| Chain sequence(s) |
A: GLLALNPEPPLLPDTEYVTPTDLYYYAETDLITEKGNPFADIVVNGKVVVPRVSAYQYRVFKLTLPDPNKLPLPSEDFVDFSTERLIWRLLAFKIKVFGPLGKGTYGHPNFNRLGDVDNPTEYQHETEDVTVNLSFRPVRLQEYIIGNLPPIGVYTTKAAPAPGLPPGARPPLEKKTSYIQHGDIADIGFGAKNYKELLPEKNDVPDLILNTTTKVIDYEGMKADPWGDRMFDYDEKRSSSASRTLRRSGPDLDPPPNAPPPPLTYVPPPPGSPFAVPPPRDLFTLPDEGEITKEDELFNKPRFLTKTAGLNNGVLWNNQLYITVLDNTRAEIEVNKTKIATPANNVYNPAYYVTSLTYTREYQLELIIQLCKIPLTPEVLELIRRRDPSILVNANLPDIPPVEREDPYKGLKFIEIDLTNKLSSDLEKSPLGREFLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.7246 | |
| 2 | L | A | 2.2990 | |
| 3 | L | A | 2.4241 | |
| 4 | A | A | 1.5127 | |
| 5 | L | A | 1.2856 | |
| 6 | N | A | -0.9270 | |
| 7 | P | A | -1.4106 | |
| 8 | E | A | -2.1636 | |
| 9 | P | A | -1.5011 | |
| 10 | P | A | -0.5325 | |
| 11 | L | A | 0.1912 | |
| 12 | L | A | 0.2513 | |
| 13 | P | A | -0.2098 | |
| 14 | D | A | 0.0000 | |
| 15 | T | A | -1.0931 | |
| 16 | E | A | -1.7324 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.5921 | |
| 20 | P | A | -0.6450 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.5885 | |
| 23 | L | A | -0.4077 | |
| 24 | Y | A | 0.0071 | |
| 25 | Y | A | 0.2195 | |
| 26 | Y | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9815 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2920 | |
| 31 | L | A | 0.3280 | |
| 32 | I | A | 0.2423 | |
| 33 | T | A | -0.5014 | |
| 34 | E | A | -1.1432 | |
| 35 | K | A | -1.9381 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -0.5275 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | 0.0183 | |
| 40 | A | A | 0.0114 | |
| 41 | D | A | 0.3280 | |
| 42 | I | A | 2.2538 | |
| 43 | V | A | 2.7107 | |
| 44 | V | A | 1.8986 | |
| 45 | N | A | -0.5056 | |
| 46 | G | A | -0.3029 | |
| 47 | K | A | -0.0127 | |
| 48 | V | A | 2.3180 | |
| 49 | V | A | 2.7874 | |
| 50 | V | A | 1.7726 | |
| 51 | P | A | 0.2609 | |
| 52 | R | A | -0.5101 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.1540 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2494 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.2042 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2672 | |
| 70 | K | A | -1.8173 | |
| 71 | L | A | -0.7747 | |
| 72 | P | A | -0.6630 | |
| 73 | L | A | -0.6695 | |
| 74 | P | A | -0.7060 | |
| 75 | S | A | -1.5519 | |
| 76 | E | A | -2.9142 | |
| 77 | D | A | -2.8510 | |
| 78 | F | A | -1.4683 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -2.1725 | |
| 81 | F | A | -0.4934 | |
| 82 | S | A | -0.5304 | |
| 83 | T | A | -0.6363 | |
| 84 | E | A | -0.8994 | |
| 85 | R | A | -0.7652 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.2458 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.0914 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -0.9073 | |
| 95 | I | A | 0.0000 | |
| 96 | K | A | -0.4870 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.3855 | |
| 99 | G | A | -0.3950 | |
| 100 | P | A | -0.3583 | |
| 101 | L | A | -0.2128 | |
| 102 | G | A | -0.7865 | |
| 103 | K | A | -1.4788 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.7684 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.8255 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.4542 | |
| 110 | N | A | -2.2056 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.4910 | |
| 113 | R | A | -0.9056 | |
| 114 | L | A | -0.9127 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.6110 | |
| 117 | V | A | -1.4536 | |
| 118 | D | A | -2.8498 | |
| 119 | N | A | -2.6570 | |
| 120 | P | A | -1.8621 | |
| 121 | T | A | -1.5216 | |
| 122 | E | A | -2.0156 | |
| 123 | Y | A | -0.3839 | |
| 124 | Q | A | -0.7331 | |
| 125 | H | A | -1.0608 | |
| 126 | E | A | -2.0900 | |
| 127 | T | A | -1.9196 | |
| 128 | E | A | -3.0086 | |
| 129 | D | A | -2.8602 | |
| 130 | V | A | -1.5202 | |
| 131 | T | A | -1.4036 | |
| 132 | V | A | -0.9461 | |
| 133 | N | A | -1.5944 | |
| 134 | L | A | -0.8097 | |
| 135 | S | A | -0.6063 | |
| 136 | F | A | 0.0000 | |
| 137 | R | A | -0.9951 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | N | A | 0.0000 | |
| 149 | L | A | 0.2465 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | 0.5176 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | -0.1993 | |
| 155 | Y | A | -0.8531 | |
| 156 | T | A | -1.2111 | |
| 157 | T | A | 0.0000 | |
| 158 | K | A | -1.8693 | |
| 159 | A | A | -0.5945 | |
| 160 | A | A | -0.2105 | |
| 161 | P | A | -0.3708 | |
| 162 | A | A | -0.1191 | |
| 163 | P | A | -0.3201 | |
| 164 | G | A | -0.3255 | |
| 165 | L | A | -0.0771 | |
| 166 | P | A | -0.4931 | |
| 167 | P | A | -0.7177 | |
| 168 | G | A | -0.7573 | |
| 169 | A | A | -0.8690 | |
| 170 | R | A | -1.8260 | |
| 171 | P | A | -1.1100 | |
| 172 | P | A | -0.2244 | |
| 173 | L | A | -0.0246 | |
| 174 | E | A | -1.3787 | |
| 175 | K | A | -2.2982 | |
| 176 | K | A | -1.8580 | |
| 177 | T | A | -0.5880 | |
| 178 | S | A | 0.0683 | |
| 179 | Y | A | 0.3868 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.7060 | |
| 182 | H | A | -0.9413 | |
| 183 | G | A | -0.6725 | |
| 184 | D | A | -0.5487 | |
| 185 | I | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2902 | |
| 190 | F | A | -0.0383 | |
| 191 | G | A | -0.2154 | |
| 192 | A | A | -0.3619 | |
| 193 | K | A | -1.4029 | |
| 194 | N | A | -1.8113 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -3.3785 | |
| 197 | E | A | -2.9759 | |
| 198 | L | A | -1.6841 | |
| 199 | L | A | -1.8476 | |
| 200 | P | A | -2.1547 | |
| 201 | E | A | -2.5131 | |
| 202 | K | A | -2.8813 | |
| 203 | N | A | -2.0356 | |
| 204 | D | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.0297 | |
| 208 | L | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.2972 | |
| 211 | N | A | -2.1341 | |
| 212 | T | A | -1.3037 | |
| 213 | T | A | -0.9693 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.4376 | |
| 217 | I | A | 0.0000 | |
| 218 | D | A | -0.7389 | |
| 219 | Y | A | -1.2091 | |
| 220 | E | A | -2.4887 | |
| 221 | G | A | -1.6185 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.2623 | |
| 224 | A | A | -1.3843 | |
| 225 | D | A | -1.1682 | |
| 226 | P | A | -0.4469 | |
| 227 | W | A | -0.1377 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.3198 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.6012 | |
| 234 | Y | A | -0.1756 | |
| 235 | D | A | -0.8563 | |
| 236 | E | A | -1.3338 | |
| 237 | K | A | -1.6657 | |
| 238 | R | A | -1.4240 | |
| 239 | S | A | -1.1417 | |
| 240 | S | A | -0.9256 | |
| 241 | S | A | -0.7022 | |
| 242 | A | A | -0.7896 | |
| 243 | S | A | -1.3960 | |
| 244 | R | A | -2.4226 | |
| 245 | T | A | -1.2634 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | -0.8340 | |
| 248 | R | A | -0.9354 | |
| 249 | S | A | -1.4902 | |
| 250 | G | A | -0.8022 | |
| 251 | P | A | -0.9424 | |
| 252 | D | A | -1.0841 | |
| 253 | L | A | -0.4128 | |
| 254 | D | A | -1.8937 | |
| 255 | P | A | -1.4120 | |
| 256 | P | A | -1.0450 | |
| 257 | P | A | -1.0035 | |
| 258 | N | A | -1.5539 | |
| 259 | A | A | -1.1816 | |
| 260 | P | A | -0.7258 | |
| 261 | P | A | -0.1893 | |
| 262 | P | A | 0.1883 | |
| 263 | P | A | 0.7215 | |
| 264 | L | A | 1.7135 | |
| 265 | T | A | 1.1525 | |
| 266 | Y | A | 1.4991 | |
| 267 | V | A | 2.0251 | |
| 268 | P | A | 0.9705 | |
| 269 | P | A | 0.6618 | |
| 270 | P | A | -0.1781 | |
| 271 | P | A | -0.4905 | |
| 272 | G | A | -0.2950 | |
| 273 | S | A | 0.2618 | |
| 274 | P | A | 0.6471 | |
| 275 | F | A | 1.7220 | |
| 276 | A | A | 1.2287 | |
| 277 | V | A | 1.7632 | |
| 278 | P | A | 0.5699 | |
| 279 | P | A | -0.5516 | |
| 280 | P | A | 0.0000 | |
| 281 | R | A | -1.9043 | |
| 282 | D | A | -1.3035 | |
| 283 | L | A | 0.4336 | |
| 284 | F | A | 0.0856 | |
| 285 | T | A | -0.4483 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.1582 | |
| 289 | E | A | 0.0000 | |
| 290 | G | A | -1.3254 | |
| 291 | E | A | -2.0024 | |
| 292 | I | A | -1.4879 | |
| 293 | T | A | -1.9536 | |
| 294 | K | A | -2.7219 | |
| 295 | E | A | -3.0375 | |
| 296 | D | A | -2.5343 | |
| 297 | E | A | 0.0000 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1560 | |
| 301 | K | A | -1.5242 | |
| 302 | P | A | -1.0899 | |
| 303 | R | A | -0.6800 | |
| 304 | F | A | -0.3127 | |
| 305 | L | A | -0.3881 | |
| 306 | T | A | -0.7689 | |
| 307 | K | A | -1.6952 | |
| 308 | T | A | 0.0000 | |
| 309 | A | A | -0.6416 | |
| 310 | G | A | -0.6741 | |
| 311 | L | A | -0.0620 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -0.6426 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | N | A | -0.8792 | |
| 319 | N | A | -0.7718 | |
| 320 | Q | A | -0.6232 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.0817 | |
| 333 | I | A | -0.9957 | |
| 334 | E | A | -1.1706 | |
| 335 | V | A | 0.2867 | |
| 336 | N | A | -0.6864 | |
| 337 | K | A | -1.3672 | |
| 338 | T | A | -0.6603 | |
| 339 | K | A | -0.3790 | |
| 340 | I | A | 1.6198 | |
| 341 | A | A | 0.7963 | |
| 342 | T | A | 0.1325 | |
| 343 | P | A | 0.1624 | |
| 344 | A | A | -0.4316 | |
| 345 | N | A | -1.1277 | |
| 346 | N | A | -0.7715 | |
| 347 | V | A | 1.2448 | |
| 348 | Y | A | 1.4559 | |
| 349 | N | A | 0.4245 | |
| 350 | P | A | -0.0818 | |
| 351 | A | A | 0.5555 | |
| 352 | Y | A | 0.7770 | |
| 353 | Y | A | 0.6144 | |
| 354 | V | A | 0.9334 | |
| 355 | T | A | 0.0386 | |
| 356 | S | A | 0.0095 | |
| 357 | L | A | 0.2396 | |
| 358 | T | A | -0.5525 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -1.3795 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.3627 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.3761 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | I | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.6169 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.5968 | |
| 376 | L | A | -0.3523 | |
| 377 | T | A | -0.8083 | |
| 378 | P | A | -1.2975 | |
| 379 | E | A | -2.3405 | |
| 380 | V | A | 0.0000 | |
| 381 | L | A | -1.3018 | |
| 382 | E | A | -2.2870 | |
| 383 | L | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | R | A | -2.2695 | |
| 386 | R | A | -1.6832 | |
| 387 | R | A | -1.2774 | |
| 388 | D | A | -1.4042 | |
| 389 | P | A | -1.3430 | |
| 390 | S | A | -1.1944 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.2109 | |
| 394 | N | A | -1.4664 | |
| 395 | A | A | -1.2782 | |
| 396 | N | A | -1.9073 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | -1.2721 | |
| 399 | D | A | -1.8870 | |
| 400 | I | A | -0.6090 | |
| 401 | P | A | -0.4346 | |
| 402 | P | A | -0.6874 | |
| 403 | V | A | -0.0634 | |
| 404 | E | A | -2.5115 | |
| 405 | R | A | -3.3912 | |
| 406 | E | A | -3.8338 | |
| 407 | D | A | -3.2459 | |
| 408 | P | A | -1.9915 | |
| 409 | Y | A | -1.5751 | |
| 410 | K | A | -2.7987 | |
| 411 | G | A | -1.6484 | |
| 412 | L | A | -1.2680 | |
| 413 | K | A | -2.1055 | |
| 414 | F | A | -1.1409 | |
| 415 | I | A | -1.1169 | |
| 416 | E | A | -2.2733 | |
| 417 | I | A | -1.7629 | |
| 418 | D | A | -2.4756 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.3458 | |
| 421 | N | A | -1.7957 | |
| 422 | K | A | -1.6550 | |
| 423 | L | A | -0.5543 | |
| 424 | S | A | -0.7472 | |
| 425 | S | A | -0.7204 | |
| 426 | D | A | -1.8679 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.4034 | |
| 429 | K | A | -3.1912 | |
| 430 | S | A | 0.0000 | |
| 431 | P | A | -1.5683 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.3546 | |
| 435 | E | A | -2.4280 | |
| 436 | F | A | -1.3402 | |
| 437 | L | A | -1.0664 | |
| 438 | N | A | -2.2677 | |
| 439 | R | A | -2.4024 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine