| Chain sequence(s) |
A: RVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARRFS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:41)
[INFO] Main: Simulation completed successfully. (00:06:45)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 34 | R | A | -1.7886 | |
| 35 | V | A | -1.2176 | |
| 36 | P | A | -1.2874 | |
| 37 | K | A | -2.0945 | |
| 38 | G | A | -1.2779 | |
| 39 | L | A | -0.7916 | |
| 40 | K | A | -1.6247 | |
| 41 | S | A | -0.7863 | |
| 42 | P | A | 0.0000 | |
| 43 | P | A | -0.5350 | |
| 44 | E | A | -0.6790 | |
| 45 | P | A | 0.0000 | |
| 46 | W | A | 0.9425 | |
| 47 | G | A | 0.8900 | |
| 48 | W | A | 1.2568 | |
| 49 | P | A | 0.9436 | |
| 50 | L | A | 1.6495 | |
| 51 | L | A | 1.4100 | |
| 52 | G | A | 0.0000 | |
| 53 | H | A | 0.0000 | |
| 54 | V | A | 1.0198 | |
| 55 | L | A | 1.3959 | |
| 56 | T | A | 0.4389 | |
| 57 | L | A | 0.0000 | |
| 58 | G | A | -0.8084 | |
| 59 | K | A | -1.6207 | |
| 60 | N | A | -0.8291 | |
| 61 | P | A | 0.0000 | |
| 62 | H | A | 0.0000 | |
| 63 | L | A | -0.0932 | |
| 64 | A | A | -0.7638 | |
| 65 | L | A | 0.0000 | |
| 66 | S | A | 0.0000 | |
| 67 | R | A | -2.4537 | |
| 68 | M | A | -1.6453 | |
| 69 | S | A | 0.0000 | |
| 70 | Q | A | -2.8082 | |
| 71 | R | A | -2.7071 | |
| 72 | Y | A | -1.3194 | |
| 73 | G | A | -1.3057 | |
| 74 | D | A | -1.4055 | |
| 75 | V | A | 0.0000 | |
| 76 | L | A | 0.0000 | |
| 77 | Q | A | -0.6160 | |
| 78 | I | A | 0.0000 | |
| 79 | R | A | -0.3350 | |
| 80 | I | A | 0.0000 | |
| 81 | G | A | 0.0000 | |
| 82 | S | A | 0.1167 | |
| 83 | T | A | -0.1489 | |
| 84 | P | A | -0.5163 | |
| 85 | V | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | L | A | 0.0000 | |
| 89 | S | A | 0.0000 | |
| 90 | R | A | -1.5186 | |
| 91 | L | A | -1.8097 | |
| 92 | D | A | -2.7266 | |
| 93 | T | A | 0.0000 | |
| 94 | I | A | 0.0000 | |
| 95 | R | A | -2.9706 | |
| 96 | Q | A | -2.5645 | |
| 97 | A | A | 0.0000 | |
| 98 | L | A | 0.0000 | |
| 99 | V | A | -1.8509 | |
| 100 | R | A | -2.4602 | |
| 101 | Q | A | -1.8267 | |
| 102 | G | A | 0.0000 | |
| 103 | D | A | -1.7564 | |
| 104 | D | A | -2.0725 | |
| 105 | F | A | 0.0000 | |
| 106 | K | A | -1.1760 | |
| 107 | G | A | 0.0000 | |
| 108 | R | A | 0.0000 | |
| 109 | P | A | 0.0000 | |
| 110 | D | A | -2.0096 | |
| 111 | L | A | -0.6302 | |
| 112 | Y | A | -0.2540 | |
| 113 | T | A | 0.0000 | |
| 114 | S | A | -0.4049 | |
| 115 | T | A | -0.4589 | |
| 116 | L | A | -0.3106 | |
| 117 | I | A | 0.0000 | |
| 118 | T | A | -0.8767 | |
| 119 | D | A | -1.7574 | |
| 120 | G | A | -0.9842 | |
| 121 | Q | A | -1.6011 | |
| 122 | S | A | 0.0000 | |
| 123 | L | A | 0.0000 | |
| 124 | T | A | -0.1218 | |
| 125 | F | A | -0.2752 | |
| 126 | S | A | -0.9412 | |
| 127 | T | A | -1.1078 | |
| 128 | D | A | -1.2270 | |
| 129 | S | A | -0.8375 | |
| 130 | G | A | -0.5357 | |
| 131 | P | A | -0.6797 | |
| 132 | V | A | -0.3091 | |
| 133 | W | A | 0.0000 | |
| 134 | A | A | -0.7788 | |
| 135 | A | A | -0.9789 | |
| 136 | R | A | 0.0000 | |
| 137 | R | A | -1.4138 | |
| 138 | R | A | -2.2746 | |
| 139 | L | A | -1.4101 | |
| 140 | A | A | 0.0000 | |
| 141 | Q | A | -1.5574 | |
| 142 | N | A | -2.0374 | |
| 143 | A | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | N | A | -0.7769 | |
| 146 | T | A | -0.8395 | |
| 147 | F | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | I | A | 0.3189 | |
| 150 | A | A | -0.2689 | |
| 151 | S | A | -0.5101 | |
| 152 | D | A | -0.5857 | |
| 153 | P | A | -0.4592 | |
| 154 | A | A | -0.2402 | |
| 155 | S | A | -0.4874 | |
| 156 | S | A | -0.4568 | |
| 157 | S | A | -0.5589 | |
| 158 | S | A | -0.6310 | |
| 159 | C | A | 0.0000 | |
| 160 | Y | A | -0.3926 | |
| 161 | L | A | 0.0000 | |
| 162 | E | A | -1.0245 | |
| 163 | E | A | -1.5346 | |
| 164 | H | A | -1.2873 | |
| 165 | V | A | 0.0000 | |
| 166 | S | A | -1.9030 | |
| 167 | K | A | -2.5720 | |
| 168 | E | A | -1.6654 | |
| 169 | A | A | 0.0000 | |
| 170 | K | A | -2.1879 | |
| 171 | A | A | -1.3726 | |
| 172 | L | A | 0.0000 | |
| 173 | I | A | 0.0000 | |
| 174 | S | A | -1.3480 | |
| 175 | R | A | -1.3705 | |
| 176 | L | A | 0.0000 | |
| 177 | Q | A | -2.3299 | |
| 178 | E | A | -2.2913 | |
| 179 | L | A | -1.2024 | |
| 180 | M | A | 0.0000 | |
| 181 | A | A | -1.2159 | |
| 182 | G | A | -1.0625 | |
| 183 | P | A | -0.8164 | |
| 184 | G | A | -1.1152 | |
| 185 | H | A | -1.4228 | |
| 186 | F | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | P | A | 0.0000 | |
| 189 | Y | A | -0.6619 | |
| 190 | N | A | -0.7584 | |
| 191 | Q | A | -0.2273 | |
| 192 | V | A | 0.0000 | |
| 193 | V | A | 0.0000 | |
| 194 | V | A | -0.1350 | |
| 195 | S | A | 0.0000 | |
| 196 | V | A | 0.0000 | |
| 197 | A | A | 0.0000 | |
| 198 | N | A | -0.8521 | |
| 199 | V | A | 0.0000 | |
| 200 | I | A | 0.0000 | |
| 201 | G | A | 0.0000 | |
| 202 | A | A | -0.8727 | |
| 203 | M | A | 0.0000 | |
| 204 | C | A | 0.0000 | |
| 205 | F | A | 0.0000 | |
| 206 | G | A | -1.1627 | |
| 207 | Q | A | -1.9617 | |
| 208 | H | A | -1.6011 | |
| 209 | F | A | 0.0000 | |
| 210 | P | A | -1.7736 | |
| 211 | E | A | -2.5267 | |
| 212 | S | A | -1.8110 | |
| 213 | S | A | -2.1346 | |
| 214 | D | A | -2.9326 | |
| 215 | E | A | -2.9436 | |
| 216 | M | A | 0.0000 | |
| 217 | L | A | -1.5822 | |
| 218 | S | A | -1.5644 | |
| 219 | L | A | 0.0000 | |
| 220 | V | A | 0.0000 | |
| 221 | K | A | -1.1866 | |
| 222 | N | A | -1.3100 | |
| 223 | T | A | 0.0000 | |
| 224 | H | A | -1.2064 | |
| 225 | E | A | -1.7288 | |
| 226 | F | A | -0.8138 | |
| 227 | V | A | 0.0000 | |
| 228 | E | A | -0.8918 | |
| 229 | T | A | 0.0000 | |
| 230 | A | A | 0.0000 | |
| 231 | S | A | 0.0000 | |
| 232 | S | A | 0.0000 | |
| 233 | G | A | 0.0000 | |
| 234 | N | A | -0.4969 | |
| 235 | P | A | 0.2001 | |
| 236 | L | A | 0.0000 | |
| 237 | D | A | -0.2032 | |
| 238 | F | A | 0.0000 | |
| 239 | F | A | 0.8618 | |
| 240 | P | A | 1.1311 | |
| 241 | I | A | 2.5479 | |
| 242 | L | A | 1.6813 | |
| 243 | R | A | 1.0716 | |
| 244 | Y | A | 2.1603 | |
| 245 | L | A | 1.8940 | |
| 246 | P | A | 0.1783 | |
| 247 | N | A | -0.6669 | |
| 248 | P | A | -1.3685 | |
| 249 | A | A | -1.5309 | |
| 250 | L | A | 0.0000 | |
| 251 | Q | A | -2.6304 | |
| 252 | R | A | -3.0398 | |
| 253 | F | A | 0.0000 | |
| 254 | K | A | -2.0935 | |
| 255 | A | A | -1.8099 | |
| 256 | F | A | 0.0000 | |
| 257 | N | A | 0.0000 | |
| 258 | Q | A | -1.4252 | |
| 259 | R | A | -1.2133 | |
| 260 | F | A | -0.6703 | |
| 261 | L | A | -0.5491 | |
| 262 | W | A | -0.1992 | |
| 263 | F | A | 0.0000 | |
| 264 | L | A | 0.0000 | |
| 265 | Q | A | -2.1858 | |
| 266 | K | A | -2.6451 | |
| 267 | T | A | 0.0000 | |
| 268 | V | A | 0.0000 | |
| 269 | Q | A | -3.0301 | |
| 270 | E | A | -3.1241 | |
| 271 | H | A | 0.0000 | |
| 272 | Y | A | -1.4419 | |
| 273 | Q | A | -2.4833 | |
| 274 | D | A | -2.8134 | |
| 275 | F | A | -2.2466 | |
| 276 | D | A | -3.0578 | |
| 277 | K | A | -3.3828 | |
| 278 | N | A | -2.6991 | |
| 279 | S | A | -2.0193 | |
| 280 | V | A | -1.8016 | |
| 281 | R | A | -2.3237 | |
| 282 | D | A | 0.0000 | |
| 283 | I | A | 0.0000 | |
| 284 | T | A | 0.0000 | |
| 285 | G | A | 0.0000 | |
| 286 | A | A | 0.0000 | |
| 287 | L | A | 0.0000 | |
| 288 | F | A | 0.0000 | |
| 289 | K | A | -2.6443 | |
| 290 | H | A | -2.1195 | |
| 291 | S | A | -2.3354 | |
| 292 | K | A | -3.2485 | |
| 293 | K | A | -2.9227 | |
| 294 | G | A | -1.9600 | |
| 295 | P | A | 0.0000 | |
| 296 | R | A | -1.9947 | |
| 297 | A | A | 0.0000 | |
| 298 | S | A | -1.0284 | |
| 299 | G | A | -1.3789 | |
| 300 | N | A | -1.4266 | |
| 301 | L | A | -0.2443 | |
| 302 | I | A | 0.0000 | |
| 303 | P | A | -1.0779 | |
| 304 | Q | A | -1.8308 | |
| 305 | E | A | -2.5565 | |
| 306 | K | A | -1.7471 | |
| 307 | I | A | 0.0000 | |
| 308 | V | A | -1.0190 | |
| 309 | N | A | -1.2619 | |
| 310 | L | A | 0.0000 | |
| 311 | V | A | 0.0000 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | -0.3157 | |
| 314 | I | A | 0.0000 | |
| 315 | F | A | 0.0000 | |
| 316 | G | A | -0.1374 | |
| 317 | A | A | -0.0433 | |
| 318 | G | A | -0.1377 | |
| 319 | F | A | 0.0000 | |
| 320 | D | A | 0.0000 | |
| 321 | T | A | -0.0032 | |
| 322 | V | A | 0.0000 | |
| 323 | T | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | A | A | 0.0000 | |
| 326 | I | A | 0.0000 | |
| 327 | S | A | 0.0000 | |
| 328 | W | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | L | A | 0.0000 | |
| 331 | M | A | 0.0000 | |
| 332 | Y | A | 0.0000 | |
| 333 | L | A | 0.0000 | |
| 334 | V | A | 0.0000 | |
| 335 | T | A | -0.6807 | |
| 336 | K | A | -1.1191 | |
| 337 | P | A | -1.6243 | |
| 338 | E | A | -2.6020 | |
| 339 | I | A | 0.0000 | |
| 340 | Q | A | 0.0000 | |
| 341 | R | A | -2.6312 | |
| 342 | K | A | -2.6336 | |
| 343 | I | A | 0.0000 | |
| 344 | Q | A | 0.0000 | |
| 345 | K | A | -2.4990 | |
| 346 | E | A | 0.0000 | |
| 347 | L | A | 0.0000 | |
| 348 | D | A | -1.8603 | |
| 349 | T | A | -0.7959 | |
| 350 | V | A | -0.3175 | |
| 351 | I | A | 0.0000 | |
| 352 | G | A | -2.1508 | |
| 353 | R | A | -3.3576 | |
| 354 | E | A | -3.3649 | |
| 355 | R | A | -2.7666 | |
| 356 | R | A | -2.4134 | |
| 357 | P | A | 0.0000 | |
| 358 | R | A | -1.4502 | |
| 359 | L | A | -0.6672 | |
| 360 | S | A | -0.8189 | |
| 361 | D | A | 0.0000 | |
| 362 | R | A | -0.9612 | |
| 363 | P | A | -1.0003 | |
| 364 | Q | A | -1.3162 | |
| 365 | L | A | 0.0000 | |
| 366 | P | A | -0.7386 | |
| 367 | Y | A | 0.0000 | |
| 368 | L | A | 0.0000 | |
| 369 | E | A | -0.3848 | |
| 370 | A | A | 0.0000 | |
| 371 | F | A | 0.0000 | |
| 372 | I | A | 0.0000 | |
| 373 | L | A | -0.0796 | |
| 374 | E | A | 0.0000 | |
| 375 | T | A | 0.0000 | |
| 376 | F | A | 0.0000 | |
| 377 | R | A | 0.0000 | |
| 378 | H | A | -0.6028 | |
| 379 | S | A | 0.0000 | |
| 380 | S | A | 0.0000 | |
| 381 | F | A | 0.0000 | |
| 382 | L | A | 0.3687 | |
| 383 | P | A | 0.0000 | |
| 384 | F | A | 0.0000 | |
| 385 | T | A | 0.1970 | |
| 386 | I | A | 0.3405 | |
| 387 | P | A | 0.0000 | |
| 388 | H | A | 0.0000 | |
| 389 | S | A | 0.0000 | |
| 390 | T | A | 0.0000 | |
| 391 | T | A | -2.1908 | |
| 392 | R | A | -3.2029 | |
| 393 | D | A | -3.2577 | |
| 394 | T | A | -1.6801 | |
| 395 | T | A | -0.9048 | |
| 396 | L | A | 0.0000 | |
| 397 | N | A | -1.5014 | |
| 398 | G | A | -1.1026 | |
| 399 | F | A | -0.6546 | |
| 400 | Y | A | 0.0000 | |
| 401 | I | A | 0.0000 | |
| 402 | P | A | -2.4568 | |
| 403 | K | A | -3.6596 | |
| 404 | K | A | -3.2360 | |
| 405 | C | A | -1.7176 | |
| 406 | C | A | 0.0000 | |
| 407 | V | A | 0.0000 | |
| 408 | F | A | 0.0000 | |
| 409 | V | A | 0.0000 | |
| 410 | N | A | 0.0000 | |
| 411 | Q | A | 0.0000 | |
| 412 | W | A | 0.2851 | |
| 413 | Q | A | 0.0000 | |
| 414 | V | A | 0.0000 | |
| 415 | N | A | 0.0000 | |
| 416 | H | A | 0.0000 | |
| 417 | D | A | 0.0000 | |
| 418 | P | A | -1.9219 | |
| 419 | E | A | -2.1189 | |
| 420 | L | A | -1.4187 | |
| 421 | W | A | 0.0000 | |
| 422 | E | A | -3.3578 | |
| 423 | D | A | -3.3893 | |
| 424 | P | A | -2.3505 | |
| 425 | S | A | -1.8989 | |
| 426 | E | A | -2.6482 | |
| 427 | F | A | 0.0000 | |
| 428 | R | A | -2.1578 | |
| 429 | P | A | 0.0000 | |
| 430 | E | A | -1.4006 | |
| 431 | R | A | -1.3947 | |
| 432 | F | A | 0.0000 | |
| 433 | L | A | -0.9887 | |
| 434 | T | A | -1.1752 | |
| 435 | A | A | -1.0668 | |
| 436 | D | A | -1.8846 | |
| 437 | G | A | -1.3500 | |
| 438 | T | A | -1.0049 | |
| 439 | A | A | -1.0172 | |
| 440 | I | A | 0.0000 | |
| 441 | N | A | -1.6104 | |
| 442 | K | A | -2.5259 | |
| 443 | P | A | -1.8981 | |
| 444 | L | A | -1.4732 | |
| 445 | S | A | -1.8268 | |
| 446 | E | A | -2.7416 | |
| 447 | K | A | -2.1036 | |
| 448 | M | A | -0.8223 | |
| 449 | M | A | 0.0000 | |
| 450 | L | A | 0.0000 | |
| 451 | F | A | 0.0812 | |
| 452 | G | A | -0.5408 | |
| 453 | M | A | 0.0000 | |
| 454 | G | A | -1.6895 | |
| 455 | K | A | -1.8862 | |
| 456 | R | A | -1.1220 | |
| 457 | R | A | -1.0366 | |
| 458 | C | A | -0.0186 | |
| 459 | I | A | -0.1677 | |
| 460 | G | A | 0.1787 | |
| 461 | E | A | 0.3020 | |
| 462 | V | A | 0.9336 | |
| 463 | L | A | 0.0000 | |
| 464 | A | A | 0.0000 | |
| 465 | K | A | -0.0316 | |
| 466 | W | A | 0.2667 | |
| 467 | E | A | 0.0000 | |
| 468 | I | A | 0.0000 | |
| 469 | F | A | 0.0000 | |
| 470 | L | A | 0.0000 | |
| 471 | F | A | 0.0000 | |
| 472 | L | A | 0.0000 | |
| 473 | A | A | 0.0000 | |
| 474 | I | A | 0.0000 | |
| 475 | L | A | 0.0000 | |
| 476 | L | A | 0.0000 | |
| 477 | Q | A | -1.4192 | |
| 478 | Q | A | -1.7068 | |
| 479 | L | A | 0.0000 | |
| 480 | E | A | -1.5676 | |
| 481 | F | A | 0.0000 | |
| 482 | S | A | -0.5624 | |
| 483 | V | A | -0.5202 | |
| 484 | P | A | -0.4509 | |
| 485 | P | A | -0.5559 | |
| 486 | G | A | -0.7419 | |
| 487 | V | A | -0.6049 | |
| 488 | K | A | -1.8266 | |
| 489 | V | A | -1.3844 | |
| 490 | D | A | -1.9306 | |
| 491 | L | A | -0.6390 | |
| 492 | T | A | -0.0944 | |
| 493 | P | A | 0.3115 | |
| 494 | I | A | 0.7241 | |
| 495 | Y | A | 0.1503 | |
| 496 | G | A | 0.0000 | |
| 497 | L | A | 0.1934 | |
| 498 | T | A | 0.0000 | |
| 499 | M | A | 0.0000 | |
| 500 | K | A | 0.0000 | |
| 501 | H | A | 0.0000 | |
| 502 | A | A | -1.1113 | |
| 503 | R | A | -2.4641 | |
| 504 | C | A | -2.1441 | |
| 505 | E | A | -2.6140 | |
| 506 | H | A | -1.8878 | |
| 507 | V | A | 0.0000 | |
| 508 | Q | A | -1.2879 | |
| 509 | A | A | 0.0000 | |
| 510 | R | A | -2.9445 | |
| 511 | R | A | -2.7476 | |
| 512 | F | A | -0.8611 | |
| 513 | S | A | -0.2649 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine