Project name: 740c6a7e64da87b

Chain sequence(s)	A: SFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETV
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:04:57)
[INFO]       Main:     Simulation completed successfully.                                          (00:05:00)

• Minimal score value: -3.5955
• Maximal score value: 4.0114
• Average score: 0.8187
• Total score value: 207.1431

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	S	A	1.0332
2	F	A	1.9092
3	Y	A	2.7022
4	I	A	2.7384
5	N	A	1.0110
6	V	A	1.8633
7	V	A	2.3330
8	S	A	1.3422
9	Y	A	0.0000
10	L	A	1.6830
11	C	A	1.5171
12	A	A	1.3384
13	M	A	0.0000
14	V	A	1.9039
15	I	A	1.8379
16	F	A	0.0000
17	T	A	1.8965
18	L	A	1.9775
19	T	A	0.0000
20	A	A	1.6393
21	Y	A	2.2282
22	Y	A	2.4524
23	Q	A	1.2592
24	P	A	0.6217
25	L	A	0.5417
26	E	A	-1.4117
27	G	A	-1.1008
28	T	A	-0.3919
29	P	A	0.0000
30	P	A	0.6211
31	Y	A	0.3493
32	P	A	-0.2644
33	Y	A	0.2661
34	R	A	-1.2187
35	T	A	0.0477
36	T	A	1.0757
37	V	A	2.5724
38	D	A	1.7896
39	Y	A	2.5280
40	L	A	3.1477
41	R	A	0.0000
42	L	A	2.4851
43	A	A	2.1153
44	G	A	0.0000
45	E	A	1.8754
46	V	A	3.1347
47	I	A	2.7362
48	T	A	0.0000
49	L	A	2.8466
50	F	A	3.5491
51	T	A	2.4687
52	G	A	0.0000
53	V	A	2.7840
54	L	A	2.7059
55	F	A	2.1370
56	F	A	2.4566
57	F	A	2.3201
58	T	A	1.1385
59	N	A	0.0000
60	I	A	1.2567
61	K	A	-0.3782
62	D	A	-0.3971
63	L	A	0.4037
64	F	A	1.0829
65	M	A	0.3406
66	K	A	-1.2948
67	K	A	-1.2982
68	C	A	0.2679
69	P	A	-0.2350
70	G	A	0.0650
71	V	A	1.2765
72	N	A	-0.2138
73	S	A	-0.3393
74	L	A	0.9056
75	F	A	0.8510
76	I	A	0.5817
77	D	A	-1.0337
78	G	A	-0.2662
79	S	A	0.6523
80	F	A	0.8846
81	Q	A	0.9009
82	L	A	1.6030
83	L	A	1.4367
84	Y	A	0.0000
85	F	A	2.0469
86	I	A	1.6013
87	Y	A	0.0000
88	S	A	0.0000
89	V	A	1.6767
90	L	A	1.7915
91	V	A	0.0000
92	I	A	1.9555
93	V	A	1.6584
94	S	A	0.0000
95	A	A	1.3860
96	A	A	1.2385
97	L	A	1.0321
98	Y	A	1.1165
99	L	A	1.8155
100	A	A	0.7252
101	G	A	0.0004
102	I	A	0.0504
103	E	A	-1.5171
104	A	A	-0.4955
105	Y	A	0.0000
106	L	A	0.9939
107	A	A	0.9886
108	V	A	1.7927
109	M	A	0.0000
110	V	A	2.7546
111	F	A	3.2705
112	A	A	0.0000
113	L	A	2.4297
114	V	A	3.1148
115	L	A	2.2327
116	G	A	0.0000
117	W	A	1.6713
118	M	A	1.5513
119	N	A	0.0000
120	A	A	0.9751
121	L	A	1.2793
122	Y	A	1.2301
123	F	A	0.7072
124	T	A	0.5901
125	R	A	0.0438
126	G	A	-0.0443
127	L	A	0.2504
128	K	A	-0.8991
129	L	A	0.9146
130	T	A	0.8123
131	G	A	0.5147
132	T	A	1.1956
133	Y	A	2.1551
134	S	A	0.0000
135	I	A	1.8695
136	M	A	1.6709
137	I	A	1.4277
138	Q	A	0.6807
139	K	A	0.3884
140	I	A	1.3291
141	L	A	1.2626
142	F	A	1.2989
143	K	A	0.0235
144	D	A	0.0000
145	L	A	1.6536
146	F	A	2.1367
147	R	A	0.2107
148	F	A	1.6821
149	L	A	2.5876
150	L	A	2.7793
151	V	A	3.2090
152	Y	A	2.9176
153	L	A	3.3105
154	L	A	3.6411
155	F	A	2.6448
156	M	A	0.0000
157	I	A	2.8348
158	G	A	1.2826
159	Y	A	0.0000
160	A	A	0.0000
161	S	A	0.5311
162	A	A	0.2629
163	L	A	0.0000
164	V	A	-0.2140
165	S	A	-0.3755
166	L	A	-0.0010
167	L	A	0.0000
168	N	A	-0.9758
169	P	A	-0.8122
170	C	A	0.0000
171	A	A	-0.5575
172	N	A	-1.3515
173	M	A	-0.6269
174	K	A	-0.6700
175	V	A	0.3691
176	C	A	-0.8781
177	N	A	-2.9132
178	E	A	-3.5511
179	D	A	-3.5955
180	Q	A	-3.1769
181	T	A	-1.9231
182	N	A	-1.9564
183	C	A	-0.4428
184	T	A	0.5105
185	V	A	1.5747
186	P	A	0.8755
187	T	A	0.6961
188	Y	A	0.6437
189	P	A	-0.2488
190	S	A	-0.0645
191	C	A	-0.6653
192	R	A	-1.8646
193	D	A	-2.4474
194	S	A	-1.6263
195	E	A	-1.7612
196	T	A	0.0000
197	F	A	-0.2504
198	S	A	-0.1551
199	T	A	0.1247
200	F	A	0.0000
201	L	A	1.1792
202	L	A	1.4820
203	D	A	-0.1480
204	L	A	0.0000
205	F	A	1.3526
206	K	A	0.2006
207	L	A	0.6170
208	T	A	1.1375
209	I	A	2.0376
210	G	A	0.7559
211	M	A	0.7531
212	G	A	-0.7227
213	D	A	-2.1476
214	L	A	-1.0315
215	E	A	-2.1416
216	M	A	-0.9793
217	L	A	0.0545
218	S	A	-0.6363
219	S	A	-0.4386
220	T	A	0.0000
221	K	A	-0.7899
222	Y	A	1.3425
223	P	A	1.7589
224	V	A	3.1800
225	V	A	2.9819
226	F	A	0.0000
227	I	A	3.6586
228	I	A	3.8043
229	L	A	2.9753
230	L	A	0.0000
231	V	A	3.5089
232	T	A	2.5954
233	Y	A	0.0000
234	I	A	2.8703
235	I	A	4.0114
236	L	A	3.1367
237	T	A	0.0000
238	F	A	3.0659
239	V	A	3.6755
240	L	A	3.2257
241	L	A	0.0000
242	L	A	2.2481
243	N	A	1.4688
244	M	A	2.3356
245	L	A	1.9044
246	I	A	2.1694
247	A	A	1.2399
248	L	A	1.4460
249	M	A	1.1032
250	G	A	0.3983
251	E	A	-0.6865
252	T	A	0.2418
253	V	A	1.3707