Project name: 77de5e1b0891097

Chain sequence(s)	A: RYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANVEALIQETDFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDNIVAEIKAQYDDIASRSRAEAESWYRSKCEEIKATVIRHGETLRRTKEEINELNRVIQRLTAEVENAKCQNSKLEAAVTQAEQQGEAALADAKRKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCSGNLAVSTGLCAPCGPCNSVTSCGLGAGGVGSCGISSYGVGSCASVCRKC
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:05:17)
[INFO]       Main:     Simulation completed successfully.                                          (00:05:19)

• Minimal score value: -4.803
• Maximal score value: 3.349
• Average score: -0.9446
• Total score value: -297.5435

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	R	A	-2.4321
2	Y	A	-0.8204
3	E	A	-2.3090
4	E	A	-2.5105
5	E	A	-1.9239
6	V	A	-0.3977
7	A	A	-0.7511
8	L	A	-0.2564
9	R	A	-2.1948
10	A	A	-1.4107
11	T	A	-1.2322
12	A	A	-1.4711
13	E	A	-2.3899
14	N	A	-2.3359
15	E	A	-2.2279
16	F	A	-0.4618
17	V	A	-0.7455
18	A	A	-1.2720
19	L	A	-0.6264
20	K	A	-2.2932
21	K	A	-2.8780
22	D	A	-2.1684
23	V	A	-1.3097
24	D	A	-2.3210
25	C	A	-1.3092
26	A	A	-1.2853
27	Y	A	-0.0648
28	L	A	-0.2091
29	R	A	-2.1364
30	K	A	-2.4978
31	S	A	-1.7819
32	D	A	-2.6876
33	L	A	-1.4397
34	E	A	-2.6539
35	A	A	-2.1624
36	N	A	-1.5781
37	V	A	-0.4761
38	E	A	-1.7045
39	A	A	-0.8095
40	L	A	0.5596
41	I	A	0.6112
42	Q	A	-1.2703
43	E	A	-1.3371
44	T	A	-0.9609
45	D	A	-1.4578
46	F	A	0.0123
47	L	A	-0.8709
48	R	A	-2.8296
49	R	A	-2.5738
50	L	A	-1.0683
51	Y	A	-0.6337
52	E	A	-2.4853
53	E	A	-2.8393
54	E	A	-1.7004
55	I	A	0.2645
56	R	A	-1.2248
57	V	A	0.7857
58	L	A	1.3510
59	Q	A	-0.3547
60	A	A	-0.2215
61	H	A	-0.4100
62	I	A	0.8068
63	S	A	-0.4036
64	D	A	-1.5696
65	T	A	0.1463
66	S	A	1.0582
67	V	A	2.6175
68	I	A	3.3490
69	V	A	2.5193
70	K	A	-0.1942
71	M	A	-0.2465
72	D	A	-2.4787
73	N	A	-2.6989
74	S	A	-2.2765
75	R	A	-3.1265
76	D	A	-2.3961
77	L	A	-0.7914
78	N	A	-1.5438
79	M	A	-0.5189
80	D	A	-1.8336
81	N	A	-1.9000
82	I	A	-0.3740
83	V	A	-0.1822
84	A	A	-1.1233
85	E	A	-2.0445
86	I	A	-0.7895
87	K	A	-1.8205
88	A	A	-1.7232
89	Q	A	-1.5582
90	Y	A	-0.7321
91	D	A	-2.5485
92	D	A	-2.5815
93	I	A	-0.5400
94	A	A	-1.4700
95	S	A	-2.4505
96	R	A	-3.1829
97	S	A	-2.7230
98	R	A	-3.3222
99	A	A	-2.5182
100	E	A	-3.1410
101	A	A	-2.0862
102	E	A	-2.5822
103	S	A	-1.5337
104	W	A	-0.1559
105	Y	A	-0.3982
106	R	A	-2.1742
107	S	A	-1.7510
108	K	A	-1.6419
109	C	A	-1.3248
110	E	A	-2.9796
111	E	A	-2.6294
112	I	A	-0.7331
113	K	A	-1.5013
114	A	A	-0.9869
115	T	A	-0.4189
116	V	A	0.8023
117	I	A	0.9442
118	R	A	-1.4881
119	H	A	-1.4276
120	G	A	-0.9089
121	E	A	-2.3531
122	T	A	-2.1147
123	L	A	-1.9012
124	R	A	-4.0790
125	R	A	-4.3653
126	T	A	-3.2539
127	K	A	-4.0271
128	E	A	-4.8030
129	E	A	-4.1352
130	I	A	-2.1738
131	N	A	-3.2137
132	E	A	-3.1519
133	L	A	-0.9130
134	N	A	-1.9193
135	R	A	-2.3127
136	V	A	-0.1449
137	I	A	0.2406
138	Q	A	-1.5568
139	R	A	-1.8508
140	L	A	-0.1807
141	T	A	-0.6386
142	A	A	-1.6850
143	E	A	-2.2133
144	V	A	-0.9031
145	E	A	-2.8825
146	N	A	-2.8708
147	A	A	-2.5138
148	K	A	-3.1330
149	C	A	-2.4703
150	Q	A	-2.6288
151	N	A	-3.0549
152	S	A	-2.2317
153	K	A	-2.1611
154	L	A	-0.6523
155	E	A	-1.6218
156	A	A	-1.1801
157	A	A	-0.5266
158	V	A	0.1438
159	T	A	-1.3477
160	Q	A	-2.2395
161	A	A	-2.1115
162	E	A	-3.2768
163	Q	A	-3.4250
164	Q	A	-3.0272
165	G	A	-2.8125
166	E	A	-3.1499
167	A	A	-2.1165
168	A	A	-1.6929
169	L	A	-1.1907
170	A	A	-1.9247
171	D	A	-2.7683
172	A	A	-2.0505
173	K	A	-2.5832
174	R	A	-3.3674
175	K	A	-2.7667
176	L	A	-0.9602
177	A	A	-1.6101
178	G	A	-1.4651
179	L	A	-0.3081
180	E	A	-2.0549
181	E	A	-2.7833
182	A	A	-1.3511
183	L	A	-1.1765
184	Q	A	-3.2423
185	K	A	-3.6570
186	A	A	-2.6112
187	K	A	-3.1430
188	Q	A	-2.9148
189	D	A	-2.5712
190	M	A	-1.0421
191	A	A	-0.7719
192	C	A	-0.5806
193	L	A	-0.0216
194	L	A	0.6008
195	K	A	-1.5972
196	E	A	-1.5813
197	Y	A	0.1994
198	Q	A	-1.6568
199	E	A	-2.2845
200	V	A	-0.0906
201	M	A	-0.3857
202	N	A	-1.6256
203	S	A	-0.7080
204	K	A	-1.1497
205	L	A	0.0511
206	G	A	0.1789
207	L	A	0.5965
208	D	A	-0.3840
209	I	A	1.1855
210	E	A	-0.1514
211	I	A	0.6055
212	A	A	0.0369
213	T	A	-0.0345
214	Y	A	0.3067
215	R	A	-1.6394
216	R	A	-2.3202
217	L	A	-0.2227
218	L	A	-1.0754
219	E	A	-3.2522
220	G	A	-2.5857
221	E	A	-3.4820
222	E	A	-3.5720
223	Q	A	-3.3321
224	R	A	-3.2510
225	L	A	-0.9925
226	C	A	-0.7802
227	E	A	-2.2047
228	G	A	-0.7542
229	V	A	1.4491
230	G	A	0.2159
231	S	A	0.5078
232	V	A	1.9196
233	N	A	0.7687
234	V	A	2.4994
235	C	A	2.2231
236	V	A	2.2929
237	S	A	0.7216
238	S	A	-0.3587
239	S	A	-1.1511
240	R	A	-2.3569
241	G	A	-1.3134
242	G	A	0.1820
243	V	A	2.5106
244	V	A	2.8228
245	C	A	1.3601
246	G	A	-0.2332
247	D	A	-0.6958
248	L	A	1.2765
249	C	A	1.8532
250	V	A	2.1173
251	S	A	0.7153
252	G	A	-0.6158
253	S	A	-1.2670
254	R	A	-1.8270
255	P	A	-0.5540
256	V	A	1.0788
257	T	A	0.2716
258	G	A	0.2174
259	S	A	0.7582
260	V	A	1.8847
261	C	A	1.4886
262	S	A	0.4765
263	A	A	0.1410
264	P	A	-0.0275
265	C	A	0.2372
266	S	A	-0.2893
267	G	A	-0.5950
268	N	A	-0.4940
269	L	A	1.2615
270	A	A	1.1902
271	V	A	1.8844
272	S	A	0.8854
273	T	A	0.5742
274	G	A	0.6196
275	L	A	1.6160
276	C	A	1.4090
277	A	A	0.7719
278	P	A	0.3299
279	C	A	0.5286
280	G	A	-0.2686
281	P	A	-0.3388
282	C	A	0.1288
283	N	A	-0.6580
284	S	A	0.1564
285	V	A	1.3926
286	T	A	0.6037
287	S	A	0.6179
288	C	A	0.8236
289	G	A	0.5201
290	L	A	1.2442
291	G	A	0.1261
292	A	A	-0.1552
293	G	A	-0.4321
294	G	A	-0.0216
295	V	A	1.1657
296	G	A	0.2358
297	S	A	0.3755
298	C	A	0.6651
299	G	A	0.7532
300	I	A	1.9112
301	S	A	0.9111
302	S	A	0.8636
303	Y	A	1.4727
304	G	A	0.8247
305	V	A	1.6056
306	G	A	0.5283
307	S	A	0.3176
308	C	A	0.8866
309	A	A	0.7540
310	S	A	0.8162
311	V	A	1.4610
312	C	A	0.3111
313	R	A	-1.7106
314	K	A	-1.8658
315	C	A	-0.4735