| Chain sequence(s) |
A: GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL
B: GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS input PDB |
| Selected Chain(s) | A,B |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:50)
[INFO] Main: Simulation completed successfully. (00:05:52)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 237 | G | A | -1.0560 | |
| 238 | P | A | 0.0000 | |
| 239 | S | A | -0.2955 | |
| 240 | V | A | 0.0000 | |
| 241 | F | A | 1.2956 | |
| 242 | L | A | 0.9758 | |
| 243 | F | A | 1.2068 | |
| 244 | P | A | -0.1148 | |
| 245 | P | A | 0.0000 | |
| 246 | K | A | -2.0858 | |
| 247 | P | A | -1.5597 | |
| 248 | K | A | -1.1936 | |
| 249 | D | A | -1.1677 | |
| 250 | T | A | 0.0000 | |
| 251 | L | A | 0.0000 | |
| 252 | M | A | 0.3202 | |
| 253 | I | A | 1.5084 | |
| 254 | S | A | 0.1277 | |
| 255 | R | A | -1.0268 | |
| 256 | T | A | -0.6261 | |
| 257 | P | A | 0.0000 | |
| 258 | E | A | -0.7580 | |
| 259 | V | A | 0.0000 | |
| 260 | T | A | 0.3589 | |
| 261 | C | A | 0.0000 | |
| 262 | V | A | 0.0000 | |
| 263 | V | A | 0.0000 | |
| 264 | V | A | -1.0570 | |
| 265 | D | A | -2.4278 | |
| 266 | V | A | 0.0000 | |
| 267 | S | A | -2.5444 | |
| 268 | H | A | -2.7442 | |
| 269 | E | A | -3.0094 | |
| 270 | D | A | -2.7104 | |
| 271 | P | A | -2.6466 | |
| 272 | E | A | -3.0708 | |
| 273 | V | A | -1.9642 | |
| 274 | K | A | -2.1716 | |
| 275 | F | A | -1.1176 | |
| 276 | N | A | -1.1353 | |
| 277 | W | A | 0.0000 | |
| 278 | Y | A | -0.5640 | |
| 279 | V | A | -0.8388 | |
| 280 | D | A | -1.9111 | |
| 281 | G | A | -0.7458 | |
| 282 | V | A | 0.6663 | |
| 283 | E | A | -0.5953 | |
| 284 | V | A | -0.4615 | |
| 285 | H | A | -1.8461 | |
| 286 | N | A | -2.1682 | |
| 287 | A | A | -1.7959 | |
| 288 | K | A | -2.2748 | |
| 289 | T | A | -1.7829 | |
| 290 | K | A | -2.1107 | |
| 291 | P | A | -2.0098 | |
| 292 | R | A | -3.2893 | |
| 293 | E | A | -3.6643 | |
| 294 | E | A | -3.5687 | |
| 295 | Q | A | -1.9443 | |
| 296 | Y | A | -0.0826 | |
| 297 | N | A | -1.3382 | |
| 298 | S | A | -1.6602 | |
| 299 | T | A | -2.2168 | |
| 300 | Y | A | -2.9363 | |
| 301 | R | A | -2.6133 | |
| 302 | V | A | 0.0000 | |
| 303 | V | A | -0.6983 | |
| 304 | S | A | 0.0000 | |
| 305 | V | A | 0.0000 | |
| 306 | L | A | 0.0000 | |
| 307 | T | A | -0.4474 | |
| 308 | V | A | 0.0000 | |
| 309 | L | A | 0.9219 | |
| 310 | H | A | -0.0816 | |
| 311 | Q | A | -1.0920 | |
| 312 | D | A | -1.4987 | |
| 313 | W | A | 0.0000 | |
| 314 | L | A | -1.1202 | |
| 315 | N | A | -2.0276 | |
| 316 | G | A | -2.2569 | |
| 317 | K | A | -2.3168 | |
| 318 | E | A | -2.2668 | |
| 319 | Y | A | 0.0000 | |
| 320 | K | A | -1.6545 | |
| 321 | C | A | 0.0000 | |
| 322 | K | A | -1.5526 | |
| 323 | V | A | 0.0000 | |
| 324 | S | A | -1.4510 | |
| 325 | N | A | 0.0000 | |
| 326 | K | A | -2.6013 | |
| 327 | A | A | -1.5194 | |
| 328 | L | A | -0.6026 | |
| 329 | P | A | -0.4779 | |
| 330 | A | A | -0.3983 | |
| 331 | P | A | -0.8363 | |
| 332 | I | A | -0.7482 | |
| 333 | E | A | -1.9359 | |
| 334 | K | A | -1.2545 | |
| 335 | T | A | -1.0356 | |
| 336 | I | A | -0.3224 | |
| 337 | S | A | -1.0865 | |
| 338 | K | A | -1.5117 | |
| 339 | A | A | -1.3663 | |
| 340 | K | A | -2.2271 | |
| 341 | G | A | -1.9079 | |
| 342 | Q | A | -1.9155 | |
| 343 | P | A | -1.7256 | |
| 344 | R | A | -1.8977 | |
| 345 | E | A | -2.2669 | |
| 346 | P | A | 0.0000 | |
| 347 | Q | A | -1.0872 | |
| 348 | V | A | 0.0000 | |
| 349 | Y | A | 0.0000 | |
| 350 | T | A | -0.8266 | |
| 351 | L | A | 0.0000 | |
| 352 | P | A | -0.2091 | |
| 353 | P | A | -0.7501 | |
| 354 | S | A | 0.0000 | |
| 355 | R | A | -2.6752 | |
| 356 | D | A | -2.7807 | |
| 357 | E | A | 0.0000 | |
| 358 | L | A | -1.6952 | |
| 359 | T | A | -1.4513 | |
| 360 | K | A | -1.9788 | |
| 361 | N | A | -2.3561 | |
| 362 | Q | A | -2.1553 | |
| 363 | V | A | 0.0000 | |
| 364 | S | A | 0.0000 | |
| 365 | L | A | 0.0000 | |
| 366 | T | A | 0.0000 | |
| 367 | C | A | 0.0000 | |
| 368 | L | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | K | A | -0.4812 | |
| 371 | G | A | -0.9435 | |
| 372 | F | A | 0.0000 | |
| 373 | Y | A | -1.1436 | |
| 374 | P | A | 0.0000 | |
| 375 | S | A | -0.6473 | |
| 376 | D | A | -1.9781 | |
| 377 | I | A | -0.9551 | |
| 378 | A | A | -0.6220 | |
| 379 | V | A | 0.0000 | |
| 380 | E | A | -1.2060 | |
| 381 | W | A | 0.0000 | |
| 382 | E | A | -1.7961 | |
| 383 | S | A | 0.0000 | |
| 384 | N | A | -1.8520 | |
| 385 | G | A | -1.8984 | |
| 386 | Q | A | -2.3383 | |
| 387 | P | A | -2.0218 | |
| 388 | E | A | -1.9208 | |
| 389 | N | A | -2.0849 | |
| 390 | N | A | -1.4888 | |
| 391 | Y | A | -0.9826 | |
| 392 | K | A | -0.7398 | |
| 393 | T | A | -0.2398 | |
| 394 | T | A | 0.0000 | |
| 395 | P | A | -0.0816 | |
| 396 | P | A | -0.0462 | |
| 397 | V | A | 0.4724 | |
| 398 | L | A | 0.6864 | |
| 399 | D | A | -0.5614 | |
| 400 | S | A | -1.1721 | |
| 401 | D | A | -1.8794 | |
| 402 | G | A | -0.8353 | |
| 403 | S | A | 0.0000 | |
| 404 | F | A | 0.0116 | |
| 405 | F | A | 0.0000 | |
| 406 | L | A | 0.0000 | |
| 407 | Y | A | 0.0000 | |
| 408 | S | A | 0.0000 | |
| 409 | K | A | 0.0000 | |
| 410 | L | A | 0.0000 | |
| 411 | T | A | -0.9112 | |
| 412 | V | A | 0.0000 | |
| 413 | D | A | -2.4616 | |
| 414 | K | A | -2.5039 | |
| 415 | S | A | -2.2152 | |
| 416 | R | A | -1.8654 | |
| 417 | W | A | 0.0000 | |
| 418 | Q | A | -2.0592 | |
| 419 | Q | A | -1.9133 | |
| 420 | G | A | -0.7311 | |
| 421 | N | A | -0.4125 | |
| 422 | V | A | 0.7855 | |
| 423 | F | A | 0.0000 | |
| 424 | S | A | -0.8490 | |
| 425 | C | A | 0.0000 | |
| 426 | S | A | 0.0000 | |
| 427 | V | A | 0.0000 | |
| 428 | M | A | 0.0000 | |
| 429 | H | A | 0.0000 | |
| 430 | E | A | -1.2458 | |
| 431 | A | A | -1.4991 | |
| 432 | L | A | 0.0000 | |
| 433 | H | A | -1.8366 | |
| 434 | N | A | -1.7308 | |
| 435 | H | A | -1.2081 | |
| 436 | Y | A | -0.6013 | |
| 437 | T | A | -0.9401 | |
| 438 | Q | A | -1.4845 | |
| 439 | K | A | -1.2000 | |
| 440 | S | A | -0.5205 | |
| 441 | L | A | 0.0000 | |
| 442 | S | A | 0.5830 | |
| 443 | L | A | 1.0271 | |
| 237 | G | B | -0.7692 | |
| 238 | P | B | -0.8507 | |
| 239 | S | B | -0.2822 | |
| 240 | V | B | 0.0000 | |
| 241 | F | B | 1.2060 | |
| 242 | L | B | 0.8822 | |
| 243 | F | B | 1.1981 | |
| 244 | P | B | -0.1098 | |
| 245 | P | B | 0.0000 | |
| 246 | K | B | -2.1580 | |
| 247 | P | B | -1.3624 | |
| 248 | K | B | -1.0677 | |
| 249 | D | B | -1.1971 | |
| 250 | T | B | 0.0000 | |
| 251 | L | B | 0.0000 | |
| 252 | M | B | 0.4423 | |
| 253 | I | B | 1.4934 | |
| 254 | S | B | 0.0984 | |
| 255 | R | B | -1.2401 | |
| 256 | T | B | -0.6959 | |
| 257 | P | B | 0.0000 | |
| 258 | E | B | -0.8092 | |
| 259 | V | B | 0.0000 | |
| 260 | T | B | 0.2786 | |
| 261 | C | B | 0.0000 | |
| 262 | V | B | 0.0000 | |
| 263 | V | B | 0.0000 | |
| 264 | V | B | -1.1848 | |
| 265 | D | B | -2.2632 | |
| 266 | V | B | 0.0000 | |
| 267 | S | B | -2.2763 | |
| 268 | H | B | -2.3556 | |
| 269 | E | B | -2.7502 | |
| 270 | D | B | -2.4713 | |
| 271 | P | B | -2.4463 | |
| 272 | E | B | -3.0006 | |
| 273 | V | B | -1.9176 | |
| 274 | K | B | -2.2113 | |
| 275 | F | B | -1.2394 | |
| 276 | N | B | -1.1162 | |
| 277 | W | B | 0.0000 | |
| 278 | Y | B | -0.5214 | |
| 279 | V | B | -0.8349 | |
| 280 | D | B | -2.0621 | |
| 281 | G | B | -0.7755 | |
| 282 | V | B | 0.8634 | |
| 283 | E | B | -0.3873 | |
| 284 | V | B | -0.3765 | |
| 285 | H | B | -1.8075 | |
| 286 | N | B | -2.1544 | |
| 287 | A | B | -1.7417 | |
| 288 | K | B | -2.3888 | |
| 289 | T | B | -1.7751 | |
| 290 | K | B | -2.0901 | |
| 291 | P | B | -2.0919 | |
| 292 | R | B | -3.0484 | |
| 293 | E | B | -3.4867 | |
| 294 | E | B | -3.3788 | |
| 295 | Q | B | -1.8329 | |
| 296 | Y | B | -0.0419 | |
| 297 | N | B | -1.2662 | |
| 298 | S | B | -1.3065 | |
| 299 | T | B | -2.1831 | |
| 300 | Y | B | -2.7489 | |
| 301 | R | B | -2.6932 | |
| 302 | V | B | 0.0000 | |
| 303 | V | B | -0.8344 | |
| 304 | S | B | 0.0000 | |
| 305 | V | B | 0.0000 | |
| 306 | L | B | 0.0000 | |
| 307 | T | B | -0.4863 | |
| 308 | V | B | 0.0000 | |
| 309 | L | B | 0.9697 | |
| 310 | H | B | -0.0312 | |
| 311 | Q | B | -1.0950 | |
| 312 | D | B | -1.4261 | |
| 313 | W | B | 0.0000 | |
| 314 | L | B | -1.2874 | |
| 315 | N | B | -2.0202 | |
| 316 | G | B | -2.2963 | |
| 317 | K | B | -2.3441 | |
| 318 | E | B | -2.4992 | |
| 319 | Y | B | 0.0000 | |
| 320 | K | B | -1.7254 | |
| 321 | C | B | 0.0000 | |
| 322 | K | B | -1.6357 | |
| 323 | V | B | 0.0000 | |
| 324 | S | B | -1.4776 | |
| 325 | N | B | 0.0000 | |
| 326 | K | B | -2.5489 | |
| 327 | A | B | -1.4335 | |
| 328 | L | B | -0.5422 | |
| 329 | P | B | -0.4880 | |
| 330 | A | B | -0.4172 | |
| 331 | P | B | -0.9651 | |
| 332 | I | B | -0.9110 | |
| 333 | E | B | -2.1930 | |
| 334 | K | B | -1.3880 | |
| 335 | T | B | -1.1111 | |
| 336 | I | B | -0.3258 | |
| 337 | S | B | -1.2829 | |
| 338 | K | B | -1.4530 | |
| 339 | A | B | -1.1387 | |
| 340 | K | B | -2.1628 | |
| 341 | G | B | -1.9485 | |
| 342 | Q | B | -2.0981 | |
| 343 | P | B | -2.2338 | |
| 344 | R | B | -2.9978 | |
| 345 | E | B | -2.8667 | |
| 346 | P | B | 0.0000 | |
| 347 | Q | B | -1.3141 | |
| 348 | V | B | 0.0000 | |
| 349 | Y | B | 0.0000 | |
| 350 | T | B | -0.8350 | |
| 351 | L | B | 0.0000 | |
| 352 | P | B | -0.3923 | |
| 353 | P | B | -0.9015 | |
| 354 | S | B | -1.5788 | |
| 355 | R | B | -2.6992 | |
| 356 | D | B | -2.8021 | |
| 357 | E | B | 0.0000 | |
| 358 | L | B | -1.7795 | |
| 359 | T | B | -1.4982 | |
| 360 | K | B | -2.0544 | |
| 361 | N | B | -2.3777 | |
| 362 | Q | B | -2.1656 | |
| 363 | V | B | 0.0000 | |
| 364 | S | B | 0.0000 | |
| 365 | L | B | 0.0000 | |
| 366 | T | B | 0.0000 | |
| 367 | C | B | 0.0000 | |
| 368 | L | B | 0.0000 | |
| 369 | V | B | 0.0000 | |
| 370 | K | B | -0.5364 | |
| 371 | G | B | -1.1316 | |
| 372 | F | B | 0.0000 | |
| 373 | Y | B | -1.3215 | |
| 374 | P | B | 0.0000 | |
| 375 | S | B | -0.5524 | |
| 376 | D | B | -1.1725 | |
| 377 | I | B | -0.5845 | |
| 378 | A | B | 0.0000 | |
| 379 | V | B | 0.0000 | |
| 380 | E | B | -1.3037 | |
| 381 | W | B | 0.0000 | |
| 382 | E | B | -1.9975 | |
| 383 | S | B | 0.0000 | |
| 384 | N | B | -1.8350 | |
| 385 | G | B | -1.7930 | |
| 386 | Q | B | -2.3434 | |
| 387 | P | B | -2.1043 | |
| 388 | E | B | -2.0453 | |
| 389 | N | B | -2.2985 | |
| 390 | N | B | -1.7056 | |
| 391 | Y | B | -1.1392 | |
| 392 | K | B | -0.9168 | |
| 393 | T | B | -0.3090 | |
| 394 | T | B | 0.0000 | |
| 395 | P | B | -0.0720 | |
| 396 | P | B | 0.1606 | |
| 397 | V | B | 0.6582 | |
| 398 | L | B | 1.0264 | |
| 399 | D | B | -0.3678 | |
| 400 | S | B | -1.0935 | |
| 401 | D | B | -1.8466 | |
| 402 | G | B | -0.7886 | |
| 403 | S | B | -0.7149 | |
| 404 | F | B | 0.1518 | |
| 405 | F | B | 0.0000 | |
| 406 | L | B | 0.0000 | |
| 407 | Y | B | 0.0000 | |
| 408 | S | B | 0.0000 | |
| 409 | K | B | 0.0000 | |
| 410 | L | B | 0.0000 | |
| 411 | T | B | -0.9121 | |
| 412 | V | B | 0.0000 | |
| 413 | D | B | -2.3449 | |
| 414 | K | B | -2.4736 | |
| 415 | S | B | -2.1446 | |
| 416 | R | B | -1.9426 | |
| 417 | W | B | 0.0000 | |
| 418 | Q | B | -2.2377 | |
| 419 | Q | B | -2.0676 | |
| 420 | G | B | -1.0537 | |
| 421 | N | B | -0.6534 | |
| 422 | V | B | 0.4472 | |
| 423 | F | B | 0.0000 | |
| 424 | S | B | 0.0000 | |
| 425 | C | B | 0.0000 | |
| 426 | S | B | 0.0000 | |
| 427 | V | B | 0.0000 | |
| 428 | M | B | 0.0000 | |
| 429 | H | B | 0.0000 | |
| 430 | E | B | -1.2763 | |
| 431 | A | B | -1.7794 | |
| 432 | L | B | 0.0000 | |
| 433 | H | B | -1.7972 | |
| 434 | N | B | -1.6527 | |
| 435 | H | B | -0.8942 | |
| 436 | Y | B | -0.3732 | |
| 437 | T | B | -0.8284 | |
| 438 | Q | B | -1.4435 | |
| 439 | K | B | -1.2963 | |
| 440 | S | B | -0.5899 | |
| 441 | L | B | 0.0000 | |
| 442 | S | B | -0.0032 | |
| 443 | L | B | -0.1454 | |
| 444 | S | B | -0.3407 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine