Project name: 497

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCTASGYTNRLKCMGWFRQAPGKEREEIATISTGTGNTYYADSVKGRFTFSRDNSKNTLYLQMNSLRAEDTAVYYCAADVRPDGTTCHYNSGGQGTQVTVSS
Selected Chain(s)	H
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with H chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:34)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:34)

• Minimal score value: -3.6672
• Maximal score value: 1.1179
• Average score: -0.8575
• Total score value: -104.6151

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.5532
2	V	H	-0.1738
3	Q	H	-0.5190
4	L	H	0.0000
5	V	H	0.9936
6	E	H	0.1234
7	S	H	-0.6082
8	G	H	-1.1491
9	G	H	-0.6642
11	G	H	0.2926
12	L	H	1.1179
13	V	H	0.0301
14	Q	H	-1.2865
15	P	H	-1.6296
16	G	H	-1.3016
17	G	H	-0.9056
18	S	H	-1.1695
19	L	H	-0.8515
20	R	H	-2.0180
21	L	H	0.0000
22	S	H	-0.3623
23	C	H	0.0000
24	T	H	-0.2254
25	A	H	0.0000
26	S	H	-0.5584
27	G	H	-1.0284
28	Y	H	-0.9628
29	T	H	-1.2264
30	N	H	-2.5231
35	R	H	-2.6913
36	L	H	0.0000
37	K	H	-1.8162
38	C	H	-0.8379
39	M	H	0.0000
40	G	H	0.0000
41	W	H	0.0000
42	F	H	-0.6762
43	R	H	0.0000
44	Q	H	-1.9754
45	A	H	-1.8090
46	P	H	-1.2589
47	G	H	-1.9511
48	K	H	-3.3690
49	E	H	-3.6672
50	R	H	-2.9615
51	E	H	-2.2422
52	E	H	-1.0815
53	I	H	0.0000
54	A	H	0.0000
55	T	H	0.3082
56	I	H	0.0000
57	S	H	-0.7512
58	T	H	-1.5491
59	G	H	-1.2046
62	T	H	-0.7470
63	G	H	-0.8672
64	N	H	-0.9915
65	T	H	0.0724
66	Y	H	0.7034
67	Y	H	-0.3035
68	A	H	-1.1947
69	D	H	-2.3568
70	S	H	-1.7585
71	V	H	0.0000
72	K	H	-2.4274
74	G	H	-1.8016
75	R	H	-1.5866
76	F	H	0.0000
77	T	H	-0.6920
78	F	H	0.0000
79	S	H	-0.6715
80	R	H	-1.3916
81	D	H	-2.0345
82	N	H	-2.6271
83	S	H	-1.9967
84	K	H	-2.6926
85	N	H	-2.2753
86	T	H	0.0000
87	L	H	0.0000
88	Y	H	-0.4461
89	L	H	0.0000
90	Q	H	-1.0993
91	M	H	0.0000
92	N	H	-1.3560
93	S	H	-1.2021
94	L	H	0.0000
95	R	H	-2.0792
96	A	H	-1.6002
97	E	H	-2.1754
98	D	H	0.0000
99	T	H	-0.6861
100	A	H	0.0000
101	V	H	-0.1882
102	Y	H	0.0000
103	Y	H	-0.3395
104	C	H	0.0000
105	A	H	0.0000
106	A	H	0.0000
107	D	H	0.0000
108	V	H	-0.5551
109	R	H	-1.1067
110	P	H	-1.4142
111	D	H	-2.2180
111A	G	H	-1.4282
112A	T	H	-1.1209
112	T	H	-0.5928
113	C	H	-0.5901
114	H	H	-1.0629
115	Y	H	-0.8300
116	N	H	-1.4468
117	S	H	-0.7362
118	G	H	-0.7828
119	G	H	-0.4808
120	Q	H	-1.0094
121	G	H	-0.5256
122	T	H	-0.5134
123	Q	H	-0.4750
124	V	H	0.0000
125	T	H	-0.1095
126	V	H	0.0000
127	S	H	-0.6224
128	S	H	-0.4888