| Chain sequence(s) |
A: GPLLLNPEPELRSTDEYVTPTDLLFVAETDLITEEGDPTKDIVKDGKVVKPRVSAYQYKVFKLTLPDPNKLPLPSEDFVDFSTERLIWRLEALKIGVFGPLGKGSYGLSNFNALGDVTNPTSYQHETSNVNQNLSFTPVRKQFYIVGDKPPKGKYIAPAAPEPGLPPGALPPLEVKYTYIEHGDMADIGFGAKDFKALEPRKDDVPEIILDTTTKVPDYEGMKAEPTGRSMFDYGEKTSSSNSRNLVRAGPVLVPLPAAPPPSPLYVKPPPSSPYWVLPPYDYFSIPDAGEITEEDLLFNKPYFFEKTEGLNNGVLWHNTLYITVLDNTRAEIETKTTQICTPEENVYDPECYVTSKTYKREYKLELIIRLCKIPLTPEVLEEIRRIDPRILVDWDLPDIPAVERPDPYAGKKFHEIDLTDKLSTDLSAYELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.0870 | |
| 2 | P | A | 0.9382 | |
| 3 | L | A | 2.3460 | |
| 4 | L | A | 2.4514 | |
| 5 | L | A | 1.7606 | |
| 6 | N | A | -0.4623 | |
| 7 | P | A | -1.3938 | |
| 8 | E | A | -2.5983 | |
| 9 | P | A | -2.2908 | |
| 10 | E | A | -2.5387 | |
| 11 | L | A | -1.3555 | |
| 12 | R | A | -1.6143 | |
| 13 | S | A | -1.5121 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.7425 | |
| 16 | E | A | -2.7168 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.8888 | |
| 20 | P | A | -0.8898 | |
| 21 | T | A | -0.9115 | |
| 22 | D | A | -1.6368 | |
| 23 | L | A | -0.5327 | |
| 24 | L | A | -0.3410 | |
| 25 | F | A | -0.2809 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.3003 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.4813 | |
| 31 | L | A | 0.2686 | |
| 32 | I | A | 0.0000 | |
| 33 | T | A | -0.6131 | |
| 34 | E | A | -1.1640 | |
| 35 | E | A | -2.0803 | |
| 36 | G | A | 0.0000 | |
| 37 | D | A | -1.6803 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | 0.0000 | |
| 40 | K | A | -2.1674 | |
| 41 | D | A | -0.9508 | |
| 42 | I | A | 0.8412 | |
| 43 | V | A | 0.8728 | |
| 44 | K | A | -1.4548 | |
| 45 | D | A | -2.4503 | |
| 46 | G | A | -1.4608 | |
| 47 | K | A | -1.1836 | |
| 48 | V | A | 1.2040 | |
| 49 | V | A | 1.6384 | |
| 50 | K | A | 0.1502 | |
| 51 | P | A | -0.4590 | |
| 52 | R | A | -1.0905 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.4349 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.3797 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3020 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.0730 | |
| 70 | K | A | -1.8165 | |
| 71 | L | A | -0.7520 | |
| 72 | P | A | -0.6028 | |
| 73 | L | A | -0.6319 | |
| 74 | P | A | -0.6711 | |
| 75 | S | A | -1.5422 | |
| 76 | E | A | -2.8906 | |
| 77 | D | A | -2.8465 | |
| 78 | F | A | -1.4805 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -2.1241 | |
| 81 | F | A | -0.5472 | |
| 82 | S | A | -0.5099 | |
| 83 | T | A | -0.6189 | |
| 84 | E | A | -0.8874 | |
| 85 | R | A | -0.6030 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3974 | |
| 90 | L | A | 0.0000 | |
| 91 | E | A | 0.0000 | |
| 92 | A | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | K | A | -0.7017 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.5007 | |
| 99 | G | A | -0.4259 | |
| 100 | P | A | -0.3758 | |
| 101 | L | A | -0.2688 | |
| 102 | G | A | -0.9921 | |
| 103 | K | A | -1.4244 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.6394 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.7644 | |
| 108 | L | A | -1.3463 | |
| 109 | S | A | -1.6386 | |
| 110 | N | A | -2.3696 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.1029 | |
| 117 | V | A | -0.3971 | |
| 118 | T | A | -1.2424 | |
| 119 | N | A | -1.7224 | |
| 120 | P | A | -0.8705 | |
| 121 | T | A | -0.5483 | |
| 122 | S | A | -0.3417 | |
| 123 | Y | A | 0.3180 | |
| 124 | Q | A | -0.3366 | |
| 125 | H | A | -0.5371 | |
| 126 | E | A | -1.9733 | |
| 127 | T | A | -1.5584 | |
| 128 | S | A | -1.3713 | |
| 129 | N | A | -1.8610 | |
| 130 | V | A | -1.3121 | |
| 131 | N | A | -1.7911 | |
| 132 | Q | A | -2.1232 | |
| 133 | N | A | -2.1242 | |
| 134 | L | A | -1.0333 | |
| 135 | S | A | -0.6368 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.6332 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | -0.4697 | |
| 140 | R | A | -0.8418 | |
| 141 | K | A | -0.7600 | |
| 142 | Q | A | 0.0000 | |
| 143 | F | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | K | A | -0.5008 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | K | A | -0.3502 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | 0.1898 | |
| 155 | Y | A | 0.3414 | |
| 156 | I | A | 0.9053 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | 0.5115 | |
| 159 | A | A | -0.0262 | |
| 160 | A | A | -0.5371 | |
| 161 | P | A | -0.8325 | |
| 162 | E | A | -1.9952 | |
| 163 | P | A | -1.2334 | |
| 164 | G | A | -0.7930 | |
| 165 | L | A | -0.0274 | |
| 166 | P | A | -0.0566 | |
| 167 | P | A | -0.2548 | |
| 168 | G | A | -0.1387 | |
| 169 | A | A | 0.7219 | |
| 170 | L | A | 1.7809 | |
| 171 | P | A | 0.5618 | |
| 172 | P | A | 0.3605 | |
| 173 | L | A | 1.3101 | |
| 174 | E | A | 0.5890 | |
| 175 | V | A | 1.3820 | |
| 176 | K | A | 0.5374 | |
| 177 | Y | A | 1.0112 | |
| 178 | T | A | 0.3588 | |
| 179 | Y | A | -0.3358 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.2642 | |
| 182 | H | A | -1.3201 | |
| 183 | G | A | -0.7790 | |
| 184 | D | A | -0.7217 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2908 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.4019 | |
| 190 | F | A | -0.0760 | |
| 191 | G | A | -0.1776 | |
| 192 | A | A | -0.0877 | |
| 193 | K | A | -0.5911 | |
| 194 | D | A | -1.2347 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -2.8632 | |
| 197 | A | A | -1.2848 | |
| 198 | L | A | -0.8084 | |
| 199 | E | A | -2.1080 | |
| 200 | P | A | -2.1154 | |
| 201 | R | A | -2.5258 | |
| 202 | K | A | -3.3524 | |
| 203 | D | A | 0.0000 | |
| 204 | D | A | -1.3346 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | E | A | -1.8796 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -2.1949 | |
| 211 | D | A | -3.0907 | |
| 212 | T | A | -1.6815 | |
| 213 | T | A | -1.0544 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.1258 | |
| 217 | P | A | -0.2069 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | -1.3302 | |
| 220 | E | A | -2.4178 | |
| 221 | G | A | -1.6180 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.7038 | |
| 224 | A | A | -1.6001 | |
| 225 | E | A | -1.2700 | |
| 226 | P | A | -0.9256 | |
| 227 | T | A | -0.5508 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | S | A | 0.0000 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.6694 | |
| 234 | Y | A | -0.1812 | |
| 235 | G | A | -0.6723 | |
| 236 | E | A | -1.5082 | |
| 237 | K | A | -1.4950 | |
| 238 | T | A | -0.8698 | |
| 239 | S | A | -0.7297 | |
| 240 | S | A | -1.0178 | |
| 241 | S | A | -1.4990 | |
| 242 | N | A | -2.2314 | |
| 243 | S | A | -1.9353 | |
| 244 | R | A | -2.7839 | |
| 245 | N | A | -1.5671 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.1859 | |
| 249 | A | A | 0.0000 | |
| 250 | G | A | -0.4377 | |
| 251 | P | A | 0.4581 | |
| 252 | V | A | 1.5459 | |
| 253 | L | A | 2.6663 | |
| 254 | V | A | 2.6231 | |
| 255 | P | A | 1.4060 | |
| 256 | L | A | 1.4733 | |
| 257 | P | A | 0.5697 | |
| 258 | A | A | -0.0206 | |
| 259 | A | A | 0.0800 | |
| 260 | P | A | -0.6458 | |
| 261 | P | A | -0.4377 | |
| 262 | P | A | -0.1092 | |
| 263 | S | A | 0.4091 | |
| 264 | P | A | 0.6728 | |
| 265 | L | A | 1.7910 | |
| 266 | Y | A | 1.4537 | |
| 267 | V | A | 1.3581 | |
| 268 | K | A | 0.1017 | |
| 269 | P | A | 0.2641 | |
| 270 | P | A | -0.1682 | |
| 271 | P | A | -0.1900 | |
| 272 | S | A | -0.2384 | |
| 273 | S | A | 0.1822 | |
| 274 | P | A | 0.6360 | |
| 275 | Y | A | 1.5118 | |
| 276 | W | A | 1.1936 | |
| 277 | V | A | 1.6491 | |
| 278 | L | A | 1.2367 | |
| 279 | P | A | 0.2302 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | 0.6308 | |
| 282 | D | A | 0.2837 | |
| 283 | Y | A | 1.0192 | |
| 284 | F | A | 0.1112 | |
| 285 | S | A | -0.8666 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.5846 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -1.4458 | |
| 291 | E | A | -2.0357 | |
| 292 | I | A | -1.4710 | |
| 293 | T | A | -1.9281 | |
| 294 | E | A | -2.7745 | |
| 295 | E | A | -3.0039 | |
| 296 | D | A | -2.4250 | |
| 297 | L | A | -1.5623 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -0.9057 | |
| 301 | K | A | -0.9578 | |
| 302 | P | A | -0.5917 | |
| 303 | Y | A | -0.0665 | |
| 304 | F | A | -0.2811 | |
| 305 | F | A | 0.0000 | |
| 306 | E | A | -2.5034 | |
| 307 | K | A | -2.9652 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -1.7735 | |
| 310 | G | A | -1.4102 | |
| 311 | L | A | -0.8097 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8880 | |
| 319 | N | A | -0.7129 | |
| 320 | T | A | -0.5822 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.3296 | |
| 333 | I | A | -2.0132 | |
| 334 | E | A | -2.8414 | |
| 335 | T | A | -2.0241 | |
| 336 | K | A | -2.0829 | |
| 337 | T | A | -0.4740 | |
| 338 | T | A | 0.1959 | |
| 339 | Q | A | 0.3037 | |
| 340 | I | A | 1.8375 | |
| 341 | C | A | 0.7384 | |
| 342 | T | A | -0.3834 | |
| 343 | P | A | -1.1493 | |
| 344 | E | A | -2.3871 | |
| 345 | E | A | -2.6593 | |
| 346 | N | A | -1.6158 | |
| 347 | V | A | 0.2391 | |
| 348 | Y | A | 0.6483 | |
| 349 | D | A | -0.5980 | |
| 350 | P | A | -0.6513 | |
| 351 | E | A | -1.2970 | |
| 352 | C | A | 0.0000 | |
| 353 | Y | A | 0.5905 | |
| 354 | V | A | 1.1206 | |
| 355 | T | A | -0.1473 | |
| 356 | S | A | -1.0072 | |
| 357 | K | A | -1.5529 | |
| 358 | T | A | -1.9581 | |
| 359 | Y | A | 0.0000 | |
| 360 | K | A | -2.1533 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.3554 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.5843 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | I | A | 0.0000 | |
| 370 | R | A | -0.5276 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.7059 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6018 | |
| 376 | L | A | -0.4453 | |
| 377 | T | A | -0.9079 | |
| 378 | P | A | -1.4916 | |
| 379 | E | A | -2.6136 | |
| 380 | V | A | 0.0000 | |
| 381 | L | A | -1.7481 | |
| 382 | E | A | -3.1345 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | R | A | -2.9435 | |
| 386 | R | A | -1.9713 | |
| 387 | I | A | -1.0375 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.5402 | |
| 390 | R | A | -1.3256 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.4613 | |
| 394 | D | A | -2.1019 | |
| 395 | W | A | -1.5462 | |
| 396 | D | A | -2.3112 | |
| 397 | L | A | -1.3233 | |
| 398 | P | A | -1.3157 | |
| 399 | D | A | -1.9120 | |
| 400 | I | A | -0.7314 | |
| 401 | P | A | -0.3638 | |
| 402 | A | A | -0.3922 | |
| 403 | V | A | 0.6686 | |
| 404 | E | A | -1.6474 | |
| 405 | R | A | -1.8149 | |
| 406 | P | A | -1.7065 | |
| 407 | D | A | -2.1876 | |
| 408 | P | A | -1.1752 | |
| 409 | Y | A | -1.0651 | |
| 410 | A | A | -1.1945 | |
| 411 | G | A | -1.3953 | |
| 412 | K | A | -1.9778 | |
| 413 | K | A | -2.5789 | |
| 414 | F | A | -1.7086 | |
| 415 | H | A | -1.6915 | |
| 416 | E | A | -2.5552 | |
| 417 | I | A | -1.8975 | |
| 418 | D | A | -2.7397 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8714 | |
| 421 | D | A | -2.7367 | |
| 422 | K | A | -2.7377 | |
| 423 | L | A | -1.1915 | |
| 424 | S | A | -0.9554 | |
| 425 | T | A | -0.6195 | |
| 426 | D | A | -1.6600 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.2104 | |
| 429 | A | A | -0.9262 | |
| 430 | Y | A | -1.1642 | |
| 431 | E | A | -1.7588 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.1309 | |
| 435 | E | A | -1.7807 | |
| 436 | Y | A | -0.7967 | |
| 437 | L | A | -0.2394 | |
| 438 | N | A | -1.9165 | |
| 439 | R | A | -2.1478 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine