Project name: 71283995fb50a1b

Chain sequence(s)	H: AQQLKESGGGLVKPGTPLTLTCTVSGIDLNNNAMSWVRQAPGEGLEWIGTISIGHTTYYSSWAKGRFTISKTSTTVDLEMTSLTASDTATYFCATRYGGGNAMGWFDLWGQGTLVTVSS; L: SFVLTQPASVQVNLGQTVSLTCTADILSKEYVSWYQQKPGQAPVLLIHRDTSRPSGVPDRFSGSSSGNTATLTISGAQAGDEADYYCATDDNTNSNYQYVFGGGTQLTVT
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:08)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:08)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:08)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:08)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:08)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:45)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:46)

• Minimal score value: -2.3528
• Maximal score value: 1.5122
• Average score: -0.5178
• Total score value: -118.5785

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	H	-0.7740
2	Q	H	-1.6001
3	Q	H	-2.0804
4	L	H	0.0000
5	K	H	-2.2712
6	E	H	0.0000
7	S	H	-0.7962
8	G	H	-0.4696
9	G	H	0.2445
11	G	H	0.5883
12	L	H	1.2526
13	V	H	0.0000
14	K	H	-1.3741
15	P	H	-1.0743
16	G	H	-1.0372
17	T	H	-0.8612
18	P	H	-0.8146
19	L	H	-0.3897
20	T	H	-0.6796
21	L	H	0.0000
22	T	H	-0.8053
23	C	H	0.0000
24	T	H	-0.8647
25	V	H	-0.9573
26	S	H	-1.2309
27	G	H	-1.1736
28	I	H	-1.2681
29	D	H	-1.7896
30	L	H	0.0000
35	N	H	-2.1806
36	N	H	-1.9128
37	N	H	-1.1149
38	A	H	0.0000
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.8043
45	A	H	-0.9209
46	P	H	-0.9098
47	G	H	-1.5259
48	E	H	-2.3528
49	G	H	-1.5018
50	L	H	0.0000
51	E	H	-0.9596
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	T	H	0.0000
56	I	H	0.0000
57	S	H	-0.4109
58	I	H	-0.6039
59	G	H	-0.9772
63	H	H	-1.1631
64	T	H	-0.4297
65	T	H	-0.0701
66	Y	H	0.1535
67	Y	H	-0.0362
68	S	H	0.0000
69	S	H	-0.4427
70	W	H	-0.1569
71	A	H	0.0000
72	K	H	-1.3663
74	G	H	-1.2148
75	R	H	-1.1788
76	F	H	0.0000
77	T	H	-0.8464
78	I	H	0.0000
79	S	H	-0.8022
80	K	H	-0.5765
81	T	H	-0.4988
84	S	H	-0.6817
85	T	H	-0.4550
86	T	H	-0.4546
87	V	H	0.0000
88	D	H	-0.8004
89	L	H	0.0000
90	E	H	-1.2868
91	M	H	0.0000
92	T	H	-0.7702
93	S	H	-0.7834
94	L	H	0.0000
95	T	H	-0.5995
96	A	H	-0.4040
97	S	H	-0.2278
98	D	H	0.0000
99	T	H	0.2767
100	A	H	0.0000
101	T	H	0.3734
102	Y	H	0.0000
103	F	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	T	H	0.0000
107	R	H	0.0380
108	Y	H	0.3082
109	G	H	-0.6692
110	G	H	-0.7526
111	G	H	-1.0893
111A	N	H	-1.5231
112A	A	H	-0.6609
112	M	H	-0.1996
113	G	H	0.0000
114	W	H	0.0000
115	F	H	0.0000
116	D	H	0.0022
117	L	H	-0.0145
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.8487
121	G	H	-0.8534
122	T	H	-0.0016
123	L	H	1.3688
124	V	H	0.0000
125	T	H	0.5159
126	V	H	0.0000
127	S	H	-0.3909
128	S	H	-0.6422
1	S	L	0.2713
2	F	L	0.0000
3	V	L	1.4312
4	L	L	0.0000
5	T	L	-0.0103
6	Q	L	-0.1935
7	P	L	-0.3994
8	A	L	-0.5028
9	S	L	-0.8401
11	V	L	-0.6277
12	Q	L	-1.4124
13	V	L	0.0000
14	N	L	-1.1335
15	L	L	0.1318
16	G	L	-0.7841
17	Q	L	-1.2116
18	T	L	-0.8612
19	V	L	0.0000
20	S	L	-0.2332
21	L	L	0.0000
22	T	L	-0.2088
23	C	L	0.0000
24	T	L	-0.5270
25	A	L	-0.7532
26	D	L	-2.0969
27	I	L	-1.3268
28	L	L	0.0000
29	S	L	-1.8093
36	K	L	-2.2095
37	E	L	-1.1472
38	Y	L	0.4274
39	V	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.1464
44	Q	L	0.0000
45	K	L	-1.2516
46	P	L	-1.2368
47	G	L	-1.3426
48	Q	L	-1.5148
49	A	L	-0.6254
50	P	L	0.0000
51	V	L	1.5122
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	H	L	0.0000
56	R	L	-0.5683
57	D	L	0.0000
65	T	L	-0.4901
66	S	L	-0.7526
67	R	L	-1.4002
68	P	L	-0.7290
69	S	L	-0.8091
70	G	L	-0.8681
71	V	L	-0.6451
72	P	L	-1.3087
74	D	L	-2.2202
75	R	L	-1.4382
76	F	L	0.0000
77	S	L	-0.8138
78	G	L	0.0000
79	S	L	-0.4918
80	S	L	-0.4874
83	S	L	-0.7881
84	G	L	-1.5070
85	N	L	-1.9803
86	T	L	-0.9976
87	A	L	0.0000
88	T	L	-0.2629
89	L	L	0.0000
90	T	L	-0.2995
91	I	L	0.0000
92	S	L	-1.0971
93	G	L	-0.9644
94	A	L	0.0000
95	Q	L	-1.3258
96	A	L	-0.7663
97	G	L	-1.1212
98	D	L	0.0000
99	E	L	-1.9696
100	A	L	0.0000
101	D	L	-1.4345
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	A	L	0.0000
106	T	L	0.0000
107	D	L	0.0000
108	D	L	0.0000
109	N	L	-1.9910
110	T	L	-1.4402
111	N	L	-1.9206
112	S	L	-1.2758
113	N	L	-1.0932
114	Y	L	-0.8049
115	Q	L	0.0000
116	Y	L	0.0000
117	V	L	0.4326
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.8252
121	G	L	0.0000
122	T	L	0.0000
123	Q	L	-1.7589
124	L	L	0.0000
125	T	L	-1.0325
126	V	L	-0.8474
127	T	L	-0.5954