| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFRDIVVDGKVVVPKVSGNQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTAPVHGGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRNGPVGHPLPDAPPPSPLYTRPPPTSPYAVLPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPAPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9415 | |
| 2 | L | A | 1.9614 | |
| 3 | P | A | 0.8370 | |
| 4 | P | A | 0.3806 | |
| 5 | T | A | 0.1273 | |
| 6 | T | A | 0.1330 | |
| 7 | P | A | 0.1816 | |
| 8 | V | A | 1.2092 | |
| 9 | A | A | 0.0833 | |
| 10 | K | A | -1.0297 | |
| 11 | V | A | -0.1793 | |
| 12 | Q | A | -1.4107 | |
| 13 | S | A | -1.5539 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4097 | |
| 16 | E | A | -2.4326 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4613 | |
| 20 | P | A | 0.1292 | |
| 21 | T | A | 0.1590 | |
| 22 | S | A | -0.0968 | |
| 23 | L | A | 0.0900 | |
| 24 | F | A | -0.0298 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.3011 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9176 | |
| 31 | R | A | -2.7078 | |
| 32 | L | A | -0.8201 | |
| 33 | L | A | 1.1467 | |
| 34 | T | A | 1.3587 | |
| 35 | V | A | 1.8029 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2794 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6768 | |
| 40 | R | A | -1.7782 | |
| 41 | D | A | -0.6270 | |
| 42 | I | A | 1.2733 | |
| 43 | V | A | 2.1234 | |
| 44 | V | A | 1.6535 | |
| 45 | D | A | -0.9321 | |
| 46 | G | A | -0.5477 | |
| 47 | K | A | -0.1614 | |
| 48 | V | A | 2.0763 | |
| 49 | V | A | 2.7101 | |
| 50 | V | A | 1.5534 | |
| 51 | P | A | 0.3708 | |
| 52 | K | A | -0.6854 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | N | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1326 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3808 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2654 | |
| 70 | K | A | -1.7844 | |
| 71 | F | A | -0.6313 | |
| 72 | A | A | -0.5773 | |
| 73 | L | A | -0.8696 | |
| 74 | P | A | -1.2056 | |
| 75 | Q | A | -2.5058 | |
| 76 | K | A | -3.1095 | |
| 77 | D | A | -2.9940 | |
| 78 | F | A | -1.6675 | |
| 79 | Y | A | -1.8948 | |
| 80 | D | A | -2.6939 | |
| 81 | P | A | -2.3057 | |
| 82 | E | A | -3.0488 | |
| 83 | K | A | -3.3890 | |
| 84 | E | A | -2.4542 | |
| 85 | R | A | -1.2884 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6575 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9777 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3895 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7114 | |
| 99 | G | A | -0.5359 | |
| 100 | P | A | -0.3949 | |
| 101 | L | A | 0.0605 | |
| 102 | G | A | -0.1406 | |
| 103 | K | A | -0.4556 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.3867 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1501 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4292 | |
| 110 | L | A | 0.3140 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2097 | |
| 113 | K | A | -0.6034 | |
| 114 | L | A | -1.1592 | |
| 115 | G | A | -0.9242 | |
| 116 | D | A | -1.2995 | |
| 117 | T | A | -0.8589 | |
| 118 | E | A | -1.7743 | |
| 119 | N | A | -1.9316 | |
| 120 | P | A | -1.3637 | |
| 121 | T | A | -0.6842 | |
| 122 | A | A | -0.4386 | |
| 123 | P | A | -0.0796 | |
| 124 | V | A | -0.3975 | |
| 125 | H | A | -0.7646 | |
| 126 | G | A | -1.5858 | |
| 127 | G | A | -1.6244 | |
| 128 | A | A | -1.3714 | |
| 129 | D | A | -2.3629 | |
| 130 | D | A | -1.9515 | |
| 131 | R | A | -1.1690 | |
| 132 | V | A | 0.2433 | |
| 133 | A | A | 0.4557 | |
| 134 | F | A | 0.2876 | |
| 135 | S | A | -0.0653 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.5646 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5551 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1877 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1538 | |
| 157 | D | A | 0.3274 | |
| 158 | L | A | 0.7925 | |
| 159 | A | A | 0.1644 | |
| 160 | E | A | -1.4554 | |
| 161 | P | A | -0.2109 | |
| 162 | C | A | 0.1873 | |
| 163 | P | A | -0.1709 | |
| 164 | G | A | -0.0808 | |
| 165 | L | A | 0.5826 | |
| 166 | P | A | -0.1195 | |
| 167 | P | A | -0.3434 | |
| 168 | G | A | -0.4506 | |
| 169 | A | A | -0.0348 | |
| 170 | C | A | 0.6493 | |
| 171 | P | A | 0.5209 | |
| 172 | P | A | 0.8330 | |
| 173 | I | A | 1.9740 | |
| 174 | Q | A | 0.8443 | |
| 175 | L | A | 1.4968 | |
| 176 | V | A | 0.8601 | |
| 177 | N | A | -0.2932 | |
| 178 | S | A | 0.0305 | |
| 179 | V | A | 0.4288 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3785 | |
| 182 | D | A | 0.0831 | |
| 183 | G | A | -0.1592 | |
| 184 | D | A | -0.5235 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1030 | |
| 190 | F | A | 0.0614 | |
| 191 | G | A | -0.1037 | |
| 192 | N | A | -0.2467 | |
| 193 | M | A | -0.1032 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3930 | |
| 197 | E | A | -2.6103 | |
| 198 | L | A | -1.2345 | |
| 199 | Q | A | -2.5691 | |
| 200 | Q | A | -3.3283 | |
| 201 | D | A | -3.6038 | |
| 202 | R | A | -3.3436 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1440 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3501 | |
| 211 | S | A | -1.9069 | |
| 212 | T | A | -1.4100 | |
| 213 | R | A | -2.0222 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1527 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3755 | |
| 220 | L | A | 0.6065 | |
| 221 | K | A | -1.1142 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8174 | |
| 224 | N | A | -1.4935 | |
| 225 | E | A | -1.2344 | |
| 226 | A | A | -0.6078 | |
| 227 | Y | A | -0.3739 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6786 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0748 | |
| 234 | F | A | 0.2552 | |
| 235 | G | A | -0.8168 | |
| 236 | R | A | -2.5865 | |
| 237 | R | A | -2.8301 | |
| 238 | E | A | -2.0718 | |
| 239 | Q | A | -0.1778 | |
| 240 | V | A | 1.4222 | |
| 241 | Y | A | 1.1178 | |
| 242 | A | A | 0.2569 | |
| 243 | R | A | -0.8435 | |
| 244 | H | A | -0.7784 | |
| 245 | F | A | 0.0425 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.7467 | |
| 249 | N | A | -1.3250 | |
| 250 | G | A | -1.1488 | |
| 251 | P | A | -0.7594 | |
| 252 | V | A | -0.5579 | |
| 253 | G | A | -0.9374 | |
| 254 | H | A | -1.1491 | |
| 255 | P | A | -0.7372 | |
| 256 | L | A | 0.0270 | |
| 257 | P | A | -0.8563 | |
| 258 | D | A | -1.9711 | |
| 259 | A | A | -1.1838 | |
| 260 | P | A | -1.2410 | |
| 261 | P | A | -1.0643 | |
| 262 | P | A | -0.5216 | |
| 263 | S | A | -0.4610 | |
| 264 | P | A | 0.4001 | |
| 265 | L | A | 1.1754 | |
| 266 | Y | A | 0.2026 | |
| 267 | T | A | -0.9549 | |
| 268 | R | A | -1.7555 | |
| 269 | P | A | -0.6056 | |
| 270 | P | A | -0.7668 | |
| 271 | P | A | -0.3252 | |
| 272 | T | A | -0.2095 | |
| 273 | S | A | 0.0356 | |
| 274 | P | A | 0.4295 | |
| 275 | Y | A | 1.1582 | |
| 276 | A | A | 0.9244 | |
| 277 | V | A | 1.9976 | |
| 278 | L | A | 1.5563 | |
| 279 | P | A | 0.4820 | |
| 280 | P | A | -0.0037 | |
| 281 | Y | A | 0.1370 | |
| 282 | D | A | -0.5556 | |
| 283 | Y | A | 0.9234 | |
| 284 | F | A | 0.7476 | |
| 285 | G | A | 0.2668 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9385 | |
| 291 | L | A | 1.6345 | |
| 292 | V | A | 0.6583 | |
| 293 | S | A | -0.1631 | |
| 294 | S | A | -0.9636 | |
| 295 | D | A | -1.8418 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1127 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6657 | |
| 301 | R | A | -1.8622 | |
| 302 | P | A | -0.9528 | |
| 303 | F | A | -0.1927 | |
| 304 | W | A | -0.5613 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0847 | |
| 307 | R | A | -2.8338 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2642 | |
| 310 | G | A | -1.2293 | |
| 311 | N | A | -1.2763 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7711 | |
| 319 | N | A | -0.9108 | |
| 320 | E | A | -1.0257 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3009 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0181 | |
| 333 | N | A | 0.5788 | |
| 334 | F | A | 1.7388 | |
| 335 | T | A | 0.8562 | |
| 336 | I | A | 0.4394 | |
| 337 | S | A | -0.8387 | |
| 338 | Q | A | -1.4943 | |
| 339 | Q | A | -0.8545 | |
| 340 | L | A | 0.7975 | |
| 341 | C | A | 0.4260 | |
| 342 | T | A | 0.1539 | |
| 343 | P | A | -0.2713 | |
| 344 | A | A | 0.1979 | |
| 345 | P | A | 0.1641 | |
| 346 | N | A | -0.2828 | |
| 347 | V | A | 1.5495 | |
| 348 | Y | A | 1.4463 | |
| 349 | D | A | 0.0629 | |
| 350 | P | A | -0.3310 | |
| 351 | S | A | -0.2647 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5593 | |
| 354 | K | A | -1.6621 | |
| 355 | N | A | -1.7011 | |
| 356 | Y | A | -0.0909 | |
| 357 | L | A | 0.6331 | |
| 358 | R | A | 0.9593 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3845 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0906 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.1140 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.7048 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3013 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3002 | |
| 376 | L | A | -1.6925 | |
| 377 | D | A | -1.9608 | |
| 378 | P | A | -1.0248 | |
| 379 | G | A | -1.0055 | |
| 380 | V | A | -0.9253 | |
| 381 | L | A | -0.5250 | |
| 382 | A | A | -0.6523 | |
| 383 | H | A | -0.8077 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4142 | |
| 386 | T | A | -0.5570 | |
| 387 | M | A | -0.3050 | |
| 388 | N | A | -0.8676 | |
| 389 | P | A | -1.2382 | |
| 390 | T | A | -1.4157 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4071 | |
| 393 | E | A | -2.7396 | |
| 394 | N | A | -2.2971 | |
| 395 | W | A | -1.3243 | |
| 396 | N | A | -1.0815 | |
| 397 | L | A | -0.1978 | |
| 398 | G | A | 0.5352 | |
| 399 | F | A | 2.4172 | |
| 400 | V | A | 1.8389 | |
| 401 | P | A | 0.0476 | |
| 402 | P | A | -1.7832 | |
| 403 | K | A | -3.2998 | |
| 404 | E | A | -3.7402 | |
| 405 | R | A | -3.8290 | |
| 406 | E | A | -3.7413 | |
| 407 | D | A | -2.8229 | |
| 408 | P | A | -1.7412 | |
| 409 | Y | A | -0.9727 | |
| 410 | K | A | -2.1085 | |
| 411 | G | A | -0.6283 | |
| 412 | L | A | 0.6836 | |
| 413 | I | A | 1.5945 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3760 | |
| 416 | E | A | -1.6557 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9409 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0534 | |
| 421 | E | A | -2.7871 | |
| 422 | R | A | -2.6455 | |
| 423 | F | A | -1.2846 | |
| 424 | S | A | -1.4721 | |
| 425 | Q | A | -1.8599 | |
| 426 | D | A | -2.9015 | |
| 427 | L | A | -1.9847 | |
| 428 | D | A | -2.7690 | |
| 429 | Q | A | -2.6193 | |
| 430 | F | A | -1.4252 | |
| 431 | A | A | -0.8996 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5954 | |
| 435 | K | A | -0.7126 | |
| 436 | F | A | 0.1388 | |
| 437 | L | A | 1.0208 | |
| 438 | Y | A | 0.8216 | |
| 439 | Q | A | -0.2726 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine