Chain sequence(s) |
A: MGSSHHHHHHSSGENLYFQGAMAVERNSGDLQLPQEIAMLVPNKTQVVPKSGGEGKVKDIFASPALVRAGGVMIAFVEGRTKNKLFPEVIDLSSSDIVAGYIKAPETWQSLVAEVTKEYWQAHTVLESANNSNHRVGVARLPTGITRGNKVFLLVGSYEERREIDDYIWKAEAWNIKVIEGEATQSTEVQPTQPINWSEPKPLFQTDSPNNKGDLKEFLGGGGSGIVMGNGTLVFPLTAKDESNKVFSLITYSTDDGQKWEIPGGVSSVACRSPRVTEWEEGTLLMVTYCEDGRKVFESRDMGKTWTEARGTLPGVWLKSGPELPEVSLRVDALITATIEGRKVMLYTQKVRHFLEVDEPNALHLWVTDNNRTFHLGPFSVDSAENKTFANTLLYSDDALHLLQAKGDHESTAVSLARLTEELNTI
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:01) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:11) [INFO] Main: Simulation completed successfully. (00:06:14) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | 0.7752 | |
2 | G | A | -0.1939 | |
3 | S | A | -0.6804 | |
4 | S | A | -1.2782 | |
5 | H | A | -2.0041 | |
6 | H | A | -2.3514 | |
7 | H | A | -2.5860 | |
8 | H | A | -2.5599 | |
9 | H | A | -2.3961 | |
10 | H | A | -2.0647 | |
11 | S | A | -1.5436 | |
12 | S | A | -1.5673 | |
13 | G | A | -1.8167 | |
14 | E | A | -2.1161 | |
15 | N | A | -0.9439 | |
16 | L | A | 1.3230 | |
17 | Y | A | 1.9215 | |
18 | F | A | 2.1467 | |
19 | Q | A | 0.2631 | |
20 | G | A | -0.0979 | |
21 | A | A | 0.4691 | |
22 | M | A | 1.0782 | |
23 | A | A | 0.2631 | |
24 | V | A | 0.3970 | |
25 | E | A | -1.9746 | |
26 | R | A | -3.4242 | |
27 | N | A | -3.0456 | |
28 | S | A | -1.8757 | |
29 | G | A | -1.7157 | |
30 | D | A | -2.1099 | |
31 | L | A | 0.0457 | |
32 | Q | A | -1.5593 | |
33 | L | A | -0.6156 | |
34 | P | A | -1.2477 | |
35 | Q | A | -1.4938 | |
36 | E | A | -1.9127 | |
37 | I | A | 0.0000 | |
38 | A | A | -0.2483 | |
39 | M | A | 0.0000 | |
40 | L | A | 0.0000 | |
41 | V | A | -0.4747 | |
42 | P | A | -1.3044 | |
43 | N | A | -2.2283 | |
44 | K | A | -2.4709 | |
45 | T | A | 0.0000 | |
46 | Q | A | -2.1244 | |
47 | V | A | 0.0000 | |
48 | V | A | -1.5806 | |
49 | P | A | -1.7935 | |
50 | K | A | -1.5334 | |
51 | S | A | -1.3092 | |
52 | G | A | -1.4665 | |
53 | G | A | -1.9918 | |
54 | E | A | -2.7642 | |
55 | G | A | -2.3831 | |
56 | K | A | -2.5488 | |
57 | V | A | -1.2930 | |
58 | K | A | 0.0000 | |
59 | D | A | -1.3925 | |
60 | I | A | 0.0000 | |
61 | F | A | 0.0000 | |
62 | A | A | -0.1286 | |
63 | S | A | -0.0448 | |
64 | P | A | 0.0000 | |
65 | A | A | 0.0000 | |
66 | L | A | 0.0000 | |
67 | V | A | 0.0000 | |
68 | R | A | -1.0615 | |
69 | A | A | 0.0000 | |
70 | G | A | -1.7451 | |
71 | G | A | -1.7003 | |
72 | V | A | 0.0000 | |
73 | M | A | 0.0000 | |
74 | I | A | 0.0000 | |
75 | A | A | 0.0000 | |
76 | F | A | 0.0000 | |
77 | V | A | 0.0000 | |
78 | E | A | 0.0000 | |
79 | G | A | 0.0000 | |
80 | R | A | -0.8646 | |
81 | T | A | -1.3121 | |
82 | K | A | -1.7552 | |
83 | N | A | -1.7038 | |
84 | K | A | -1.8317 | |
85 | L | A | -0.7183 | |
86 | F | A | 0.0000 | |
87 | P | A | -1.2497 | |
88 | E | A | -1.5231 | |
89 | V | A | 0.2181 | |
90 | I | A | 0.7363 | |
91 | D | A | -1.5910 | |
92 | L | A | 0.0000 | |
93 | S | A | 0.0000 | |
94 | S | A | 0.0000 | |
95 | S | A | 0.0000 | |
96 | D | A | -0.9142 | |
97 | I | A | 0.0000 | |
98 | V | A | 0.0000 | |
99 | A | A | 0.0000 | |
100 | G | A | 0.0000 | |
101 | Y | A | 0.0000 | |
102 | I | A | 0.0000 | |
103 | K | A | -1.8139 | |
104 | A | A | -1.3869 | |
105 | P | A | -1.5791 | |
106 | E | A | -2.6601 | |
107 | T | A | -1.2221 | |
108 | W | A | -1.1719 | |
109 | Q | A | -1.2935 | |
110 | S | A | -1.0950 | |
111 | L | A | 0.0000 | |
112 | V | A | -0.3641 | |
113 | A | A | -0.3779 | |
114 | E | A | -0.8101 | |
115 | V | A | 0.0000 | |
116 | T | A | -0.6666 | |
117 | K | A | -1.3065 | |
118 | E | A | -1.6362 | |
119 | Y | A | -0.0827 | |
120 | W | A | -0.5439 | |
121 | Q | A | -0.8797 | |
122 | A | A | 0.0000 | |
123 | H | A | -0.8789 | |
124 | T | A | 0.0000 | |
125 | V | A | 0.0000 | |
126 | L | A | 0.0000 | |
127 | E | A | -1.6985 | |
128 | S | A | -1.3456 | |
129 | A | A | -1.3494 | |
130 | N | A | -2.4811 | |
131 | N | A | -2.6077 | |
132 | S | A | -2.2568 | |
133 | N | A | -2.1757 | |
134 | H | A | -1.8127 | |
135 | R | A | -2.5379 | |
136 | V | A | 0.0000 | |
137 | G | A | 0.0000 | |
138 | V | A | 0.0000 | |
139 | A | A | 0.0000 | |
140 | R | A | -0.7708 | |
141 | L | A | -0.1461 | |
142 | P | A | 0.0000 | |
143 | T | A | 0.0000 | |
144 | G | A | 0.0000 | |
145 | I | A | 0.0000 | |
146 | T | A | -1.0284 | |
147 | R | A | -1.7290 | |
148 | G | A | -1.6795 | |
149 | N | A | -2.0294 | |
150 | K | A | -2.3635 | |
151 | V | A | 0.0000 | |
152 | F | A | 0.0000 | |
153 | L | A | 0.0000 | |
154 | L | A | 0.0000 | |
155 | V | A | 0.0000 | |
156 | G | A | 0.0000 | |
157 | S | A | -0.7215 | |
158 | Y | A | 0.0000 | |
159 | E | A | 0.0000 | |
160 | E | A | -1.5261 | |
161 | R | A | -1.3853 | |
162 | R | A | -0.8436 | |
163 | E | A | -0.4130 | |
164 | I | A | 0.8103 | |
165 | D | A | -1.2947 | |
166 | D | A | -1.2253 | |
167 | Y | A | 0.8129 | |
168 | I | A | 0.6518 | |
169 | W | A | -0.1376 | |
170 | K | A | -1.0746 | |
171 | A | A | -0.8869 | |
172 | E | A | -0.9520 | |
173 | A | A | -0.6180 | |
174 | W | A | -0.9415 | |
175 | N | A | -1.5278 | |
176 | I | A | 0.0000 | |
177 | K | A | -1.0241 | |
178 | V | A | 0.0000 | |
179 | I | A | 0.0000 | |
180 | E | A | -1.7407 | |
181 | G | A | 0.0000 | |
182 | E | A | -2.5259 | |
183 | A | A | 0.0000 | |
184 | T | A | -1.7552 | |
185 | Q | A | -1.8590 | |
186 | S | A | -1.3094 | |
187 | T | A | -1.0384 | |
188 | E | A | -1.6382 | |
189 | V | A | 0.2837 | |
190 | Q | A | -1.0729 | |
191 | P | A | -1.1919 | |
192 | T | A | -0.7068 | |
193 | Q | A | -0.7746 | |
194 | P | A | -1.3163 | |
195 | I | A | 0.0000 | |
196 | N | A | -1.8809 | |
197 | W | A | -1.6584 | |
198 | S | A | -1.7365 | |
199 | E | A | -2.2022 | |
200 | P | A | -1.4959 | |
201 | K | A | -1.5683 | |
202 | P | A | -1.1479 | |
203 | L | A | 0.0000 | |
204 | F | A | -1.2927 | |
205 | Q | A | -2.0726 | |
206 | T | A | -1.5883 | |
207 | D | A | -2.6009 | |
208 | S | A | -2.4853 | |
209 | P | A | -2.5129 | |
210 | N | A | -3.6219 | |
211 | N | A | -3.3130 | |
212 | K | A | -3.3576 | |
213 | G | A | -3.1333 | |
214 | D | A | -4.0184 | |
215 | L | A | -3.1446 | |
216 | K | A | -3.2747 | |
217 | E | A | -2.1810 | |
218 | F | A | 0.0000 | |
219 | L | A | -0.4745 | |
220 | G | A | 0.0000 | |
221 | G | A | 0.0000 | |
222 | G | A | 0.0000 | |
223 | G | A | 0.0000 | |
224 | S | A | 0.1476 | |
225 | G | A | 0.0000 | |
226 | I | A | 0.4251 | |
227 | V | A | 0.2900 | |
228 | M | A | 0.0000 | |
229 | G | A | -1.6233 | |
230 | N | A | -1.7755 | |
231 | G | A | -1.0791 | |
232 | T | A | 0.0000 | |
233 | L | A | 0.0000 | |
234 | V | A | 0.0000 | |
235 | F | A | 0.0000 | |
236 | P | A | 0.0000 | |
237 | L | A | 0.0000 | |
238 | T | A | -0.1710 | |
239 | A | A | 0.0000 | |
240 | K | A | -2.3845 | |
241 | D | A | -3.2922 | |
242 | E | A | -3.6828 | |
243 | S | A | -2.4391 | |
244 | N | A | -3.0689 | |
245 | K | A | -2.1102 | |
246 | V | A | 0.0000 | |
247 | F | A | 0.0370 | |
248 | S | A | 0.0000 | |
249 | L | A | 0.0000 | |
250 | I | A | 0.0000 | |
251 | T | A | 0.0000 | |
252 | Y | A | -0.5813 | |
253 | S | A | 0.0000 | |
254 | T | A | -1.4298 | |
255 | D | A | -1.6368 | |
256 | D | A | -2.0701 | |
257 | G | A | 0.0000 | |
258 | Q | A | -2.4727 | |
259 | K | A | -2.9566 | |
260 | W | A | -1.9561 | |
261 | E | A | -1.9996 | |
262 | I | A | -1.0830 | |
263 | P | A | 0.0000 | |
264 | G | A | -1.6814 | |
265 | G | A | 0.0000 | |
266 | V | A | 0.5533 | |
267 | S | A | 0.0000 | |
268 | S | A | 0.2391 | |
269 | V | A | 0.6864 | |
270 | A | A | -0.7152 | |
271 | C | A | 0.0000 | |
272 | R | A | -0.8795 | |
273 | S | A | -0.3932 | |
274 | P | A | 0.0000 | |
275 | R | A | 0.0000 | |
276 | V | A | 0.0000 | |
277 | T | A | 0.0000 | |
278 | E | A | -0.9702 | |
279 | W | A | -1.5696 | |
280 | E | A | -3.1567 | |
281 | E | A | -3.3509 | |
282 | G | A | -2.4864 | |
283 | T | A | 0.0000 | |
284 | L | A | 0.0000 | |
285 | L | A | 0.0000 | |
286 | M | A | 0.0000 | |
287 | V | A | 0.0000 | |
288 | T | A | 0.0000 | |
289 | Y | A | -1.1572 | |
290 | C | A | 0.0000 | |
291 | E | A | -3.1017 | |
292 | D | A | -3.2085 | |
293 | G | A | 0.0000 | |
294 | R | A | 0.0000 | |
295 | K | A | -1.5267 | |
296 | V | A | 0.0000 | |
297 | F | A | 0.0000 | |
298 | E | A | -1.4194 | |
299 | S | A | 0.0000 | |
300 | R | A | -2.9692 | |
301 | D | A | -2.0757 | |
302 | M | A | -1.1767 | |
303 | G | A | 0.0000 | |
304 | K | A | -2.0935 | |
305 | T | A | -1.3130 | |
306 | W | A | -0.9797 | |
307 | T | A | -1.1605 | |
308 | E | A | -1.9956 | |
309 | A | A | -1.8198 | |
310 | R | A | -2.5348 | |
311 | G | A | -1.7708 | |
312 | T | A | -1.4308 | |
313 | L | A | 0.0000 | |
314 | P | A | -1.1422 | |
315 | G | A | -0.2838 | |
316 | V | A | 0.0000 | |
317 | W | A | -0.6542 | |
318 | L | A | -0.9435 | |
319 | K | A | -2.4252 | |
320 | S | A | -2.4344 | |
321 | G | A | -1.7965 | |
322 | P | A | -1.4199 | |
323 | E | A | -2.2028 | |
324 | L | A | -1.3818 | |
325 | P | A | -1.3530 | |
326 | E | A | -2.0512 | |
327 | V | A | -0.3018 | |
328 | S | A | 0.0000 | |
329 | L | A | 0.0000 | |
330 | R | A | -0.5420 | |
331 | V | A | 0.0000 | |
332 | D | A | 0.0000 | |
333 | A | A | 0.0000 | |
334 | L | A | 0.0000 | |
335 | I | A | 0.3028 | |
336 | T | A | -0.0510 | |
337 | A | A | 0.0000 | |
338 | T | A | -1.7642 | |
339 | I | A | -2.0145 | |
340 | E | A | -2.7935 | |
341 | G | A | -2.4202 | |
342 | R | A | -3.0538 | |
343 | K | A | -2.4460 | |
344 | V | A | 0.0000 | |
345 | M | A | 0.0000 | |
346 | L | A | 0.0000 | |
347 | Y | A | 0.0000 | |
348 | T | A | 0.0000 | |
349 | Q | A | 0.0000 | |
350 | K | A | 0.0000 | |
351 | V | A | 0.2377 | |
352 | R | A | -0.3466 | |
353 | H | A | -0.4061 | |
354 | F | A | 1.6578 | |
355 | L | A | 1.2405 | |
356 | E | A | -0.9442 | |
357 | V | A | 0.2995 | |
358 | D | A | -1.9597 | |
359 | E | A | -2.0879 | |
360 | P | A | -1.4352 | |
361 | N | A | -0.9670 | |
362 | A | A | -0.3475 | |
363 | L | A | 0.0000 | |
364 | H | A | -0.2131 | |
365 | L | A | 0.0000 | |
366 | W | A | 0.1064 | |
367 | V | A | 0.0000 | |
368 | T | A | 0.0000 | |
369 | D | A | -1.8086 | |
370 | N | A | -1.9413 | |
371 | N | A | -2.5671 | |
372 | R | A | -2.4865 | |
373 | T | A | -1.0609 | |
374 | F | A | 0.3169 | |
375 | H | A | -0.2116 | |
376 | L | A | -0.3215 | |
377 | G | A | -0.3169 | |
378 | P | A | -0.0202 | |
379 | F | A | 0.0000 | |
380 | S | A | 0.0000 | |
381 | V | A | 0.0793 | |
382 | D | A | 0.0000 | |
383 | S | A | -1.3429 | |
384 | A | A | -1.3918 | |
385 | E | A | -2.7553 | |
386 | N | A | -2.3523 | |
387 | K | A | -1.7106 | |
388 | T | A | 0.0000 | |
389 | F | A | -0.1121 | |
390 | A | A | 0.0946 | |
391 | N | A | 0.0000 | |
392 | T | A | 0.0000 | |
393 | L | A | 0.0000 | |
394 | L | A | 0.0668 | |
395 | Y | A | -0.4498 | |
396 | S | A | -1.5624 | |
397 | D | A | -2.9484 | |
398 | D | A | -2.9533 | |
399 | A | A | 0.0000 | |
400 | L | A | 0.0000 | |
401 | H | A | 0.0000 | |
402 | L | A | 0.0000 | |
403 | L | A | 0.0000 | |
404 | Q | A | 0.0000 | |
405 | A | A | 0.0000 | |
406 | K | A | -1.1927 | |
407 | G | A | 0.0000 | |
408 | D | A | -2.7497 | |
409 | H | A | -2.9009 | |
410 | E | A | -2.9991 | |
411 | S | A | -2.1320 | |
412 | T | A | 0.0000 | |
413 | A | A | -0.3168 | |
414 | V | A | 0.0000 | |
415 | S | A | -0.4387 | |
416 | L | A | 0.0000 | |
417 | A | A | 0.0000 | |
418 | R | A | -1.1245 | |
419 | L | A | 0.0000 | |
420 | T | A | -1.5882 | |
421 | E | A | -2.3772 | |
422 | E | A | -1.4743 | |
423 | L | A | -1.1878 | |
424 | N | A | -1.7627 | |
425 | T | A | -0.8997 | |
426 | I | A | -0.3056 |