| Chain sequence(s) |
A: GGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGEFSINPGMMAAAQAALQSSWGMMGMLASQQNQSGPSG
C: GGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGEFSINPGMMAAAQAALQSSWGMMGMLASQQNQSGPSG B: GGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGEFSINPGMMAAAQAALQSSWGMMGMLASQQNQSGPSG E: GGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGEFSINPGMMAAAQAALQSSWGMMGMLASQQNQSGPSG D: GGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGEFSINPGMMAAAQAALQSSWGMMGMLASQQNQSGPSG input PDB |
| Selected Chain(s) | A,C,B,E,D |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:14)
[INFO] Main: Simulation completed successfully. (00:02:18)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 281 | G | A | -1.2662 | |
| 282 | G | A | -1.0356 | |
| 283 | F | A | 0.0000 | |
| 284 | G | A | -1.0501 | |
| 285 | N | A | 0.0000 | |
| 286 | Q | A | -1.6569 | |
| 287 | G | A | 0.0000 | |
| 288 | G | A | -0.8440 | |
| 289 | F | A | 0.0000 | |
| 290 | G | A | -1.3547 | |
| 291 | N | A | 0.0000 | |
| 292 | S | A | 0.0000 | |
| 293 | R | A | -3.6339 | |
| 294 | G | A | -2.6275 | |
| 295 | G | A | -1.7507 | |
| 296 | G | A | 0.0000 | |
| 297 | A | A | 0.1281 | |
| 298 | G | A | 0.6627 | |
| 299 | L | A | 1.4085 | |
| 300 | G | A | 0.0000 | |
| 301 | N | A | 0.0000 | |
| 302 | N | A | 0.0000 | |
| 303 | Q | A | 0.0000 | |
| 304 | G | A | 0.0000 | |
| 305 | S | A | 0.0000 | |
| 306 | N | A | 0.0000 | |
| 307 | M | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | G | A | 0.0000 | |
| 310 | G | A | 0.0000 | |
| 311 | M | A | 0.0000 | |
| 312 | N | A | 0.0000 | |
| 313 | F | A | 1.0058 | |
| 314 | G | A | -0.1885 | |
| 315 | E | A | -1.3667 | |
| 316 | F | A | 0.0000 | |
| 317 | S | A | -0.8759 | |
| 318 | I | A | 0.0000 | |
| 319 | N | A | -1.2880 | |
| 320 | P | A | 0.0000 | |
| 321 | G | A | -0.4769 | |
| 322 | M | A | 0.0000 | |
| 323 | M | A | 0.6348 | |
| 324 | A | A | 0.0000 | |
| 325 | A | A | 0.1698 | |
| 326 | A | A | -0.1698 | |
| 327 | Q | A | -0.4796 | |
| 328 | A | A | 0.0000 | |
| 329 | A | A | 0.0000 | |
| 330 | L | A | 0.0000 | |
| 331 | Q | A | 0.0000 | |
| 332 | S | A | 0.0000 | |
| 333 | S | A | 0.0000 | |
| 334 | W | A | 0.0000 | |
| 335 | G | A | 0.0000 | |
| 336 | M | A | 0.0000 | |
| 337 | M | A | 0.0000 | |
| 338 | G | A | 0.0000 | |
| 339 | M | A | 0.0000 | |
| 340 | L | A | 0.0000 | |
| 341 | A | A | 0.0000 | |
| 342 | S | A | 0.0000 | |
| 343 | Q | A | 0.0000 | |
| 344 | Q | A | -1.7091 | |
| 345 | N | A | 0.0000 | |
| 346 | Q | A | -2.2241 | |
| 347 | S | A | -1.6446 | |
| 348 | G | A | -1.2323 | |
| 349 | P | A | 0.0000 | |
| 350 | S | A | -1.0057 | |
| 351 | G | A | -1.0783 | |
| 281 | G | B | -1.2860 | |
| 282 | G | B | -1.0459 | |
| 283 | F | B | -0.3021 | |
| 284 | G | B | 0.0000 | |
| 285 | N | B | 0.0000 | |
| 286 | Q | B | -1.5671 | |
| 287 | G | B | 0.0000 | |
| 288 | G | B | -0.8811 | |
| 289 | F | B | 0.0000 | |
| 290 | G | B | 0.0000 | |
| 291 | N | B | 0.0000 | |
| 292 | S | B | 0.0000 | |
| 293 | R | B | -3.7449 | |
| 294 | G | B | -2.5595 | |
| 295 | G | B | -1.6077 | |
| 296 | G | B | 0.0000 | |
| 297 | A | B | 0.1923 | |
| 298 | G | B | 0.6434 | |
| 299 | L | B | 1.2836 | |
| 300 | G | B | 0.0000 | |
| 301 | N | B | 0.0000 | |
| 302 | N | B | 0.0000 | |
| 303 | Q | B | 0.0000 | |
| 304 | G | B | 0.0000 | |
| 305 | S | B | 0.0000 | |
| 306 | N | B | 0.0000 | |
| 307 | M | B | 0.0000 | |
| 308 | G | B | 0.0000 | |
| 309 | G | B | 0.0000 | |
| 310 | G | B | 0.0000 | |
| 311 | M | B | 0.0000 | |
| 312 | N | B | 0.0000 | |
| 313 | F | B | 1.6889 | |
| 314 | G | B | 0.2594 | |
| 315 | E | B | -1.3141 | |
| 316 | F | B | 0.0000 | |
| 317 | S | B | -0.7838 | |
| 318 | I | B | 0.0000 | |
| 319 | N | B | -1.3995 | |
| 320 | P | B | 0.0000 | |
| 321 | G | B | -0.5202 | |
| 322 | M | B | 0.0000 | |
| 323 | M | B | 0.5867 | |
| 324 | A | B | 0.0000 | |
| 325 | A | B | 0.0684 | |
| 326 | A | B | -0.2149 | |
| 327 | Q | B | -0.6853 | |
| 328 | A | B | 0.0000 | |
| 329 | A | B | 0.0000 | |
| 330 | L | B | 0.0000 | |
| 331 | Q | B | 0.0000 | |
| 332 | S | B | 0.0000 | |
| 333 | S | B | 0.0000 | |
| 334 | W | B | 0.0000 | |
| 335 | G | B | 0.0000 | |
| 336 | M | B | 0.0000 | |
| 337 | M | B | 0.0000 | |
| 338 | G | B | 0.0000 | |
| 339 | M | B | 0.0000 | |
| 340 | L | B | 0.0000 | |
| 341 | A | B | 0.0000 | |
| 342 | S | B | 0.0000 | |
| 343 | Q | B | 0.0000 | |
| 344 | Q | B | -1.0548 | |
| 345 | N | B | 0.0000 | |
| 346 | Q | B | -1.7942 | |
| 347 | S | B | 0.0000 | |
| 348 | G | B | -1.0520 | |
| 349 | P | B | 0.0000 | |
| 350 | S | B | -0.9467 | |
| 351 | G | B | -1.1122 | |
| 281 | G | C | -1.0988 | |
| 282 | G | C | -0.8744 | |
| 283 | F | C | -0.4228 | |
| 284 | G | C | -0.9242 | |
| 285 | N | C | -1.3265 | |
| 286 | Q | C | -1.8647 | |
| 287 | G | C | -1.1102 | |
| 288 | G | C | -0.8873 | |
| 289 | F | C | -0.2780 | |
| 290 | G | C | -1.0436 | |
| 291 | N | C | -1.3660 | |
| 292 | S | C | -2.2098 | |
| 293 | R | C | -3.0890 | |
| 294 | G | C | -2.4435 | |
| 295 | G | C | -1.5584 | |
| 296 | G | C | -1.3710 | |
| 297 | A | C | -0.0524 | |
| 298 | G | C | 0.5425 | |
| 299 | L | C | 1.5548 | |
| 300 | G | C | 0.0000 | |
| 301 | N | C | -0.1844 | |
| 302 | N | C | -0.7994 | |
| 303 | Q | C | -0.6469 | |
| 304 | G | C | 0.0000 | |
| 305 | S | C | -0.0185 | |
| 306 | N | C | -0.1573 | |
| 307 | M | C | 0.2193 | |
| 308 | G | C | -0.0923 | |
| 309 | G | C | -0.4610 | |
| 310 | G | C | -0.5248 | |
| 311 | M | C | 0.2793 | |
| 312 | N | C | -0.0878 | |
| 313 | F | C | 1.4270 | |
| 314 | G | C | -0.2696 | |
| 315 | E | C | -1.7212 | |
| 316 | F | C | -0.5856 | |
| 317 | S | C | -0.6664 | |
| 318 | I | C | -0.6265 | |
| 319 | N | C | -1.4051 | |
| 320 | P | C | -0.8865 | |
| 321 | G | C | -0.4157 | |
| 322 | M | C | 0.5527 | |
| 323 | M | C | 0.8445 | |
| 324 | A | C | 0.4922 | |
| 325 | A | C | 0.1987 | |
| 326 | A | C | -0.1230 | |
| 327 | Q | C | -0.4447 | |
| 328 | A | C | 0.0800 | |
| 329 | A | C | 0.1884 | |
| 330 | L | C | 0.0163 | |
| 331 | Q | C | -0.7643 | |
| 332 | S | C | -0.0792 | |
| 333 | S | C | 0.1040 | |
| 334 | W | C | 0.3646 | |
| 335 | G | C | 0.0000 | |
| 336 | M | C | 0.3294 | |
| 337 | M | C | 0.3881 | |
| 338 | G | C | 0.2998 | |
| 339 | M | C | 0.4228 | |
| 340 | L | C | 0.1233 | |
| 341 | A | C | -0.0108 | |
| 342 | S | C | -0.5148 | |
| 343 | Q | C | -1.3713 | |
| 344 | Q | C | -2.3586 | |
| 345 | N | C | -2.5386 | |
| 346 | Q | C | -2.5266 | |
| 347 | S | C | -1.5249 | |
| 348 | G | C | -1.3217 | |
| 349 | P | C | -0.7952 | |
| 350 | S | C | -0.8983 | |
| 351 | G | C | -0.8798 | |
| 281 | G | D | -1.1961 | |
| 282 | G | D | -0.7924 | |
| 283 | F | D | 0.0000 | |
| 284 | G | D | -1.0406 | |
| 285 | N | D | 0.0000 | |
| 286 | Q | D | -1.9161 | |
| 287 | G | D | 0.0000 | |
| 288 | G | D | -0.8941 | |
| 289 | F | D | 0.0000 | |
| 290 | G | D | -1.4531 | |
| 291 | N | D | 0.0000 | |
| 292 | S | D | 0.0000 | |
| 293 | R | D | -3.7091 | |
| 294 | G | D | -2.4509 | |
| 295 | G | D | -1.6943 | |
| 296 | G | D | 0.0000 | |
| 297 | A | D | 0.1724 | |
| 298 | G | D | 0.5065 | |
| 299 | L | D | 1.2766 | |
| 300 | G | D | 0.0000 | |
| 301 | N | D | 0.0000 | |
| 302 | N | D | 0.0000 | |
| 303 | Q | D | 0.0000 | |
| 304 | G | D | 0.0000 | |
| 305 | S | D | 0.0000 | |
| 306 | N | D | 0.0000 | |
| 307 | M | D | 0.0000 | |
| 308 | G | D | 0.0000 | |
| 309 | G | D | 0.0000 | |
| 310 | G | D | 0.0000 | |
| 311 | M | D | 0.0000 | |
| 312 | N | D | 0.0000 | |
| 313 | F | D | 1.6011 | |
| 314 | G | D | 0.2374 | |
| 315 | E | D | -1.2212 | |
| 316 | F | D | 0.0000 | |
| 317 | S | D | -0.9922 | |
| 318 | I | D | 0.0000 | |
| 319 | N | D | -1.3757 | |
| 320 | P | D | 0.0000 | |
| 321 | G | D | -0.5399 | |
| 322 | M | D | 0.0000 | |
| 323 | M | D | 0.6270 | |
| 324 | A | D | 0.0000 | |
| 325 | A | D | 0.0562 | |
| 326 | A | D | -0.4859 | |
| 327 | Q | D | -0.8770 | |
| 328 | A | D | 0.0000 | |
| 329 | A | D | 0.0000 | |
| 330 | L | D | 0.0000 | |
| 331 | Q | D | 0.0000 | |
| 332 | S | D | 0.0000 | |
| 333 | S | D | 0.0000 | |
| 334 | W | D | 0.0000 | |
| 335 | G | D | 0.0000 | |
| 336 | M | D | 0.0000 | |
| 337 | M | D | 0.0000 | |
| 338 | G | D | 0.0000 | |
| 339 | M | D | 0.0000 | |
| 340 | L | D | 0.0000 | |
| 341 | A | D | 0.0000 | |
| 342 | S | D | 0.0000 | |
| 343 | Q | D | 0.0000 | |
| 344 | Q | D | -1.1652 | |
| 345 | N | D | 0.0000 | |
| 346 | Q | D | -1.8986 | |
| 347 | S | D | 0.0000 | |
| 348 | G | D | -1.1288 | |
| 349 | P | D | 0.0000 | |
| 350 | S | D | -0.9145 | |
| 351 | G | D | -1.0966 | |
| 281 | G | E | -1.0508 | |
| 282 | G | E | -0.5170 | |
| 283 | F | E | 0.2229 | |
| 284 | G | E | -0.8577 | |
| 285 | N | E | -1.0085 | |
| 286 | Q | E | -1.8778 | |
| 287 | G | E | -1.0036 | |
| 288 | G | E | -0.8127 | |
| 289 | F | E | -0.4844 | |
| 290 | G | E | -1.1958 | |
| 291 | N | E | -1.5531 | |
| 292 | S | E | 0.0000 | |
| 293 | R | E | -3.2566 | |
| 294 | G | E | -2.2036 | |
| 295 | G | E | -1.7233 | |
| 296 | G | E | -1.0379 | |
| 297 | A | E | -0.0677 | |
| 298 | G | E | 0.2573 | |
| 299 | L | E | 1.4236 | |
| 300 | G | E | 0.0909 | |
| 301 | N | E | -0.5012 | |
| 302 | N | E | -1.4690 | |
| 303 | Q | E | -1.1971 | |
| 304 | G | E | -0.8619 | |
| 305 | S | E | -0.5581 | |
| 306 | N | E | -0.7796 | |
| 307 | M | E | 0.0000 | |
| 308 | G | E | -0.2703 | |
| 309 | G | E | -0.3807 | |
| 310 | G | E | 0.0000 | |
| 311 | M | E | 0.8816 | |
| 312 | N | E | 0.7462 | |
| 313 | F | E | 1.8354 | |
| 314 | G | E | -0.1479 | |
| 315 | E | E | -1.6650 | |
| 316 | F | E | -0.8091 | |
| 317 | S | E | -0.8197 | |
| 318 | I | E | -0.5419 | |
| 319 | N | E | -1.4802 | |
| 320 | P | E | -0.7548 | |
| 321 | G | E | -0.4667 | |
| 322 | M | E | 0.4964 | |
| 323 | M | E | 1.0888 | |
| 324 | A | E | 0.0000 | |
| 325 | A | E | -0.0158 | |
| 326 | A | E | -0.6032 | |
| 327 | Q | E | -1.1950 | |
| 328 | A | E | -0.4453 | |
| 329 | A | E | 0.0000 | |
| 330 | L | E | -0.3261 | |
| 331 | Q | E | -1.2452 | |
| 332 | S | E | -0.4892 | |
| 333 | S | E | -0.1796 | |
| 334 | W | E | 0.2420 | |
| 335 | G | E | 0.0822 | |
| 336 | M | E | 0.2696 | |
| 337 | M | E | 0.0374 | |
| 338 | G | E | -0.2027 | |
| 339 | M | E | 0.1567 | |
| 340 | L | E | -0.2122 | |
| 341 | A | E | 0.0091 | |
| 342 | S | E | -0.1254 | |
| 343 | Q | E | -0.7173 | |
| 344 | Q | E | -1.4433 | |
| 345 | N | E | -1.8934 | |
| 346 | Q | E | -2.1181 | |
| 347 | S | E | -1.5273 | |
| 348 | G | E | -1.0921 | |
| 349 | P | E | -0.7469 | |
| 350 | S | E | -0.8453 | |
| 351 | G | E | -1.0591 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine