Project name: Lenvervimab

Chain sequence(s)	H: EVQLVESGGGLVKPGGSLRLSCSASGFSLTKYKMTWVRQAPGKGLEWVSSISSTSRDIDYADSVKGRFTISRDNAKNSLFLQMSSLRVDDTAVYYCTRDGWLWGWDVRSNYYYNALDVWGQGTTVTVSS; L: DIVVTQSPSSLSASVGDRVTITCRASQGIYNSIAWYQQKPGKAPKLLLYSTSTLLSGVPSRFSGSGSGTDYTLTITNLQPEDFATYYCQQYFVTPETFGQGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:08)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:09)

• Minimal score value: -2.7052
• Maximal score value: 1.5728
• Average score: -0.4683
• Total score value: -110.5203

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.6533
2	V	H	-0.3614
3	Q	H	-0.7986
4	L	H	0.0000
5	V	H	0.2374
6	E	H	0.0000
7	S	H	-0.5629
8	G	H	-0.8254
9	G	H	-0.3430
11	G	H	0.4480
12	L	H	1.0932
13	V	H	-0.0558
14	K	H	-1.5228
15	P	H	-1.0651
16	G	H	-1.1822
17	G	H	-0.9901
18	S	H	-1.0150
19	L	H	-0.8572
20	R	H	-1.8584
21	L	H	0.0000
22	S	H	-0.4681
23	C	H	0.0000
24	S	H	-0.4133
25	A	H	-0.4228
26	S	H	-0.5559
27	G	H	-0.8214
28	F	H	-0.4291
29	S	H	-0.6257
30	L	H	0.0000
35	T	H	-0.7995
36	K	H	-1.0404
37	Y	H	-0.2848
38	K	H	0.0000
39	M	H	0.0000
40	T	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.8293
45	A	H	-1.2265
46	P	H	-1.0029
47	G	H	-1.5321
48	K	H	-2.3643
49	G	H	-1.6219
50	L	H	0.0000
51	E	H	-1.0015
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	S	H	0.0000
56	I	H	0.0000
57	S	H	0.0000
58	S	H	-0.8656
59	T	H	-1.0810
62	S	H	-1.3412
63	R	H	-2.2819
64	D	H	-1.7216
65	I	H	-0.2122
66	D	H	-0.5877
67	Y	H	-0.7911
68	A	H	-1.6438
69	D	H	-2.7052
70	S	H	-1.7086
71	V	H	0.0000
72	K	H	-2.6465
74	G	H	-1.6755
75	R	H	-1.4987
76	F	H	0.0000
77	T	H	-0.7676
78	I	H	0.0000
79	S	H	-0.2846
80	R	H	-0.8268
81	D	H	-1.3265
82	N	H	-1.5025
83	A	H	-1.2289
84	K	H	-2.1160
85	N	H	-1.4189
86	S	H	0.0000
87	L	H	0.0000
88	F	H	-0.5085
89	L	H	0.0000
90	Q	H	-1.4113
91	M	H	0.0000
92	S	H	-0.9999
93	S	H	-1.0926
94	L	H	0.0000
95	R	H	-1.3862
96	V	H	0.0103
97	D	H	-1.3433
98	D	H	0.0000
99	T	H	-0.1437
100	A	H	0.0000
101	V	H	0.0105
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	T	H	0.0000
106	R	H	-0.3512
107	D	H	0.0000
108	G	H	0.0782
109	W	H	0.5459
110	L	H	1.2447
111	W	H	0.8913
111A	G	H	0.7080
111B	W	H	1.1751
111C	D	H	0.2715
111D	V	H	0.7358
112E	R	H	-1.1856
112D	S	H	-0.7423
112C	N	H	-0.1486
112B	Y	H	0.7948
112A	Y	H	1.2077
112	Y	H	1.2980
113	N	H	0.0000
114	A	H	0.0000
115	L	H	0.0000
116	D	H	-0.4306
117	V	H	-0.0559
118	W	H	-0.2320
119	G	H	0.0000
120	Q	H	-1.4571
121	G	H	-0.6789
122	T	H	-0.3045
123	T	H	0.0552
124	V	H	0.0000
125	T	H	0.1932
126	V	H	0.0000
127	S	H	-0.2626
128	S	H	-0.4289
1	D	L	-1.4972
2	I	L	0.0000
3	V	L	0.7335
4	V	L	0.0000
5	T	L	-0.7165
6	Q	L	0.0000
7	S	L	-0.7476
8	P	L	-0.6431
9	S	L	-0.9453
10	S	L	-1.0399
11	L	L	-0.7293
12	S	L	-1.0146
13	A	L	0.0000
14	S	L	-0.7879
15	V	L	-0.0397
16	G	L	-1.1443
17	D	L	-1.7165
18	R	L	-2.4645
19	V	L	0.0000
20	T	L	-0.5679
21	I	L	0.0000
22	T	L	-0.7826
23	C	L	0.0000
24	R	L	-2.1873
25	A	L	0.0000
26	S	L	-0.7573
27	Q	L	-0.9690
28	G	L	-0.4611
29	I	L	0.0000
36	Y	L	0.9210
37	N	L	0.0255
38	S	L	0.6591
39	I	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7380
44	Q	L	0.0000
45	K	L	-1.6705
46	P	L	-1.2104
47	G	L	-1.7207
48	K	L	-2.5415
49	A	L	-1.5296
50	P	L	0.0000
51	K	L	-1.1740
52	L	L	0.0000
53	L	L	0.0000
54	L	L	0.0000
55	Y	L	0.2487
56	S	L	0.1183
57	T	L	0.0000
65	S	L	-0.2034
66	T	L	0.1816
67	L	L	0.4642
68	L	L	0.1766
69	S	L	-0.1905
70	G	L	-0.3828
71	V	L	-0.1508
72	P	L	-0.2807
74	S	L	-0.3557
75	R	L	-0.9786
76	F	L	0.0000
77	S	L	-0.2612
78	G	L	-0.2237
79	S	L	-0.6419
80	G	L	-0.9468
83	S	L	-0.7194
84	G	L	-0.6730
85	T	L	-1.3316
86	D	L	-1.8560
87	Y	L	0.0000
88	T	L	-0.6969
89	L	L	0.0000
90	T	L	-0.6737
91	I	L	0.0000
92	T	L	-1.6662
93	N	L	-2.0500
94	L	L	0.0000
95	Q	L	-0.9081
96	P	L	-0.9562
97	E	L	-1.6207
98	D	L	0.0000
99	F	L	-0.3793
100	A	L	0.0000
101	T	L	-0.9930
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	F	L	1.5728
109	V	L	1.0110
114	T	L	0.2965
115	P	L	-0.4186
116	E	L	0.0000
117	T	L	0.1193
118	F	L	0.0006
119	G	L	0.0000
120	Q	L	-1.5784
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.8011
124	L	L	0.0000
125	E	L	-1.3762
126	I	L	-0.5610
127	K	L	-1.4492