Project name: 71899359533edad

Chain sequence(s)	H: EVQLVQSGAEVKKPGATVKISCKASGFSIKDDYIHWVQQAPGKGLEWMGWIDAMNDDSQYSSKFQGRVTITVDTSTNTAYMKLSSLRSEDTAVYYCTYAFGGYWGQGTTVTVSS; L: DIVMTQTPLSLSVTPGQPASISCRSSQSLVHSDSNTYLHWYLQKPGQSPQLLIYLVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCGQSTHVPYAFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:40)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:42)

• Minimal score value: -2.8975
• Maximal score value: 1.8496
• Average score: -0.5982
• Total score value: -135.1863

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0172
2	V	H	-1.0210
3	Q	H	-1.2067
4	L	H	0.0000
5	V	H	0.7583
6	Q	H	0.0000
7	S	H	-0.4093
8	G	H	-0.5391
9	A	H	0.0095
11	E	H	0.0739
12	V	H	0.9527
13	K	H	-0.8177
14	K	H	-2.0770
15	P	H	-2.0556
16	G	H	-1.4182
17	A	H	-1.1313
18	T	H	-1.1044
19	V	H	0.0000
20	K	H	-1.6869
21	I	H	0.0000
22	S	H	-0.2571
23	C	H	0.0000
24	K	H	-0.3324
25	A	H	0.0000
26	S	H	-0.7744
27	G	H	-1.1423
28	F	H	-0.8622
29	S	H	-0.8656
30	I	H	0.0000
35	K	H	-1.5935
36	D	H	-1.9299
37	D	H	-0.6664
38	Y	H	-0.1016
39	I	H	0.0000
40	H	H	0.1489
41	W	H	0.0000
42	V	H	0.0000
43	Q	H	0.0000
44	Q	H	-0.8400
45	A	H	-1.2267
46	P	H	-1.1730
47	G	H	-1.4559
48	K	H	-2.2885
49	G	H	-1.3843
50	L	H	0.0000
51	E	H	-1.1671
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	W	H	0.0000
56	I	H	0.0000
57	D	H	-1.4600
58	A	H	0.0000
59	M	H	-0.8213
62	N	H	-1.9295
63	D	H	-2.3092
64	D	H	-2.5973
65	S	H	-1.5566
66	Q	H	-1.1078
67	Y	H	-0.8299
68	S	H	0.0000
69	S	H	-1.3908
70	K	H	-1.7673
71	F	H	0.0000
72	Q	H	-1.9158
74	G	H	-1.3362
75	R	H	-1.0766
76	V	H	0.0000
77	T	H	-0.6375
78	I	H	0.0000
79	T	H	-0.3989
80	V	H	-0.5459
81	D	H	-0.6793
82	T	H	-0.5341
83	S	H	-0.4271
84	T	H	-0.4862
85	N	H	-0.7313
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.2434
89	M	H	0.0000
90	K	H	-0.9661
91	L	H	0.0000
92	S	H	-0.8472
93	S	H	-1.0194
94	L	H	0.0000
95	R	H	-2.5054
96	S	H	-2.1249
97	E	H	-2.3954
98	D	H	0.0000
99	T	H	-0.7955
100	A	H	0.0000
101	V	H	0.1439
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	T	H	0.0000
106	Y	H	0.0000
107	A	H	0.7126
108	F	H	1.8496
115	G	H	0.0000
116	G	H	0.7060
117	Y	H	0.4750
118	W	H	-0.1180
119	G	H	0.0000
120	Q	H	-1.2111
121	G	H	-0.5230
122	T	H	0.0000
123	T	H	0.0260
124	V	H	0.0000
125	T	H	-0.2609
126	V	H	0.0000
127	S	H	-1.0779
128	S	H	-0.8064
1	D	L	-1.4671
2	I	L	0.0000
3	V	L	0.7582
4	M	L	0.0000
5	T	L	-0.3249
6	Q	L	0.0000
7	T	L	-0.0115
8	P	L	0.3740
9	L	L	1.1564
10	S	L	0.0790
11	L	L	-0.2517
12	S	L	-0.9417
13	V	L	0.0000
14	T	L	-1.6064
15	P	L	-1.7927
16	G	L	-2.0208
17	Q	L	-2.3490
18	P	L	-1.9131
19	A	L	0.0000
20	S	L	-0.6909
21	I	L	0.0000
22	S	L	-0.7824
23	C	L	0.0000
24	R	L	-2.2242
25	S	L	0.0000
26	S	L	-0.9837
27	Q	L	-1.5143
28	S	L	-0.7990
29	L	L	0.0000
30	V	L	0.5764
31	H	L	-0.6233
32	S	L	-1.0869
34	D	L	-2.0329
35	S	L	-1.0887
36	N	L	-0.7818
37	T	L	0.0836
38	Y	L	0.6291
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	L	L	0.0000
44	Q	L	-0.8881
45	K	L	-1.3197
46	P	L	-0.9372
47	G	L	-1.4216
48	Q	L	-2.0396
49	S	L	-1.2771
50	P	L	0.0000
51	Q	L	-0.9355
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.3940
56	L	L	0.4307
57	V	L	-0.1765
65	S	L	-0.6187
66	N	L	-1.0497
67	R	L	-1.5798
68	F	L	-0.3976
69	S	L	-0.5708
70	G	L	-0.7941
71	V	L	-0.9521
72	P	L	-1.2044
74	D	L	-2.3077
75	R	L	-1.9263
76	F	L	0.0000
77	S	L	-1.2764
78	G	L	0.0000
79	S	L	-0.6317
80	G	L	-0.9387
83	S	L	-0.6390
84	G	L	-0.6610
85	T	L	-1.4110
86	D	L	-1.9779
87	F	L	0.0000
88	T	L	-0.9333
89	L	L	0.0000
90	K	L	-1.4423
91	I	L	0.0000
92	S	L	-2.0596
93	R	L	-2.8975
94	V	L	0.0000
95	E	L	-2.6349
96	A	L	-1.4900
97	E	L	-1.9873
98	D	L	0.0000
99	V	L	-0.7727
100	G	L	0.0000
101	V	L	-0.0818
102	Y	L	0.0000
103	F	L	0.0000
104	C	L	0.0000
105	G	L	0.0000
106	Q	L	0.0000
107	S	L	0.3370
108	T	L	0.0000
109	H	L	-0.3997
114	V	L	0.1669
115	P	L	-0.3618
116	Y	L	-0.0111
117	A	L	0.0866
118	F	L	0.2506
119	G	L	0.0000
120	G	L	-0.3939
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.6212
124	V	L	0.0000
125	E	L	-1.2847
126	I	L	-1.0024
127	K	L	-1.7933