| Chain sequence(s) |
A: DIVMTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCHQYGSTPLTFGGGTKAEIKAGGGGSGGGGSGGGGSQVQLQESGPGLVKPSQTLSLTCTVSGGSISSGDYYWSWIRQPPGKGLEWIGYIYYSGSTDYNPSLKSRVTMSVDTSKNQFSLKVNSVTAADTAVYYCARVSIFGVGTFDYWGQGTLVTVSSAAGGGGSDVQLVQSGAEVKKPGASVKVSCKASGYTFTRYTMHWVRQAPGQGLEWIGYINPSRGYTNYADSVKGRFTITTDKSTSTAYMELSSLRSEDTATYYCARYYDDHYCLDYWGQGTTVTVSSAAGGGGSGGGGSGGGGSDIVLTQSPATLSLSPGERATLSCRASQSVSYMNWYQQKPGKAPKRWIYDTSKVASGVPARFSGSGSGTDYSLTINSLEAEDAATYYCQQWSSNPLTFGGGTKVEIKAGSHHHHHH
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:42)
[INFO] Main: Simulation completed successfully. (00:02:45)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | D | A | -1.4744 | |
| 2 | I | A | -0.4248 | |
| 3 | V | A | 0.7988 | |
| 4 | M | A | 0.0000 | |
| 5 | T | A | -0.6094 | |
| 6 | Q | A | -0.6940 | |
| 7 | S | A | -0.7469 | |
| 8 | P | A | -0.3828 | |
| 9 | A | A | -0.3612 | |
| 10 | T | A | -0.5874 | |
| 11 | L | A | -0.3110 | |
| 12 | S | A | -0.6279 | |
| 13 | L | A | -0.8390 | |
| 14 | S | A | -1.2056 | |
| 15 | P | A | -1.5162 | |
| 16 | G | A | -1.7776 | |
| 17 | E | A | -2.5135 | |
| 18 | R | A | -2.7617 | |
| 19 | A | A | 0.0000 | |
| 20 | T | A | -0.6674 | |
| 21 | L | A | 0.0000 | |
| 22 | S | A | -0.8883 | |
| 23 | C | A | 0.0000 | |
| 24 | R | A | -2.3080 | |
| 25 | A | A | 0.0000 | |
| 26 | S | A | -0.9340 | |
| 27 | Q | A | -1.6434 | |
| 28 | S | A | -1.2178 | |
| 29 | V | A | 0.0000 | |
| 30 | S | A | -0.4636 | |
| 31 | S | A | -0.1876 | |
| 32 | Y | A | 0.7144 | |
| 33 | L | A | 0.0000 | |
| 34 | A | A | 0.0000 | |
| 35 | W | A | 0.0000 | |
| 36 | Y | A | 0.0000 | |
| 37 | Q | A | 0.0000 | |
| 38 | Q | A | 0.0000 | |
| 39 | K | A | -1.0395 | |
| 40 | P | A | -0.6810 | |
| 41 | G | A | -0.9029 | |
| 42 | Q | A | -0.8672 | |
| 43 | A | A | -0.6278 | |
| 44 | P | A | 0.0000 | |
| 45 | R | A | -1.1632 | |
| 46 | L | A | -0.5602 | |
| 47 | L | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | Y | A | -0.3366 | |
| 50 | D | A | -0.5883 | |
| 51 | A | A | 0.0000 | |
| 52 | S | A | -1.1172 | |
| 53 | N | A | -1.7057 | |
| 54 | R | A | -1.5928 | |
| 55 | A | A | -0.9779 | |
| 56 | T | A | -0.7046 | |
| 57 | G | A | -0.9161 | |
| 58 | I | A | -0.6542 | |
| 59 | P | A | -0.5865 | |
| 60 | A | A | -0.4129 | |
| 61 | R | A | -0.7775 | |
| 62 | F | A | 0.0000 | |
| 63 | S | A | -0.7179 | |
| 64 | G | A | 0.0000 | |
| 65 | S | A | -0.8331 | |
| 66 | G | A | -1.1719 | |
| 67 | S | A | -0.9736 | |
| 68 | G | A | -1.0527 | |
| 69 | T | A | -1.7315 | |
| 70 | D | A | -2.1234 | |
| 71 | F | A | 0.0000 | |
| 72 | T | A | -0.7679 | |
| 73 | L | A | 0.0000 | |
| 74 | T | A | -0.6274 | |
| 75 | I | A | 0.0000 | |
| 76 | S | A | -1.5168 | |
| 77 | S | A | -1.7152 | |
| 78 | L | A | 0.0000 | |
| 79 | E | A | -1.6443 | |
| 80 | P | A | -1.1872 | |
| 81 | E | A | -1.8971 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | -0.5295 | |
| 84 | A | A | 0.0000 | |
| 85 | V | A | -0.3949 | |
| 86 | Y | A | 0.0000 | |
| 87 | Y | A | 0.0000 | |
| 88 | C | A | 0.0000 | |
| 89 | H | A | 0.0000 | |
| 90 | Q | A | 0.0000 | |
| 91 | Y | A | 0.2433 | |
| 92 | G | A | -0.0445 | |
| 93 | S | A | -0.3704 | |
| 94 | T | A | -0.5621 | |
| 95 | P | A | -0.6314 | |
| 96 | L | A | 0.0000 | |
| 97 | T | A | 0.0277 | |
| 98 | F | A | 0.2492 | |
| 99 | G | A | 0.0000 | |
| 100 | G | A | -0.8338 | |
| 101 | G | A | -0.7307 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | -1.1232 | |
| 104 | A | A | 0.0000 | |
| 105 | E | A | -0.7902 | |
| 106 | I | A | 0.5395 | |
| 107 | K | A | -0.8892 | |
| 108 | A | A | -0.6106 | |
| 109 | G | A | -0.8771 | |
| 110 | G | A | -1.0529 | |
| 111 | G | A | -1.0795 | |
| 112 | G | A | -1.2358 | |
| 113 | S | A | -1.0036 | |
| 114 | G | A | -1.2786 | |
| 115 | G | A | -1.3936 | |
| 116 | G | A | -1.5168 | |
| 117 | G | A | -1.2733 | |
| 118 | S | A | -1.0862 | |
| 119 | G | A | -1.1945 | |
| 120 | G | A | -1.3067 | |
| 121 | G | A | -1.2239 | |
| 122 | G | A | -1.2142 | |
| 123 | S | A | -1.2518 | |
| 124 | Q | A | -1.6060 | |
| 125 | V | A | -1.2735 | |
| 126 | Q | A | -1.8549 | |
| 127 | L | A | 0.0000 | |
| 128 | Q | A | -1.6819 | |
| 129 | E | A | 0.0000 | |
| 130 | S | A | -0.7381 | |
| 131 | G | A | -0.4468 | |
| 132 | P | A | -0.0132 | |
| 133 | G | A | 0.3237 | |
| 134 | L | A | 0.8194 | |
| 135 | V | A | 0.0000 | |
| 136 | K | A | -1.0536 | |
| 137 | P | A | -0.9091 | |
| 138 | S | A | -1.1164 | |
| 139 | Q | A | -1.4302 | |
| 140 | T | A | -1.2995 | |
| 141 | L | A | 0.0000 | |
| 142 | S | A | -0.9106 | |
| 143 | L | A | 0.0000 | |
| 144 | T | A | -0.6947 | |
| 145 | C | A | 0.0000 | |
| 146 | T | A | -1.2455 | |
| 147 | V | A | 0.0000 | |
| 148 | S | A | -1.2662 | |
| 149 | G | A | -1.2085 | |
| 150 | G | A | -0.9273 | |
| 151 | S | A | -0.6963 | |
| 152 | I | A | 0.0000 | |
| 153 | S | A | -0.3468 | |
| 154 | S | A | -0.3527 | |
| 155 | G | A | -0.1164 | |
| 156 | D | A | -0.2570 | |
| 157 | Y | A | 0.3825 | |
| 158 | Y | A | 0.4564 | |
| 159 | W | A | 0.0000 | |
| 160 | S | A | 0.0000 | |
| 161 | W | A | 0.0000 | |
| 162 | I | A | 0.0000 | |
| 163 | R | A | -0.4548 | |
| 164 | Q | A | -0.7461 | |
| 165 | P | A | -0.8536 | |
| 166 | P | A | -1.0909 | |
| 167 | G | A | -1.4536 | |
| 168 | K | A | -2.2848 | |
| 169 | G | A | -1.3490 | |
| 170 | L | A | 0.0000 | |
| 171 | E | A | -0.8669 | |
| 172 | W | A | 0.0000 | |
| 173 | I | A | 0.0000 | |
| 174 | G | A | 0.0000 | |
| 175 | Y | A | 0.1098 | |
| 176 | I | A | 0.0000 | |
| 177 | Y | A | 0.3513 | |
| 178 | Y | A | 0.2560 | |
| 179 | S | A | -0.1327 | |
| 180 | G | A | -0.2416 | |
| 181 | S | A | -0.2373 | |
| 182 | T | A | -0.1804 | |
| 183 | D | A | -0.6284 | |
| 184 | Y | A | -0.7853 | |
| 185 | N | A | -1.1221 | |
| 186 | P | A | -1.3223 | |
| 187 | S | A | -0.9234 | |
| 188 | L | A | 0.0000 | |
| 189 | K | A | -2.1207 | |
| 190 | S | A | -1.3879 | |
| 191 | R | A | -1.4985 | |
| 192 | V | A | 0.0000 | |
| 193 | T | A | -1.0552 | |
| 194 | M | A | 0.0000 | |
| 195 | S | A | -0.3872 | |
| 196 | V | A | -0.3777 | |
| 197 | D | A | -1.2308 | |
| 198 | T | A | -1.0723 | |
| 199 | S | A | -1.3452 | |
| 200 | K | A | -2.1885 | |
| 201 | N | A | -1.4696 | |
| 202 | Q | A | -1.2959 | |
| 203 | F | A | 0.0000 | |
| 204 | S | A | -0.5398 | |
| 205 | L | A | 0.0000 | |
| 206 | K | A | -1.4744 | |
| 207 | V | A | 0.0000 | |
| 208 | N | A | -1.5727 | |
| 209 | S | A | -1.2745 | |
| 210 | V | A | 0.0000 | |
| 211 | T | A | -0.5048 | |
| 212 | A | A | -0.1385 | |
| 213 | A | A | 0.0157 | |
| 214 | D | A | 0.0000 | |
| 215 | T | A | 0.2382 | |
| 216 | A | A | 0.0000 | |
| 217 | V | A | 0.4620 | |
| 218 | Y | A | 0.0000 | |
| 219 | Y | A | 0.0000 | |
| 220 | C | A | 0.0000 | |
| 221 | A | A | 0.0000 | |
| 222 | R | A | -0.2690 | |
| 223 | V | A | 0.0000 | |
| 224 | S | A | 0.4990 | |
| 225 | I | A | 1.2581 | |
| 226 | F | A | 1.8487 | |
| 227 | G | A | 0.7317 | |
| 228 | V | A | 0.7217 | |
| 229 | G | A | 0.5458 | |
| 230 | T | A | 0.0000 | |
| 231 | F | A | 0.0000 | |
| 232 | D | A | -0.7206 | |
| 233 | Y | A | -0.6451 | |
| 234 | W | A | -0.6504 | |
| 235 | G | A | 0.0000 | |
| 236 | Q | A | -0.9037 | |
| 237 | G | A | -0.4260 | |
| 238 | T | A | -0.0999 | |
| 239 | L | A | 0.6692 | |
| 240 | V | A | 0.0000 | |
| 241 | T | A | 0.4275 | |
| 242 | V | A | 0.0000 | |
| 243 | S | A | -0.2273 | |
| 244 | S | A | -0.5616 | |
| 245 | A | A | -0.4277 | |
| 246 | A | A | -0.6841 | |
| 247 | G | A | -0.9109 | |
| 248 | G | A | -1.1305 | |
| 249 | G | A | -1.1862 | |
| 250 | G | A | -1.2012 | |
| 251 | S | A | -1.2468 | |
| 252 | D | A | -1.5813 | |
| 253 | V | A | -0.6287 | |
| 254 | Q | A | -0.6289 | |
| 255 | L | A | 0.0000 | |
| 256 | V | A | -0.1836 | |
| 257 | Q | A | 0.0000 | |
| 258 | S | A | -0.6649 | |
| 259 | G | A | -0.6445 | |
| 260 | A | A | -0.4978 | |
| 261 | E | A | -0.8501 | |
| 262 | V | A | -0.4506 | |
| 263 | K | A | -1.4809 | |
| 264 | K | A | -2.3113 | |
| 265 | P | A | -2.0022 | |
| 266 | G | A | -1.4402 | |
| 267 | A | A | -1.1638 | |
| 268 | S | A | -1.3825 | |
| 269 | V | A | 0.0000 | |
| 270 | K | A | -2.1287 | |
| 271 | V | A | 0.0000 | |
| 272 | S | A | -0.7385 | |
| 273 | C | A | 0.0000 | |
| 274 | K | A | -1.0194 | |
| 275 | A | A | 0.0000 | |
| 276 | S | A | -0.7354 | |
| 277 | G | A | -0.9828 | |
| 278 | Y | A | -0.5699 | |
| 279 | T | A | -0.7360 | |
| 280 | F | A | 0.0000 | |
| 281 | T | A | -1.6134 | |
| 282 | R | A | -2.2097 | |
| 283 | Y | A | -1.0084 | |
| 284 | T | A | 0.0000 | |
| 285 | M | A | 0.0000 | |
| 286 | H | A | 0.0000 | |
| 287 | W | A | 0.0000 | |
| 288 | V | A | 0.0000 | |
| 289 | R | A | -0.7381 | |
| 290 | Q | A | -0.9476 | |
| 291 | A | A | -1.2148 | |
| 292 | P | A | -1.1632 | |
| 293 | G | A | -1.2165 | |
| 294 | Q | A | -1.8125 | |
| 295 | G | A | -1.2138 | |
| 296 | L | A | 0.0000 | |
| 297 | E | A | -0.9235 | |
| 298 | W | A | 0.0000 | |
| 299 | I | A | 0.0000 | |
| 300 | G | A | 0.0000 | |
| 301 | Y | A | 0.0748 | |
| 302 | I | A | 0.0000 | |
| 303 | N | A | -0.8837 | |
| 304 | P | A | 0.0000 | |
| 305 | S | A | -1.6321 | |
| 306 | R | A | -1.9626 | |
| 307 | G | A | -0.8177 | |
| 308 | Y | A | 0.2413 | |
| 309 | T | A | -0.1221 | |
| 310 | N | A | -1.0920 | |
| 311 | Y | A | -1.3750 | |
| 312 | A | A | 0.0000 | |
| 313 | D | A | -2.7190 | |
| 314 | S | A | -1.8289 | |
| 315 | V | A | 0.0000 | |
| 316 | K | A | -2.7966 | |
| 317 | G | A | -1.7831 | |
| 318 | R | A | -1.4271 | |
| 319 | F | A | 0.0000 | |
| 320 | T | A | -1.0177 | |
| 321 | I | A | 0.0000 | |
| 322 | T | A | -0.3936 | |
| 323 | T | A | -1.0424 | |
| 324 | D | A | -1.6916 | |
| 325 | K | A | -2.1974 | |
| 326 | S | A | -1.2896 | |
| 327 | T | A | -1.1263 | |
| 328 | S | A | -1.2902 | |
| 329 | T | A | 0.0000 | |
| 330 | A | A | 0.0000 | |
| 331 | Y | A | -0.7112 | |
| 332 | M | A | 0.0000 | |
| 333 | E | A | -1.6544 | |
| 334 | L | A | 0.0000 | |
| 335 | S | A | -1.1519 | |
| 336 | S | A | -1.1295 | |
| 337 | L | A | 0.0000 | |
| 338 | R | A | -2.4608 | |
| 339 | S | A | -2.0917 | |
| 340 | E | A | -2.3665 | |
| 341 | D | A | 0.0000 | |
| 342 | T | A | -1.0604 | |
| 343 | A | A | 0.0000 | |
| 344 | T | A | -0.4742 | |
| 345 | Y | A | 0.0000 | |
| 346 | Y | A | 0.0000 | |
| 347 | C | A | 0.0000 | |
| 348 | A | A | 0.0000 | |
| 349 | R | A | 0.0000 | |
| 350 | Y | A | -0.4880 | |
| 351 | Y | A | -1.4349 | |
| 352 | D | A | -2.7322 | |
| 353 | D | A | -2.6223 | |
| 354 | H | A | -1.4272 | |
| 355 | Y | A | -0.3529 | |
| 356 | C | A | 0.0000 | |
| 357 | L | A | 0.0000 | |
| 358 | D | A | -0.1122 | |
| 359 | Y | A | 0.1142 | |
| 360 | W | A | -0.1937 | |
| 361 | G | A | 0.0000 | |
| 362 | Q | A | -1.1348 | |
| 363 | G | A | -0.8615 | |
| 364 | T | A | 0.0000 | |
| 365 | T | A | -0.4778 | |
| 366 | V | A | 0.0000 | |
| 367 | T | A | -0.9122 | |
| 368 | V | A | 0.0000 | |
| 369 | S | A | -1.2910 | |
| 370 | S | A | -1.4657 | |
| 371 | A | A | -1.0754 | |
| 372 | A | A | -0.8809 | |
| 373 | G | A | -0.9566 | |
| 374 | G | A | -1.0827 | |
| 375 | G | A | -1.1475 | |
| 376 | G | A | -1.1785 | |
| 377 | S | A | -1.0383 | |
| 378 | G | A | -1.1694 | |
| 379 | G | A | -1.1961 | |
| 380 | G | A | -1.1853 | |
| 381 | G | A | -1.2523 | |
| 382 | S | A | -1.0976 | |
| 383 | G | A | -1.5342 | |
| 384 | G | A | -1.2997 | |
| 385 | G | A | -1.2504 | |
| 386 | G | A | -1.4523 | |
| 387 | S | A | -0.9088 | |
| 388 | D | A | -1.1219 | |
| 389 | I | A | 0.0000 | |
| 390 | V | A | 0.9566 | |
| 391 | L | A | 0.0000 | |
| 392 | T | A | -0.6530 | |
| 393 | Q | A | -0.8635 | |
| 394 | S | A | -0.7810 | |
| 395 | P | A | -0.4383 | |
| 396 | A | A | -0.4943 | |
| 397 | T | A | -0.6725 | |
| 398 | L | A | -0.5303 | |
| 399 | S | A | -0.8437 | |
| 400 | L | A | -1.3417 | |
| 401 | S | A | -1.6784 | |
| 402 | P | A | -1.9908 | |
| 403 | G | A | -2.1257 | |
| 404 | E | A | -2.7861 | |
| 405 | R | A | -3.2502 | |
| 406 | A | A | 0.0000 | |
| 407 | T | A | -0.8351 | |
| 408 | L | A | 0.0000 | |
| 409 | S | A | -0.9247 | |
| 410 | C | A | 0.0000 | |
| 411 | R | A | -2.4044 | |
| 412 | A | A | 0.0000 | |
| 413 | S | A | -0.9037 | |
| 414 | Q | A | -1.6361 | |
| 415 | S | A | -1.3657 | |
| 416 | V | A | 0.0000 | |
| 417 | S | A | -0.1879 | |
| 418 | Y | A | 0.1746 | |
| 419 | M | A | 0.0000 | |
| 420 | N | A | 0.0000 | |
| 421 | W | A | 0.0000 | |
| 422 | Y | A | 0.0000 | |
| 423 | Q | A | 0.0000 | |
| 424 | Q | A | 0.0000 | |
| 425 | K | A | -1.7016 | |
| 426 | P | A | -1.1613 | |
| 427 | G | A | -1.6780 | |
| 428 | K | A | -2.5447 | |
| 429 | A | A | -1.6660 | |
| 430 | P | A | 0.0000 | |
| 431 | K | A | -1.9874 | |
| 432 | R | A | -0.8689 | |
| 433 | W | A | 0.0000 | |
| 434 | I | A | 0.0000 | |
| 435 | Y | A | -0.2991 | |
| 436 | D | A | -0.4019 | |
| 437 | T | A | -0.4513 | |
| 438 | S | A | -0.8839 | |
| 439 | K | A | -1.3695 | |
| 440 | V | A | -0.1598 | |
| 441 | A | A | 0.0000 | |
| 442 | S | A | -0.4166 | |
| 443 | G | A | -0.3740 | |
| 444 | V | A | -0.2082 | |
| 445 | P | A | -0.1104 | |
| 446 | A | A | -0.2144 | |
| 447 | R | A | -1.0842 | |
| 448 | F | A | 0.0000 | |
| 449 | S | A | -0.6229 | |
| 450 | G | A | 0.0000 | |
| 451 | S | A | -0.8435 | |
| 452 | G | A | -1.0475 | |
| 453 | S | A | -1.0126 | |
| 454 | G | A | -1.2639 | |
| 455 | T | A | -1.8521 | |
| 456 | D | A | -2.2818 | |
| 457 | Y | A | 0.0000 | |
| 458 | S | A | -0.8139 | |
| 459 | L | A | 0.0000 | |
| 460 | T | A | -0.9181 | |
| 461 | I | A | 0.0000 | |
| 462 | N | A | -2.6504 | |
| 463 | S | A | -2.4118 | |
| 464 | L | A | 0.0000 | |
| 465 | E | A | -2.5468 | |
| 466 | A | A | -1.7021 | |
| 467 | E | A | -2.2769 | |
| 468 | D | A | 0.0000 | |
| 469 | A | A | -1.2243 | |
| 470 | A | A | 0.0000 | |
| 471 | T | A | -0.8543 | |
| 472 | Y | A | 0.0000 | |
| 473 | Y | A | 0.0000 | |
| 474 | C | A | 0.0000 | |
| 475 | Q | A | 0.0000 | |
| 476 | Q | A | 0.0000 | |
| 477 | W | A | -0.0040 | |
| 478 | S | A | -0.3398 | |
| 479 | S | A | -1.0256 | |
| 480 | N | A | -1.6439 | |
| 481 | P | A | -1.4134 | |
| 482 | L | A | 0.0000 | |
| 483 | T | A | -0.0471 | |
| 484 | F | A | 0.1931 | |
| 485 | G | A | 0.0000 | |
| 486 | G | A | -0.8138 | |
| 487 | G | A | -0.8167 | |
| 488 | T | A | 0.0000 | |
| 489 | K | A | -1.5603 | |
| 490 | V | A | 0.0000 | |
| 491 | E | A | -1.6758 | |
| 492 | I | A | -1.3305 | |
| 493 | K | A | -1.7885 | |
| 494 | A | A | -1.1862 | |
| 495 | G | A | -1.3760 | |
| 496 | S | A | -1.5994 | |
| 497 | H | A | -2.1716 | |
| 498 | H | A | -2.5416 | |
| 499 | H | A | -2.7523 | |
| 500 | H | A | -2.6932 | |
| 501 | H | A | -2.4033 | |
| 502 | H | A | -1.8872 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine