| Chain sequence(s) |
A: APPHALSGGSDQATRVYQDLGGPSQAPEAAAKGPGTGPGNGLGEKGDTSGPEGSGGSGPQRRGGDNHGRGRGRGRGRGGGRPGAPGGSGSGPRHRDGVRRPQKRPSCIGCKGTHGGTGAGAGAGGAGAGGAGAGGGAGAGGGAGGAGGAGGAGAGGGAGAGGGAGGAGGAGAGGGAGAEAAAKRVLSVVVLLGPGPGTMFEVSVAFGPGPGACMLSAPLEKGPGPGLPQGQLTAYGPGPGFLDKGTYTLGPGPGVFSDEIPASQDMPTNTEAAAKPPMVEGAAAEGDDGDGPGPGSDREVRGSALYEAST
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:13)
[INFO] Main: Simulation completed successfully. (00:01:15)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | A | A | -0.2321 | |
| 2 | P | A | -0.5518 | |
| 3 | P | A | -0.6560 | |
| 4 | H | A | -0.9019 | |
| 5 | A | A | 0.0857 | |
| 6 | L | A | 1.1368 | |
| 7 | S | A | -0.0258 | |
| 8 | G | A | -0.6010 | |
| 9 | G | A | -1.3627 | |
| 10 | S | A | -1.7706 | |
| 11 | D | A | -2.5593 | |
| 12 | Q | A | -2.4625 | |
| 13 | A | A | -1.1841 | |
| 14 | T | A | -1.0014 | |
| 15 | R | A | -0.9649 | |
| 16 | V | A | 1.0364 | |
| 17 | Y | A | 0.9005 | |
| 18 | Q | A | -0.7970 | |
| 19 | D | A | -1.2940 | |
| 20 | L | A | -0.2437 | |
| 21 | G | A | -1.1035 | |
| 22 | G | A | -1.2591 | |
| 23 | P | A | -0.7742 | |
| 24 | S | A | -0.9990 | |
| 25 | Q | A | -1.3077 | |
| 26 | A | A | -1.3637 | |
| 27 | P | A | -1.6926 | |
| 28 | E | A | -2.5914 | |
| 29 | A | A | -1.9224 | |
| 30 | A | A | -1.3336 | |
| 31 | A | A | -0.9824 | |
| 32 | K | A | -2.1585 | |
| 33 | G | A | -1.8096 | |
| 34 | P | A | -1.5639 | |
| 35 | G | A | -1.2400 | |
| 36 | T | A | -0.9105 | |
| 37 | G | A | -1.2504 | |
| 38 | P | A | -1.6788 | |
| 39 | G | A | -2.1218 | |
| 40 | N | A | -1.8150 | |
| 41 | G | A | -0.6771 | |
| 42 | L | A | 0.4751 | |
| 43 | G | A | -0.9025 | |
| 44 | E | A | -2.1460 | |
| 45 | K | A | -2.8475 | |
| 46 | G | A | -2.4486 | |
| 47 | D | A | -3.1015 | |
| 48 | T | A | -1.7208 | |
| 49 | S | A | -1.6657 | |
| 50 | G | A | -1.6251 | |
| 51 | P | A | -1.6513 | |
| 52 | E | A | -2.5378 | |
| 53 | G | A | -1.7991 | |
| 54 | S | A | -1.1050 | |
| 55 | G | A | -1.3209 | |
| 56 | G | A | -1.3059 | |
| 57 | S | A | -0.9668 | |
| 58 | G | A | -1.7200 | |
| 59 | P | A | -2.0744 | |
| 60 | Q | A | -3.0407 | |
| 61 | R | A | -3.7992 | |
| 62 | R | A | -3.7060 | |
| 63 | G | A | -2.4862 | |
| 64 | G | A | -2.5566 | |
| 65 | D | A | -2.7374 | |
| 66 | N | A | -2.7556 | |
| 67 | H | A | -2.6258 | |
| 68 | G | A | -2.3993 | |
| 69 | R | A | -3.1765 | |
| 70 | G | A | -2.6213 | |
| 71 | R | A | -2.9518 | |
| 72 | G | A | -2.6083 | |
| 73 | R | A | -2.7411 | |
| 74 | G | A | -2.4100 | |
| 75 | R | A | -2.8620 | |
| 76 | G | A | -2.8599 | |
| 77 | R | A | -3.4985 | |
| 78 | G | A | -2.7491 | |
| 79 | G | A | -2.0086 | |
| 80 | G | A | -2.0678 | |
| 81 | R | A | -2.4536 | |
| 82 | P | A | -1.6995 | |
| 83 | G | A | -1.5079 | |
| 84 | A | A | -1.0268 | |
| 85 | P | A | -1.1977 | |
| 86 | G | A | -1.9666 | |
| 87 | G | A | -2.6898 | |
| 88 | S | A | -2.7813 | |
| 89 | G | A | -2.4998 | |
| 90 | S | A | -1.5179 | |
| 91 | G | A | -1.6841 | |
| 92 | P | A | -2.0792 | |
| 93 | R | A | -3.2204 | |
| 94 | H | A | -2.4831 | |
| 95 | R | A | -2.3533 | |
| 96 | D | A | -2.6074 | |
| 97 | G | A | -1.3726 | |
| 98 | V | A | -0.5580 | |
| 99 | R | A | -1.9921 | |
| 100 | R | A | -2.7136 | |
| 101 | P | A | -1.6701 | |
| 102 | Q | A | -1.8441 | |
| 103 | K | A | -2.2102 | |
| 104 | R | A | -2.4594 | |
| 105 | P | A | -1.3131 | |
| 106 | S | A | -0.5322 | |
| 107 | C | A | -0.3466 | |
| 108 | I | A | 1.2572 | |
| 109 | G | A | 0.0742 | |
| 110 | C | A | -1.2564 | |
| 111 | K | A | -2.0210 | |
| 112 | G | A | -1.7720 | |
| 113 | T | A | -1.3385 | |
| 114 | H | A | -1.5875 | |
| 115 | G | A | -1.1603 | |
| 116 | G | A | -0.9537 | |
| 117 | T | A | -0.7911 | |
| 118 | G | A | -0.9158 | |
| 119 | A | A | -0.7361 | |
| 120 | G | A | -0.7756 | |
| 121 | A | A | -0.4721 | |
| 122 | G | A | -0.7543 | |
| 123 | A | A | -0.7283 | |
| 124 | G | A | 0.0000 | |
| 125 | G | A | -0.8167 | |
| 126 | A | A | -0.6321 | |
| 127 | G | A | -1.0280 | |
| 128 | A | A | -0.6335 | |
| 129 | G | A | -0.8378 | |
| 130 | G | A | -0.8214 | |
| 131 | A | A | -0.5121 | |
| 132 | G | A | -0.6622 | |
| 133 | A | A | -0.4782 | |
| 134 | G | A | -0.8541 | |
| 135 | G | A | -0.9696 | |
| 136 | G | A | -1.1836 | |
| 137 | A | A | -0.8820 | |
| 138 | G | A | -1.0416 | |
| 139 | A | A | -0.7479 | |
| 140 | G | A | -1.0738 | |
| 141 | G | A | -1.4195 | |
| 142 | G | A | -1.1803 | |
| 143 | A | A | -0.6792 | |
| 144 | G | A | -1.0371 | |
| 145 | G | A | -0.9560 | |
| 146 | A | A | -0.7122 | |
| 147 | G | A | -1.1033 | |
| 148 | G | A | -1.3863 | |
| 149 | A | A | -1.0382 | |
| 150 | G | A | -1.1466 | |
| 151 | G | A | -1.1579 | |
| 152 | A | A | -0.7555 | |
| 153 | G | A | -0.8716 | |
| 154 | A | A | -0.5829 | |
| 155 | G | A | -0.8741 | |
| 156 | G | A | -0.9553 | |
| 157 | G | A | -0.8469 | |
| 158 | A | A | -0.6484 | |
| 159 | G | A | -0.9498 | |
| 160 | A | A | -0.7560 | |
| 161 | G | A | -1.1302 | |
| 162 | G | A | -1.1184 | |
| 163 | G | A | -0.9854 | |
| 164 | A | A | -1.4788 | |
| 165 | G | A | -1.4538 | |
| 166 | G | A | -1.1779 | |
| 167 | A | A | -0.5941 | |
| 168 | G | A | -0.2050 | |
| 169 | G | A | -0.6807 | |
| 170 | A | A | -1.0179 | |
| 171 | G | A | -1.4263 | |
| 172 | A | A | -1.6371 | |
| 173 | G | A | -1.2151 | |
| 174 | G | A | -1.3500 | |
| 175 | G | A | -1.1330 | |
| 176 | A | A | -0.9516 | |
| 177 | G | A | -1.1773 | |
| 178 | A | A | -1.3260 | |
| 179 | E | A | -2.0013 | |
| 180 | A | A | -1.0856 | |
| 181 | A | A | -1.4146 | |
| 182 | A | A | -1.2424 | |
| 183 | K | A | -1.9022 | |
| 184 | R | A | -1.6095 | |
| 185 | V | A | 1.1485 | |
| 186 | L | A | 1.9770 | |
| 187 | S | A | 1.9273 | |
| 188 | V | A | 3.3196 | |
| 189 | V | A | 3.6694 | |
| 190 | V | A | 3.5990 | |
| 191 | L | A | 2.7967 | |
| 192 | L | A | 1.5713 | |
| 193 | G | A | -0.1120 | |
| 194 | P | A | -0.4503 | |
| 195 | G | A | -0.4006 | |
| 196 | P | A | -0.2997 | |
| 197 | G | A | -0.1626 | |
| 198 | T | A | 0.5472 | |
| 199 | M | A | 1.6032 | |
| 200 | F | A | 2.2573 | |
| 201 | E | A | 0.2571 | |
| 202 | V | A | 1.7479 | |
| 203 | S | A | 1.2689 | |
| 204 | V | A | 2.0871 | |
| 205 | A | A | 2.1617 | |
| 206 | F | A | 2.5249 | |
| 207 | G | A | 1.0212 | |
| 208 | P | A | -0.0467 | |
| 209 | G | A | -0.4214 | |
| 210 | P | A | -0.4146 | |
| 211 | G | A | 0.1124 | |
| 212 | A | A | 0.6723 | |
| 213 | C | A | 1.9423 | |
| 214 | M | A | 2.4815 | |
| 215 | L | A | 2.2546 | |
| 216 | S | A | 1.0425 | |
| 217 | A | A | 0.5899 | |
| 218 | P | A | -0.0218 | |
| 219 | L | A | 0.3132 | |
| 220 | E | A | -1.7256 | |
| 221 | K | A | -2.0236 | |
| 222 | G | A | -1.1668 | |
| 223 | P | A | -0.8126 | |
| 224 | G | A | -0.7306 | |
| 225 | P | A | -0.6956 | |
| 226 | G | A | -0.7117 | |
| 227 | L | A | -0.1105 | |
| 228 | P | A | -0.9225 | |
| 229 | Q | A | -1.2985 | |
| 230 | G | A | -1.1246 | |
| 231 | Q | A | -0.9423 | |
| 232 | L | A | 0.8038 | |
| 233 | T | A | 0.4455 | |
| 234 | A | A | 0.3564 | |
| 235 | Y | A | 0.6108 | |
| 236 | G | A | -0.2323 | |
| 237 | P | A | -0.5277 | |
| 238 | G | A | -0.4894 | |
| 239 | P | A | -0.0145 | |
| 240 | G | A | 0.4503 | |
| 241 | F | A | 1.2681 | |
| 242 | L | A | 0.0000 | |
| 243 | D | A | -1.8107 | |
| 244 | K | A | -2.3101 | |
| 245 | G | A | -1.4138 | |
| 246 | T | A | -0.0493 | |
| 247 | Y | A | 1.3812 | |
| 248 | T | A | 1.1197 | |
| 249 | L | A | 1.4893 | |
| 250 | G | A | -0.0028 | |
| 251 | P | A | -0.4881 | |
| 252 | G | A | -1.1263 | |
| 253 | P | A | -1.5645 | |
| 254 | G | A | -0.4813 | |
| 255 | V | A | -0.1690 | |
| 256 | F | A | 0.6829 | |
| 257 | S | A | -0.9748 | |
| 258 | D | A | -2.3988 | |
| 259 | E | A | -2.3480 | |
| 260 | I | A | -0.9445 | |
| 261 | P | A | -0.5554 | |
| 262 | A | A | -0.8456 | |
| 263 | S | A | -1.3455 | |
| 264 | Q | A | -2.0962 | |
| 265 | D | A | -2.6022 | |
| 266 | M | A | -1.3547 | |
| 267 | P | A | -1.0481 | |
| 268 | T | A | -1.5541 | |
| 269 | N | A | -1.7479 | |
| 270 | T | A | -1.7142 | |
| 271 | E | A | -1.2110 | |
| 272 | A | A | -0.4357 | |
| 273 | A | A | -0.6166 | |
| 274 | A | A | -0.8713 | |
| 275 | K | A | -2.2558 | |
| 276 | P | A | -1.6608 | |
| 277 | P | A | -0.7091 | |
| 278 | M | A | -0.1403 | |
| 279 | V | A | 0.8490 | |
| 280 | E | A | -1.1378 | |
| 281 | G | A | -1.8405 | |
| 282 | A | A | -2.4497 | |
| 283 | A | A | -1.4597 | |
| 284 | A | A | -0.9678 | |
| 285 | E | A | -2.0733 | |
| 286 | G | A | -2.8661 | |
| 287 | D | A | -3.7053 | |
| 288 | D | A | -3.6022 | |
| 289 | G | A | -2.9544 | |
| 290 | D | A | -2.9193 | |
| 291 | G | A | -2.3159 | |
| 292 | P | A | -1.2703 | |
| 293 | G | A | -1.2168 | |
| 294 | P | A | -1.7716 | |
| 295 | G | A | -2.1355 | |
| 296 | S | A | -2.1500 | |
| 297 | D | A | -3.1709 | |
| 298 | R | A | -3.7615 | |
| 299 | E | A | -3.2414 | |
| 300 | V | A | -1.7164 | |
| 301 | R | A | -1.8117 | |
| 302 | G | A | -0.5168 | |
| 303 | S | A | 0.0558 | |
| 304 | A | A | 0.4508 | |
| 305 | L | A | 1.6263 | |
| 306 | Y | A | 1.1619 | |
| 307 | E | A | -0.8149 | |
| 308 | A | A | -0.6624 | |
| 309 | S | A | -0.4921 | |
| 310 | T | A | -0.1611 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine