Project name: 770374076fb819b

Chain sequence(s)	H: EVTLVESGGGTVPVGGSVTLSCHASGFTFTDFYMHWVAQPPGGPPVVLGYVRDKAKGYTTELDPRFAGKLTLSVDTVTNVLYLNMTNLQAEDTATYYCAREGHTAAPFDYWGQGVMVTVSS; L: DIVLTQSPSSLSAAVGETVTLNCTSSSNIDKYLSWYKQAPGEPPQLLIYNTNNLASGVSSRFSGSGSGTSFSLTISSLQADDVATYWCLQHISRPRCFGTGTKLELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:09)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:12)

• Minimal score value: -2.251
• Maximal score value: 1.4446
• Average score: -0.3805
• Total score value: -86.7542

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.8059
2	V	H	-0.6312
3	T	H	-0.1852
4	L	H	0.0000
5	V	H	1.0048
6	E	H	0.0000
7	S	H	-0.1667
8	G	H	-0.4710
9	G	H	-0.2626
10	G	H	-0.2044
11	T	H	-0.0901
12	V	H	0.0000
13	P	H	-0.0374
14	V	H	0.3631
15	G	H	-0.6228
16	G	H	-0.5027
17	S	H	-0.6228
18	V	H	-0.3265
19	T	H	-0.2019
20	L	H	0.0000
21	S	H	0.1191
22	C	H	0.0000
23	H	H	-0.1126
24	A	H	0.0000
25	S	H	-0.4681
26	G	H	-0.8632
27	F	H	-0.3971
28	T	H	-0.4486
29	F	H	0.0000
30	T	H	-1.1342
31	D	H	-1.4929
32	F	H	-0.7671
33	Y	H	-0.5031
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	A	H	0.0000
39	Q	H	0.0000
40	P	H	-0.6229
41	P	H	-0.5290
42	G	H	-0.7121
43	G	H	-0.6291
44	P	H	-0.3937
45	P	H	0.0000
46	V	H	0.2107
47	V	H	0.0000
48	L	H	0.0000
49	G	H	0.0000
50	Y	H	0.0000
51	V	H	0.0000
52	R	H	-1.0111
53	D	H	0.0000
54	K	H	-2.0062
55	A	H	-1.5745
56	K	H	-2.2510
57	G	H	-1.5240
58	Y	H	-0.8465
59	T	H	-0.7345
60	T	H	-0.3534
61	E	H	-0.4277
62	L	H	-0.1808
63	D	H	0.0000
64	P	H	-1.3375
65	R	H	-1.8405
66	F	H	-0.9530
67	A	H	-0.7256
68	G	H	-0.8767
69	K	H	-1.0161
70	L	H	0.0000
71	T	H	-0.2161
72	L	H	0.0000
73	S	H	-0.0161
74	V	H	-0.0452
75	D	H	-0.2385
76	T	H	0.2059
77	V	H	1.4446
78	T	H	0.3440
79	N	H	-0.2128
80	V	H	0.0807
81	L	H	0.0000
82	Y	H	0.1154
83	L	H	0.0000
84	N	H	-0.3174
85	M	H	0.0000
86	T	H	-0.9680
87	N	H	-1.5626
88	L	H	0.0000
89	Q	H	-1.3866
90	A	H	-1.0541
91	E	H	-1.9991
92	D	H	-1.1949
93	T	H	-0.8605
94	A	H	0.0000
95	T	H	-0.0323
96	Y	H	0.0000
97	Y	H	0.0000
98	C	H	0.0000
99	A	H	0.0000
100	R	H	0.0000
101	E	H	-0.3771
102	G	H	0.0000
103	H	H	-1.1638
104	T	H	-0.5429
105	A	H	-0.4314
106	A	H	0.0000
107	P	H	0.0000
108	F	H	0.0000
109	D	H	-0.2152
110	Y	H	0.3873
111	W	H	0.1958
112	G	H	0.0000
113	Q	H	-0.9027
114	G	H	-0.3265
115	V	H	0.1618
116	M	H	0.3066
117	V	H	0.0000
118	T	H	-0.3079
119	V	H	0.0000
120	S	H	-0.0391
121	S	H	-0.0104
1	D	L	-1.6716
2	I	L	0.0000
3	V	L	1.2691
4	L	L	0.0000
5	T	L	0.0952
6	Q	L	0.0000
7	S	L	-0.6659
8	P	L	-0.6271
9	S	L	-0.7661
10	S	L	-0.8398
11	L	L	-0.4838
12	S	L	-0.6223
13	A	L	0.0000
14	A	L	-0.1824
15	V	L	0.7334
16	G	L	-0.1331
17	E	L	-0.7640
18	T	L	-0.5183
19	V	L	0.0000
20	T	L	-0.2539
21	L	L	0.0000
22	N	L	-0.8063
23	C	L	0.0000
24	T	L	-0.3151
25	S	L	0.0000
26	S	L	-0.1984
27	S	L	-0.8990
28	N	L	-1.7887
29	I	L	0.0000
30	D	L	-1.9427
31	K	L	-1.9752
32	Y	L	-0.5836
33	L	L	0.0000
34	S	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	K	L	0.0000
38	Q	L	0.0000
39	A	L	-0.7794
40	P	L	-0.5878
41	G	L	-0.9986
42	E	L	-1.2002
43	P	L	-0.8602
44	P	L	0.0000
45	Q	L	-0.6156
46	L	L	0.0025
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	-0.2575
50	N	L	-0.7829
51	T	L	0.0000
52	N	L	-1.6230
53	N	L	-0.7261
54	L	L	0.0177
55	A	L	-0.1446
56	S	L	-0.3047
57	G	L	-0.4058
58	V	L	-0.1337
59	S	L	-0.2542
60	S	L	-0.3605
61	R	L	-0.5680
62	F	L	0.0000
63	S	L	-0.6237
64	G	L	-0.8221
65	S	L	-1.1375
66	G	L	-1.1890
67	S	L	-1.5112
68	G	L	-1.5382
69	T	L	-1.1587
70	S	L	-0.9806
71	F	L	0.0000
72	S	L	-0.6884
73	L	L	0.0000
74	T	L	-0.3297
75	I	L	0.0000
76	S	L	-0.6747
77	S	L	-0.5075
78	L	L	0.0000
79	Q	L	-0.6571
80	A	L	-0.4743
81	D	L	-1.5908
82	D	L	0.0000
83	V	L	-0.3196
84	A	L	0.0000
85	T	L	-0.6669
86	Y	L	0.0000
87	W	L	0.0000
88	C	L	0.0000
89	L	L	0.0000
90	Q	L	0.0000
91	H	L	0.1564
92	I	L	0.2861
93	S	L	-0.3442
94	R	L	-1.1772
95	P	L	-0.9925
96	R	L	0.0000
97	C	L	0.1815
98	F	L	0.0000
99	G	L	0.0000
100	T	L	-0.1698
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.4054
104	L	L	0.0000
105	E	L	-0.4072
106	L	L	0.0376
107	K	L	-1.1819