| Chain sequence(s) |
A: GAPPLNPEPELRSDDDYVTPTDLLYVAETDLITETGHPTSDIVVDGKVLVPRVSAYQWLVFKLTLPDPNKLKLPSEDFVDFSTEILIWRLKAYYIGVGGPLGKGSYGHPNYNALGDVDNPTAPVHETADDTVNLSFTPKLLQEYIIGDKPPLGVYVSPAPPAPGLPPGAEPPTTVVTDIIEHGDMADIGFGARDFAALDPRKDNVPDIIRDTVTKRPDLEGMKAEPWGDRMFDYDRYEKSYDVKKYRLCGPDLHPLPDAGPPSPLYVPPPPSSPYAVRPSYRYFTLPDRGEITEEDQLFNKPRFFEKAPGLNNYVLWHNQLYITVLDNSRDEIETIVTRISTPEDNVFDPSNYVTSKRYTREYQLSLIVQLCKIPLTPETLELLRRRDPSILVDANLPDVPPVERPDPYAGKKFIELDLTNKLSTDLSKFPLGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:02)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.5454 | |
| 2 | A | A | -0.1033 | |
| 3 | P | A | -0.2613 | |
| 4 | P | A | -0.0911 | |
| 5 | L | A | 0.3499 | |
| 6 | N | A | -1.3205 | |
| 7 | P | A | -1.7263 | |
| 8 | E | A | -2.4882 | |
| 9 | P | A | -2.3072 | |
| 10 | E | A | -2.1333 | |
| 11 | L | A | -0.6936 | |
| 12 | R | A | -1.2684 | |
| 13 | S | A | -1.1849 | |
| 14 | D | A | 0.0000 | |
| 15 | D | A | -2.3193 | |
| 16 | D | A | -2.5128 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.8224 | |
| 20 | P | A | -0.8176 | |
| 21 | T | A | -0.9153 | |
| 22 | D | A | -1.6456 | |
| 23 | L | A | -0.5353 | |
| 24 | L | A | -0.2057 | |
| 25 | Y | A | -0.1085 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.8109 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.1493 | |
| 31 | L | A | 0.4214 | |
| 32 | I | A | 0.1478 | |
| 33 | T | A | -0.2580 | |
| 34 | E | A | -0.5773 | |
| 35 | T | A | -0.4919 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.9717 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.7838 | |
| 40 | S | A | -0.4687 | |
| 41 | D | A | 0.0783 | |
| 42 | I | A | 1.8335 | |
| 43 | V | A | 2.4471 | |
| 44 | V | A | 1.4407 | |
| 45 | D | A | -1.0519 | |
| 46 | G | A | -0.6039 | |
| 47 | K | A | -0.2586 | |
| 48 | V | A | 2.0967 | |
| 49 | L | A | 2.4911 | |
| 50 | V | A | 1.4377 | |
| 51 | P | A | 0.2819 | |
| 52 | R | A | -0.5122 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | L | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1375 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.1839 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.4961 | |
| 70 | K | A | -2.1819 | |
| 71 | L | A | -1.5032 | |
| 72 | K | A | -2.1458 | |
| 73 | L | A | -1.4673 | |
| 74 | P | A | -1.0522 | |
| 75 | S | A | -1.7501 | |
| 76 | E | A | -3.0831 | |
| 77 | D | A | -2.8203 | |
| 78 | F | A | -1.4350 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -1.9960 | |
| 81 | F | A | -0.1154 | |
| 82 | S | A | -0.3210 | |
| 83 | T | A | -0.4639 | |
| 84 | E | A | -0.6514 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | K | A | -0.6298 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | -0.3291 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.5481 | |
| 99 | G | A | -0.9249 | |
| 100 | P | A | -0.9170 | |
| 101 | L | A | -0.7118 | |
| 102 | G | A | 0.0000 | |
| 103 | K | A | -1.8297 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.7085 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.6994 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.3786 | |
| 110 | N | A | -2.0247 | |
| 111 | Y | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -1.0423 | |
| 116 | D | A | -1.8472 | |
| 117 | V | A | -1.4851 | |
| 118 | D | A | -2.8300 | |
| 119 | N | A | -2.6120 | |
| 120 | P | A | -1.4467 | |
| 121 | T | A | -0.8111 | |
| 122 | A | A | -0.1696 | |
| 123 | P | A | 0.2133 | |
| 124 | V | A | -0.1903 | |
| 125 | H | A | -0.8414 | |
| 126 | E | A | -1.4727 | |
| 127 | T | A | -1.2690 | |
| 128 | A | A | -1.0997 | |
| 129 | D | A | -2.1190 | |
| 130 | D | A | -1.4471 | |
| 131 | T | A | -1.0890 | |
| 132 | V | A | -0.6915 | |
| 133 | N | A | -1.3997 | |
| 134 | L | A | -0.6555 | |
| 135 | S | A | -0.4816 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.2410 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | K | A | -0.6087 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.3539 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | 0.0000 | |
| 155 | Y | A | 0.1198 | |
| 156 | V | A | 0.8926 | |
| 157 | S | A | 0.4425 | |
| 158 | P | A | -0.1739 | |
| 159 | A | A | 0.0334 | |
| 160 | P | A | -0.4822 | |
| 161 | P | A | -0.4174 | |
| 162 | A | A | -0.2093 | |
| 163 | P | A | -0.3419 | |
| 164 | G | A | -0.2757 | |
| 165 | L | A | 0.0153 | |
| 166 | P | A | -0.4233 | |
| 167 | P | A | -0.6992 | |
| 168 | G | A | -0.7762 | |
| 169 | A | A | -0.9098 | |
| 170 | E | A | -1.7774 | |
| 171 | P | A | -1.1787 | |
| 172 | P | A | -0.7140 | |
| 173 | T | A | 0.0728 | |
| 174 | T | A | 0.9877 | |
| 175 | V | A | 1.9575 | |
| 176 | V | A | 1.1235 | |
| 177 | T | A | 0.2078 | |
| 178 | D | A | -0.2954 | |
| 179 | I | A | -0.5224 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.1197 | |
| 182 | H | A | -0.8773 | |
| 183 | G | A | -0.6637 | |
| 184 | D | A | -0.7657 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.8438 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2069 | |
| 190 | F | A | -0.1896 | |
| 191 | G | A | -0.6315 | |
| 192 | A | A | -0.7161 | |
| 193 | R | A | -0.8002 | |
| 194 | D | A | -0.7619 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.5424 | |
| 197 | A | A | -0.7626 | |
| 198 | L | A | -0.4535 | |
| 199 | D | A | 0.0000 | |
| 200 | P | A | -1.7285 | |
| 201 | R | A | -2.6930 | |
| 202 | K | A | -2.7711 | |
| 203 | D | A | -1.8608 | |
| 204 | N | A | -1.2457 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.5909 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | R | A | -2.5066 | |
| 211 | D | A | -2.6177 | |
| 212 | T | A | -1.3166 | |
| 213 | V | A | -0.5134 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | R | A | -1.7627 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | -1.3582 | |
| 219 | L | A | -1.4723 | |
| 220 | E | A | -2.5017 | |
| 221 | G | A | -1.6701 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.5737 | |
| 224 | A | A | -1.5579 | |
| 225 | E | A | -1.2637 | |
| 226 | P | A | -0.4351 | |
| 227 | W | A | -0.1604 | |
| 228 | G | A | -0.7176 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.6576 | |
| 231 | M | A | -0.5210 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.4201 | |
| 234 | Y | A | -0.3728 | |
| 235 | D | A | -1.1116 | |
| 236 | R | A | -1.3177 | |
| 237 | Y | A | -1.0511 | |
| 238 | E | A | -1.1447 | |
| 239 | K | A | -0.9257 | |
| 240 | S | A | -0.5903 | |
| 241 | Y | A | 0.0478 | |
| 242 | D | A | -1.0410 | |
| 243 | V | A | -0.1932 | |
| 244 | K | A | -1.5610 | |
| 245 | K | A | -1.5941 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | L | A | 0.2888 | |
| 249 | C | A | -0.4640 | |
| 250 | G | A | -0.4813 | |
| 251 | P | A | -0.3430 | |
| 252 | D | A | -0.1779 | |
| 253 | L | A | 0.2048 | |
| 254 | H | A | -0.5096 | |
| 255 | P | A | -0.5939 | |
| 256 | L | A | 0.0216 | |
| 257 | P | A | -0.8319 | |
| 258 | D | A | -1.8015 | |
| 259 | A | A | -0.4684 | |
| 260 | G | A | -0.9263 | |
| 261 | P | A | -0.3702 | |
| 262 | P | A | -0.1915 | |
| 263 | S | A | 0.2279 | |
| 264 | P | A | 0.6699 | |
| 265 | L | A | 1.7266 | |
| 266 | Y | A | 1.7804 | |
| 267 | V | A | 1.9643 | |
| 268 | P | A | 0.6167 | |
| 269 | P | A | 0.4989 | |
| 270 | P | A | -0.1299 | |
| 271 | P | A | -0.0957 | |
| 272 | S | A | -0.1140 | |
| 273 | S | A | 0.2833 | |
| 274 | P | A | 0.4250 | |
| 275 | Y | A | 1.2991 | |
| 276 | A | A | 0.9187 | |
| 277 | V | A | 1.3645 | |
| 278 | R | A | 0.0423 | |
| 279 | P | A | -0.2345 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.5536 | |
| 282 | R | A | 0.5184 | |
| 283 | Y | A | 1.2564 | |
| 284 | F | A | 0.6022 | |
| 285 | T | A | -0.1781 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -0.5228 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.0206 | |
| 291 | E | A | -1.8825 | |
| 292 | I | A | -1.7245 | |
| 293 | T | A | -2.1175 | |
| 294 | E | A | -3.0794 | |
| 295 | E | A | -3.3860 | |
| 296 | D | A | -2.8147 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1447 | |
| 301 | K | A | -1.4166 | |
| 302 | P | A | -0.9172 | |
| 303 | R | A | -0.5073 | |
| 304 | F | A | -0.6256 | |
| 305 | F | A | -1.1732 | |
| 306 | E | A | -2.4932 | |
| 307 | K | A | -2.6895 | |
| 308 | A | A | 0.0000 | |
| 309 | P | A | -0.9389 | |
| 310 | G | A | -0.8055 | |
| 311 | L | A | -0.4054 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | Y | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.5862 | |
| 319 | N | A | -0.5632 | |
| 320 | Q | A | -0.5843 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | D | A | 0.0000 | |
| 332 | E | A | -2.1294 | |
| 333 | I | A | -1.5025 | |
| 334 | E | A | -1.3059 | |
| 335 | T | A | -0.1917 | |
| 336 | I | A | 1.6565 | |
| 337 | V | A | 2.3423 | |
| 338 | T | A | 1.2855 | |
| 339 | R | A | -0.0937 | |
| 340 | I | A | 1.6476 | |
| 341 | S | A | 0.2746 | |
| 342 | T | A | -0.6834 | |
| 343 | P | A | -1.1714 | |
| 344 | E | A | -2.3448 | |
| 345 | D | A | -2.5004 | |
| 346 | N | A | -1.3865 | |
| 347 | V | A | 0.7012 | |
| 348 | F | A | 1.4335 | |
| 349 | D | A | 0.1269 | |
| 350 | P | A | 0.2974 | |
| 351 | S | A | 0.1164 | |
| 352 | N | A | 0.2856 | |
| 353 | Y | A | 1.2632 | |
| 354 | V | A | 2.2022 | |
| 355 | T | A | 1.2733 | |
| 356 | S | A | 0.3303 | |
| 357 | K | A | -1.1062 | |
| 358 | R | A | -1.2977 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.8501 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.5399 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.4960 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3782 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.6444 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.5034 | |
| 376 | L | A | -0.2155 | |
| 377 | T | A | -0.6982 | |
| 378 | P | A | -1.0887 | |
| 379 | E | A | -1.8422 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.3018 | |
| 382 | E | A | -2.2208 | |
| 383 | L | A | -1.9918 | |
| 384 | L | A | 0.0000 | |
| 385 | R | A | -3.0062 | |
| 386 | R | A | -2.8409 | |
| 387 | R | A | 0.0000 | |
| 388 | D | A | -1.5564 | |
| 389 | P | A | -1.7142 | |
| 390 | S | A | -1.0412 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.8869 | |
| 394 | D | A | -1.3545 | |
| 395 | A | A | -0.9076 | |
| 396 | N | A | -1.5115 | |
| 397 | L | A | -0.9604 | |
| 398 | P | A | -1.1937 | |
| 399 | D | A | -1.8851 | |
| 400 | V | A | -0.6355 | |
| 401 | P | A | -0.4674 | |
| 402 | P | A | -0.4877 | |
| 403 | V | A | 0.3394 | |
| 404 | E | A | -1.6543 | |
| 405 | R | A | -1.6855 | |
| 406 | P | A | -1.3857 | |
| 407 | D | A | -1.6759 | |
| 408 | P | A | -0.9354 | |
| 409 | Y | A | -0.8756 | |
| 410 | A | A | -0.9788 | |
| 411 | G | A | -1.2337 | |
| 412 | K | A | -1.7141 | |
| 413 | K | A | -2.3359 | |
| 414 | F | A | -1.3415 | |
| 415 | I | A | -1.1002 | |
| 416 | E | A | -2.2167 | |
| 417 | L | A | -1.6734 | |
| 418 | D | A | -2.4721 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.4225 | |
| 421 | N | A | -1.8686 | |
| 422 | K | A | -1.5718 | |
| 423 | L | A | -0.5924 | |
| 424 | S | A | -0.7104 | |
| 425 | T | A | -0.4442 | |
| 426 | D | A | -1.2588 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.5669 | |
| 429 | K | A | -2.1091 | |
| 430 | F | A | -1.3214 | |
| 431 | P | A | -0.9996 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.1627 | |
| 435 | E | A | -1.9778 | |
| 436 | Y | A | -0.9513 | |
| 437 | L | A | -0.3779 | |
| 438 | N | A | -2.0679 | |
| 439 | R | A | -2.2526 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine