| Chain sequence(s) |
A: GPGPLNPGPELRSTDDYVEPTNLLYVAETDLITREGHPFKDIVVDGKVLVERVSAYQYRVFLLKLPDPNKLPLPSSDFLDPSTEIAIWRLRAFKIHRFGPLGKGTYGHPNFNRLGDVTNPTEPVHGTEDMTVNLSFTPKRKQEFIIGDEPPLGVYTTKAEPEPGLAPGALPPLKKTTDIIEDGDMADIGFGAKDFKELDPSKNNVPDIILDTVTKVFDYEGMLAEPYGRRMFTHDSYEQSYDSRKYVLNGPDLIPLPDSPPPSKLYVKPPPSSPYYVRPPTNYFSLPDRGEIKESDLLFNRPYFLEKTRGLNNGVLWYNRLYITVLDNTRDEIETIETQISTPEINVYDPSNYVTSKRYKEEYKLSLIVQLCKIPLTPEILAELERLDPRILTDSNLPDIPPVERPDPLAGKKFLEIDLTNKLSSNLEETDLGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:02)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.7594 | |
| 2 | P | A | -0.5049 | |
| 3 | G | A | -0.6259 | |
| 4 | P | A | -0.2667 | |
| 5 | L | A | 0.5042 | |
| 6 | N | A | -0.9635 | |
| 7 | P | A | -1.0747 | |
| 8 | G | A | -1.1945 | |
| 9 | P | A | -1.5307 | |
| 10 | E | A | -2.0443 | |
| 11 | L | A | -0.9424 | |
| 12 | R | A | -2.0146 | |
| 13 | S | A | -1.5766 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.7962 | |
| 16 | D | A | -2.9308 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.1555 | |
| 20 | P | A | -1.3941 | |
| 21 | T | A | -0.9609 | |
| 22 | N | A | -1.0792 | |
| 23 | L | A | -0.2104 | |
| 24 | L | A | -0.0417 | |
| 25 | Y | A | -0.0510 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.0745 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2258 | |
| 31 | L | A | 0.5296 | |
| 32 | I | A | 0.3695 | |
| 33 | T | A | -0.5704 | |
| 34 | R | A | -1.5853 | |
| 35 | E | A | -2.7795 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -2.0027 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -1.1242 | |
| 40 | K | A | -2.1070 | |
| 41 | D | A | -1.2526 | |
| 42 | I | A | 0.9324 | |
| 43 | V | A | 1.9339 | |
| 44 | V | A | 1.4392 | |
| 45 | D | A | -1.0293 | |
| 46 | G | A | -0.6263 | |
| 47 | K | A | -0.3156 | |
| 48 | V | A | 1.4167 | |
| 49 | L | A | 2.0749 | |
| 50 | V | A | 0.2244 | |
| 51 | E | A | -1.5339 | |
| 52 | R | A | -1.9767 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -1.9852 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3739 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.6113 | |
| 70 | K | A | -1.8935 | |
| 71 | L | A | -0.7429 | |
| 72 | P | A | -0.3901 | |
| 73 | L | A | -0.1918 | |
| 74 | P | A | -0.2490 | |
| 75 | S | A | -0.6736 | |
| 76 | S | A | -1.1694 | |
| 77 | D | A | -2.0147 | |
| 78 | F | A | -0.9857 | |
| 79 | L | A | 0.0000 | |
| 80 | D | A | -1.8523 | |
| 81 | P | A | -1.2279 | |
| 82 | S | A | -0.8221 | |
| 83 | T | A | -0.7035 | |
| 84 | E | A | -0.9215 | |
| 85 | I | A | 0.0000 | |
| 86 | A | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.7064 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.2979 | |
| 97 | R | A | 0.0000 | |
| 98 | F | A | 0.5611 | |
| 99 | G | A | -0.3008 | |
| 100 | P | A | -0.2756 | |
| 101 | L | A | -0.3194 | |
| 102 | G | A | -0.8906 | |
| 103 | K | A | -1.8327 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5867 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.7609 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.4085 | |
| 110 | N | A | -2.0172 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1788 | |
| 113 | R | A | -0.7970 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.0950 | |
| 117 | V | A | -0.5782 | |
| 118 | T | A | -1.2974 | |
| 119 | N | A | -1.8723 | |
| 120 | P | A | -1.2714 | |
| 121 | T | A | -1.2987 | |
| 122 | E | A | -2.0727 | |
| 123 | P | A | -0.7305 | |
| 124 | V | A | -0.4731 | |
| 125 | H | A | -0.7008 | |
| 126 | G | A | -1.0679 | |
| 127 | T | A | -1.4210 | |
| 128 | E | A | -2.6873 | |
| 129 | D | A | -2.5698 | |
| 130 | M | A | -0.8999 | |
| 131 | T | A | -1.1659 | |
| 132 | V | A | -0.7927 | |
| 133 | N | A | -1.5413 | |
| 134 | L | A | -0.7817 | |
| 135 | S | A | -0.5113 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.5846 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.2824 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.2644 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | 0.0000 | |
| 155 | Y | A | -0.7721 | |
| 156 | T | A | -1.1923 | |
| 157 | T | A | -1.5995 | |
| 158 | K | A | -1.7427 | |
| 159 | A | A | -1.9193 | |
| 160 | E | A | -2.5502 | |
| 161 | P | A | -1.7014 | |
| 162 | E | A | -2.3540 | |
| 163 | P | A | -1.3783 | |
| 164 | G | A | -0.6397 | |
| 165 | L | A | 0.2302 | |
| 166 | A | A | 0.3105 | |
| 167 | P | A | -0.0753 | |
| 168 | G | A | 0.2035 | |
| 169 | A | A | 1.1936 | |
| 170 | L | A | 1.8925 | |
| 171 | P | A | 0.0997 | |
| 172 | P | A | -0.2309 | |
| 173 | L | A | -0.1193 | |
| 174 | K | A | -2.0162 | |
| 175 | K | A | -2.2031 | |
| 176 | T | A | -1.3966 | |
| 177 | T | A | -0.8538 | |
| 178 | D | A | -0.7420 | |
| 179 | I | A | -0.5683 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.1533 | |
| 182 | D | A | -1.1268 | |
| 183 | G | A | -0.6785 | |
| 184 | D | A | -0.6085 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3589 | |
| 190 | F | A | -0.0313 | |
| 191 | G | A | -0.1795 | |
| 192 | A | A | -0.2536 | |
| 193 | K | A | -1.1333 | |
| 194 | D | A | -1.4022 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.1059 | |
| 197 | E | A | -2.5012 | |
| 198 | L | A | -1.1113 | |
| 199 | D | A | 0.0000 | |
| 200 | P | A | -1.5892 | |
| 201 | S | A | -1.1841 | |
| 202 | K | A | -2.2646 | |
| 203 | N | A | -1.5546 | |
| 204 | N | A | -1.1087 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.5103 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.4831 | |
| 211 | D | A | -2.3029 | |
| 212 | T | A | -1.1648 | |
| 213 | V | A | -0.5180 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.4079 | |
| 217 | F | A | 0.0000 | |
| 218 | D | A | -0.4030 | |
| 219 | Y | A | -0.4059 | |
| 220 | E | A | -1.4412 | |
| 221 | G | A | -0.7534 | |
| 222 | M | A | 0.0000 | |
| 223 | L | A | -0.1078 | |
| 224 | A | A | -0.2141 | |
| 225 | E | A | -0.4072 | |
| 226 | P | A | -0.3479 | |
| 227 | Y | A | -0.1891 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.1899 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.8093 | |
| 234 | H | A | -0.5307 | |
| 235 | D | A | -0.6900 | |
| 236 | S | A | -0.6916 | |
| 237 | Y | A | -0.7954 | |
| 238 | E | A | -1.7985 | |
| 239 | Q | A | -1.1613 | |
| 240 | S | A | -0.7326 | |
| 241 | Y | A | -0.3182 | |
| 242 | D | A | -2.1196 | |
| 243 | S | A | -1.8299 | |
| 244 | R | A | -2.6191 | |
| 245 | K | A | -2.0941 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | 0.0313 | |
| 249 | N | A | -0.8839 | |
| 250 | G | A | -0.9113 | |
| 251 | P | A | -0.0067 | |
| 252 | D | A | 0.7172 | |
| 253 | L | A | 2.3746 | |
| 254 | I | A | 2.5367 | |
| 255 | P | A | 0.7068 | |
| 256 | L | A | 0.5513 | |
| 257 | P | A | -0.6729 | |
| 258 | D | A | -1.6237 | |
| 259 | S | A | -1.1420 | |
| 260 | P | A | -1.0548 | |
| 261 | P | A | -0.6266 | |
| 262 | P | A | -0.4255 | |
| 263 | S | A | -0.5606 | |
| 264 | K | A | -0.7703 | |
| 265 | L | A | 0.9013 | |
| 266 | Y | A | 1.0007 | |
| 267 | V | A | 1.2197 | |
| 268 | K | A | 0.2234 | |
| 269 | P | A | 0.3722 | |
| 270 | P | A | -0.0194 | |
| 271 | P | A | -0.0643 | |
| 272 | S | A | -0.2580 | |
| 273 | S | A | 0.2339 | |
| 274 | P | A | 0.1372 | |
| 275 | Y | A | 1.0883 | |
| 276 | Y | A | 1.1739 | |
| 277 | V | A | 1.4261 | |
| 278 | R | A | 0.1126 | |
| 279 | P | A | -0.0501 | |
| 280 | P | A | -0.2151 | |
| 281 | T | A | -0.0350 | |
| 282 | N | A | 0.3097 | |
| 283 | Y | A | 1.0045 | |
| 284 | F | A | 0.0317 | |
| 285 | S | A | -0.9793 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.1689 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.4106 | |
| 291 | E | A | -2.3832 | |
| 292 | I | A | -2.0587 | |
| 293 | K | A | -3.0140 | |
| 294 | E | A | -2.7034 | |
| 295 | S | A | -1.7837 | |
| 296 | D | A | -1.6567 | |
| 297 | L | A | 0.0000 | |
| 298 | L | A | -0.6804 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1372 | |
| 301 | R | A | -1.4354 | |
| 302 | P | A | -0.5741 | |
| 303 | Y | A | -0.1866 | |
| 304 | F | A | -0.3893 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.5792 | |
| 307 | K | A | -3.1179 | |
| 308 | T | A | 0.0000 | |
| 309 | R | A | -2.0369 | |
| 310 | G | A | -1.0003 | |
| 311 | L | A | -0.9375 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | Y | A | -0.5571 | |
| 319 | N | A | -0.7109 | |
| 320 | R | A | -0.8140 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | D | A | 0.0000 | |
| 332 | E | A | -2.0472 | |
| 333 | I | A | -1.4754 | |
| 334 | E | A | -1.8385 | |
| 335 | T | A | -0.9100 | |
| 336 | I | A | -0.0039 | |
| 337 | E | A | -0.9290 | |
| 338 | T | A | 0.0079 | |
| 339 | Q | A | 0.2342 | |
| 340 | I | A | 1.6934 | |
| 341 | S | A | 0.4159 | |
| 342 | T | A | -0.2591 | |
| 343 | P | A | -1.0216 | |
| 344 | E | A | -1.8062 | |
| 345 | I | A | -0.4205 | |
| 346 | N | A | -0.4935 | |
| 347 | V | A | 1.4905 | |
| 348 | Y | A | 1.4892 | |
| 349 | D | A | -0.1026 | |
| 350 | P | A | 0.0645 | |
| 351 | S | A | 0.0159 | |
| 352 | N | A | 0.2662 | |
| 353 | Y | A | 0.7108 | |
| 354 | V | A | 1.2686 | |
| 355 | T | A | 0.0175 | |
| 356 | S | A | -0.3977 | |
| 357 | K | A | -1.0036 | |
| 358 | R | A | -1.5935 | |
| 359 | Y | A | 0.0000 | |
| 360 | K | A | -2.2696 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.2695 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.3300 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.2516 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -1.0347 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7523 | |
| 376 | L | A | -0.3954 | |
| 377 | T | A | -0.6094 | |
| 378 | P | A | -0.9564 | |
| 379 | E | A | -1.8875 | |
| 380 | I | A | 0.0000 | |
| 381 | L | A | -0.6757 | |
| 382 | A | A | -1.1702 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -1.9166 | |
| 386 | R | A | -1.8313 | |
| 387 | L | A | -0.9469 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.1508 | |
| 390 | R | A | -1.6037 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | T | A | -1.5083 | |
| 394 | D | A | -1.9554 | |
| 395 | S | A | -1.5272 | |
| 396 | N | A | -2.1235 | |
| 397 | L | A | -1.3949 | |
| 398 | P | A | -1.3104 | |
| 399 | D | A | -1.8422 | |
| 400 | I | A | -0.6362 | |
| 401 | P | A | -0.4860 | |
| 402 | P | A | -0.8686 | |
| 403 | V | A | -0.0965 | |
| 404 | E | A | -2.2806 | |
| 405 | R | A | -2.7742 | |
| 406 | P | A | -2.2088 | |
| 407 | D | A | -2.6977 | |
| 408 | P | A | -1.5323 | |
| 409 | L | A | 0.0000 | |
| 410 | A | A | -1.2687 | |
| 411 | G | A | -1.3270 | |
| 412 | K | A | -1.5813 | |
| 413 | K | A | -2.3147 | |
| 414 | F | A | -1.3190 | |
| 415 | L | A | -1.0671 | |
| 416 | E | A | -2.3477 | |
| 417 | I | A | -1.8772 | |
| 418 | D | A | -2.7498 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.5802 | |
| 421 | N | A | -1.8169 | |
| 422 | K | A | -1.6391 | |
| 423 | L | A | -0.5705 | |
| 424 | S | A | -1.0545 | |
| 425 | S | A | -0.8688 | |
| 426 | N | A | -2.1569 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.4268 | |
| 429 | E | A | -3.5138 | |
| 430 | T | A | -2.4022 | |
| 431 | D | A | -1.9834 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.7325 | |
| 435 | L | A | -1.1447 | |
| 436 | Y | A | -0.6956 | |
| 437 | L | A | -0.5079 | |
| 438 | N | A | -1.7122 | |
| 439 | R | A | -1.9953 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine