| Chain sequence(s) |
A: GLLPLNPEPELRSTSEYVTPTDLLYVAETDLITETGHPTKDIVVDGKVLLPQVNAYQYDVFKLTLPDPNKLPLPSEDAIDFSTERLIWRLLALKIHKFGPLGKGTYGLANYNAFGDVDNPTEYQHETEDDDQNLSFTPKYKQSYIVGDLPPLGKYITKAPPEPGLPPGAIPPLVEKTTIIQHGDMADIGFGAKDYKELYPRKDEVPDIIKDTTTKVFDYEGMKAEPYGRRLFDSNSYEKSKDVKNYVLDGPDLIPLPDGLPPSPLYVKPPPTSPYAVLPSYKYFTLPDAGEITEEDELFNKPYFFEKTEGLNDGVLWHNQLYVTVLDNSRAEIKTIRTQISTPEINVYDPSNYVTSKLYTREYQLSLIVQLCKIPLTPETLAEIERLDPSILVNWNLPFVPKVERPDPYAGLKFIELDLTDKLSSDLSKFELGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.6515 | |
| 2 | L | A | 2.2288 | |
| 3 | L | A | 2.2534 | |
| 4 | P | A | 1.1938 | |
| 5 | L | A | 1.1405 | |
| 6 | N | A | -1.0232 | |
| 7 | P | A | -1.7566 | |
| 8 | E | A | -2.5454 | |
| 9 | P | A | -2.1447 | |
| 10 | E | A | -2.2513 | |
| 11 | L | A | -0.8348 | |
| 12 | R | A | -1.0263 | |
| 13 | S | A | -0.7950 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.4079 | |
| 16 | E | A | -2.0301 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6850 | |
| 20 | P | A | -0.7449 | |
| 21 | T | A | -1.0242 | |
| 22 | D | A | -1.7190 | |
| 23 | L | A | -0.6474 | |
| 24 | L | A | -0.2256 | |
| 25 | Y | A | -0.0823 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9432 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2215 | |
| 31 | L | A | 0.5413 | |
| 32 | I | A | 0.2474 | |
| 33 | T | A | -0.1536 | |
| 34 | E | A | -0.6521 | |
| 35 | T | A | -0.3409 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.1188 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.4415 | |
| 40 | K | A | -2.0328 | |
| 41 | D | A | -0.8211 | |
| 42 | I | A | 1.2555 | |
| 43 | V | A | 2.1870 | |
| 44 | V | A | 1.4979 | |
| 45 | D | A | -1.0127 | |
| 46 | G | A | -0.5989 | |
| 47 | K | A | -0.2637 | |
| 48 | V | A | 1.9122 | |
| 49 | L | A | 2.4851 | |
| 50 | L | A | 1.2934 | |
| 51 | P | A | -0.0908 | |
| 52 | Q | A | -1.0403 | |
| 53 | V | A | 0.0000 | |
| 54 | N | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | D | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2203 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.2738 | |
| 67 | D | A | -1.2529 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.0465 | |
| 70 | K | A | -1.8293 | |
| 71 | L | A | -0.7652 | |
| 72 | P | A | -0.4678 | |
| 73 | L | A | -0.4947 | |
| 74 | P | A | -0.8699 | |
| 75 | S | A | -1.2558 | |
| 76 | E | A | -2.1532 | |
| 77 | D | A | -1.7418 | |
| 78 | A | A | -0.9162 | |
| 79 | I | A | -0.8378 | |
| 80 | D | A | -1.2990 | |
| 81 | F | A | -0.1139 | |
| 82 | S | A | -0.4210 | |
| 83 | T | A | -0.5518 | |
| 84 | E | A | -0.7617 | |
| 85 | R | A | -0.5034 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.4778 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.0000 | |
| 92 | A | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.2799 | |
| 97 | K | A | 0.0000 | |
| 98 | F | A | 0.6036 | |
| 99 | G | A | -0.3144 | |
| 100 | P | A | -0.4222 | |
| 101 | L | A | -0.4698 | |
| 102 | G | A | -1.1049 | |
| 103 | K | A | -1.5529 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5687 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.7240 | |
| 108 | L | A | 0.0000 | |
| 109 | A | A | -1.5279 | |
| 110 | N | A | -2.6421 | |
| 111 | Y | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | F | A | -0.8604 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -2.2221 | |
| 117 | V | A | -1.6855 | |
| 118 | D | A | -2.7279 | |
| 119 | N | A | -2.5731 | |
| 120 | P | A | -2.0330 | |
| 121 | T | A | -1.5951 | |
| 122 | E | A | -2.1134 | |
| 123 | Y | A | -0.3406 | |
| 124 | Q | A | -0.8512 | |
| 125 | H | A | -0.9558 | |
| 126 | E | A | -1.9611 | |
| 127 | T | A | -2.3126 | |
| 128 | E | A | -3.0595 | |
| 129 | D | A | -3.3382 | |
| 130 | D | A | -2.4244 | |
| 131 | D | A | -2.4555 | |
| 132 | Q | A | -2.3882 | |
| 133 | N | A | -2.1830 | |
| 134 | L | A | -1.1643 | |
| 135 | S | A | -0.5550 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.4484 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -1.1687 | |
| 140 | Y | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | S | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | L | A | 0.1444 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | 0.0482 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.7504 | |
| 155 | Y | A | -0.5980 | |
| 156 | I | A | -0.2475 | |
| 157 | T | A | 0.0000 | |
| 158 | K | A | -0.7445 | |
| 159 | A | A | -0.4265 | |
| 160 | P | A | -0.7709 | |
| 161 | P | A | -1.2684 | |
| 162 | E | A | -2.0686 | |
| 163 | P | A | -1.2833 | |
| 164 | G | A | -0.7872 | |
| 165 | L | A | 0.0639 | |
| 166 | P | A | 0.0002 | |
| 167 | P | A | -0.0622 | |
| 168 | G | A | 0.1819 | |
| 169 | A | A | 1.2637 | |
| 170 | I | A | 2.2811 | |
| 171 | P | A | 0.7910 | |
| 172 | P | A | 0.7110 | |
| 173 | L | A | 1.4332 | |
| 174 | V | A | 0.2721 | |
| 175 | E | A | -1.5768 | |
| 176 | K | A | -1.6922 | |
| 177 | T | A | -0.8893 | |
| 178 | T | A | -0.1879 | |
| 179 | I | A | 0.1724 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.6813 | |
| 182 | H | A | -0.9250 | |
| 183 | G | A | -0.6850 | |
| 184 | D | A | -0.5904 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3659 | |
| 190 | F | A | -0.0279 | |
| 191 | G | A | -0.0397 | |
| 192 | A | A | -0.1896 | |
| 193 | K | A | -1.0354 | |
| 194 | D | A | -1.7261 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -3.7073 | |
| 197 | E | A | -3.0407 | |
| 198 | L | A | -1.3418 | |
| 199 | Y | A | -2.1068 | |
| 200 | P | A | -2.4093 | |
| 201 | R | A | -2.6758 | |
| 202 | K | A | -3.1987 | |
| 203 | D | A | 0.0000 | |
| 204 | E | A | -1.3838 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.6882 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | K | A | -2.6053 | |
| 211 | D | A | -2.8969 | |
| 212 | T | A | -1.7456 | |
| 213 | T | A | -1.1072 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.2322 | |
| 217 | F | A | 0.0000 | |
| 218 | D | A | -0.8777 | |
| 219 | Y | A | -1.1764 | |
| 220 | E | A | -2.3742 | |
| 221 | G | A | -1.6090 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.8008 | |
| 224 | A | A | -1.5329 | |
| 225 | E | A | -1.2234 | |
| 226 | P | A | -0.4802 | |
| 227 | Y | A | -0.3636 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.5987 | |
| 231 | L | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -1.2760 | |
| 234 | S | A | -0.7443 | |
| 235 | N | A | -0.5957 | |
| 236 | S | A | -0.5913 | |
| 237 | Y | A | -0.7567 | |
| 238 | E | A | -1.9455 | |
| 239 | K | A | -2.0588 | |
| 240 | S | A | -2.3028 | |
| 241 | K | A | -3.1555 | |
| 242 | D | A | -2.7366 | |
| 243 | V | A | -1.6246 | |
| 244 | K | A | -2.5546 | |
| 245 | N | A | -1.5731 | |
| 246 | Y | A | -0.4397 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | 0.1533 | |
| 249 | D | A | -0.9421 | |
| 250 | G | A | -0.6343 | |
| 251 | P | A | -0.0677 | |
| 252 | D | A | 0.6454 | |
| 253 | L | A | 2.2595 | |
| 254 | I | A | 2.4283 | |
| 255 | P | A | 0.7075 | |
| 256 | L | A | 0.6704 | |
| 257 | P | A | -0.1680 | |
| 258 | D | A | -1.7200 | |
| 259 | G | A | 0.0000 | |
| 260 | L | A | 0.7266 | |
| 261 | P | A | 0.3015 | |
| 262 | P | A | 0.3419 | |
| 263 | S | A | 0.5169 | |
| 264 | P | A | 0.8661 | |
| 265 | L | A | 1.6713 | |
| 266 | Y | A | 1.3130 | |
| 267 | V | A | 1.3810 | |
| 268 | K | A | -0.3458 | |
| 269 | P | A | -0.0120 | |
| 270 | P | A | -0.3104 | |
| 271 | P | A | -0.2785 | |
| 272 | T | A | -0.0154 | |
| 273 | S | A | 0.0974 | |
| 274 | P | A | 0.5457 | |
| 275 | Y | A | 1.2773 | |
| 276 | A | A | 0.9273 | |
| 277 | V | A | 1.8607 | |
| 278 | L | A | 1.3801 | |
| 279 | P | A | 0.4957 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.8405 | |
| 282 | K | A | 0.5348 | |
| 283 | Y | A | 1.3279 | |
| 284 | F | A | 0.7186 | |
| 285 | T | A | -0.1821 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -2.1484 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -2.1677 | |
| 291 | E | A | -2.2571 | |
| 292 | I | A | -1.5041 | |
| 293 | T | A | -1.9060 | |
| 294 | E | A | -2.7246 | |
| 295 | E | A | -2.8510 | |
| 296 | D | A | -2.1514 | |
| 297 | E | A | -1.5480 | |
| 298 | L | A | -0.9375 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1406 | |
| 301 | K | A | -1.5348 | |
| 302 | P | A | -0.6521 | |
| 303 | Y | A | -0.2444 | |
| 304 | F | A | -0.3899 | |
| 305 | F | A | 0.0000 | |
| 306 | E | A | -2.5547 | |
| 307 | K | A | -3.0579 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.6398 | |
| 310 | G | A | -1.5816 | |
| 311 | L | A | -0.5275 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | -1.5996 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7388 | |
| 319 | N | A | -0.6337 | |
| 320 | Q | A | -0.6206 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.6967 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.2069 | |
| 333 | I | A | -1.5906 | |
| 334 | K | A | -2.1460 | |
| 335 | T | A | -1.2408 | |
| 336 | I | A | -0.0948 | |
| 337 | R | A | -1.0654 | |
| 338 | T | A | 0.0419 | |
| 339 | Q | A | 0.0982 | |
| 340 | I | A | 1.7316 | |
| 341 | S | A | 0.3512 | |
| 342 | T | A | -0.4027 | |
| 343 | P | A | -1.2934 | |
| 344 | E | A | -1.8911 | |
| 345 | I | A | -0.4463 | |
| 346 | N | A | -0.4721 | |
| 347 | V | A | 1.5053 | |
| 348 | Y | A | 1.5194 | |
| 349 | D | A | -0.0251 | |
| 350 | P | A | -0.2871 | |
| 351 | S | A | 0.0298 | |
| 352 | N | A | 0.2411 | |
| 353 | Y | A | 0.7248 | |
| 354 | V | A | 1.2366 | |
| 355 | T | A | 0.0451 | |
| 356 | S | A | -0.6256 | |
| 357 | K | A | -1.5435 | |
| 358 | L | A | -0.9356 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.6813 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.0839 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.2457 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.4298 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.5314 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6230 | |
| 376 | L | A | -0.2994 | |
| 377 | T | A | -0.6984 | |
| 378 | P | A | -1.0397 | |
| 379 | E | A | -1.9766 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.8905 | |
| 382 | A | A | -1.2451 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | E | A | -1.8848 | |
| 386 | R | A | -1.6380 | |
| 387 | L | A | -0.8559 | |
| 388 | D | A | -0.9537 | |
| 389 | P | A | -1.1677 | |
| 390 | S | A | -1.3972 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.2478 | |
| 394 | N | A | -1.8040 | |
| 395 | W | A | -1.1419 | |
| 396 | N | A | -1.6063 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.2230 | |
| 399 | F | A | 1.5170 | |
| 400 | V | A | 0.4802 | |
| 401 | P | A | -0.3389 | |
| 402 | K | A | -1.6895 | |
| 403 | V | A | -0.5777 | |
| 404 | E | A | -2.6406 | |
| 405 | R | A | -2.9449 | |
| 406 | P | A | -2.1016 | |
| 407 | D | A | -2.2173 | |
| 408 | P | A | -1.1733 | |
| 409 | Y | A | -0.5904 | |
| 410 | A | A | -0.7845 | |
| 411 | G | A | -0.7721 | |
| 412 | L | A | -0.5705 | |
| 413 | K | A | -1.8194 | |
| 414 | F | A | -1.1042 | |
| 415 | I | A | -1.1210 | |
| 416 | E | A | -2.2357 | |
| 417 | L | A | -1.7327 | |
| 418 | D | A | -2.5489 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6129 | |
| 421 | D | A | -2.2939 | |
| 422 | K | A | -1.8650 | |
| 423 | L | A | -0.6828 | |
| 424 | S | A | -0.7867 | |
| 425 | S | A | -0.5627 | |
| 426 | D | A | -1.3218 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.5898 | |
| 429 | K | A | -2.3519 | |
| 430 | F | A | -1.5317 | |
| 431 | E | A | -1.7290 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.8275 | |
| 435 | L | A | -0.7336 | |
| 436 | Y | A | -0.2176 | |
| 437 | L | A | 0.1330 | |
| 438 | N | A | -1.5311 | |
| 439 | R | A | -1.8721 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine