| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGSVGHPLFNKLGDTENPTEYQHETADVRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFFRRAGPDGHPLPDDPPPSPLYVPPPPDSPYAVLPSRDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPAPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9515 | |
| 2 | L | A | 1.9773 | |
| 3 | P | A | 0.6560 | |
| 4 | P | A | 0.3405 | |
| 5 | T | A | 0.0952 | |
| 6 | T | A | 0.1205 | |
| 7 | P | A | 0.1417 | |
| 8 | V | A | 1.2131 | |
| 9 | A | A | 0.0037 | |
| 10 | K | A | -1.1734 | |
| 11 | V | A | -0.4293 | |
| 12 | Q | A | -1.5623 | |
| 13 | S | A | -1.6293 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4405 | |
| 16 | E | A | -2.4502 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4535 | |
| 20 | P | A | 0.1277 | |
| 21 | T | A | 0.1620 | |
| 22 | S | A | -0.0994 | |
| 23 | L | A | 0.0958 | |
| 24 | F | A | -0.0313 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1596 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.6951 | |
| 31 | R | A | -2.5783 | |
| 32 | L | A | -0.7328 | |
| 33 | L | A | 1.1811 | |
| 34 | T | A | 1.3500 | |
| 35 | V | A | 1.7904 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2349 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6186 | |
| 40 | K | A | -1.6252 | |
| 41 | D | A | -0.8976 | |
| 42 | I | A | 0.8359 | |
| 43 | V | A | 1.0296 | |
| 44 | K | A | -1.1830 | |
| 45 | N | A | -1.9264 | |
| 46 | G | A | -1.2291 | |
| 47 | K | A | -0.9378 | |
| 48 | V | A | 1.5088 | |
| 49 | V | A | 2.0673 | |
| 50 | V | A | 1.2772 | |
| 51 | P | A | 0.4684 | |
| 52 | K | A | -0.6398 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1284 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3773 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.3007 | |
| 70 | K | A | -1.8175 | |
| 71 | F | A | -0.6759 | |
| 72 | A | A | -0.5897 | |
| 73 | L | A | -0.9269 | |
| 74 | P | A | -1.2529 | |
| 75 | Q | A | -2.4781 | |
| 76 | K | A | -3.0934 | |
| 77 | D | A | -2.9846 | |
| 78 | F | A | -1.6351 | |
| 79 | Y | A | -1.9051 | |
| 80 | D | A | -2.7535 | |
| 81 | P | A | -2.3528 | |
| 82 | E | A | -3.0735 | |
| 83 | K | A | -3.4495 | |
| 84 | E | A | -2.5107 | |
| 85 | R | A | -1.3147 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6638 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9446 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.2957 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6804 | |
| 99 | G | A | -0.5530 | |
| 100 | P | A | -0.4388 | |
| 101 | L | A | -0.0227 | |
| 102 | G | A | -0.2714 | |
| 103 | K | A | -0.7622 | |
| 104 | G | A | -0.5638 | |
| 105 | S | A | -0.6084 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1183 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4061 | |
| 110 | L | A | 0.3521 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9900 | |
| 113 | K | A | -0.3163 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.7094 | |
| 117 | T | A | -1.4897 | |
| 118 | E | A | -2.6243 | |
| 119 | N | A | -2.6178 | |
| 120 | P | A | -2.1339 | |
| 121 | T | A | -1.6844 | |
| 122 | E | A | -2.1664 | |
| 123 | Y | A | -0.4327 | |
| 124 | Q | A | -1.1634 | |
| 125 | H | A | -0.9008 | |
| 126 | E | A | -1.6213 | |
| 127 | T | A | -1.2218 | |
| 128 | A | A | -1.1865 | |
| 129 | D | A | -1.9136 | |
| 130 | V | A | -1.1434 | |
| 131 | R | A | -0.7586 | |
| 132 | V | A | 0.3714 | |
| 133 | A | A | 0.4349 | |
| 134 | F | A | 0.2935 | |
| 135 | S | A | -0.0968 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7958 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2487 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5652 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2736 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0751 | |
| 157 | D | A | 0.3130 | |
| 158 | I | A | 0.8278 | |
| 159 | A | A | 0.1085 | |
| 160 | E | A | -1.4789 | |
| 161 | P | A | -0.2440 | |
| 162 | C | A | 0.1743 | |
| 163 | P | A | -0.1777 | |
| 164 | G | A | -0.0824 | |
| 165 | L | A | 0.5720 | |
| 166 | P | A | -0.1194 | |
| 167 | P | A | -0.3440 | |
| 168 | G | A | -0.4155 | |
| 169 | A | A | -0.0168 | |
| 170 | C | A | 0.7498 | |
| 171 | P | A | 0.5415 | |
| 172 | P | A | 0.7728 | |
| 173 | I | A | 2.0208 | |
| 174 | Q | A | 0.8133 | |
| 175 | L | A | 1.4160 | |
| 176 | V | A | 0.8019 | |
| 177 | N | A | -0.3451 | |
| 178 | S | A | -0.0036 | |
| 179 | V | A | 0.3904 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3608 | |
| 182 | D | A | 0.0631 | |
| 183 | G | A | -0.1661 | |
| 184 | D | A | -0.6105 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.5018 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.0890 | |
| 190 | F | A | 0.0241 | |
| 191 | G | A | -0.1498 | |
| 192 | N | A | -0.3615 | |
| 193 | M | A | -0.2172 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4415 | |
| 197 | E | A | -2.6456 | |
| 198 | L | A | -1.2330 | |
| 199 | Q | A | -2.5420 | |
| 200 | Q | A | -3.3563 | |
| 201 | D | A | -3.6196 | |
| 202 | R | A | -3.3505 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2082 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3942 | |
| 211 | S | A | -1.9261 | |
| 212 | T | A | -1.5209 | |
| 213 | R | A | -2.2923 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2309 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2825 | |
| 220 | L | A | 0.4863 | |
| 221 | K | A | -1.3398 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9769 | |
| 224 | N | A | -1.7069 | |
| 225 | E | A | -1.3330 | |
| 226 | A | A | -0.6837 | |
| 227 | Y | A | -0.4570 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7116 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1430 | |
| 234 | F | A | 0.0298 | |
| 235 | G | A | -0.9503 | |
| 236 | R | A | -2.7355 | |
| 237 | R | A | -3.0761 | |
| 238 | E | A | -2.2389 | |
| 239 | Q | A | -0.1944 | |
| 240 | V | A | 1.5426 | |
| 241 | Y | A | 1.2636 | |
| 242 | A | A | 0.2001 | |
| 243 | R | A | -1.2923 | |
| 244 | H | A | -1.1524 | |
| 245 | F | A | -0.1330 | |
| 246 | F | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.9580 | |
| 249 | A | A | -1.2478 | |
| 250 | G | A | -1.3172 | |
| 251 | P | A | -1.2636 | |
| 252 | D | A | -1.5859 | |
| 253 | G | A | -1.4562 | |
| 254 | H | A | -1.6226 | |
| 255 | P | A | -1.4159 | |
| 256 | L | A | -0.6806 | |
| 257 | P | A | -1.2943 | |
| 258 | D | A | -2.7837 | |
| 259 | D | A | -2.9964 | |
| 260 | P | A | -2.1814 | |
| 261 | P | A | -1.0278 | |
| 262 | P | A | -0.5796 | |
| 263 | S | A | -0.2098 | |
| 264 | P | A | 0.5468 | |
| 265 | L | A | 1.6987 | |
| 266 | Y | A | 1.6461 | |
| 267 | V | A | 2.0276 | |
| 268 | P | A | 0.7928 | |
| 269 | P | A | 0.5275 | |
| 270 | P | A | -0.5971 | |
| 271 | P | A | -0.9040 | |
| 272 | D | A | -1.6887 | |
| 273 | S | A | -0.5146 | |
| 274 | P | A | 0.2822 | |
| 275 | Y | A | 1.4071 | |
| 276 | A | A | 1.0089 | |
| 277 | V | A | 2.0463 | |
| 278 | L | A | 1.5952 | |
| 279 | P | A | 0.1439 | |
| 280 | S | A | 0.0000 | |
| 281 | R | A | -1.0150 | |
| 282 | D | A | -1.3380 | |
| 283 | Y | A | 0.6578 | |
| 284 | F | A | 0.6265 | |
| 285 | G | A | 0.1742 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9316 | |
| 291 | L | A | 1.6259 | |
| 292 | V | A | 0.6288 | |
| 293 | S | A | -0.1631 | |
| 294 | S | A | -0.9748 | |
| 295 | D | A | -1.8416 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1437 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6013 | |
| 301 | R | A | -1.8036 | |
| 302 | P | A | -0.9257 | |
| 303 | F | A | -0.1657 | |
| 304 | W | A | -0.5144 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0851 | |
| 307 | R | A | -2.9300 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7848 | |
| 310 | G | A | -1.4265 | |
| 311 | N | A | -1.4148 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9871 | |
| 319 | N | A | -0.9077 | |
| 320 | E | A | -1.0629 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3803 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1346 | |
| 333 | N | A | 0.5304 | |
| 334 | F | A | 1.7435 | |
| 335 | T | A | 0.8781 | |
| 336 | I | A | 0.4678 | |
| 337 | S | A | -0.8277 | |
| 338 | Q | A | -1.4738 | |
| 339 | Q | A | -0.8523 | |
| 340 | L | A | 0.8110 | |
| 341 | C | A | 0.4519 | |
| 342 | T | A | 0.1612 | |
| 343 | P | A | -0.2740 | |
| 344 | A | A | 0.1271 | |
| 345 | P | A | 0.1561 | |
| 346 | N | A | -0.2734 | |
| 347 | V | A | 1.5502 | |
| 348 | Y | A | 1.4593 | |
| 349 | D | A | 0.0604 | |
| 350 | P | A | -0.3429 | |
| 351 | S | A | -0.2699 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5380 | |
| 354 | K | A | -1.6666 | |
| 355 | N | A | -1.6957 | |
| 356 | Y | A | -0.0403 | |
| 357 | L | A | 0.6629 | |
| 358 | R | A | 0.9568 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3421 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0307 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.8845 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6646 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3054 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3337 | |
| 376 | L | A | -1.7746 | |
| 377 | D | A | -2.0588 | |
| 378 | P | A | -1.0743 | |
| 379 | G | A | -1.0288 | |
| 380 | V | A | -0.9382 | |
| 381 | L | A | -0.5462 | |
| 382 | A | A | -0.6635 | |
| 383 | H | A | -0.8520 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4061 | |
| 386 | T | A | -0.5715 | |
| 387 | M | A | -0.3348 | |
| 388 | N | A | -0.8744 | |
| 389 | P | A | -1.3008 | |
| 390 | T | A | -1.6405 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5848 | |
| 393 | E | A | -3.2023 | |
| 394 | N | A | -2.8056 | |
| 395 | W | A | -1.5750 | |
| 396 | N | A | -1.1753 | |
| 397 | L | A | -0.2384 | |
| 398 | G | A | 0.5268 | |
| 399 | F | A | 2.4392 | |
| 400 | V | A | 2.0609 | |
| 401 | P | A | 0.0745 | |
| 402 | P | A | -1.9681 | |
| 403 | K | A | -3.5817 | |
| 404 | E | A | -4.1416 | |
| 405 | R | A | -4.7424 | |
| 406 | E | A | -4.1523 | |
| 407 | D | A | -3.0151 | |
| 408 | P | A | -1.8482 | |
| 409 | Y | A | -0.9672 | |
| 410 | K | A | -2.0993 | |
| 411 | G | A | -0.6203 | |
| 412 | L | A | 0.6761 | |
| 413 | I | A | 1.5783 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4057 | |
| 416 | E | A | -1.6836 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8490 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8982 | |
| 421 | E | A | -2.5072 | |
| 422 | R | A | -2.0763 | |
| 423 | F | A | -1.0245 | |
| 424 | S | A | -1.3086 | |
| 425 | Q | A | -1.7629 | |
| 426 | D | A | -2.8760 | |
| 427 | L | A | -1.9865 | |
| 428 | D | A | -2.7798 | |
| 429 | Q | A | -2.6069 | |
| 430 | F | A | -1.4376 | |
| 431 | A | A | -0.8991 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5834 | |
| 435 | K | A | -0.7291 | |
| 436 | F | A | 0.1465 | |
| 437 | L | A | 1.0278 | |
| 438 | Y | A | 0.8205 | |
| 439 | Q | A | -0.2680 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine