Project name: AAB-PP3135

Chain sequence(s)	H: QVQLVESGGGVVQPGESLKISCAASGFTFSSYAMHWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSTYYYGASGYDYYFEPWGPGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQHIRSSLAWYQQKPGKAPKLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLQPEDFATYYCQHTYITPYTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	No
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       runJob:   FoldX not utilized. Treating input pdb file as it was already optimized.    (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:01)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:02)

• Minimal score value: -3.1593
• Maximal score value: 2.0314
• Average score: -0.5685
• Total score value: -131.8927

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
0	Q	H	-1.3003
1	V	H	-0.6905
2	Q	H	-0.7524
3	L	H	0.0000
4	V	H	1.3172
5	E	H	0.5623
6	S	H	-0.2079
7	G	H	-0.8132
8	G	H	0.1097
9	G	H	0.9280
10	V	H	1.5553
11	V	H	0.0000
12	Q	H	-1.7790
13	P	H	-1.9009
14	G	H	-2.0484
15	E	H	-2.2045
16	S	H	-1.6030
17	L	H	-1.0002
18	K	H	-1.9406
19	I	H	0.0000
20	S	H	-0.3753
21	C	H	0.0000
22	A	H	-0.0004
23	A	H	-0.3713
24	S	H	-0.5323
25	G	H	-0.8415
26	F	H	-0.2908
27	T	H	-0.1856
28	F	H	0.0000
29	S	H	-0.8247
30	S	H	-0.0879
31	Y	H	0.2625
32	A	H	0.1272
33	M	H	0.0000
34	H	H	0.0000
35	W	H	0.0000
36	V	H	0.0000
37	R	H	0.0000
38	Q	H	-0.7276
39	A	H	-1.0399
40	P	H	-0.9800
41	G	H	-1.5059
42	K	H	-2.3925
43	G	H	-1.6394
44	L	H	0.0000
45	E	H	-1.2776
46	W	H	0.0000
47	V	H	0.0000
48	S	H	0.0000
49	A	H	0.0000
50	I	H	0.0000
51	S	H	-0.2803
52	G	H	-0.4778
53	S	H	-0.7169
54	G	H	-0.8182
55	G	H	-0.7431
56	S	H	-0.2658
57	T	H	0.2939
58	Y	H	0.6904
59	Y	H	-0.3029
60	A	H	-1.1506
61	D	H	-2.3283
62	S	H	-1.7211
63	V	H	0.0000
64	K	H	-2.4166
65	G	H	-1.6988
66	R	H	-1.2549
67	F	H	0.0000
68	T	H	-0.6635
69	I	H	0.0000
70	S	H	-0.4660
71	R	H	-1.0814
72	D	H	-1.6499
73	N	H	-1.8046
74	S	H	-1.6352
75	K	H	-2.4350
76	N	H	-1.8561
77	T	H	-1.0181
78	L	H	0.0000
79	Y	H	-0.4855
80	L	H	0.0000
81	Q	H	-1.1267
82	M	H	0.0000
83	N	H	-1.7160
84	S	H	-1.6469
85	L	H	0.0000
86	R	H	-2.7565
87	A	H	-1.9073
88	E	H	-2.3085
89	D	H	0.0000
90	T	H	-0.4280
91	A	H	0.0000
92	V	H	0.8980
93	Y	H	0.0000
94	Y	H	0.0000
95	C	H	0.0000
96	A	H	0.0000
97	R	H	-0.2728
98	S	H	0.0000
99	T	H	0.8344
100	Y	H	2.0125
101	Y	H	1.7755
102	Y	H	1.6131
103	G	H	0.3981
104	A	H	-0.0913
105	S	H	-0.0988
106	G	H	0.3164
107	Y	H	1.5640
108	D	H	1.3439
109	Y	H	1.4724
110	Y	H	0.6596
111	F	H	0.0000
112	E	H	-0.8177
113	P	H	-0.8030
114	W	H	0.0000
115	G	H	0.0000
116	P	H	-0.4131
117	G	H	0.1212
118	T	H	0.6985
119	L	H	1.7204
120	V	H	0.0000
121	T	H	0.3669
122	V	H	0.0000
123	S	H	-0.6666
124	S	H	-0.5958
125	D	L	-2.0099
126	I	L	0.0000
127	Q	L	-2.1916
128	M	L	0.0000
129	T	L	-1.2848
130	Q	L	0.0000
131	S	L	-0.7331
132	P	L	-0.5979
133	S	L	-0.9664
134	S	L	-1.1332
135	L	L	-0.6519
136	S	L	-0.7040
137	A	L	0.0000
138	S	L	-0.1488
139	V	L	0.7176
140	G	L	-0.7084
141	D	L	-1.6689
142	R	L	-2.3426
143	V	L	0.0000
144	T	L	-0.6347
145	I	L	0.0000
146	T	L	-0.9690
147	C	L	0.0000
148	R	L	-3.0412
149	A	L	0.0000
150	S	L	-2.2558
151	Q	L	-2.8582
152	H	L	-2.5753
153	I	L	0.0000
154	R	L	-2.6040
155	S	L	-1.4990
156	S	L	-0.4257
157	L	L	0.0000
158	A	L	0.0000
159	W	L	0.0000
160	Y	L	0.0000
161	Q	L	-1.0263
162	Q	L	-1.6586
163	K	L	-2.2128
164	P	L	-1.4946
165	G	L	-1.6700
166	K	L	-2.5642
167	A	L	-1.5615
168	P	L	0.0000
169	K	L	-1.9989
170	L	L	0.0000
171	L	L	0.0000
172	I	L	0.0000
173	Y	L	-0.2372
174	G	L	-0.8745
175	A	L	0.0000
176	S	L	-0.8038
177	S	L	-0.8474
178	R	L	-1.6900
179	A	L	-0.9748
180	T	L	-0.6051
181	G	L	-0.9198
182	I	L	0.0000
183	P	L	-1.3875
184	D	L	-2.3079
185	R	L	-1.6193
186	F	L	0.0000
187	S	L	-1.0289
188	G	L	-0.6010
189	S	L	-0.8345
190	G	L	-1.4400
191	S	L	-1.8342
192	G	L	-2.4332
193	T	L	-2.6644
194	D	L	-3.1593
195	F	L	0.0000
196	T	L	-0.9088
197	L	L	0.0000
198	T	L	-0.6135
199	I	L	0.0000
200	S	L	-1.6827
201	S	L	-1.2899
202	L	L	0.0000
203	Q	L	-0.7789
204	P	L	-0.6489
205	E	L	-1.8869
206	D	L	0.0000
207	F	L	-0.5785
208	A	L	0.0000
209	T	L	-1.2883
210	Y	L	0.0000
211	Y	L	0.0000
212	C	L	0.0000
213	Q	L	0.0000
214	H	L	0.0000
215	T	L	1.2338
216	Y	L	1.5211
217	I	L	2.0314
218	T	L	0.8211
219	P	L	0.0057
220	Y	L	0.0000
221	T	L	-0.4769
222	F	L	-0.4952
223	G	L	0.0000
224	Q	L	-1.6137
225	G	L	0.0000
226	T	L	0.0000
227	K	L	-2.1588
228	V	L	0.0000
229	E	L	-0.9093
230	I	L	0.9387
231	K	L	-0.7859