| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTSPLHCGADDRVSFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRCGPDGHPLPSDPPPPPLYVPPPPTSPYAVLPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPLPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9452 | |
| 2 | L | A | 1.9678 | |
| 3 | P | A | 0.6515 | |
| 4 | P | A | 0.3616 | |
| 5 | T | A | 0.1150 | |
| 6 | T | A | 0.1335 | |
| 7 | P | A | 0.1983 | |
| 8 | V | A | 1.2174 | |
| 9 | A | A | 0.0259 | |
| 10 | K | A | -1.1778 | |
| 11 | V | A | -0.4515 | |
| 12 | Q | A | -1.5660 | |
| 13 | S | A | -1.6171 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4087 | |
| 16 | E | A | -2.4396 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4582 | |
| 20 | P | A | 0.1073 | |
| 21 | T | A | 0.1141 | |
| 22 | S | A | -0.1709 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1066 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2728 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8667 | |
| 31 | R | A | -2.6334 | |
| 32 | L | A | -0.7627 | |
| 33 | L | A | 1.2306 | |
| 34 | T | A | 1.4690 | |
| 35 | V | A | 2.0078 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2188 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6130 | |
| 40 | K | A | -1.6366 | |
| 41 | D | A | -0.9387 | |
| 42 | I | A | 0.8348 | |
| 43 | V | A | 1.0249 | |
| 44 | K | A | -1.1938 | |
| 45 | N | A | -1.9295 | |
| 46 | G | A | -1.2283 | |
| 47 | K | A | -0.9471 | |
| 48 | V | A | 1.5051 | |
| 49 | V | A | 2.0731 | |
| 50 | V | A | 1.2987 | |
| 51 | P | A | 0.4899 | |
| 52 | K | A | -0.6214 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1383 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4983 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2738 | |
| 70 | K | A | -1.8184 | |
| 71 | F | A | -0.6780 | |
| 72 | A | A | -0.5824 | |
| 73 | L | A | -0.8701 | |
| 74 | P | A | -1.2633 | |
| 75 | Q | A | -2.4794 | |
| 76 | K | A | -3.0960 | |
| 77 | D | A | -2.9910 | |
| 78 | F | A | -1.6416 | |
| 79 | Y | A | -1.9302 | |
| 80 | D | A | -2.7744 | |
| 81 | P | A | -2.3556 | |
| 82 | E | A | -3.0724 | |
| 83 | K | A | -3.4470 | |
| 84 | E | A | -2.5096 | |
| 85 | R | A | -1.3181 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6452 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9647 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.2993 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6670 | |
| 99 | G | A | -0.5401 | |
| 100 | P | A | -0.4353 | |
| 101 | L | A | -0.0115 | |
| 102 | G | A | -0.2397 | |
| 103 | K | A | -0.6486 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4433 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1040 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.2957 | |
| 110 | L | A | 0.1695 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1314 | |
| 113 | K | A | -0.2661 | |
| 114 | L | A | -0.7620 | |
| 115 | G | A | -0.7864 | |
| 116 | D | A | -1.2007 | |
| 117 | T | A | -0.9645 | |
| 118 | E | A | -1.9262 | |
| 119 | N | A | -2.1298 | |
| 120 | P | A | -1.4727 | |
| 121 | T | A | -0.8303 | |
| 122 | S | A | -0.6618 | |
| 123 | P | A | 0.1228 | |
| 124 | L | A | 0.0866 | |
| 125 | H | A | -0.3012 | |
| 126 | C | A | -0.7230 | |
| 127 | G | A | -1.2431 | |
| 128 | A | A | -1.1833 | |
| 129 | D | A | -2.1655 | |
| 130 | D | A | -1.7571 | |
| 131 | R | A | -1.2143 | |
| 132 | V | A | 0.0613 | |
| 133 | S | A | 0.1665 | |
| 134 | F | A | 0.1415 | |
| 135 | S | A | -0.1270 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6840 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5687 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2752 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0812 | |
| 157 | D | A | 0.3285 | |
| 158 | I | A | 0.8329 | |
| 159 | A | A | 0.1046 | |
| 160 | E | A | -1.4823 | |
| 161 | P | A | -0.2585 | |
| 162 | C | A | 0.1659 | |
| 163 | P | A | -0.1852 | |
| 164 | G | A | -0.0954 | |
| 165 | L | A | 0.5462 | |
| 166 | P | A | -0.1295 | |
| 167 | P | A | -0.3487 | |
| 168 | G | A | -0.4190 | |
| 169 | A | A | -0.0147 | |
| 170 | C | A | 0.7595 | |
| 171 | P | A | 0.5462 | |
| 172 | P | A | 0.8075 | |
| 173 | I | A | 2.0328 | |
| 174 | Q | A | 0.8324 | |
| 175 | L | A | 1.4235 | |
| 176 | V | A | 0.8060 | |
| 177 | N | A | -0.3484 | |
| 178 | S | A | -0.0099 | |
| 179 | V | A | 0.3651 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3596 | |
| 182 | D | A | 0.0797 | |
| 183 | G | A | -0.1581 | |
| 184 | D | A | -0.5787 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1555 | |
| 190 | F | A | 0.0628 | |
| 191 | G | A | -0.1094 | |
| 192 | N | A | -0.3023 | |
| 193 | M | A | -0.1756 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4149 | |
| 197 | E | A | -2.6024 | |
| 198 | L | A | -1.2046 | |
| 199 | Q | A | -2.5299 | |
| 200 | Q | A | -3.3411 | |
| 201 | D | A | -3.6011 | |
| 202 | R | A | -3.3420 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2215 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3808 | |
| 211 | S | A | -1.9071 | |
| 212 | T | A | -1.4821 | |
| 213 | R | A | -2.1969 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1817 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2587 | |
| 220 | L | A | 0.4423 | |
| 221 | K | A | -1.4256 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -1.0060 | |
| 224 | N | A | -1.7402 | |
| 225 | E | A | -1.3595 | |
| 226 | A | A | -0.6873 | |
| 227 | Y | A | -0.4585 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7241 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1423 | |
| 234 | F | A | 0.0244 | |
| 235 | G | A | -0.8992 | |
| 236 | R | A | -2.6097 | |
| 237 | R | A | -2.7935 | |
| 238 | E | A | -2.0436 | |
| 239 | Q | A | -0.0900 | |
| 240 | V | A | 1.5513 | |
| 241 | Y | A | 1.2300 | |
| 242 | A | A | 0.1380 | |
| 243 | R | A | -1.1959 | |
| 244 | H | A | -1.0858 | |
| 245 | F | A | -0.0596 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.5500 | |
| 249 | C | A | -0.8839 | |
| 250 | G | A | -0.9494 | |
| 251 | P | A | -0.9575 | |
| 252 | D | A | -1.4593 | |
| 253 | G | A | -1.3472 | |
| 254 | H | A | -1.4870 | |
| 255 | P | A | -0.9271 | |
| 256 | L | A | 0.0978 | |
| 257 | P | A | -0.5515 | |
| 258 | S | A | -0.8403 | |
| 259 | D | A | -2.2090 | |
| 260 | P | A | -1.6729 | |
| 261 | P | A | -1.1016 | |
| 262 | P | A | -0.4045 | |
| 263 | P | A | -0.0751 | |
| 264 | P | A | 0.4049 | |
| 265 | L | A | 1.9002 | |
| 266 | Y | A | 1.7647 | |
| 267 | V | A | 1.9229 | |
| 268 | P | A | 1.1165 | |
| 269 | P | A | 0.6669 | |
| 270 | P | A | -0.1319 | |
| 271 | P | A | -0.0813 | |
| 272 | T | A | -0.1721 | |
| 273 | S | A | 0.2899 | |
| 274 | P | A | 0.5343 | |
| 275 | Y | A | 1.6051 | |
| 276 | A | A | 1.3437 | |
| 277 | V | A | 2.2586 | |
| 278 | L | A | 1.7107 | |
| 279 | P | A | 0.5183 | |
| 280 | P | A | -0.2108 | |
| 281 | T | A | -0.4181 | |
| 282 | D | A | -0.9382 | |
| 283 | Y | A | 0.8551 | |
| 284 | F | A | 0.7081 | |
| 285 | G | A | 0.1105 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9413 | |
| 291 | L | A | 1.6512 | |
| 292 | V | A | 0.6673 | |
| 293 | S | A | -0.1431 | |
| 294 | S | A | -0.9684 | |
| 295 | D | A | -1.8377 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1211 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6471 | |
| 301 | R | A | -1.9209 | |
| 302 | P | A | -0.9835 | |
| 303 | F | A | -0.1940 | |
| 304 | W | A | -0.5226 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0804 | |
| 307 | R | A | -2.9194 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7835 | |
| 310 | G | A | -1.4217 | |
| 311 | N | A | -1.3984 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9581 | |
| 319 | N | A | -1.0230 | |
| 320 | E | A | -1.0634 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3496 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1444 | |
| 333 | N | A | 0.4366 | |
| 334 | F | A | 1.4937 | |
| 335 | T | A | 0.7412 | |
| 336 | I | A | 0.3725 | |
| 337 | S | A | -0.9890 | |
| 338 | Q | A | -1.7372 | |
| 339 | Q | A | -1.1645 | |
| 340 | L | A | 0.7068 | |
| 341 | C | A | 0.5977 | |
| 342 | T | A | 0.4234 | |
| 343 | P | A | 0.2152 | |
| 344 | L | A | 1.1486 | |
| 345 | P | A | 0.5720 | |
| 346 | N | A | -0.0023 | |
| 347 | V | A | 1.7101 | |
| 348 | Y | A | 1.6052 | |
| 349 | D | A | 0.2181 | |
| 350 | P | A | -0.3992 | |
| 351 | S | A | -0.3504 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7166 | |
| 354 | K | A | -1.8434 | |
| 355 | N | A | -1.7826 | |
| 356 | Y | A | -0.1063 | |
| 357 | L | A | 0.5729 | |
| 358 | R | A | 0.9113 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4878 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | 0.0152 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.8810 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6513 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2846 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3312 | |
| 376 | L | A | -1.7575 | |
| 377 | D | A | -2.0457 | |
| 378 | P | A | -1.0686 | |
| 379 | G | A | -1.0238 | |
| 380 | V | A | -0.9344 | |
| 381 | L | A | -0.5448 | |
| 382 | A | A | -0.6654 | |
| 383 | H | A | -0.8583 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4078 | |
| 386 | T | A | -0.5822 | |
| 387 | M | A | -0.3369 | |
| 388 | N | A | -0.8711 | |
| 389 | P | A | -1.2867 | |
| 390 | T | A | -1.5801 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5446 | |
| 393 | E | A | -2.9551 | |
| 394 | N | A | -2.7786 | |
| 395 | W | A | -1.5256 | |
| 396 | N | A | -1.1284 | |
| 397 | L | A | -0.1769 | |
| 398 | G | A | 0.5538 | |
| 399 | F | A | 2.4374 | |
| 400 | V | A | 1.8617 | |
| 401 | P | A | 0.0625 | |
| 402 | P | A | -1.9794 | |
| 403 | K | A | -3.5066 | |
| 404 | E | A | -4.0183 | |
| 405 | R | A | -4.4653 | |
| 406 | E | A | -4.0260 | |
| 407 | D | A | -2.9803 | |
| 408 | P | A | -1.8233 | |
| 409 | Y | A | -0.9914 | |
| 410 | K | A | -2.0963 | |
| 411 | G | A | -0.6356 | |
| 412 | L | A | 0.6569 | |
| 413 | I | A | 1.5846 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3632 | |
| 416 | E | A | -1.6089 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9250 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0750 | |
| 421 | E | A | -2.7923 | |
| 422 | R | A | -2.6595 | |
| 423 | F | A | -1.3077 | |
| 424 | S | A | -1.4709 | |
| 425 | Q | A | -1.9094 | |
| 426 | D | A | -2.8823 | |
| 427 | L | A | -1.9619 | |
| 428 | D | A | -2.7336 | |
| 429 | Q | A | -2.5887 | |
| 430 | F | A | -1.4075 | |
| 431 | A | A | -0.8707 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5088 | |
| 435 | K | A | -0.6810 | |
| 436 | F | A | 0.1794 | |
| 437 | L | A | 1.0565 | |
| 438 | Y | A | 0.8491 | |
| 439 | Q | A | -0.2571 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine