| Chain sequence(s) |
A: TGALLAAGAAAGGGSMKNARTTLIAAAIAGTLVTTSPAGIANADDAGLDPNAAAGPDAVGFDPNLPPAPDAAPVDTPPAPEDAGFDPNLPPPLAPDFLSPPAEEAPPVPVAYSVNWAIAQCESGGNWSINTGNGYYGGLRFTAGTWRANGSGSAANASREEQIRVAENVLRSQGIRAWPVCGRRGEAAAKAKFVAAWTLKAAAGGGSIILKALYMLAAYLRYGNVLDVAAYPELGAFFAIAAYYPWQTAGCFVEKAAYKEAVNHFHLAAYSIEGAWGSGVGFTLTGPGPGFAILQDMRNTIMASKGPGPGILLKALYMLTTRGRQGPGPGIPIILKALYMLSTRGGPGPGSPVMGVIGFSFFVKDGPGPGSPFVLASTNAGSINAGPGPGQNTVKVSGKGGHSGSGPGPGENKGTRIRFKDDTSKKSKTVGTAEEKLKKKKKCNPPDCPGVGTGKKLRRTQSMGIQLDQRKKPDCPGVGTGCTAKKHHHHHH
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:07:30)
[INFO] Main: Simulation completed successfully. (00:07:34)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | T | A | -0.1529 | |
| 2 | G | A | -0.3072 | |
| 3 | A | A | 0.0065 | |
| 4 | L | A | 0.3190 | |
| 5 | L | A | 0.1476 | |
| 6 | A | A | 0.2150 | |
| 7 | A | A | 0.1289 | |
| 8 | G | A | 0.0000 | |
| 9 | A | A | -0.4823 | |
| 10 | A | A | -0.1382 | |
| 11 | A | A | -0.4691 | |
| 12 | G | A | -0.9192 | |
| 13 | G | A | -0.9900 | |
| 14 | G | A | -1.2866 | |
| 15 | S | A | -1.2441 | |
| 16 | M | A | -0.8748 | |
| 17 | K | A | -2.5187 | |
| 18 | N | A | -2.2333 | |
| 19 | A | A | 0.0000 | |
| 20 | R | A | -1.4303 | |
| 21 | T | A | -1.1468 | |
| 22 | T | A | -0.4526 | |
| 23 | L | A | 0.0000 | |
| 24 | I | A | 0.2463 | |
| 25 | A | A | 0.6003 | |
| 26 | A | A | 0.7221 | |
| 27 | A | A | 0.0000 | |
| 28 | I | A | 1.4511 | |
| 29 | A | A | 0.8191 | |
| 30 | G | A | 0.4941 | |
| 31 | T | A | 0.3949 | |
| 32 | L | A | 0.9753 | |
| 33 | V | A | 0.3390 | |
| 34 | T | A | 0.1091 | |
| 35 | T | A | -0.2280 | |
| 36 | S | A | -0.5134 | |
| 37 | P | A | -0.7130 | |
| 38 | A | A | -0.4583 | |
| 39 | G | A | -0.4862 | |
| 40 | I | A | 0.0000 | |
| 41 | A | A | -0.2581 | |
| 42 | N | A | -0.9491 | |
| 43 | A | A | 0.0000 | |
| 44 | D | A | -2.0709 | |
| 45 | D | A | -2.5377 | |
| 46 | A | A | -1.5365 | |
| 47 | G | A | -1.2937 | |
| 48 | L | A | 0.0000 | |
| 49 | D | A | -1.2882 | |
| 50 | P | A | -0.9689 | |
| 51 | N | A | -1.3735 | |
| 52 | A | A | 0.0000 | |
| 53 | A | A | 0.0000 | |
| 54 | A | A | -0.2393 | |
| 55 | G | A | 0.0000 | |
| 56 | P | A | -1.1486 | |
| 57 | D | A | -2.1834 | |
| 58 | A | A | -1.7177 | |
| 59 | V | A | 0.0000 | |
| 60 | G | A | -1.7124 | |
| 61 | F | A | 0.0000 | |
| 62 | D | A | -2.3884 | |
| 63 | P | A | -1.6197 | |
| 64 | N | A | -1.7771 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -0.7987 | |
| 67 | P | A | -0.4071 | |
| 68 | A | A | 0.0000 | |
| 69 | P | A | -0.7648 | |
| 70 | D | A | -0.3052 | |
| 71 | A | A | 0.0000 | |
| 72 | A | A | 0.0000 | |
| 73 | P | A | -0.1911 | |
| 74 | V | A | 0.5158 | |
| 75 | D | A | -1.2471 | |
| 76 | T | A | -0.7998 | |
| 77 | P | A | -0.4444 | |
| 78 | P | A | -0.2834 | |
| 79 | A | A | -0.3327 | |
| 80 | P | A | -0.7565 | |
| 81 | E | A | -1.4287 | |
| 82 | D | A | -2.0207 | |
| 83 | A | A | -1.2591 | |
| 84 | G | A | -0.6428 | |
| 85 | F | A | 0.2316 | |
| 86 | D | A | -1.3635 | |
| 87 | P | A | -0.9591 | |
| 88 | N | A | -1.2902 | |
| 89 | L | A | -0.3494 | |
| 90 | P | A | -0.4562 | |
| 91 | P | A | -0.0565 | |
| 92 | P | A | 0.4983 | |
| 93 | L | A | 1.2473 | |
| 94 | A | A | 0.3231 | |
| 95 | P | A | -0.3473 | |
| 96 | D | A | -1.5787 | |
| 97 | F | A | -0.2090 | |
| 98 | L | A | 0.4477 | |
| 99 | S | A | -0.7743 | |
| 100 | P | A | -0.7319 | |
| 101 | P | A | 0.0000 | |
| 102 | A | A | -1.3476 | |
| 103 | E | A | -3.0261 | |
| 104 | E | A | -3.1787 | |
| 105 | A | A | -2.1262 | |
| 106 | P | A | -1.4994 | |
| 107 | P | A | -1.3755 | |
| 108 | V | A | 0.0000 | |
| 109 | P | A | 0.0000 | |
| 110 | V | A | 0.0000 | |
| 111 | A | A | 0.0000 | |
| 112 | Y | A | 0.0483 | |
| 113 | S | A | 0.0000 | |
| 114 | V | A | 0.0000 | |
| 115 | N | A | 0.0000 | |
| 116 | W | A | 0.0529 | |
| 117 | A | A | 0.0000 | |
| 118 | I | A | 0.0000 | |
| 119 | A | A | -0.7462 | |
| 120 | Q | A | -0.9374 | |
| 121 | C | A | -0.8177 | |
| 122 | E | A | 0.0000 | |
| 123 | S | A | -0.8621 | |
| 124 | G | A | -0.9712 | |
| 125 | G | A | -1.0288 | |
| 126 | N | A | -1.1045 | |
| 127 | W | A | -0.9254 | |
| 128 | S | A | -0.8010 | |
| 129 | I | A | 0.0000 | |
| 130 | N | A | 0.0000 | |
| 131 | T | A | 0.0000 | |
| 132 | G | A | -0.7389 | |
| 133 | N | A | -1.1688 | |
| 134 | G | A | -0.1450 | |
| 135 | Y | A | 1.3092 | |
| 136 | Y | A | 1.0620 | |
| 137 | G | A | 0.1872 | |
| 138 | G | A | -0.0944 | |
| 139 | L | A | 0.0747 | |
| 140 | R | A | 0.0000 | |
| 141 | F | A | 0.0000 | |
| 142 | T | A | 0.0000 | |
| 143 | A | A | 0.0000 | |
| 144 | G | A | -1.2438 | |
| 145 | T | A | -0.6695 | |
| 146 | W | A | -1.0417 | |
| 147 | R | A | -2.2754 | |
| 148 | A | A | -1.7472 | |
| 149 | N | A | -2.0296 | |
| 150 | G | A | -1.4164 | |
| 151 | S | A | -1.2963 | |
| 152 | G | A | -0.9457 | |
| 153 | S | A | -1.0328 | |
| 154 | A | A | -0.4540 | |
| 155 | A | A | -0.3573 | |
| 156 | N | A | -0.8796 | |
| 157 | A | A | 0.0000 | |
| 158 | S | A | -1.0544 | |
| 159 | R | A | -1.4353 | |
| 160 | E | A | 0.0000 | |
| 161 | E | A | 0.0000 | |
| 162 | Q | A | -0.6564 | |
| 163 | I | A | 0.0000 | |
| 164 | R | A | -0.4017 | |
| 165 | V | A | 0.0000 | |
| 166 | A | A | 0.0000 | |
| 167 | E | A | 0.0000 | |
| 168 | N | A | 0.0000 | |
| 169 | V | A | 0.0000 | |
| 170 | L | A | 0.0000 | |
| 171 | R | A | 0.0000 | |
| 172 | S | A | -0.9337 | |
| 173 | Q | A | -1.7685 | |
| 174 | G | A | -1.5249 | |
| 175 | I | A | -1.2697 | |
| 176 | R | A | -2.5037 | |
| 177 | A | A | -1.2588 | |
| 178 | W | A | -0.4141 | |
| 179 | P | A | -0.5133 | |
| 180 | V | A | -0.3276 | |
| 181 | C | A | -0.5805 | |
| 182 | G | A | -1.5211 | |
| 183 | R | A | -2.9108 | |
| 184 | R | A | -2.8067 | |
| 185 | G | A | -2.2143 | |
| 186 | E | A | -2.0971 | |
| 187 | A | A | -1.1124 | |
| 188 | A | A | 0.0000 | |
| 189 | A | A | -0.4023 | |
| 190 | K | A | 0.0000 | |
| 191 | A | A | 0.2063 | |
| 192 | K | A | 0.0082 | |
| 193 | F | A | 0.0000 | |
| 194 | V | A | 0.5833 | |
| 195 | A | A | 0.0000 | |
| 196 | A | A | 0.0000 | |
| 197 | W | A | 0.1737 | |
| 198 | T | A | 0.2858 | |
| 199 | L | A | 0.0000 | |
| 200 | K | A | -0.7093 | |
| 201 | A | A | -0.2344 | |
| 202 | A | A | -0.2287 | |
| 203 | A | A | -0.4564 | |
| 204 | G | A | -0.8605 | |
| 205 | G | A | -0.8924 | |
| 206 | G | A | -0.7089 | |
| 207 | S | A | -0.4754 | |
| 208 | I | A | 0.3379 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | 0.3255 | |
| 211 | K | A | 0.0886 | |
| 212 | A | A | 0.3301 | |
| 213 | L | A | 0.0000 | |
| 214 | Y | A | 0.0000 | |
| 215 | M | A | 0.5087 | |
| 216 | L | A | 0.6129 | |
| 217 | A | A | 0.0000 | |
| 218 | A | A | 0.0000 | |
| 219 | Y | A | 1.3928 | |
| 220 | L | A | 0.5780 | |
| 221 | R | A | -0.2048 | |
| 222 | Y | A | 0.4919 | |
| 223 | G | A | -0.2738 | |
| 224 | N | A | -0.7027 | |
| 225 | V | A | 0.0000 | |
| 226 | L | A | 0.0000 | |
| 227 | D | A | 0.2813 | |
| 228 | V | A | 1.1740 | |
| 229 | A | A | 0.7719 | |
| 230 | A | A | 0.0000 | |
| 231 | Y | A | 0.5346 | |
| 232 | P | A | -0.1894 | |
| 233 | E | A | -1.0365 | |
| 234 | L | A | 0.0000 | |
| 235 | G | A | 0.0570 | |
| 236 | A | A | 0.0000 | |
| 237 | F | A | -0.1880 | |
| 238 | F | A | 0.1542 | |
| 239 | A | A | 0.0000 | |
| 240 | I | A | 0.0000 | |
| 241 | A | A | 0.0000 | |
| 242 | A | A | 0.0000 | |
| 243 | Y | A | 0.0000 | |
| 244 | Y | A | 0.0000 | |
| 245 | P | A | 0.0000 | |
| 246 | W | A | 0.0298 | |
| 247 | Q | A | -0.7352 | |
| 248 | T | A | 0.0000 | |
| 249 | A | A | 0.0000 | |
| 250 | G | A | -0.2057 | |
| 251 | C | A | 0.0000 | |
| 252 | F | A | 0.9624 | |
| 253 | V | A | 0.0000 | |
| 254 | E | A | -1.9138 | |
| 255 | K | A | -2.7249 | |
| 256 | A | A | -1.9480 | |
| 257 | A | A | -1.9397 | |
| 258 | Y | A | -1.9013 | |
| 259 | K | A | -3.4082 | |
| 260 | E | A | -3.4013 | |
| 261 | A | A | 0.0000 | |
| 262 | V | A | -1.5090 | |
| 263 | N | A | -2.5329 | |
| 264 | H | A | -2.1024 | |
| 265 | F | A | -0.6598 | |
| 266 | H | A | -0.9292 | |
| 267 | L | A | 0.0000 | |
| 268 | A | A | 0.0000 | |
| 269 | A | A | 0.2416 | |
| 270 | Y | A | 0.0000 | |
| 271 | S | A | -0.2495 | |
| 272 | I | A | 0.0000 | |
| 273 | E | A | -0.9017 | |
| 274 | G | A | -0.2900 | |
| 275 | A | A | 0.3121 | |
| 276 | W | A | 0.7087 | |
| 277 | G | A | 0.0743 | |
| 278 | S | A | 0.2243 | |
| 279 | G | A | 0.0000 | |
| 280 | V | A | 0.0000 | |
| 281 | G | A | -0.2644 | |
| 282 | F | A | 0.3314 | |
| 283 | T | A | 0.1775 | |
| 284 | L | A | 0.1420 | |
| 285 | T | A | -0.2508 | |
| 286 | G | A | -0.6414 | |
| 287 | P | A | -0.7130 | |
| 288 | G | A | -0.3682 | |
| 289 | P | A | -0.3366 | |
| 290 | G | A | 0.0000 | |
| 291 | F | A | 0.5515 | |
| 292 | A | A | 0.0297 | |
| 293 | I | A | 0.0000 | |
| 294 | L | A | 0.0000 | |
| 295 | Q | A | -0.8023 | |
| 296 | D | A | -0.8367 | |
| 297 | M | A | 0.0000 | |
| 298 | R | A | -1.0205 | |
| 299 | N | A | -1.2449 | |
| 300 | T | A | -0.4066 | |
| 301 | I | A | 0.0000 | |
| 302 | M | A | 0.1156 | |
| 303 | A | A | -0.2712 | |
| 304 | S | A | -0.8276 | |
| 305 | K | A | -1.7875 | |
| 306 | G | A | -1.2268 | |
| 307 | P | A | -1.0837 | |
| 308 | G | A | -0.7902 | |
| 309 | P | A | 0.0000 | |
| 310 | G | A | 0.1860 | |
| 311 | I | A | 0.8804 | |
| 312 | L | A | 0.0000 | |
| 313 | L | A | 0.0000 | |
| 314 | K | A | 0.4333 | |
| 315 | A | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | Y | A | 0.0000 | |
| 318 | M | A | 0.0000 | |
| 319 | L | A | 0.0000 | |
| 320 | T | A | -0.5560 | |
| 321 | T | A | -1.0613 | |
| 322 | R | A | -2.6793 | |
| 323 | G | A | -2.6116 | |
| 324 | R | A | -3.1868 | |
| 325 | Q | A | -2.7038 | |
| 326 | G | A | -1.6204 | |
| 327 | P | A | -1.3038 | |
| 328 | G | A | -1.0354 | |
| 329 | P | A | -0.9519 | |
| 330 | G | A | -0.7137 | |
| 331 | I | A | -0.6313 | |
| 332 | P | A | 0.0000 | |
| 333 | I | A | -0.1827 | |
| 334 | I | A | 0.0000 | |
| 335 | L | A | 0.0000 | |
| 336 | K | A | 0.0000 | |
| 337 | A | A | 0.0000 | |
| 338 | L | A | 0.0000 | |
| 339 | Y | A | 1.9336 | |
| 340 | M | A | 0.7618 | |
| 341 | L | A | 0.0000 | |
| 342 | S | A | -0.1760 | |
| 343 | T | A | 0.0000 | |
| 344 | R | A | -0.8591 | |
| 345 | G | A | -0.9983 | |
| 346 | G | A | -0.9176 | |
| 347 | P | A | -0.8074 | |
| 348 | G | A | -0.8752 | |
| 349 | P | A | -0.7154 | |
| 350 | G | A | -0.7292 | |
| 351 | S | A | 0.0000 | |
| 352 | P | A | -0.4337 | |
| 353 | V | A | 0.0000 | |
| 354 | M | A | 0.0000 | |
| 355 | G | A | 0.8306 | |
| 356 | V | A | 0.0000 | |
| 357 | I | A | 2.4110 | |
| 358 | G | A | 1.0526 | |
| 359 | F | A | 1.1430 | |
| 360 | S | A | 0.6299 | |
| 361 | F | A | 0.0000 | |
| 362 | F | A | 0.5527 | |
| 363 | V | A | 0.0000 | |
| 364 | K | A | -0.7226 | |
| 365 | D | A | 0.0000 | |
| 366 | G | A | -0.7930 | |
| 367 | P | A | -0.8146 | |
| 368 | G | A | 0.0000 | |
| 369 | P | A | -0.9059 | |
| 370 | G | A | -1.1956 | |
| 371 | S | A | 0.0000 | |
| 372 | P | A | -0.9432 | |
| 373 | F | A | 0.0000 | |
| 374 | V | A | 0.0000 | |
| 375 | L | A | 0.0000 | |
| 376 | A | A | 0.0000 | |
| 377 | S | A | 0.0000 | |
| 378 | T | A | -0.3902 | |
| 379 | N | A | -1.3877 | |
| 380 | A | A | -0.6294 | |
| 381 | G | A | -0.5616 | |
| 382 | S | A | -0.2628 | |
| 383 | I | A | 0.0921 | |
| 384 | N | A | -0.2347 | |
| 385 | A | A | -0.1863 | |
| 386 | G | A | 0.0000 | |
| 387 | P | A | -0.7011 | |
| 388 | G | A | 0.0000 | |
| 389 | P | A | -1.1713 | |
| 390 | G | A | -1.3115 | |
| 391 | Q | A | -1.7044 | |
| 392 | N | A | -1.3089 | |
| 393 | T | A | -0.6193 | |
| 394 | V | A | 0.0000 | |
| 395 | K | A | -0.6083 | |
| 396 | V | A | -0.8712 | |
| 397 | S | A | 0.0000 | |
| 398 | G | A | -1.9218 | |
| 399 | K | A | -2.4589 | |
| 400 | G | A | -1.9368 | |
| 401 | G | A | -1.7307 | |
| 402 | H | A | -1.8591 | |
| 403 | S | A | -1.3608 | |
| 404 | G | A | -1.0928 | |
| 405 | S | A | -1.1341 | |
| 406 | G | A | -1.1005 | |
| 407 | P | A | -0.8466 | |
| 408 | G | A | 0.0000 | |
| 409 | P | A | -1.1057 | |
| 410 | G | A | -1.1535 | |
| 411 | E | A | -1.1346 | |
| 412 | N | A | -1.4143 | |
| 413 | K | A | -1.9270 | |
| 414 | G | A | -1.6416 | |
| 415 | T | A | -1.5923 | |
| 416 | R | A | -2.0163 | |
| 417 | I | A | 0.0000 | |
| 418 | R | A | -1.8366 | |
| 419 | F | A | -2.0882 | |
| 420 | K | A | -2.9497 | |
| 421 | D | A | -2.7136 | |
| 422 | D | A | -2.9559 | |
| 423 | T | A | -1.8513 | |
| 424 | S | A | -2.1586 | |
| 425 | K | A | -3.3859 | |
| 426 | K | A | -3.8756 | |
| 427 | S | A | -2.3799 | |
| 428 | K | A | -2.6787 | |
| 429 | T | A | -1.4271 | |
| 430 | V | A | -0.7868 | |
| 431 | G | A | -1.0032 | |
| 432 | T | A | -1.7560 | |
| 433 | A | A | 0.0000 | |
| 434 | E | A | -2.3765 | |
| 435 | E | A | -3.1006 | |
| 436 | K | A | -2.8396 | |
| 437 | L | A | -3.6086 | |
| 438 | K | A | -4.6177 | |
| 439 | K | A | -4.3105 | |
| 440 | K | A | -4.0720 | |
| 441 | K | A | -4.6207 | |
| 442 | K | A | -3.5959 | |
| 443 | C | A | -2.0716 | |
| 444 | N | A | -2.5183 | |
| 445 | P | A | -2.5239 | |
| 446 | P | A | -2.4006 | |
| 447 | D | A | -2.7692 | |
| 448 | C | A | 0.0000 | |
| 449 | P | A | -1.4513 | |
| 450 | G | A | -1.2881 | |
| 451 | V | A | -0.0128 | |
| 452 | G | A | -0.6481 | |
| 453 | T | A | -1.1555 | |
| 454 | G | A | -2.1199 | |
| 455 | K | A | -3.4849 | |
| 456 | K | A | -3.0444 | |
| 457 | L | A | 0.0000 | |
| 458 | R | A | -2.6243 | |
| 459 | R | A | -2.5540 | |
| 460 | T | A | -1.6131 | |
| 461 | Q | A | -0.8214 | |
| 462 | S | A | -0.0435 | |
| 463 | M | A | 0.7454 | |
| 464 | G | A | 0.1186 | |
| 465 | I | A | -0.2030 | |
| 466 | Q | A | -1.7179 | |
| 467 | L | A | 0.0000 | |
| 468 | D | A | -2.4131 | |
| 469 | Q | A | -2.8726 | |
| 470 | R | A | -3.4505 | |
| 471 | K | A | -2.6206 | |
| 472 | K | A | -2.7702 | |
| 473 | P | A | -2.6383 | |
| 474 | D | A | -2.7998 | |
| 475 | C | A | -1.9968 | |
| 476 | P | A | -1.3549 | |
| 477 | G | A | -1.4118 | |
| 478 | V | A | -1.4372 | |
| 479 | G | A | -1.2316 | |
| 480 | T | A | -0.5400 | |
| 481 | G | A | -0.7484 | |
| 482 | C | A | -0.6557 | |
| 483 | T | A | -1.1549 | |
| 484 | A | A | -2.2094 | |
| 485 | K | A | -2.6758 | |
| 486 | K | A | -3.5079 | |
| 487 | H | A | -2.7380 | |
| 488 | H | A | -2.5975 | |
| 489 | H | A | -2.6560 | |
| 490 | H | A | -2.3640 | |
| 491 | H | A | -2.5096 | |
| 492 | H | A | -1.7825 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine