Project name: 70f920978dfd9ff

Chain sequence(s)	H: QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP; L: EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:04:25)
[INFO]       Main:     Simulation completed successfully.                                          (00:04:27)

• Minimal score value: -3.7167
• Maximal score value: 2.1535
• Average score: -0.6763
• Total score value: -286.7691

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.5604
2	V	H	-0.9402
3	Q	H	-1.0600
4	L	H	0.0000
5	V	H	1.1322
6	E	H	0.0000
7	S	H	-0.3479
8	G	H	-0.9413
9	G	H	-0.3938
10	G	H	0.0337
11	V	H	0.6010
12	V	H	-0.5180
13	Q	H	-1.3069
14	P	H	-1.9725
15	G	H	-2.1664
16	R	H	-2.6010
17	S	H	-1.9565
18	L	H	-1.3695
19	R	H	-2.0824
20	L	H	0.0000
21	S	H	-0.4208
22	C	H	0.0000
23	A	H	-0.0153
24	A	H	0.0000
25	S	H	-0.7356
26	G	H	-1.1659
27	F	H	-0.4586
28	T	H	-0.1661
29	F	H	0.0000
30	S	H	-0.4794
31	S	H	0.1198
32	Y	H	0.4285
33	T	H	0.3237
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	0.0000
40	A	H	-0.9583
41	P	H	-0.7874
42	G	H	-1.4636
43	K	H	-2.3390
44	G	H	-1.5682
45	L	H	0.0000
46	E	H	-1.1433
47	W	H	0.0000
48	V	H	0.0000
49	T	H	0.0000
50	F	H	0.0898
51	I	H	0.0000
52	S	H	-0.8285
53	Y	H	-0.3523
54	D	H	-2.0504
55	G	H	-1.9770
56	N	H	-2.4266
57	N	H	-2.2015
58	K	H	-1.0679
59	Y	H	-0.1658
60	Y	H	-0.6459
61	A	H	-1.2997
62	D	H	-2.4718
63	S	H	-1.9072
64	V	H	0.0000
65	K	H	-2.5560
66	G	H	-1.7945
67	R	H	-1.5389
68	F	H	0.0000
69	T	H	-0.8062
70	I	H	0.0000
71	S	H	-0.5938
72	R	H	-0.9869
73	D	H	-1.6524
74	N	H	-1.6692
75	S	H	-1.5065
76	K	H	-2.2685
77	N	H	-1.5876
78	T	H	0.0000
79	L	H	0.0000
80	Y	H	-0.5115
81	L	H	0.0000
82	Q	H	-1.1919
83	M	H	0.0000
84	N	H	-1.8595
85	S	H	-1.7810
86	L	H	0.0000
87	R	H	-3.0185
88	A	H	-1.8976
89	E	H	-2.4581
90	D	H	0.0000
91	T	H	-0.5531
92	A	H	0.0000
93	I	H	0.6182
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	T	H	0.6144
100	G	H	1.0982
101	W	H	1.8666
102	L	H	2.1535
103	G	H	1.1258
104	P	H	0.0000
105	F	H	0.0000
106	D	H	0.1514
107	Y	H	0.0902
108	W	H	-0.0821
109	G	H	0.0000
110	Q	H	-1.1316
111	G	H	-0.2942
112	T	H	0.0000
113	L	H	0.9429
114	V	H	0.0000
115	T	H	-0.1211
116	V	H	0.0000
117	S	H	-0.7070
118	S	H	-0.5922
119	A	H	-0.3196
120	S	H	-0.4184
121	T	H	-0.6922
122	K	H	-1.1642
123	G	H	-1.4725
124	P	H	0.0000
125	S	H	-0.5481
126	V	H	0.0000
127	F	H	0.0000
128	P	H	-1.2396
129	L	H	0.0000
130	A	H	-0.8586
131	P	H	0.0000
132	S	H	-0.5202
133	S	H	-0.3821
140	T	H	-0.2937
141	A	H	0.0000
142	A	H	0.0000
143	L	H	0.0000
144	G	H	0.0000
145	C	H	0.0000
146	L	H	0.0000
147	V	H	0.0000
148	K	H	0.0000
149	D	H	-0.7374
150	Y	H	0.0000
151	F	H	0.0000
152	P	H	-0.8575
153	E	H	-0.8806
154	P	H	-1.0425
155	V	H	-0.8077
156	T	H	-0.6046
157	V	H	-0.1773
158	S	H	-0.3567
159	W	H	0.0000
160	N	H	-0.7746
161	S	H	-0.6340
162	G	H	-0.4239
163	A	H	-0.2043
164	L	H	-0.0223
165	T	H	-0.1578
166	S	H	-0.1961
167	G	H	-0.2239
168	V	H	0.1613
169	H	H	-0.2393
170	T	H	0.0657
171	F	H	0.0000
172	P	H	-0.3981
173	A	H	0.0373
174	V	H	0.3731
175	L	H	1.0332
176	Q	H	0.2219
177	S	H	-0.0677
178	S	H	-0.2515
179	G	H	-0.0544
180	L	H	-0.1330
181	Y	H	0.0000
182	S	H	0.0000
183	L	H	0.0000
184	S	H	0.0000
185	S	H	0.0000
186	V	H	0.0000
187	V	H	0.0000
188	T	H	-0.1507
189	V	H	0.0000
190	P	H	-0.3800
191	S	H	-0.4436
192	S	H	-0.5389
193	S	H	-0.6022
194	L	H	-0.8876
195	G	H	-1.1295
196	T	H	-0.7278
197	Q	H	-1.2323
198	T	H	-1.1975
199	Y	H	0.0000
200	I	H	-1.3113
201	C	H	0.0000
202	N	H	-1.4416
203	V	H	0.0000
204	N	H	-2.0115
205	H	H	0.0000
206	K	H	-2.9006
207	P	H	-1.7312
208	S	H	-1.8696
209	N	H	-2.7287
210	T	H	-2.1272
211	K	H	-2.6900
212	V	H	-1.4655
213	D	H	-2.5616
214	K	H	-1.9873
215	R	H	-2.7094
216	V	H	0.0000
217	E	H	-2.5566
218	P	H	-1.2647
1	E	L	-1.4712
2	I	L	-0.4046
3	V	L	0.7851
4	L	L	0.0000
5	T	L	-0.7033
6	Q	L	0.0000
7	S	L	-0.8723
8	P	L	-0.6510
9	G	L	-0.9178
10	T	L	-0.4823
11	L	L	-0.2689
12	S	L	-0.5692
13	L	L	-1.0173
14	S	L	-1.5939
15	P	L	-2.0687
16	G	L	-2.4532
17	E	L	-3.0023
18	R	L	-3.2842
19	A	L	0.0000
20	T	L	-0.6205
21	L	L	0.0000
22	S	L	-0.7913
23	C	L	0.0000
24	R	L	-2.0291
25	A	L	0.0000
26	S	L	-0.9246
27	Q	L	-1.5801
28	S	L	-1.2854
29	V	L	0.0000
30	G	L	-0.5722
31	S	L	0.0125
32	S	L	0.4583
33	Y	L	0.7585
34	L	L	0.0000
35	A	L	0.0000
36	W	L	0.0000
37	Y	L	0.0000
38	Q	L	0.0000
39	Q	L	0.0000
40	K	L	-1.4091
41	P	L	-1.3075
42	G	L	-1.4128
43	Q	L	-2.0644
44	A	L	-1.3424
45	P	L	0.0000
46	R	L	-1.3618
47	L	L	0.0000
48	L	L	0.0000
49	I	L	0.0000
50	Y	L	0.6913
51	G	L	0.7501
52	A	L	0.0000
53	F	L	1.3343
54	S	L	0.3391
55	R	L	-0.6795
56	A	L	-0.4608
57	T	L	-0.4799
58	G	L	-0.7473
59	I	L	-0.8740
60	P	L	-1.2007
61	D	L	-2.1123
62	R	L	-1.9545
63	F	L	0.0000
64	S	L	-0.3207
65	G	L	0.3532
66	S	L	0.0114
67	G	L	-0.6477
68	S	L	-0.8537
69	G	L	-1.2130
70	T	L	-1.6849
71	D	L	-2.0539
72	F	L	0.0000
73	T	L	-0.4739
74	L	L	0.0000
75	T	L	-0.8048
76	I	L	0.0000
77	S	L	-2.4563
78	R	L	-3.4647
79	L	L	0.0000
80	E	L	-2.6345
81	P	L	-1.8031
82	E	L	-2.2520
83	D	L	0.0000
84	F	L	-0.6707
85	A	L	0.0000
86	V	L	-0.2751
87	Y	L	0.0000
88	Y	L	0.0000
89	C	L	0.0000
90	Q	L	0.0000
91	Q	L	0.0000
92	Y	L	0.0000
93	G	L	-0.1386
94	S	L	-0.4816
95	S	L	-0.4395
96	P	L	-0.4817
97	W	L	-0.1076
98	T	L	-0.0689
99	F	L	0.0466
100	G	L	0.0000
101	Q	L	-1.4839
102	G	L	-1.1585
103	T	L	0.0000
104	K	L	-0.7940
105	V	L	0.0000
106	E	L	0.0000
107	I	L	-0.7320
108	K	L	-1.6082
109	R	L	-1.1935
110	T	L	-0.1829
111	V	L	0.4582
112	A	L	0.0838
113	A	L	-0.1210
114	P	L	0.0000
115	S	L	-0.1699
116	V	L	0.0000
117	F	L	0.0702
118	I	L	0.0672
119	F	L	0.0000
120	P	L	-0.7364
121	P	L	-0.9866
122	S	L	-1.7101
123	D	L	-3.0603
124	E	L	-3.2306
125	Q	L	0.0000
126	L	L	-2.3619
127	K	L	-2.9470
128	S	L	-1.8442
129	G	L	-1.3015
130	T	L	-0.9360
131	A	L	0.0000
132	S	L	0.0000
133	V	L	0.0000
134	V	L	0.0000
135	C	L	0.0000
136	L	L	0.0000
137	L	L	0.0000
138	N	L	0.0000
139	N	L	-0.7633
140	F	L	0.0000
141	Y	L	0.0000
142	P	L	-1.2522
143	R	L	-1.8270
144	E	L	-2.6746
145	A	L	-2.0384
146	K	L	-2.2840
147	V	L	-1.0142
148	Q	L	-0.4764
149	W	L	0.0000
150	K	L	-0.4698
151	V	L	0.0000
152	D	L	-1.6160
153	N	L	-1.3782
154	A	L	-0.1320
155	L	L	0.7966
156	Q	L	-0.0740
157	S	L	-0.4073
158	G	L	-0.8747
159	N	L	-0.7785
160	S	L	-1.0802
161	Q	L	-1.3183
162	E	L	-1.8765
163	S	L	-0.8985
164	V	L	-0.4053
165	T	L	-0.8913
166	E	L	-2.0100
167	Q	L	-1.5701
168	D	L	-1.7465
169	S	L	-1.6420
170	K	L	-2.2655
171	D	L	-1.8122
172	S	L	0.0000
173	T	L	0.0000
174	Y	L	0.0000
175	S	L	0.0000
176	L	L	0.0000
177	S	L	0.0000
178	S	L	0.0000
179	T	L	-0.6230
180	L	L	0.0000
181	T	L	-0.2826
182	L	L	-0.7616
183	S	L	-1.1685
184	K	L	-2.1380
185	A	L	-1.9741
186	D	L	-2.8392
187	Y	L	0.0000
188	E	L	-3.7167
189	K	L	-3.6094
190	H	L	-3.2863
191	K	L	-3.4070
192	V	L	-1.6881
193	Y	L	0.0000
194	A	L	0.0000
195	C	L	0.0000
196	E	L	-0.5599
197	V	L	0.0000
198	T	L	-1.1194
199	H	L	0.0000
200	Q	L	-1.6519
201	G	L	-0.4284
202	L	L	-0.2510
203	S	L	-0.4751
204	S	L	-0.4174
205	P	L	-0.4707
206	V	L	0.0426
207	T	L	-0.4221
208	K	L	-0.6729
209	S	L	-0.6088
210	F	L	-1.1488
211	N	L	-2.5888
212	R	L	-3.0939