Chain sequence(s) |
A: AVTVVPDPTCCGTLSFKVPKDAKKGKHLGTFDIRQAIMDYGGLHSQEWCAKGIVNPTFTVRMHAPRNAFAGLSIACTFDDYKRGSGSGNECPPSEMFELPTKVFMLKDADVHEWQFNYGELTGHGLCNWANVATQPTLYFFVASTNQVTMAADWQCIVTMHVDMGPVIDRFELNPTMTWPIQLGDTFAIDRYYEAKEIKLDGSTSMLSISYNFGGPVKHSKKHAISYSRAVMSRNLGWSGTISGSVKSVSSLFCTASFVIFPWECEAPPTLRQVLWGPHQIMHGDGQFEIAIKTRLHSAATTEEGFGRLGILPLSGPIAPDAHVGSYEFIVHINTWRPDSQVHPPMFSSSELYNWFTLTNLKPDANTGVVNFDIPGYIHDFASKDATVTLASNPLSWLVAATGWHYGEVDLCISWSRSKQAQAQEGSVSITTNYRDWGAYWQGQARIYDLRRTEAEIPIFLGSYAGATPSGALGKQNYVRISIVNAKDIVALRVCLRPKSIKFWGRSATLF
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:01) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:33) [INFO] Main: Simulation completed successfully. (00:04:37) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | A | A | 1.1071 | |
2 | V | A | 2.6580 | |
3 | T | A | 2.1144 | |
4 | V | A | 2.9362 | |
5 | V | A | 2.5649 | |
6 | P | A | 0.3658 | |
7 | D | A | -0.6622 | |
8 | P | A | -0.4435 | |
9 | T | A | -0.7733 | |
10 | C | A | 0.0000 | |
11 | C | A | 0.0000 | |
12 | G | A | 0.0000 | |
13 | T | A | 0.1367 | |
14 | L | A | 0.2461 | |
15 | S | A | -0.3322 | |
16 | F | A | 0.0000 | |
17 | K | A | -2.3305 | |
18 | V | A | 0.0000 | |
19 | P | A | -2.4114 | |
20 | K | A | -2.3979 | |
21 | D | A | -2.9271 | |
22 | A | A | 0.0000 | |
23 | K | A | -3.2792 | |
24 | K | A | -2.4746 | |
25 | G | A | -1.6432 | |
26 | K | A | -2.2267 | |
27 | H | A | -1.4931 | |
28 | L | A | -0.7872 | |
29 | G | A | -0.4654 | |
30 | T | A | -0.1104 | |
31 | F | A | 0.0000 | |
32 | D | A | -0.9016 | |
33 | I | A | 0.0000 | |
34 | R | A | -1.4922 | |
35 | Q | A | -1.8533 | |
36 | A | A | -1.1099 | |
37 | I | A | 0.0000 | |
38 | M | A | -1.2487 | |
39 | D | A | -1.7908 | |
40 | Y | A | -0.5295 | |
41 | G | A | -0.3427 | |
42 | G | A | -0.4527 | |
43 | L | A | 0.5650 | |
44 | H | A | 0.0000 | |
45 | S | A | -0.7630 | |
46 | Q | A | -1.2150 | |
47 | E | A | -1.1053 | |
48 | W | A | 0.0000 | |
49 | C | A | -0.7040 | |
50 | A | A | -0.9170 | |
51 | K | A | -0.9069 | |
52 | G | A | -0.6484 | |
53 | I | A | -0.3555 | |
54 | V | A | 0.0000 | |
55 | N | A | -0.2459 | |
56 | P | A | 0.0000 | |
57 | T | A | -1.1881 | |
58 | F | A | 0.0000 | |
59 | T | A | -1.1712 | |
60 | V | A | 0.0000 | |
61 | R | A | -1.0824 | |
62 | M | A | 0.0000 | |
63 | H | A | -0.9102 | |
64 | A | A | 0.0000 | |
65 | P | A | -0.8715 | |
66 | R | A | -1.4097 | |
67 | N | A | 0.1238 | |
68 | A | A | 0.0000 | |
69 | F | A | 2.4324 | |
70 | A | A | 0.0000 | |
71 | G | A | 0.0000 | |
72 | L | A | 0.0000 | |
73 | S | A | 0.0000 | |
74 | I | A | 0.0000 | |
75 | A | A | 0.0000 | |
76 | C | A | 0.0000 | |
77 | T | A | 0.0000 | |
78 | F | A | 0.0000 | |
79 | D | A | 0.0000 | |
80 | D | A | -0.7430 | |
81 | Y | A | -0.4597 | |
82 | K | A | -1.2080 | |
83 | R | A | -0.8780 | |
84 | G | A | -1.0998 | |
85 | S | A | -1.0127 | |
86 | G | A | -1.0918 | |
87 | S | A | -0.9832 | |
88 | G | A | -1.1658 | |
89 | N | A | -1.5919 | |
90 | E | A | 0.0000 | |
91 | C | A | -0.9169 | |
92 | P | A | -0.9497 | |
93 | P | A | 0.0000 | |
94 | S | A | 0.0000 | |
95 | E | A | -0.6441 | |
96 | M | A | -0.3054 | |
97 | F | A | -0.2651 | |
98 | E | A | -0.6566 | |
99 | L | A | 0.0000 | |
100 | P | A | -0.6593 | |
101 | T | A | -0.2967 | |
102 | K | A | -0.5904 | |
103 | V | A | 0.0000 | |
104 | F | A | 0.0000 | |
105 | M | A | 0.0000 | |
106 | L | A | -0.9359 | |
107 | K | A | -1.7654 | |
108 | D | A | -1.3610 | |
109 | A | A | -1.4054 | |
110 | D | A | -1.6935 | |
111 | V | A | 0.1648 | |
112 | H | A | 0.0000 | |
113 | E | A | -1.1599 | |
114 | W | A | 0.0000 | |
115 | Q | A | -1.5545 | |
116 | F | A | 0.0000 | |
117 | N | A | -1.2031 | |
118 | Y | A | 0.0000 | |
119 | G | A | 0.0000 | |
120 | E | A | -1.6014 | |
121 | L | A | -0.8285 | |
122 | T | A | 0.0000 | |
123 | G | A | 0.0000 | |
124 | H | A | 0.0000 | |
125 | G | A | 0.0000 | |
126 | L | A | 0.0000 | |
127 | C | A | -0.4196 | |
128 | N | A | -1.0298 | |
129 | W | A | 0.2878 | |
130 | A | A | 0.2451 | |
131 | N | A | 0.4890 | |
132 | V | A | 1.6063 | |
133 | A | A | 0.5563 | |
134 | T | A | -0.1605 | |
135 | Q | A | -1.0809 | |
136 | P | A | 0.0000 | |
137 | T | A | -0.7074 | |
138 | L | A | 0.0000 | |
139 | Y | A | 0.0158 | |
140 | F | A | 0.0000 | |
141 | F | A | 0.0000 | |
142 | V | A | 0.0000 | |
143 | A | A | -1.0715 | |
144 | S | A | 0.0000 | |
145 | T | A | -2.0020 | |
146 | N | A | -1.8334 | |
147 | Q | A | -0.8074 | |
148 | V | A | 0.9729 | |
149 | T | A | -0.6818 | |
150 | M | A | 0.0000 | |
151 | A | A | -0.3348 | |
152 | A | A | -1.1841 | |
153 | D | A | -2.1874 | |
154 | W | A | -1.0601 | |
155 | Q | A | -1.6862 | |
156 | C | A | 0.0000 | |
157 | I | A | 0.4368 | |
158 | V | A | 0.0000 | |
159 | T | A | -0.1684 | |
160 | M | A | 0.0000 | |
161 | H | A | -0.9432 | |
162 | V | A | -1.0283 | |
163 | D | A | -1.8762 | |
164 | M | A | -0.8974 | |
165 | G | A | -0.5256 | |
166 | P | A | 0.1292 | |
167 | V | A | 0.6545 | |
168 | I | A | -0.4420 | |
169 | D | A | -2.2687 | |
170 | R | A | -2.5146 | |
171 | F | A | -1.3998 | |
172 | E | A | -1.7494 | |
173 | L | A | -1.3399 | |
174 | N | A | -1.7012 | |
175 | P | A | -1.1850 | |
176 | T | A | -0.8744 | |
177 | M | A | 0.0000 | |
178 | T | A | -0.6367 | |
179 | W | A | 0.0000 | |
180 | P | A | -0.8867 | |
181 | I | A | -0.6096 | |
182 | Q | A | -1.2613 | |
183 | L | A | -0.9345 | |
184 | G | A | -1.8700 | |
185 | D | A | -2.7848 | |
186 | T | A | -1.7346 | |
187 | F | A | -0.9156 | |
188 | A | A | -1.0225 | |
189 | I | A | 0.0000 | |
190 | D | A | -2.4316 | |
191 | R | A | -1.6473 | |
192 | Y | A | -1.0874 | |
193 | Y | A | 0.0000 | |
194 | E | A | -2.0226 | |
195 | A | A | -1.4737 | |
196 | K | A | -1.1481 | |
197 | E | A | -1.0562 | |
198 | I | A | 0.0000 | |
199 | K | A | -1.5921 | |
200 | L | A | 0.2184 | |
201 | D | A | -1.7054 | |
202 | G | A | -1.3831 | |
203 | S | A | -0.9481 | |
204 | T | A | -0.3559 | |
205 | S | A | -0.2730 | |
206 | M | A | 0.0000 | |
207 | L | A | -0.0509 | |
208 | S | A | 0.0000 | |
209 | I | A | -0.0948 | |
210 | S | A | 0.0000 | |
211 | Y | A | 0.0000 | |
212 | N | A | -1.0005 | |
213 | F | A | 0.0000 | |
214 | G | A | 0.0000 | |
215 | G | A | -0.4157 | |
216 | P | A | -0.5130 | |
217 | V | A | -1.0761 | |
218 | K | A | -1.9741 | |
219 | H | A | -1.4355 | |
220 | S | A | -1.4903 | |
221 | K | A | -1.8172 | |
222 | K | A | -1.1543 | |
223 | H | A | -0.9360 | |
224 | A | A | 0.0000 | |
225 | I | A | 0.0000 | |
226 | S | A | 0.0000 | |
227 | Y | A | -0.0606 | |
228 | S | A | -0.2482 | |
229 | R | A | 0.0000 | |
230 | A | A | 0.0000 | |
231 | V | A | 0.0000 | |
232 | M | A | 0.0000 | |
233 | S | A | 0.0000 | |
234 | R | A | -0.4920 | |
235 | N | A | -0.0092 | |
236 | L | A | 0.3121 | |
237 | G | A | -0.0692 | |
238 | W | A | 0.0000 | |
239 | S | A | 0.0000 | |
240 | G | A | -1.9428 | |
241 | T | A | -1.5081 | |
242 | I | A | 0.0000 | |
243 | S | A | -1.7297 | |
244 | G | A | 0.0000 | |
245 | S | A | -1.7554 | |
246 | V | A | 0.0000 | |
247 | K | A | -1.6650 | |
248 | S | A | -0.7745 | |
249 | V | A | 0.0000 | |
250 | S | A | 0.0000 | |
251 | S | A | 0.0000 | |
252 | L | A | 2.5670 | |
253 | F | A | 3.0652 | |
254 | C | A | 0.0000 | |
255 | T | A | 0.8001 | |
256 | A | A | 0.0000 | |
257 | S | A | 0.0212 | |
258 | F | A | 0.0000 | |
259 | V | A | 0.0000 | |
260 | I | A | 0.0000 | |
261 | F | A | 0.0000 | |
262 | P | A | 0.0000 | |
263 | W | A | -0.4769 | |
264 | E | A | 0.0000 | |
265 | C | A | -0.5795 | |
266 | E | A | -1.6145 | |
267 | A | A | -0.7065 | |
268 | P | A | 0.0000 | |
269 | P | A | -0.7436 | |
270 | T | A | -0.4792 | |
271 | L | A | -0.1839 | |
272 | R | A | -1.3004 | |
273 | Q | A | -0.6352 | |
274 | V | A | 0.0000 | |
275 | L | A | 0.4438 | |
276 | W | A | 0.7382 | |
277 | G | A | 0.0800 | |
278 | P | A | -0.2297 | |
279 | H | A | -0.4640 | |
280 | Q | A | -0.5883 | |
281 | I | A | 0.5157 | |
282 | M | A | 0.0000 | |
283 | H | A | -1.1872 | |
284 | G | A | -1.6612 | |
285 | D | A | -2.5995 | |
286 | G | A | -1.9734 | |
287 | Q | A | -2.3446 | |
288 | F | A | 0.0000 | |
289 | E | A | -2.2429 | |
290 | I | A | 0.0000 | |
291 | A | A | -0.9218 | |
292 | I | A | 0.0000 | |
293 | K | A | -1.3054 | |
294 | T | A | 0.0000 | |
295 | R | A | -1.5521 | |
296 | L | A | -0.2077 | |
297 | H | A | -1.3659 | |
298 | S | A | -0.5390 | |
299 | A | A | 0.0000 | |
300 | A | A | -0.6963 | |
301 | T | A | 0.0000 | |
302 | T | A | -1.1997 | |
303 | E | A | -2.5398 | |
304 | E | A | -2.6100 | |
305 | G | A | -1.3203 | |
306 | F | A | -0.6659 | |
307 | G | A | 0.0000 | |
308 | R | A | 0.0000 | |
309 | L | A | 0.0000 | |
310 | G | A | 0.0000 | |
311 | I | A | 0.0000 | |
312 | L | A | 0.0000 | |
313 | P | A | -0.1427 | |
314 | L | A | 0.4026 | |
315 | S | A | 0.1721 | |
316 | G | A | 0.0892 | |
317 | P | A | 0.0000 | |
318 | I | A | 2.1982 | |
319 | A | A | 1.3329 | |
320 | P | A | -0.0778 | |
321 | D | A | -1.3347 | |
322 | A | A | -0.3483 | |
323 | H | A | 0.6909 | |
324 | V | A | 1.4975 | |
325 | G | A | 0.3116 | |
326 | S | A | -0.4348 | |
327 | Y | A | 0.0000 | |
328 | E | A | 0.0000 | |
329 | F | A | 0.0000 | |
330 | I | A | 0.0000 | |
331 | V | A | 0.0000 | |
332 | H | A | -1.3768 | |
333 | I | A | 0.0000 | |
334 | N | A | -2.1542 | |
335 | T | A | -1.6762 | |
336 | W | A | 0.0000 | |
337 | R | A | -2.7228 | |
338 | P | A | -2.5590 | |
339 | D | A | -2.8920 | |
340 | S | A | -1.7510 | |
341 | Q | A | -1.1413 | |
342 | V | A | 0.7447 | |
343 | H | A | 0.2950 | |
344 | P | A | 0.3263 | |
345 | P | A | 0.3687 | |
346 | M | A | 0.8193 | |
347 | F | A | 1.7035 | |
348 | S | A | 0.4043 | |
349 | S | A | -0.1931 | |
350 | S | A | -0.3166 | |
351 | E | A | -0.7865 | |
352 | L | A | 0.0349 | |
353 | Y | A | 0.0000 | |
354 | N | A | -0.7043 | |
355 | W | A | 0.0000 | |
356 | F | A | 0.0000 | |
357 | T | A | -0.1342 | |
358 | L | A | 0.0000 | |
359 | T | A | -0.4632 | |
360 | N | A | -1.4264 | |
361 | L | A | -1.7571 | |
362 | K | A | -2.9755 | |
363 | P | A | -2.0624 | |
364 | D | A | -2.4285 | |
365 | A | A | -1.6196 | |
366 | N | A | -1.7945 | |
367 | T | A | -0.7088 | |
368 | G | A | -0.5704 | |
369 | V | A | -0.1553 | |
370 | V | A | 0.0000 | |
371 | N | A | -0.9089 | |
372 | F | A | 0.0000 | |
373 | D | A | -0.6804 | |
374 | I | A | 0.0000 | |
375 | P | A | -0.0660 | |
376 | G | A | 0.0000 | |
377 | Y | A | 0.0000 | |
378 | I | A | 0.0000 | |
379 | H | A | -0.8805 | |
380 | D | A | -1.6226 | |
381 | F | A | 0.0000 | |
382 | A | A | -0.6493 | |
383 | S | A | -1.0284 | |
384 | K | A | -2.2406 | |
385 | D | A | -2.5343 | |
386 | A | A | 0.0000 | |
387 | T | A | -0.8642 | |
388 | V | A | -0.2011 | |
389 | T | A | 0.2528 | |
390 | L | A | 0.3617 | |
391 | A | A | -0.1362 | |
392 | S | A | -0.3534 | |
393 | N | A | 0.0000 | |
394 | P | A | 0.0000 | |
395 | L | A | 0.0000 | |
396 | S | A | -0.4390 | |
397 | W | A | 0.0000 | |
398 | L | A | 0.0000 | |
399 | V | A | 0.0000 | |
400 | A | A | -0.2917 | |
401 | A | A | 0.0000 | |
402 | T | A | 0.0000 | |
403 | G | A | 0.0000 | |
404 | W | A | 0.0000 | |
405 | H | A | 0.0000 | |
406 | Y | A | 0.6080 | |
407 | G | A | -0.5679 | |
408 | E | A | -1.4786 | |
409 | V | A | 0.0000 | |
410 | D | A | -1.3863 | |
411 | L | A | 0.0000 | |
412 | C | A | -1.1569 | |
413 | I | A | 0.0000 | |
414 | S | A | -1.3400 | |
415 | W | A | 0.0000 | |
416 | S | A | 0.1381 | |
417 | R | A | 0.0000 | |
418 | S | A | -0.8379 | |
419 | K | A | -2.0071 | |
420 | Q | A | -2.0732 | |
421 | A | A | -1.4011 | |
422 | Q | A | -1.7172 | |
423 | A | A | -1.3730 | |
424 | Q | A | 0.0000 | |
425 | E | A | -2.0066 | |
426 | G | A | -0.2975 | |
427 | S | A | 0.1315 | |
428 | V | A | 0.0000 | |
429 | S | A | -0.2567 | |
430 | I | A | 0.0000 | |
431 | T | A | -0.4691 | |
432 | T | A | 0.0160 | |
433 | N | A | 0.0000 | |
434 | Y | A | 0.7258 | |
435 | R | A | -0.4028 | |
436 | D | A | -0.5144 | |
437 | W | A | 0.8038 | |
438 | G | A | 0.4348 | |
439 | A | A | 0.7144 | |
440 | Y | A | 1.3655 | |
441 | W | A | 1.0327 | |
442 | Q | A | -0.9339 | |
443 | G | A | -1.3985 | |
444 | Q | A | -1.7162 | |
445 | A | A | -0.7096 | |
446 | R | A | -0.7660 | |
447 | I | A | 0.0488 | |
448 | Y | A | -0.0524 | |
449 | D | A | -1.5971 | |
450 | L | A | -1.1756 | |
451 | R | A | -2.5725 | |
452 | R | A | -2.3836 | |
453 | T | A | -1.5343 | |
454 | E | A | -1.4057 | |
455 | A | A | -0.9757 | |
456 | E | A | 0.0000 | |
457 | I | A | 0.6638 | |
458 | P | A | 0.0000 | |
459 | I | A | 0.0000 | |
460 | F | A | 1.9843 | |
461 | L | A | 0.8277 | |
462 | G | A | 0.0000 | |
463 | S | A | 0.0000 | |
464 | Y | A | 0.5510 | |
465 | A | A | 0.5374 | |
466 | G | A | 0.1489 | |
467 | A | A | -0.0583 | |
468 | T | A | -0.5296 | |
469 | P | A | -0.3753 | |
470 | S | A | -0.0546 | |
471 | G | A | 0.2634 | |
472 | A | A | 0.0000 | |
473 | L | A | 1.0814 | |
474 | G | A | 0.0000 | |
475 | K | A | 0.0000 | |
476 | Q | A | 0.0000 | |
477 | N | A | 0.0000 | |
478 | Y | A | 0.0000 | |
479 | V | A | 0.2564 | |
480 | R | A | 0.0000 | |
481 | I | A | 1.3513 | |
482 | S | A | 0.7318 | |
483 | I | A | 1.1647 | |
484 | V | A | 0.0000 | |
485 | N | A | -0.9295 | |
486 | A | A | -0.4870 | |
487 | K | A | -0.8119 | |
488 | D | A | -0.1418 | |
489 | I | A | 1.0219 | |
490 | V | A | 0.7315 | |
491 | A | A | 0.0000 | |
492 | L | A | 0.0000 | |
493 | R | A | -1.0033 | |
494 | V | A | 0.0000 | |
495 | C | A | 0.0000 | |
496 | L | A | 0.0000 | |
497 | R | A | -1.8299 | |
498 | P | A | 0.0000 | |
499 | K | A | -2.4726 | |
500 | S | A | -1.6783 | |
501 | I | A | 0.0000 | |
502 | K | A | -1.2252 | |
503 | F | A | 0.0000 | |
504 | W | A | 0.0000 | |
505 | G | A | 0.0000 | |
506 | R | A | -0.9217 | |
507 | S | A | 0.0000 | |
508 | A | A | 0.0000 | |
509 | T | A | 0.1287 | |
510 | L | A | 0.0000 | |
511 | F | A | 1.0393 |