Project name: 2F11

Chain sequence(s)	H: QVQLVQSGAEGRKPGSSVKVSCKVSGDTFSSYAISWVRQAPGQGLEWMGGIIPIFGAADYAQKFKGRVTISADESTSTAYMELSSLRSEDTAVYYCAKGPDYYGSFDPWGQGTLITVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQSIGTYLNWYQQKPGKAPKLLIYDASSLEDGVPSRFSGSGSGTDFTLTISSLQPEDSATYYCQQSYTMPLYTFGQGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:49)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:51)

• Minimal score value: -3.1763
• Maximal score value: 2.5193
• Average score: -0.5795
• Total score value: -131.5433

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.8027
2	V	H	-1.3608
3	Q	H	-1.4279
4	L	H	0.0000
5	V	H	0.3822
6	Q	H	0.0000
7	S	H	-0.3616
8	G	H	-0.3326
9	A	H	0.0405
11	E	H	-0.7119
12	G	H	-1.1332
13	R	H	-2.1425
14	K	H	-2.7629
15	P	H	-2.3453
16	G	H	-1.6899
17	S	H	-1.3576
18	S	H	-1.4009
19	V	H	0.0000
20	K	H	-1.7872
21	V	H	0.0000
22	S	H	-0.4660
23	C	H	0.0000
24	K	H	-0.6061
25	V	H	0.0000
26	S	H	-1.1129
27	G	H	-2.0072
28	D	H	-2.3564
29	T	H	-1.2578
30	F	H	0.0000
35	S	H	0.3115
36	S	H	0.3739
37	Y	H	0.4029
38	A	H	0.4416
39	I	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.4902
45	A	H	-0.8799
46	P	H	-0.9026
47	G	H	-1.2161
48	Q	H	-1.8018
49	G	H	-1.2596
50	L	H	0.0000
51	E	H	-0.6622
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	G	H	0.0000
56	I	H	0.0000
57	I	H	1.0435
58	P	H	0.8641
59	I	H	1.9642
62	F	H	2.5193
63	G	H	0.9183
64	A	H	0.6792
65	A	H	0.0416
66	D	H	-0.5983
67	Y	H	-1.0221
68	A	H	-1.3712
69	Q	H	-2.3722
70	K	H	-2.6218
71	F	H	0.0000
72	K	H	-2.2127
74	G	H	-1.5583
75	R	H	-1.3720
76	V	H	0.0000
77	T	H	-0.8277
78	I	H	0.0000
79	S	H	-0.2598
80	A	H	-0.5384
81	D	H	-1.2548
82	E	H	-1.4924
83	S	H	-1.0553
84	T	H	-0.8893
85	S	H	-1.3613
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.5112
89	M	H	0.0000
90	E	H	-1.3739
91	L	H	0.0000
92	S	H	-1.1645
93	S	H	-1.3020
94	L	H	0.0000
95	R	H	-3.1763
96	S	H	-2.4248
97	E	H	-2.6003
98	D	H	0.0000
99	T	H	-0.9696
100	A	H	0.0000
101	V	H	0.5953
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	K	H	0.0000
107	G	H	0.0000
108	P	H	-0.2291
109	D	H	-0.4943
110	Y	H	1.1696
112	Y	H	1.5499
113	G	H	0.0000
114	S	H	0.0000
115	F	H	0.0000
116	D	H	-0.6380
117	P	H	-0.8444
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.4020
121	G	H	-0.5210
122	T	H	0.0000
123	L	H	0.9787
124	I	H	0.0000
125	T	H	-0.8751
126	V	H	0.0000
127	S	H	-1.5785
128	S	H	-1.1626
1	D	L	-2.1448
2	I	L	0.0000
3	Q	L	-2.2191
4	M	L	0.0000
5	T	L	-1.4212
6	Q	L	0.0000
7	S	L	-0.8184
8	P	L	-0.5124
9	S	L	-0.8432
10	S	L	-1.0579
11	L	L	-0.8153
12	S	L	-1.1300
13	A	L	0.0000
14	S	L	-0.7953
15	V	L	0.0663
16	G	L	-0.7082
17	D	L	-1.6909
18	R	L	-2.3238
19	V	L	0.0000
20	T	L	-0.6092
21	I	L	0.0000
22	T	L	-0.8405
23	C	L	0.0000
24	R	L	-2.7647
25	A	L	0.0000
26	S	L	-1.8018
27	Q	L	-1.7100
28	S	L	-0.9502
29	I	L	0.0000
36	G	L	-0.5067
37	T	L	-0.3229
38	Y	L	0.6620
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7943
44	Q	L	0.0000
45	K	L	-1.8340
46	P	L	-1.2868
47	G	L	-1.6663
48	K	L	-2.5748
49	A	L	-1.6025
50	P	L	0.0000
51	K	L	-1.1115
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.3977
56	D	L	-0.2106
57	A	L	0.0000
65	S	L	-0.3480
66	S	L	-0.2303
67	L	L	-0.1511
68	E	L	-1.0590
69	D	L	-2.0116
70	G	L	-1.3087
71	V	L	-0.8356
72	P	L	-0.5990
74	S	L	-0.4445
75	R	L	-0.7737
76	F	L	0.0000
77	S	L	-0.3264
78	G	L	-0.2935
79	S	L	-0.7283
80	G	L	-1.1017
83	S	L	-1.1180
84	G	L	-1.1486
85	T	L	-1.7042
86	D	L	-2.2490
87	F	L	0.0000
88	T	L	-0.7603
89	L	L	0.0000
90	T	L	-0.6334
91	I	L	0.0000
92	S	L	-1.4087
93	S	L	-1.2338
94	L	L	0.0000
95	Q	L	-1.0339
96	P	L	-1.3032
97	E	L	-2.0931
98	D	L	0.0000
99	S	L	-1.5630
100	A	L	0.0000
101	T	L	-1.1571
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	0.0000
108	Y	L	1.5950
109	T	L	0.5817
113	M	L	1.1784
114	P	L	0.6711
115	L	L	0.1074
116	Y	L	0.0000
117	T	L	-0.4782
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.4771
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.9484
124	L	L	0.0000
125	E	L	-2.1801
126	I	L	-1.0212
127	K	L	-1.5782