Project name: 1RZ7

Chain sequence(s)	H: EVQLVQSGAEVKKPGATVKISCKASGYTFSDFYMYWVRQAPGKGLEWMGLIDPEDADTMYAEKFRGRVTITADTSTDTGYLELSSLRSEDTAVYYCAADPWELNAFNVWGQGTLVTVSS; L: DIQMTQSPSSVSASVGDRVTITCRASQDISTWLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFSLTINSLQPEDFATYYCQQANSFFTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:08)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:09)

• Minimal score value: -3.333
• Maximal score value: 1.0146
• Average score: -0.6808
• Total score value: -153.1868

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0455
2	V	H	-1.1661
3	Q	H	-1.0643
4	L	H	0.0000
5	V	H	0.6257
6	Q	H	0.0000
7	S	H	-0.3714
8	G	H	-0.4168
9	A	H	0.2897
11	E	H	0.1264
12	V	H	1.0146
13	K	H	-0.9343
14	K	H	-2.1181
15	P	H	-2.1240
16	G	H	-1.4795
17	A	H	-1.1402
18	T	H	-1.2155
19	V	H	0.0000
20	K	H	-1.8973
21	I	H	0.0000
22	S	H	-0.4151
23	C	H	0.0000
24	K	H	-0.5653
25	A	H	0.0000
26	S	H	-0.9127
27	G	H	-1.1458
28	Y	H	-0.6476
29	T	H	-0.6937
30	F	H	0.0000
35	S	H	-1.8608
36	D	H	-2.1031
37	F	H	-0.7240
38	Y	H	-0.4586
39	M	H	0.0000
40	Y	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6954
45	A	H	-1.1001
46	P	H	-0.8938
47	G	H	-1.5338
48	K	H	-2.2232
49	G	H	-1.3726
50	L	H	0.0000
51	E	H	-0.9388
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	L	H	0.0000
56	I	H	0.0000
57	D	H	-1.8725
58	P	H	0.0000
59	E	H	-3.3153
62	D	H	-3.2248
63	A	H	-2.2616
64	D	H	-2.4911
65	T	H	-0.8783
66	M	H	-0.3241
67	Y	H	-0.9105
68	A	H	0.0000
69	E	H	-3.3330
70	K	H	-3.2093
71	F	H	0.0000
72	R	H	-2.4098
74	G	H	-1.6730
75	R	H	-1.3339
76	V	H	0.0000
77	T	H	-0.7124
78	I	H	0.0000
79	T	H	-0.5590
80	A	H	-1.0008
81	D	H	-1.1663
82	T	H	-1.1785
83	S	H	-0.7040
84	T	H	-0.8899
85	D	H	-1.3701
86	T	H	0.0000
87	G	H	0.0000
88	Y	H	-0.4679
89	L	H	0.0000
90	E	H	-1.3395
91	L	H	0.0000
92	S	H	-1.0116
93	S	H	-1.0494
94	L	H	0.0000
95	R	H	-2.8434
96	S	H	-2.2632
97	E	H	-2.4900
98	D	H	0.0000
99	T	H	-0.7100
100	A	H	0.0000
101	V	H	0.3575
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	A	H	0.0000
107	D	H	0.0000
108	P	H	0.0000
109	W	H	0.1935
110	E	H	-1.4939
112	L	H	-0.5759
113	N	H	-0.8955
114	A	H	0.0000
115	F	H	0.0000
116	N	H	-0.4390
117	V	H	-0.2090
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.2453
121	G	H	-0.5107
122	T	H	0.0000
123	L	H	0.9520
124	V	H	0.0000
125	T	H	-0.0804
126	V	H	0.0000
127	S	H	-1.2217
128	S	H	-1.0134
1	D	L	-2.5994
2	I	L	-1.6087
3	Q	L	-2.1021
4	M	L	0.0000
5	T	L	-1.4220
6	Q	L	-1.0646
7	S	L	-0.8189
8	P	L	-0.5476
9	S	L	-0.6906
10	S	L	-0.7666
11	V	L	-0.3677
12	S	L	-0.5149
13	A	L	0.0000
14	S	L	0.0537
15	V	L	0.8477
16	G	L	-0.4395
17	D	L	-1.2186
18	R	L	-2.1759
19	V	L	0.0000
20	T	L	-0.5999
21	I	L	0.0000
22	T	L	-0.9074
23	C	L	0.0000
24	R	L	-3.0700
25	A	L	0.0000
26	S	L	-2.2469
27	Q	L	-2.8991
28	D	L	-2.9021
29	I	L	0.0000
36	S	L	-1.1204
37	T	L	-0.5102
38	W	L	-0.1694
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.8614
44	Q	L	0.0000
45	K	L	-1.7880
46	P	L	-1.3641
47	G	L	-1.7179
48	K	L	-2.5476
49	A	L	-1.5809
50	P	L	0.0000
51	K	L	-1.3919
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.2618
56	A	L	0.0347
57	A	L	0.0000
65	S	L	-0.1382
66	T	L	0.1459
67	L	L	0.3295
68	Q	L	-0.1740
69	S	L	-0.3412
70	G	L	-0.5000
71	V	L	-0.3148
72	P	L	-0.3347
74	S	L	-0.4336
75	R	L	-0.8760
76	F	L	0.0000
77	S	L	-0.2667
78	G	L	0.0000
79	S	L	-0.6081
80	G	L	-1.1015
83	S	L	-1.2565
84	G	L	-1.8093
85	T	L	-2.3995
86	D	L	-2.5738
87	F	L	0.0000
88	S	L	-0.8076
89	L	L	0.0000
90	T	L	-0.6484
91	I	L	0.0000
92	N	L	-1.5131
93	S	L	-1.1445
94	L	L	0.0000
95	Q	L	-0.7265
96	P	L	-0.6945
97	E	L	-1.8379
98	D	L	0.0000
99	F	L	-0.3787
100	A	L	0.0000
101	T	L	-0.8145
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	A	L	0.0000
108	N	L	-0.9004
114	S	L	-0.2709
115	F	L	-0.1957
116	F	L	0.0000
117	T	L	-0.6180
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-1.1720
121	G	L	-0.9278
122	T	L	0.0000
123	K	L	-1.3248
124	V	L	0.0000
125	E	L	-0.5854
126	I	L	0.9829
127	K	L	-0.7641