| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGGGGGSGGGGSFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:17)
[INFO] Main: Simulation completed successfully. (00:02:19)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.3607 | |
| 2 | S | A | -0.1813 | |
| 3 | R | A | -1.6511 | |
| 4 | P | A | -1.1201 | |
| 5 | G | A | -0.9982 | |
| 6 | L | A | -0.6031 | |
| 7 | P | A | -0.1852 | |
| 8 | V | A | -0.1660 | |
| 9 | E | A | -0.3030 | |
| 10 | Y | A | 0.5983 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -1.8253 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.6263 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -0.9974 | |
| 17 | S | A | -0.6917 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3367 | |
| 20 | R | A | -1.9212 | |
| 21 | D | A | -2.7091 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -1.4242 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.9202 | |
| 29 | G | A | -1.0904 | |
| 30 | G | A | -1.6667 | |
| 31 | N | A | -2.3877 | |
| 32 | N | A | -2.4502 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.1346 | |
| 43 | R | A | -2.5126 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.5551 | |
| 46 | D | A | -3.0211 | |
| 47 | D | A | -2.1695 | |
| 48 | Y | A | -0.5083 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.7550 | |
| 54 | N | A | -0.1592 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.0869 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.4945 | |
| 60 | W | A | -0.1763 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | 0.0790 | |
| 63 | Q | A | -1.0391 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.2513 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | 0.0000 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.4112 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.6086 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.9510 | |
| 84 | S | A | 0.0789 | |
| 85 | P | A | -0.1736 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.5064 | |
| 88 | G | A | -1.5294 | |
| 89 | K | A | -1.9867 | |
| 90 | A | A | -0.8992 | |
| 91 | G | A | -0.6108 | |
| 92 | C | A | 0.0166 | |
| 93 | Q | A | -0.6221 | |
| 94 | T | A | -0.4813 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.8675 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.5766 | |
| 99 | T | A | -0.5174 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3824 | |
| 103 | S | A | -0.5373 | |
| 104 | E | A | -0.6915 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.5403 | |
| 108 | W | A | -0.8599 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.4963 | |
| 111 | A | A | -0.9339 | |
| 112 | N | A | -1.2573 | |
| 113 | R | A | -1.7041 | |
| 114 | A | A | -1.8169 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.9187 | |
| 117 | P | A | -1.2832 | |
| 118 | T | A | -0.9026 | |
| 119 | G | A | -0.5398 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | -0.0081 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.2342 | |
| 139 | H | A | -0.4137 | |
| 140 | P | A | -0.9444 | |
| 141 | Q | A | -1.2574 | |
| 142 | Q | A | -0.7991 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.2019 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.1556 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | 0.0000 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.4172 | |
| 157 | Q | A | -1.4342 | |
| 158 | G | A | -0.5269 | |
| 159 | M | A | 0.4519 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | 0.0073 | |
| 162 | S | A | 0.3983 | |
| 163 | L | A | 0.8792 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.0998 | |
| 166 | L | A | 0.6606 | |
| 167 | A | A | -0.3746 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.4593 | |
| 170 | D | A | -2.1754 | |
| 171 | A | A | -1.6171 | |
| 172 | G | A | 0.0000 | |
| 173 | G | A | -1.7992 | |
| 174 | Y | A | 0.0000 | |
| 175 | K | A | -1.8828 | |
| 176 | A | A | -0.7587 | |
| 177 | A | A | -0.6659 | |
| 178 | D | A | -0.4759 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6293 | |
| 183 | S | A | -0.9969 | |
| 184 | S | A | -0.9029 | |
| 185 | D | A | -1.1510 | |
| 186 | P | A | -1.2806 | |
| 187 | A | A | -0.9535 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -2.6743 | |
| 190 | R | A | -1.6616 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -1.4334 | |
| 195 | Q | A | -2.0255 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -1.1070 | |
| 199 | K | A | -1.4164 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.2914 | |
| 202 | A | A | -0.9618 | |
| 203 | N | A | -1.4859 | |
| 204 | N | A | -1.8402 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.8668 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.1355 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -1.0214 | |
| 214 | G | A | 0.0000 | |
| 215 | T | A | -1.0727 | |
| 216 | P | A | -1.1213 | |
| 217 | N | A | -1.1650 | |
| 218 | E | A | -1.6520 | |
| 219 | L | A | -0.5351 | |
| 220 | G | A | -1.0205 | |
| 221 | G | A | -1.4024 | |
| 222 | A | A | -0.8220 | |
| 223 | N | A | -0.8928 | |
| 224 | I | A | 0.7496 | |
| 225 | P | A | -0.1676 | |
| 226 | A | A | -0.5451 | |
| 227 | E | A | -1.0713 | |
| 228 | F | A | 0.4717 | |
| 229 | L | A | 0.4108 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -1.1654 | |
| 232 | F | A | 0.0323 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.4309 | |
| 235 | S | A | -0.5113 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.2376 | |
| 239 | K | A | -1.6415 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.4881 | |
| 242 | D | A | -2.5206 | |
| 243 | A | A | -1.7818 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.4302 | |
| 246 | A | A | -1.3471 | |
| 247 | A | A | -0.9953 | |
| 248 | G | A | -1.1080 | |
| 249 | G | A | -1.7736 | |
| 250 | H | A | -1.6833 | |
| 251 | N | A | -1.3048 | |
| 252 | A | A | -0.5589 | |
| 253 | V | A | 0.3135 | |
| 254 | F | A | 0.6064 | |
| 255 | N | A | 0.1026 | |
| 256 | F | A | 0.1572 | |
| 257 | P | A | -0.2971 | |
| 258 | P | A | -0.6061 | |
| 259 | N | A | -0.9452 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.8107 | |
| 263 | S | A | -0.6653 | |
| 264 | W | A | -0.6211 | |
| 265 | E | A | -1.5726 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.6429 | |
| 270 | Q | A | -0.6103 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.8660 | |
| 273 | A | A | -0.5949 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0127 | |
| 276 | G | A | -1.0628 | |
| 277 | D | A | -0.7946 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -1.0017 | |
| 280 | S | A | -0.8724 | |
| 281 | S | A | -0.5010 | |
| 282 | L | A | -0.3772 | |
| 283 | G | A | -0.8716 | |
| 284 | A | A | -1.0516 | |
| 285 | G | A | -1.3760 | |
| 286 | G | A | -1.3194 | |
| 287 | G | A | -1.4814 | |
| 288 | G | A | -1.2767 | |
| 289 | G | A | -1.2168 | |
| 290 | S | A | -1.0587 | |
| 291 | G | A | -1.1587 | |
| 292 | G | A | -1.1855 | |
| 293 | G | A | -0.8714 | |
| 294 | G | A | -0.4469 | |
| 295 | S | A | 0.5474 | |
| 296 | F | A | 2.1650 | |
| 297 | A | A | 1.5474 | |
| 298 | V | A | 1.7207 | |
| 299 | T | A | -0.1394 | |
| 300 | N | A | -1.6495 | |
| 301 | D | A | -1.7245 | |
| 302 | G | A | -0.3079 | |
| 303 | V | A | 1.9705 | |
| 304 | I | A | 2.5104 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine