7375 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -3.2060 | |
| 16 | E | A | -3.0481 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.2563 | |
| 20 | P | A | -1.5959 | |
| 21 | T | A | -1.1782 | |
| 22 | D | A | -1.5910 | |
| 23 | L | A | -0.3774 | |
| 24 | Y | A | 0.0465 | |
| 25 | Y | A | 0.1182 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.4568 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.6631 | |
| 31 | L | A | -0.1696 | |
| 32 | L | A | -0.1850 | |
| 33 | T | A | -0.4104 | |
| 34 | E | A | -0.6177 | |
| 35 | T | A | -0.5258 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.7421 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.6838 | |
| 40 | A | A | -0.5750 | |
| 41 | D | A | -0.1318 | |
| 42 | I | A | 1.8255 | |
| 43 | V | A | 2.5803 | |
| 44 | V | A | 1.8391 | |
| 45 | N | A | -0.4640 | |
| 46 | G | A | -0.2723 | |
| 47 | K | A | -0.0366 | |
| 48 | V | A | 2.2389 | |
| 49 | V | A | 2.7010 | |
| 50 | L | A | 1.4937 | |
| 51 | P | A | 0.2231 | |
| 52 | R | A | -0.5377 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -1.9103 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.6022 | |
| 67 | D | A | -1.6005 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -2.0587 | |
| 70 | K | A | -2.1394 | |
| 71 | M | A | -1.0470 | |
| 72 | P | A | -0.7336 | |
| 73 | L | A | -0.6042 | |
| 74 | P | A | -0.6581 | |
| 75 | S | A | -1.4924 | |
| 76 | E | A | -2.7302 | |
| 77 | D | A | -2.7167 | |
| 78 | F | A | -1.3344 | |
| 79 | I | A | -1.5881 | |
| 80 | N | A | -2.2700 | |
| 81 | P | A | -1.8853 | |
| 82 | E | A | -2.3114 | |
| 83 | T | A | -1.4074 | |
| 84 | E | A | -1.3099 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.2267 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.1692 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -1.1354 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -1.3265 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.5944 | |
| 99 | G | A | -0.6199 | |
| 100 | P | A | -0.3566 | |
| 101 | L | A | -0.1920 | |
| 102 | G | A | -0.4841 | |
| 103 | E | A | -1.4438 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5179 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.5972 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.2635 | |
| 110 | N | A | -2.3477 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -0.9164 | |
| 116 | D | A | -1.4007 | |
| 117 | V | A | -1.2023 | |
| 118 | D | A | -2.4308 | |
| 119 | N | A | -2.3979 | |
| 120 | P | A | -1.3819 | |
| 121 | T | A | -0.7185 | |
| 122 | A | A | -0.4321 | |
| 123 | P | A | -0.1293 | |
| 124 | V | A | -0.4113 | |
| 125 | H | A | -1.0347 | |
| 126 | E | A | -1.8141 | |
| 127 | T | A | -1.4177 | |
| 128 | A | A | -1.1872 | |
| 129 | D | A | -2.2082 | |
| 130 | V | A | -1.5365 | |
| 131 | T | A | -1.5706 | |
| 132 | Q | A | -1.8060 | |
| 133 | A | A | -0.9872 | |
| 134 | L | A | -0.4541 | |
| 135 | S | A | -0.4331 | |
| 136 | W | A | 0.0000 | |
| 137 | R | A | -0.5945 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | R | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.4527 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | -0.3609 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.4956 | |
| 155 | Y | A | -0.3662 | |
| 156 | T | A | -0.2937 | |
| 157 | A | A | -0.6476 | |
| 158 | R | A | -1.1760 | |
| 159 | A | A | -0.5055 | |
| 160 | P | A | -0.6216 | |
| 161 | P | A | -0.2686 | |
| 162 | A | A | -0.2278 | |
| 163 | P | A | -0.3992 | |
| 164 | G | A | -0.3905 | |
| 165 | L | A | 0.3480 | |
| 166 | P | A | -0.0748 | |
| 167 | P | A | -0.2321 | |
| 168 | G | A | -0.1234 | |
| 169 | A | A | 0.9446 | |
| 170 | I | A | 2.1067 | |
| 171 | P | A | 0.7965 | |
| 172 | P | A | 0.5366 | |
| 173 | L | A | 1.0101 | |
| 174 | T | A | 0.2067 | |
| 175 | T | A | -0.0123 | |
| 176 | V | A | 0.0183 | |
| 177 | S | A | -0.1954 | |
| 178 | T | A | -0.0501 | |
| 179 | I | A | -0.0792 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -0.7621 | |
| 182 | H | A | -0.9312 | |
| 183 | G | A | -0.6355 | |
| 184 | D | A | -0.5952 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2674 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.5611 | |
| 190 | F | A | -0.1213 | |
| 191 | G | A | -0.2972 | |
| 192 | A | A | -0.4509 | |
| 193 | R | A | -0.7010 | |
| 194 | D | A | -1.1079 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.2241 | |
| 197 | A | A | -0.8310 | |
| 198 | L | A | -0.0126 | |
| 199 | L | A | -0.8756 | |
| 200 | P | A | -1.2299 | |
| 201 | N | A | -1.7821 | |
| 202 | K | A | -2.9866 | |
| 203 | D | A | -2.2747 | |
| 204 | D | A | -1.3931 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.6551 | |
| 208 | L | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -2.2612 | |
| 211 | D | A | -2.4481 | |
| 212 | T | A | -1.3089 | |
| 213 | T | A | -0.8557 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | -0.0315 | |
| 217 | V | A | 0.0000 | |
| 218 | D | A | -0.8290 | |
| 219 | Y | A | -1.0576 | |
| 220 | D | A | -1.8742 | |
| 221 | G | A | -1.2783 | |
| 222 | M | A | 0.0000 | |
| 223 | A | A | -0.7624 | |
| 224 | A | A | -0.6914 | |
| 225 | E | A | -0.8605 | |
| 226 | P | A | -0.5290 | |
| 227 | Y | A | -0.5096 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.3693 | |
| 231 | M | A | -0.3711 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.9824 | |
| 234 | R | A | -1.8106 | |
| 235 | D | A | -1.5860 | |
| 236 | R | A | -1.3138 | |
| 237 | L | A | -0.5979 | |
| 238 | E | A | -0.9335 | |
| 239 | S | A | -1.1450 | |
| 240 | S | A | -1.4150 | |
| 241 | E | A | -1.5795 | |
| 242 | A | A | -0.2419 | |
| 243 | I | A | 0.7307 | |
| 244 | K | A | -0.7662 | |
| 245 | T | A | -0.4547 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | -0.2719 | |
| 248 | R | A | -0.7231 | |
| 249 | A | A | -1.1328 | |
| 250 | G | A | -0.9063 | |
| 251 | P | A | -0.7814 | |
| 252 | E | A | -0.4578 | |
| 253 | A | A | 0.8429 | |
| 254 | V | A | 1.7719 | |
| 255 | P | A | 0.3839 | |
| 256 | L | A | 0.6711 | |
| 257 | P | A | -0.0826 | |
| 258 | D | A | -1.5360 | |
| 259 | S | A | -0.8731 | |
| 260 | P | A | -0.6759 | |
| 261 | P | A | -0.7564 | |
| 262 | P | A | -0.4429 | |
| 263 | P | A | 0.0123 | |
| 264 | L | A | 0.4566 | |
| 265 | L | A | 1.4138 | |
| 266 | Y | A | 0.5239 | |
| 267 | T | A | -0.5783 | |
| 268 | K | A | -1.3520 | |
| 269 | P | A | -0.3001 | |
| 270 | P | A | -0.2186 | |
| 271 | P | A | 0.3508 | |
| 272 | W | A | 1.0748 | |
| 273 | S | A | 0.7157 | |
| 274 | P | A | 0.6801 | |
| 275 | L | A | 1.2199 | |
| 276 | A | A | 1.1435 | |
| 277 | V | A | 1.7154 | |
| 278 | L | A | 1.1531 | |
| 279 | P | A | -0.0336 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.3693 | |
| 282 | D | A | -1.2083 | |
| 283 | L | A | 0.4427 | |
| 284 | F | A | 0.2906 | |
| 285 | T | A | 0.2365 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.2473 | |
| 291 | E | A | -2.0190 | |
| 292 | I | A | -1.3730 | |
| 293 | T | A | -1.5145 | |
| 294 | E | A | -2.0546 | |
| 295 | S | A | -1.5021 | |
| 296 | D | A | -1.6584 | |
| 297 | L | A | -1.0018 | |
| 298 | L | A | -0.8252 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.5663 | |
| 301 | R | A | -2.0449 | |
| 302 | P | A | -1.0523 | |
| 303 | F | A | -0.0197 | |
| 304 | F | A | -0.4297 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.4804 | |
| 307 | K | A | -2.8605 | |
| 308 | T | A | 0.0000 | |
| 309 | A | A | -0.5948 | |
| 310 | G | A | -0.9350 | |
| 311 | K | A | -1.8439 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.5756 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9903 | |
| 319 | N | A | -1.0547 | |
| 320 | R | A | -1.1291 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | T | A | -1.0571 | |
| 333 | I | A | -1.3914 | |
| 334 | E | A | -2.3296 | |
| 335 | E | A | -2.3291 | |
| 336 | L | A | -0.2822 | |
| 337 | T | A | 0.1692 | |
| 338 | T | A | 0.2444 | |
| 339 | K | A | -0.5021 | |
| 340 | I | A | 1.3799 | |
| 341 | S | A | 0.3269 | |
| 342 | T | A | -0.3150 | |
| 343 | P | A | -0.3122 | |
| 344 | A | A | -0.5370 | |
| 345 | E | A | -1.6976 | |
| 346 | N | A | -1.0526 | |
| 347 | V | A | 1.0479 | |
| 348 | Y | A | 1.1619 | |
| 349 | D | A | 0.0295 | |
| 350 | P | A | 0.0416 | |
| 351 | S | A | -0.0428 | |
| 352 | N | A | 0.1627 | |
| 353 | Y | A | 0.6947 | |
| 354 | V | A | 1.3847 | |
| 355 | T | A | 0.0634 | |
| 356 | S | A | -0.6130 | |
| 357 | R | A | -1.7294 | |
| 358 | R | A | -1.5477 | |
| 359 | F | A | 0.0000 | |
| 360 | T | A | -0.6930 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.6863 | |
| 363 | Y | A | 0.0000 | |
| 364 | R | A | -1.5206 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.9736 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.9069 | |
| 376 | L | A | -0.6264 | |
| 377 | T | A | -0.5933 | |
| 378 | P | A | -0.9231 | |
| 379 | E | A | -1.7475 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.2214 | |
| 382 | A | A | -0.5979 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -0.2486 | |
| 386 | R | A | -0.7650 | |
| 387 | L | A | -0.2713 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -0.8499 | |
| 390 | R | A | -1.4523 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.6514 | |
| 394 | D | A | -2.4924 | |
| 395 | A | A | -1.6521 | |
| 396 | N | A | -1.9689 | |
| 397 | L | A | -1.3694 | |
| 398 | P | A | -1.3904 | |
| 399 | D | A | -1.8718 | |
| 400 | I | A | -0.7324 | |
| 401 | P | A | -0.6796 | |
| 402 | P | A | -0.9424 | |
| 403 | V | A | -1.0837 | |
| 404 | E | A | -2.6981 | |
| 405 | R | A | -3.0044 | |
| 406 | A | A | -1.6894 | |
| 407 | D | A | -1.3875 | |
| 408 | P | A | -0.8629 | |
| 409 | L | A | -0.3247 | |
| 410 | A | A | -0.4728 | |
| 411 | G | A | -0.7111 | |
| 412 | L | A | -0.6618 | |
| 413 | R | A | -1.9361 | |
| 414 | F | A | -1.1071 | |
| 415 | I | A | -1.0282 | |
| 416 | E | A | -2.3029 | |
| 417 | I | A | -1.8437 | |
| 418 | D | A | -2.8763 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.9363 | |
| 421 | D | A | -2.6465 | |
| 422 | R | A | -2.5802 | |
| 423 | F | A | -1.0754 | |
| 424 | S | A | -1.0872 | |
| 425 | S | A | -0.8612 | |
| 426 | E | A | -2.1833 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.7212 | |
| 429 | K | A | -3.5102 | |
| 430 | S | A | 0.0000 | |
| 431 | D | A | -2.5438 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.4937 | |
| 435 | E | A | -2.3524 | |
| 436 | F | A | -1.0145 | |
| 437 | L | A | -0.5969 | |
| 438 | N | A | -2.1014 | |
| 439 | K | A | -2.0517 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine