Project name: 761eb787615e44d

Chain sequence(s)	H: EVQLVESGGGLVQPGRSLRLSCAASGFTFSSYAMNWVRRTPGKGLDWVSTISGIGKNTYYADSVKGRFTISRDNSKNTLYLQMNSLRADDTAVYYCAKTTFPGIVGEVDAFDIWGHGTMVTVSS; L: QSVLTQPPSVSVAPGKTATITCGGNNIGSKSVHWYQQKPGQAPVMVIYYDTDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQAWDSHIDHFVFGAGTKVTVL
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:56)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:57)

• Minimal score value: -2.8149
• Maximal score value: 1.972
• Average score: -0.5205
• Total score value: -120.762

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.7723
2	V	H	-0.6154
3	Q	H	-0.6999
4	L	H	0.0000
5	V	H	0.3736
6	E	H	0.0000
7	S	H	-0.3988
8	G	H	-0.6543
9	G	H	-0.0776
11	G	H	0.5308
12	L	H	1.2591
13	V	H	-0.3846
14	Q	H	-1.7536
15	P	H	-2.0052
16	G	H	-2.1471
17	R	H	-2.7265
18	S	H	-1.6555
19	L	H	-0.8329
20	R	H	-1.0818
21	L	H	0.0000
22	S	H	-0.2894
23	C	H	0.0000
24	A	H	-0.2714
25	A	H	0.0000
26	S	H	-0.7465
27	G	H	-0.8590
28	F	H	-0.2803
29	T	H	-0.1613
30	F	H	0.0000
35	S	H	-0.3187
36	S	H	0.3651
37	Y	H	0.7310
38	A	H	0.3308
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	R	H	-0.8820
45	T	H	-1.2661
46	P	H	-1.2623
47	G	H	-1.4760
48	K	H	-2.1898
49	G	H	-1.2956
50	L	H	0.0000
51	D	H	-0.8072
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	T	H	0.0000
56	I	H	0.0000
57	S	H	-0.0756
58	G	H	0.3791
59	I	H	1.1518
62	G	H	-0.3595
63	K	H	-1.3978
64	N	H	-0.9767
65	T	H	-0.6085
66	Y	H	-0.3556
67	Y	H	-0.7697
68	A	H	-1.2069
69	D	H	-2.3242
70	S	H	-1.6635
71	V	H	0.0000
72	K	H	-2.1630
74	G	H	-1.5252
75	R	H	-1.2952
76	F	H	0.0000
77	T	H	-0.5772
78	I	H	0.0000
79	S	H	-0.5089
80	R	H	-0.6395
81	D	H	-1.2624
82	N	H	-1.3994
83	S	H	-1.5736
84	K	H	-2.3529
85	N	H	-1.6681
86	T	H	-1.0228
87	L	H	0.0000
88	Y	H	-0.2727
89	L	H	0.0000
90	Q	H	-0.7192
91	M	H	0.0000
92	N	H	-1.5922
93	S	H	-1.7208
94	L	H	0.0000
95	R	H	-2.3271
96	A	H	-1.6067
97	D	H	-2.1811
98	D	H	0.0000
99	T	H	-0.5552
100	A	H	0.0000
101	V	H	0.2683
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	K	H	0.0000
107	T	H	0.0000
108	T	H	0.3893
109	F	H	0.7495
110	P	H	0.5986
111	G	H	0.9276
111A	I	H	1.9720
111B	V	H	1.0501
112B	G	H	-0.2434
112A	E	H	-1.2628
112	V	H	-0.0471
113	D	H	0.0000
114	A	H	0.0000
115	F	H	0.0000
116	D	H	-0.0442
117	I	H	0.2566
118	W	H	0.0000
119	G	H	0.0000
120	H	H	-1.1110
121	G	H	-0.4798
122	T	H	-0.0031
123	M	H	0.5246
124	V	H	0.0000
125	T	H	0.1232
126	V	H	0.0000
127	S	H	-0.6328
128	S	H	-0.6494
1	Q	L	-0.7870
2	S	L	-0.1014
3	V	L	1.2016
4	L	L	0.0000
5	T	L	0.1887
6	Q	L	0.0000
7	P	L	-0.3574
8	P	L	-0.5866
9	S	L	-0.6314
11	V	L	-0.1719
12	S	L	0.2011
13	V	L	0.0450
14	A	L	-0.2661
15	P	L	-1.2849
16	G	L	-2.3494
17	K	L	-2.6309
18	T	L	-1.6015
19	A	L	0.0000
20	T	L	-0.0644
21	I	L	0.0000
22	T	L	-0.1426
23	C	L	0.0000
24	G	L	-0.8194
25	G	L	-1.2445
26	N	L	-2.2395
27	N	L	-2.8149
28	I	L	0.0000
29	G	L	-1.9587
36	S	L	-1.4015
37	K	L	-0.9181
38	S	L	-0.2414
39	V	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.1047
44	Q	L	0.0000
45	K	L	-1.3230
46	P	L	-1.2376
47	G	L	-1.4250
48	Q	L	-1.6866
49	A	L	-0.7266
50	P	L	0.0000
51	V	L	1.2941
52	M	L	0.0000
53	V	L	0.0000
54	I	L	0.0000
55	Y	L	-0.3518
56	Y	L	-0.2252
57	D	L	-0.7871
65	T	L	-0.9136
66	D	L	-1.6791
67	R	L	-1.5396
68	P	L	-0.6545
69	S	L	-0.6668
70	G	L	-0.7644
71	I	L	-0.5755
72	P	L	-1.1286
74	E	L	-2.1245
75	R	L	0.0000
76	F	L	0.0000
77	S	L	-0.9232
78	G	L	0.0000
79	S	L	-0.6577
80	N	L	-0.9973
83	S	L	-1.4173
84	G	L	-2.0803
85	N	L	-2.6510
86	T	L	-1.4679
87	A	L	0.0000
88	T	L	-0.2881
89	L	L	0.0000
90	T	L	-0.2806
91	I	L	0.0000
92	S	L	-1.7541
93	R	L	-2.6046
94	V	L	0.0000
95	E	L	-2.4590
96	A	L	-0.9725
97	G	L	-1.2845
98	D	L	0.0000
99	E	L	-1.2431
100	A	L	0.0000
101	D	L	-1.0569
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	A	L	0.0000
107	W	L	-0.3679
108	D	L	0.0000
109	S	L	-0.8872
110	H	L	-0.9945
113	I	L	-0.1467
114	D	L	-0.6317
115	H	L	-0.4525
116	F	L	0.0000
117	V	L	0.2916
118	F	L	0.0000
119	G	L	0.0000
120	A	L	-0.1883
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.1984
124	V	L	0.0000
125	T	L	0.0639
126	V	L	0.1602
127	L	L	1.4296