| Chain sequence(s) |
A: HMGPGPGYKAADMWGPPNDPAGPGPGPGIKADSLDIGPGPGELGGTNVPAEGPGPGRQWVSAGRRVGPGPGPENAKEKPGPGPGRQWVSAGRRVGPGPGPGIKADSLDIGPGPGPENAKEKPGPGPGPGIKADSLDIGPGPGRQWVSAGRRVGPGPGYKAADMWGPPNDPAGPGPGRQWVSAGRRVGPGPGELGGTNVPAEGPGPGYKAADMWGPPNDPAGPGPGRQWVSAGRRVGPGPGYKAADMWGPPNDPAGPGPGPENAKEKPGPGPGYKAADMWGPPNDPAGPGPGPGIKADSLDIGPGPGYKAADMWGPPNDPAGPGPGYKAADMWGPPNDPAGPGPGYKAADMWGPPNDPAGPGPGELGGTNVPAEGPGPGPENAKEKPGPGPGELGGTNVPAEGPGPGRQWVSAGRRV
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:09)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:09)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:09)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:09)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:09)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:58)
[INFO] Main: Simulation completed successfully. (00:02:01)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | H | A | -0.5778 | |
| 2 | M | A | 0.2200 | |
| 3 | G | A | -0.3936 | |
| 4 | P | A | -0.6117 | |
| 5 | G | A | -0.8140 | |
| 6 | P | A | -0.7748 | |
| 7 | G | A | -0.4757 | |
| 8 | Y | A | 0.2114 | |
| 9 | K | A | -1.3854 | |
| 10 | A | A | -0.7377 | |
| 11 | A | A | -0.7255 | |
| 12 | D | A | -1.1229 | |
| 13 | M | A | 0.6330 | |
| 14 | W | A | 0.8306 | |
| 15 | G | A | -0.1618 | |
| 16 | P | A | -0.6765 | |
| 17 | P | A | -1.4877 | |
| 18 | N | A | -2.5716 | |
| 19 | D | A | -2.7637 | |
| 20 | P | A | -1.5493 | |
| 21 | A | A | -0.7525 | |
| 22 | G | A | -0.9298 | |
| 23 | P | A | -0.8230 | |
| 24 | G | A | -0.9843 | |
| 25 | P | A | -0.9210 | |
| 26 | G | A | -0.7099 | |
| 27 | P | A | -0.6097 | |
| 28 | G | A | -0.2423 | |
| 29 | I | A | 0.7738 | |
| 30 | K | A | -1.1994 | |
| 31 | A | A | -1.1121 | |
| 32 | D | A | -2.1100 | |
| 33 | S | A | -0.7066 | |
| 34 | L | A | 0.6813 | |
| 35 | D | A | -0.4684 | |
| 36 | I | A | 1.1867 | |
| 37 | G | A | -0.0254 | |
| 38 | P | A | -0.6004 | |
| 39 | G | A | -0.9851 | |
| 40 | P | A | -1.2272 | |
| 41 | G | A | -1.3143 | |
| 42 | E | A | -1.5216 | |
| 43 | L | A | 0.0357 | |
| 44 | G | A | -0.5407 | |
| 45 | G | A | -0.5870 | |
| 46 | T | A | -0.3879 | |
| 47 | N | A | -0.6444 | |
| 48 | V | A | 0.6873 | |
| 49 | P | A | -0.1587 | |
| 50 | A | A | -0.7847 | |
| 51 | E | A | -1.9459 | |
| 52 | G | A | -1.6256 | |
| 53 | P | A | -1.1629 | |
| 54 | G | A | -1.1391 | |
| 55 | P | A | -1.3665 | |
| 56 | G | A | -1.7692 | |
| 57 | R | A | -2.2074 | |
| 58 | Q | A | -1.2167 | |
| 59 | W | A | 0.8931 | |
| 60 | V | A | 1.6837 | |
| 61 | S | A | 0.5252 | |
| 62 | A | A | -0.3445 | |
| 63 | G | A | -1.4652 | |
| 64 | R | A | -2.6091 | |
| 65 | R | A | -2.1263 | |
| 66 | V | A | 0.0520 | |
| 67 | G | A | -0.6004 | |
| 68 | P | A | -0.6592 | |
| 69 | G | A | -0.7639 | |
| 70 | P | A | -1.1015 | |
| 71 | G | A | -1.5537 | |
| 72 | P | A | -1.8274 | |
| 73 | E | A | -2.7291 | |
| 74 | N | A | -2.6082 | |
| 75 | A | A | -2.2478 | |
| 76 | K | A | -3.2128 | |
| 77 | E | A | -3.5972 | |
| 78 | K | A | -3.2429 | |
| 79 | P | A | -2.0132 | |
| 80 | G | A | -1.4969 | |
| 81 | P | A | -1.0736 | |
| 82 | G | A | -1.1896 | |
| 83 | P | A | -1.2673 | |
| 84 | G | A | -1.9620 | |
| 85 | R | A | -2.4963 | |
| 86 | Q | A | -1.2257 | |
| 87 | W | A | 1.0070 | |
| 88 | V | A | 1.9296 | |
| 89 | S | A | 0.4338 | |
| 90 | A | A | -0.0816 | |
| 91 | G | A | -1.6119 | |
| 92 | R | A | -2.6426 | |
| 93 | R | A | -2.0870 | |
| 94 | V | A | 0.1328 | |
| 95 | G | A | -0.2512 | |
| 96 | P | A | -0.4125 | |
| 97 | G | A | -0.9868 | |
| 98 | P | A | -0.9663 | |
| 99 | G | A | -0.9531 | |
| 100 | P | A | -0.4357 | |
| 101 | G | A | -0.0588 | |
| 102 | I | A | 0.9123 | |
| 103 | K | A | -1.2595 | |
| 104 | A | A | -1.2903 | |
| 105 | D | A | -1.9580 | |
| 106 | S | A | -0.8503 | |
| 107 | L | A | 0.6543 | |
| 108 | D | A | -0.2281 | |
| 109 | I | A | 1.2090 | |
| 110 | G | A | -0.2504 | |
| 111 | P | A | -0.5769 | |
| 112 | G | A | -0.9927 | |
| 113 | P | A | -1.1327 | |
| 114 | G | A | -1.4056 | |
| 115 | P | A | -1.8538 | |
| 116 | E | A | -2.9107 | |
| 117 | N | A | -2.9884 | |
| 118 | A | A | -2.2932 | |
| 119 | K | A | -3.6083 | |
| 120 | E | A | -3.9275 | |
| 121 | K | A | -3.2958 | |
| 122 | P | A | -2.0152 | |
| 123 | G | A | -1.3827 | |
| 124 | P | A | -0.9011 | |
| 125 | G | A | -0.9887 | |
| 126 | P | A | -0.8987 | |
| 127 | G | A | -0.9554 | |
| 128 | P | A | -0.5382 | |
| 129 | G | A | -0.1223 | |
| 130 | I | A | 0.7336 | |
| 131 | K | A | -1.3636 | |
| 132 | A | A | -1.2614 | |
| 133 | D | A | -2.0708 | |
| 134 | S | A | -0.8614 | |
| 135 | L | A | 0.6780 | |
| 136 | D | A | -0.5451 | |
| 137 | I | A | 1.2000 | |
| 138 | G | A | -0.0499 | |
| 139 | P | A | -0.7067 | |
| 140 | G | A | -1.0560 | |
| 141 | P | A | -1.4905 | |
| 142 | G | A | -1.7853 | |
| 143 | R | A | -2.2587 | |
| 144 | Q | A | -1.2635 | |
| 145 | W | A | 0.8354 | |
| 146 | V | A | 1.3887 | |
| 147 | S | A | 0.1868 | |
| 148 | A | A | -0.6573 | |
| 149 | G | A | -1.5013 | |
| 150 | R | A | -2.5579 | |
| 151 | R | A | -2.2665 | |
| 152 | V | A | -0.4708 | |
| 153 | G | A | -0.6632 | |
| 154 | P | A | -0.7524 | |
| 155 | G | A | -0.6845 | |
| 156 | P | A | -0.5630 | |
| 157 | G | A | -0.4393 | |
| 158 | Y | A | 0.1277 | |
| 159 | K | A | -1.0822 | |
| 160 | A | A | -0.7231 | |
| 161 | A | A | -0.6583 | |
| 162 | D | A | -0.9125 | |
| 163 | M | A | 0.4936 | |
| 164 | W | A | 0.9276 | |
| 165 | G | A | -0.0204 | |
| 166 | P | A | -0.7264 | |
| 167 | P | A | -1.5028 | |
| 168 | N | A | -2.4801 | |
| 169 | D | A | -2.6806 | |
| 170 | P | A | -1.5415 | |
| 171 | A | A | -0.8003 | |
| 172 | G | A | -0.7568 | |
| 173 | P | A | -0.7528 | |
| 174 | G | A | -1.1572 | |
| 175 | P | A | -1.2497 | |
| 176 | G | A | -1.8278 | |
| 177 | R | A | -2.3916 | |
| 178 | Q | A | -1.2798 | |
| 179 | W | A | 0.9698 | |
| 180 | V | A | 1.7400 | |
| 181 | S | A | 0.6405 | |
| 182 | A | A | -0.2444 | |
| 183 | G | A | -1.6075 | |
| 184 | R | A | -2.6008 | |
| 185 | R | A | -2.0345 | |
| 186 | V | A | 0.0763 | |
| 187 | G | A | -0.4163 | |
| 188 | P | A | -0.4146 | |
| 189 | G | A | -1.1207 | |
| 190 | P | A | -1.1932 | |
| 191 | G | A | -1.3557 | |
| 192 | E | A | -1.5159 | |
| 193 | L | A | 0.2031 | |
| 194 | G | A | -0.2651 | |
| 195 | G | A | -0.6501 | |
| 196 | T | A | -0.6196 | |
| 197 | N | A | -0.5730 | |
| 198 | V | A | 1.0089 | |
| 199 | P | A | -0.0695 | |
| 200 | A | A | -0.7615 | |
| 201 | E | A | -2.1279 | |
| 202 | G | A | -1.6141 | |
| 203 | P | A | -1.1805 | |
| 204 | G | A | -0.9375 | |
| 205 | P | A | -0.5907 | |
| 206 | G | A | -0.4149 | |
| 207 | Y | A | 0.2080 | |
| 208 | K | A | -1.1106 | |
| 209 | A | A | -0.9107 | |
| 210 | A | A | -0.9631 | |
| 211 | D | A | -0.9765 | |
| 212 | M | A | 0.6055 | |
| 213 | W | A | 0.9865 | |
| 214 | G | A | -0.2115 | |
| 215 | P | A | -0.8723 | |
| 216 | P | A | -1.3646 | |
| 217 | N | A | -2.5570 | |
| 218 | D | A | -2.7672 | |
| 219 | P | A | -1.6431 | |
| 220 | A | A | -1.0206 | |
| 221 | G | A | -0.9952 | |
| 222 | P | A | -0.8046 | |
| 223 | G | A | -1.1454 | |
| 224 | P | A | -1.3717 | |
| 225 | G | A | -1.7841 | |
| 226 | R | A | -2.5030 | |
| 227 | Q | A | -1.2354 | |
| 228 | W | A | 0.9419 | |
| 229 | V | A | 1.8999 | |
| 230 | S | A | 0.5573 | |
| 231 | A | A | -0.5956 | |
| 232 | G | A | -1.5330 | |
| 233 | R | A | -2.5731 | |
| 234 | R | A | -2.1693 | |
| 235 | V | A | -0.0963 | |
| 236 | G | A | -0.7280 | |
| 237 | P | A | -0.6507 | |
| 238 | G | A | -0.7598 | |
| 239 | P | A | -0.5237 | |
| 240 | G | A | -0.4050 | |
| 241 | Y | A | 0.3264 | |
| 242 | K | A | -1.1691 | |
| 243 | A | A | -0.6434 | |
| 244 | A | A | -0.7935 | |
| 245 | D | A | -1.1233 | |
| 246 | M | A | 0.5639 | |
| 247 | W | A | 0.7494 | |
| 248 | G | A | -0.1879 | |
| 249 | P | A | -0.7073 | |
| 250 | P | A | -1.4642 | |
| 251 | N | A | -2.4760 | |
| 252 | D | A | -2.7046 | |
| 253 | P | A | -1.7199 | |
| 254 | A | A | -0.9850 | |
| 255 | G | A | -1.0053 | |
| 256 | P | A | -0.8251 | |
| 257 | G | A | -0.9700 | |
| 258 | P | A | -0.8936 | |
| 259 | G | A | -1.2091 | |
| 260 | P | A | -1.7303 | |
| 261 | E | A | -2.8422 | |
| 262 | N | A | -2.8554 | |
| 263 | A | A | -2.4201 | |
| 264 | K | A | -3.5630 | |
| 265 | E | A | -3.7334 | |
| 266 | K | A | -3.2820 | |
| 267 | P | A | -2.1450 | |
| 268 | G | A | -1.4414 | |
| 269 | P | A | -0.9941 | |
| 270 | G | A | -0.9252 | |
| 271 | P | A | -0.5398 | |
| 272 | G | A | -0.3994 | |
| 273 | Y | A | 0.1172 | |
| 274 | K | A | -1.2173 | |
| 275 | A | A | -0.7576 | |
| 276 | A | A | -0.6964 | |
| 277 | D | A | -1.1699 | |
| 278 | M | A | 0.6607 | |
| 279 | W | A | 0.9595 | |
| 280 | G | A | -0.2807 | |
| 281 | P | A | -0.7456 | |
| 282 | P | A | -1.5743 | |
| 283 | N | A | -2.4356 | |
| 284 | D | A | -2.6886 | |
| 285 | P | A | -1.5682 | |
| 286 | A | A | -1.1103 | |
| 287 | G | A | -1.0737 | |
| 288 | P | A | -0.8233 | |
| 289 | G | A | -0.9615 | |
| 290 | P | A | -0.9697 | |
| 291 | G | A | -0.7375 | |
| 292 | P | A | -0.4063 | |
| 293 | G | A | -0.1080 | |
| 294 | I | A | 0.5837 | |
| 295 | K | A | -1.1911 | |
| 296 | A | A | -1.0428 | |
| 297 | D | A | -1.9405 | |
| 298 | S | A | -0.9271 | |
| 299 | L | A | 0.6003 | |
| 300 | D | A | -0.3667 | |
| 301 | I | A | 1.1521 | |
| 302 | G | A | -0.0934 | |
| 303 | P | A | -0.5515 | |
| 304 | G | A | -0.6286 | |
| 305 | P | A | -0.5879 | |
| 306 | G | A | -0.4028 | |
| 307 | Y | A | 0.1469 | |
| 308 | K | A | -1.2805 | |
| 309 | A | A | -0.9609 | |
| 310 | A | A | -0.8074 | |
| 311 | D | A | -1.1775 | |
| 312 | M | A | 0.6532 | |
| 313 | W | A | 0.9282 | |
| 314 | G | A | -0.1957 | |
| 315 | P | A | -0.6689 | |
| 316 | P | A | -1.4431 | |
| 317 | N | A | -2.4806 | |
| 318 | D | A | -2.6366 | |
| 319 | P | A | -1.5538 | |
| 320 | A | A | -0.7876 | |
| 321 | G | A | -0.7749 | |
| 322 | P | A | -0.7905 | |
| 323 | G | A | -0.7943 | |
| 324 | P | A | -0.5446 | |
| 325 | G | A | -0.4194 | |
| 326 | Y | A | 0.1734 | |
| 327 | K | A | -1.3141 | |
| 328 | A | A | -0.7419 | |
| 329 | A | A | -0.7166 | |
| 330 | D | A | -1.1262 | |
| 331 | M | A | 0.6150 | |
| 332 | W | A | 0.8687 | |
| 333 | G | A | -0.1471 | |
| 334 | P | A | -0.4059 | |
| 335 | P | A | -1.3225 | |
| 336 | N | A | -2.4732 | |
| 337 | D | A | -2.6758 | |
| 338 | P | A | -1.6468 | |
| 339 | A | A | -0.8102 | |
| 340 | G | A | -0.9809 | |
| 341 | P | A | -0.7987 | |
| 342 | G | A | -0.9348 | |
| 343 | P | A | -0.7897 | |
| 344 | G | A | -0.5282 | |
| 345 | Y | A | 0.2091 | |
| 346 | K | A | -1.4034 | |
| 347 | A | A | -0.8420 | |
| 348 | A | A | -0.7252 | |
| 349 | D | A | -1.1622 | |
| 350 | M | A | 0.6707 | |
| 351 | W | A | 0.9297 | |
| 352 | G | A | -0.0541 | |
| 353 | P | A | -0.8611 | |
| 354 | P | A | -1.5510 | |
| 355 | N | A | -2.3928 | |
| 356 | D | A | -2.6793 | |
| 357 | P | A | -1.6134 | |
| 358 | A | A | -0.8139 | |
| 359 | G | A | -0.9860 | |
| 360 | P | A | -0.8533 | |
| 361 | G | A | -1.1506 | |
| 362 | P | A | -1.0241 | |
| 363 | G | A | -1.3589 | |
| 364 | E | A | -1.5072 | |
| 365 | L | A | 0.1074 | |
| 366 | G | A | -0.4562 | |
| 367 | G | A | -0.6967 | |
| 368 | T | A | -0.6949 | |
| 369 | N | A | -0.5891 | |
| 370 | V | A | 0.7425 | |
| 371 | P | A | 0.0167 | |
| 372 | A | A | -0.9030 | |
| 373 | E | A | -1.9367 | |
| 374 | G | A | -1.6227 | |
| 375 | P | A | -1.2096 | |
| 376 | G | A | -0.9860 | |
| 377 | P | A | -1.1221 | |
| 378 | G | A | -1.4517 | |
| 379 | P | A | -1.7969 | |
| 380 | E | A | -2.9105 | |
| 381 | N | A | -2.9799 | |
| 382 | A | A | -2.4916 | |
| 383 | K | A | -3.6581 | |
| 384 | E | A | -3.8130 | |
| 385 | K | A | -3.3164 | |
| 386 | P | A | -1.9711 | |
| 387 | G | A | -1.4559 | |
| 388 | P | A | -1.0725 | |
| 389 | G | A | -0.9738 | |
| 390 | P | A | -1.2007 | |
| 391 | G | A | -1.4005 | |
| 392 | E | A | -1.5137 | |
| 393 | L | A | 0.1342 | |
| 394 | G | A | -0.6802 | |
| 395 | G | A | -0.6807 | |
| 396 | T | A | -0.4894 | |
| 397 | N | A | -0.6496 | |
| 398 | V | A | 0.7617 | |
| 399 | P | A | 0.0329 | |
| 400 | A | A | -0.7340 | |
| 401 | E | A | -1.9371 | |
| 402 | G | A | -1.6090 | |
| 403 | P | A | -1.1243 | |
| 404 | G | A | -1.1537 | |
| 405 | P | A | -1.3822 | |
| 406 | G | A | -1.8155 | |
| 407 | R | A | -2.2482 | |
| 408 | Q | A | -1.2936 | |
| 409 | W | A | 0.8836 | |
| 410 | V | A | 1.7126 | |
| 411 | S | A | 0.5517 | |
| 412 | A | A | -0.1614 | |
| 413 | G | A | -1.5440 | |
| 414 | R | A | -2.5144 | |
| 415 | R | A | -1.9729 | |
| 416 | V | A | 0.3976 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine