Project name: Bevacizumab

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVT; L: DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:19)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:20)

• Minimal score value: -3.3296
• Maximal score value: 1.4584
• Average score: -0.532
• Total score value: -120.7544

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9231
2	V	H	-0.8625
3	Q	H	-0.9343
4	L	H	0.0000
5	V	H	1.1596
6	E	H	0.0000
7	S	H	-0.2005
8	G	H	-0.4954
9	G	H	0.0602
11	G	H	0.6531
12	L	H	1.2474
13	V	H	0.0000
14	Q	H	-1.4424
15	P	H	-1.9787
16	G	H	-1.6877
17	G	H	-1.3993
18	S	H	-1.4788
19	L	H	-0.9498
20	R	H	-1.7121
21	L	H	0.0000
22	S	H	-0.1769
23	C	H	0.0000
24	A	H	0.0953
25	A	H	0.0000
26	S	H	-0.7574
27	G	H	-1.0527
28	Y	H	-0.5540
29	T	H	-0.3872
30	F	H	0.0000
35	T	H	-0.1153
36	N	H	-0.9523
37	Y	H	-0.3205
38	G	H	-0.2413
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6750
45	A	H	0.0000
46	P	H	-0.8314
47	G	H	-1.4779
48	K	H	-2.3236
49	G	H	-1.5463
50	L	H	0.0000
51	E	H	-1.0203
52	W	H	0.0000
53	V	H	0.0000
54	G	H	0.0000
55	W	H	-0.0897
56	I	H	0.0000
57	N	H	-0.6126
58	T	H	0.0000
59	Y	H	0.6278
62	T	H	-0.1265
63	G	H	-0.7776
64	E	H	-1.7945
65	P	H	-1.0067
66	T	H	-0.4715
67	Y	H	-0.6655
68	A	H	0.0000
69	A	H	-1.6398
70	D	H	-2.6867
71	F	H	0.0000
72	K	H	-3.1410
74	R	H	-3.3296
75	R	H	-2.4598
76	F	H	0.0000
77	T	H	-1.1694
78	F	H	0.0000
79	S	H	-0.3751
80	L	H	-0.2374
81	D	H	-0.8287
82	T	H	-0.6609
83	S	H	-1.1351
84	K	H	-1.9256
85	S	H	-1.0127
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.2858
89	L	H	0.0000
90	Q	H	-1.2987
91	M	H	0.0000
92	N	H	-2.2053
93	S	H	-1.8012
94	L	H	0.0000
95	R	H	-3.0506
96	A	H	-1.9946
97	E	H	-2.4603
98	D	H	0.0000
99	T	H	-0.5308
100	A	H	0.0000
101	V	H	0.5913
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	K	H	0.0000
107	Y	H	0.0000
108	P	H	0.0000
109	H	H	0.0584
110	Y	H	1.3803
111	Y	H	1.4584
111A	G	H	0.3592
112B	S	H	0.2342
112A	S	H	0.3756
112	H	H	0.5382
113	W	H	0.4887
114	Y	H	0.0000
115	F	H	0.0000
116	D	H	-0.3956
117	V	H	-0.0952
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.2948
121	G	H	-0.3891
122	T	H	0.0000
123	L	H	1.4317
124	V	H	0.0000
125	T	H	0.1429
1	D	L	-2.0166
2	I	L	0.0000
3	Q	L	-1.9684
4	M	L	0.0000
5	T	L	-0.8891
6	Q	L	0.0000
7	S	L	-0.4509
8	P	L	-0.6001
9	S	L	-0.9622
10	S	L	-1.1475
11	L	L	-0.8432
12	S	L	-0.8930
13	A	L	-1.0109
14	S	L	-0.8140
15	V	L	-0.0430
16	G	L	-0.7547
17	D	L	-1.7222
18	R	L	-2.2744
19	V	L	0.0000
20	T	L	-0.6159
21	I	L	0.0000
22	T	L	-0.5860
23	C	L	0.0000
24	S	L	-1.5093
25	A	L	0.0000
26	S	L	-1.9093
27	Q	L	-2.5288
28	D	L	-2.6465
29	I	L	0.0000
36	S	L	-1.0253
37	N	L	-0.4352
38	Y	L	0.5524
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.6843
44	Q	L	0.0000
45	K	L	-1.4740
46	P	L	-1.1026
47	G	L	-1.6341
48	K	L	-2.5291
49	A	L	-1.4928
50	P	L	0.0000
51	K	L	-1.0981
52	V	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.7078
56	F	L	0.8636
57	T	L	0.0000
65	S	L	0.0445
66	S	L	0.2685
67	L	L	0.3709
68	H	L	-0.1982
69	S	L	-0.3669
70	G	L	-0.5002
71	V	L	-0.2707
72	P	L	-0.3472
74	S	L	-0.4074
75	R	L	-0.6894
76	F	L	0.0000
77	S	L	-0.3249
78	G	L	0.0000
79	S	L	-0.6900
80	G	L	-1.0706
83	S	L	-1.2209
84	G	L	-1.7530
85	T	L	-2.1108
86	D	L	-2.4804
87	F	L	0.0000
88	T	L	-0.6563
89	L	L	0.0000
90	T	L	-0.5915
91	I	L	0.0000
92	S	L	-1.2420
93	S	L	-1.1128
94	L	L	0.0000
95	Q	L	-0.7883
96	P	L	-0.9082
97	E	L	-1.5866
98	D	L	0.0000
99	F	L	-0.1072
100	A	L	0.0000
101	T	L	-0.9885
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	S	L	-0.0473
109	T	L	0.1540
114	V	L	0.6331
115	P	L	0.0851
116	W	L	0.0000
117	T	L	-0.6889
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.6077
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.9711
124	V	L	0.0000
125	E	L	-1.2322
126	I	L	-0.6953
127	K	L	-1.5755