Project name: 7905ccee1d7a2fc

Chain sequence(s)	P: GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDFKLS
Selected Chain(s)	P
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with P chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:12)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:13)

• Minimal score value: -3.9619
• Maximal score value: 1.4499
• Average score: -0.6196
• Total score value: -160.4665

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
244	G	P	-0.1254
245	C	P	0.2204
246	G	P	-0.5954
247	E	P	-1.0004
248	L	P	0.0000
249	V	P	0.3403
250	W	P	0.5097
251	V	P	-0.5647
252	G	P	-1.4751
253	E	P	-2.0678
254	P	P	-0.8039
255	L	P	0.6840
256	T	P	0.3033
257	L	P	-0.1288
258	R	P	-1.8397
259	T	P	-1.4905
260	A	P	-1.3972
261	E	P	-2.3272
262	T	P	-0.6987
263	I	P	-0.4670
264	T	P	-0.9061
265	G	P	-1.4787
266	K	P	-1.1320
267	Y	P	-0.3369
268	G	P	0.0000
269	V	P	0.0000
270	W	P	-0.5562
271	M	P	0.0000
272	R	P	-2.3572
273	D	P	-1.7321
274	P	P	-1.2680
275	K	P	-0.6744
276	P	P	-0.1483
277	T	P	0.4693
278	Y	P	1.4452
279	P	P	0.8570
280	Y	P	0.9854
281	T	P	0.0255
282	Q	P	-1.0408
283	E	P	-1.5582
284	T	P	0.0000
285	T	P	0.0000
286	W	P	0.0000
287	R	P	-0.4884
288	I	P	0.0000
289	D	P	-0.6693
290	T	P	-0.0083
291	V	P	1.2743
292	G	P	0.0447
293	T	P	-0.7344
294	D	P	-1.9321
295	V	P	-0.5583
296	R	P	-0.2958
297	Q	P	0.4099
298	V	P	0.0000
299	F	P	0.1980
300	E	P	-0.6403
301	Y	P	0.0000
302	D	P	-0.8726
303	L	P	0.0407
304	I	P	0.7379
305	S	P	0.1151
306	Q	P	-0.3368
307	F	P	1.3859
308	M	P	0.5084
309	Q	P	0.2787
310	G	P	0.1957
311	Y	P	0.5975
312	P	P	-0.0414
313	S	P	-0.5312
314	K	P	-0.7539
315	V	P	0.7252
316	H	P	0.0000
317	I	P	1.1829
318	L	P	0.0000
319	P	P	-0.5471
320	R	P	-1.3624
321	P	P	-1.7288
322	L	P	0.0000
323	E	P	-1.6632
324	S	P	-0.8534
325	T	P	0.0000
326	G	P	-0.2343
327	A	P	0.0000
328	V	P	0.2390
329	V	P	0.0522
330	Y	P	-0.0645
331	S	P	-0.3903
332	G	P	-0.4824
333	S	P	0.0000
334	L	P	0.0000
335	Y	P	0.0000
336	F	P	0.0000
337	Q	P	0.0000
338	G	P	-1.3538
339	A	P	-1.3343
340	E	P	-1.6460
341	S	P	-1.1192
342	R	P	-1.3689
343	T	P	-2.0798
344	V	P	0.0000
345	I	P	0.0000
346	R	P	-1.7005
347	Y	P	0.0000
348	E	P	-1.5524
349	L	P	-1.3146
350	N	P	-1.8758
351	T	P	-1.6691
352	E	P	-2.1940
353	T	P	-1.2944
354	V	P	-1.2776
355	K	P	-2.6660
356	A	P	0.0000
357	E	P	-3.7338
358	K	P	-3.9619
359	E	P	-3.1942
360	I	P	0.0000
361	P	P	-1.0711
362	G	P	-1.3672
363	A	P	-0.4686
364	G	P	-0.4176
365	Y	P	0.0000
366	H	P	-1.1375
367	G	P	-1.4284
368	Q	P	-1.4439
369	F	P	-0.6682
370	P	P	-0.3838
371	Y	P	0.1161
372	S	P	-0.2494
373	W	P	0.1526
374	G	P	-0.1346
375	G	P	-0.3539
376	Y	P	0.4857
377	T	P	-0.0722
378	D	P	-0.3169
379	I	P	0.0048
380	D	P	-0.3741
381	L	P	0.0000
382	A	P	0.0712
383	V	P	0.0361
384	D	P	-0.7994
385	E	P	-1.6182
386	A	P	-0.8647
387	G	P	0.0000
388	L	P	0.0000
389	W	P	0.0000
390	V	P	0.0000
391	I	P	0.0000
392	Y	P	0.0000
393	S	P	0.0000
394	T	P	-2.4666
395	D	P	-3.4682
396	E	P	-3.5247
397	A	P	-3.2109
398	K	P	-3.4505
399	G	P	0.0000
400	A	P	0.0000
401	I	P	0.0000
402	V	P	0.0000
403	L	P	0.0000
404	S	P	0.0000
405	K	P	-1.1208
406	L	P	0.0000
407	N	P	-1.9537
408	P	P	-1.4051
409	E	P	-2.7510
410	N	P	-3.3310
411	L	P	0.0000
412	E	P	-2.8691
413	L	P	-0.8198
414	E	P	-2.2472
415	Q	P	-1.9296
416	T	P	-1.1133
417	W	P	-1.2370
418	E	P	-2.3361
419	T	P	0.0000
420	N	P	-2.1776
421	I	P	0.0000
422	R	P	-2.5610
423	K	P	-2.6197
424	Q	P	-2.3217
425	S	P	-1.3956
426	V	P	0.0000
427	A	P	-0.8307
428	N	P	-0.5578
429	A	P	0.0000
430	F	P	0.0000
431	I	P	0.1452
432	I	P	0.0000
433	C	P	-0.3144
434	G	P	0.0000
435	T	P	-0.2336
436	L	P	0.0000
437	Y	P	0.0000
438	T	P	0.0000
439	V	P	0.0000
440	S	P	-0.2953
441	S	P	-0.3378
442	Y	P	0.7149
443	T	P	0.1263
444	S	P	-0.2740
445	A	P	-0.5661
446	D	P	-2.2155
447	A	P	0.0000
448	T	P	-0.6352
449	V	P	0.0000
450	N	P	-0.2002
451	F	P	0.0343
452	A	P	0.0000
453	Y	P	0.0505
454	D	P	-0.0693
455	T	P	-0.0171
456	G	P	-0.3247
457	T	P	0.0661
458	G	P	0.2262
459	I	P	1.4499
460	S	P	0.2363
461	K	P	0.0180
462	T	P	-0.1475
463	L	P	0.1162
464	T	P	0.0716
465	I	P	0.0000
466	P	P	-0.9847
467	F	P	0.0000
468	K	P	-2.7876
469	N	P	-2.2695
470	R	P	-2.6447
471	Y	P	-1.3889
472	K	P	-1.5530
473	Y	P	-0.0614
474	S	P	-0.2643
475	S	P	-0.4064
476	M	P	0.2394
477	I	P	0.0000
478	D	P	-0.6209
479	Y	P	-0.7370
480	N	P	-1.2806
481	P	P	0.0000
482	L	P	-0.4197
483	E	P	-2.0317
484	K	P	-2.4483
485	K	P	-2.0242
486	L	P	0.0000
487	F	P	-0.2570
488	A	P	0.0000
489	W	P	0.0000
490	D	P	-0.7653
491	N	P	-0.8870
492	L	P	0.2884
493	N	P	-0.8186
494	M	P	0.0000
495	V	P	0.3791
496	T	P	-0.0546
497	Y	P	0.0000
498	D	P	-1.9652
499	F	P	-1.0310
500	K	P	-1.4122
501	L	P	-0.4540
502	S	P	-0.5585