| Chain sequence(s) |
A: GLPPLGPEPELLSTDDYVEPTDLLYVAETDLITETGHPTRDIIENGKVVVPRVSAYDYKVFLLKLPDPNKLPLPSEDFIDPETEILIWRLVAYKIHVFGELGKGTYGHPNFNRLGDVDNPTAPQHGTSNNTVNLSFTPVRKQLYVIGDLPPTGKYTAKAAPAPGLPPGAVPPTTTVSTTIQHGDRADIGFGAKDFAALEPRKNNVPEIILNTTTKVLDLDGMKAEPTGRRMFDYDEKTSSKDVKNYVLDGPDKRPPPDAPPPSPLYVKPPPSSPYAVRPSTNYFTLPDAGEITEADLLFNKPKFFEKAAGKNNYVLWHNRLYITVLDNTRAAIEKIETLLSTPKENVYDPSYYKTSERYTREYKISLIVQLCRIPLTPEVLALLERIDPSILVDAELPEIPPVERPDPLAGLKFHEIDLTDKLSRDLEKSELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.1668 | |
| 2 | L | A | 1.3888 | |
| 3 | P | A | 0.5668 | |
| 4 | P | A | 0.5115 | |
| 5 | L | A | 0.9675 | |
| 6 | G | A | -0.4863 | |
| 7 | P | A | -1.3764 | |
| 8 | E | A | -2.3297 | |
| 9 | P | A | -1.9643 | |
| 10 | E | A | -2.1461 | |
| 11 | L | A | -0.8813 | |
| 12 | L | A | -0.4126 | |
| 13 | S | A | -1.2526 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.9837 | |
| 16 | D | A | -2.6781 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.4053 | |
| 20 | P | A | -1.7774 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.8020 | |
| 23 | L | A | 0.0000 | |
| 24 | L | A | -0.8532 | |
| 25 | Y | A | 0.0000 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.1737 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.4179 | |
| 31 | L | A | 0.2854 | |
| 32 | I | A | 0.0000 | |
| 33 | T | A | -0.1738 | |
| 34 | E | A | -0.3127 | |
| 35 | T | A | -0.4187 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.3793 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.5680 | |
| 40 | R | A | -2.1707 | |
| 41 | D | A | -1.0576 | |
| 42 | I | A | 0.4753 | |
| 43 | I | A | 0.8615 | |
| 44 | E | A | -1.4409 | |
| 45 | N | A | -2.0440 | |
| 46 | G | A | -1.3608 | |
| 47 | K | A | -1.1639 | |
| 48 | V | A | 1.0393 | |
| 49 | V | A | 1.3208 | |
| 50 | V | A | 0.5528 | |
| 51 | P | A | -0.2189 | |
| 52 | R | A | -1.2926 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0106 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4785 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.9486 | |
| 70 | K | A | -2.0223 | |
| 71 | L | A | -0.8683 | |
| 72 | P | A | -0.6561 | |
| 73 | L | A | -0.6012 | |
| 74 | P | A | -0.6640 | |
| 75 | S | A | -1.5067 | |
| 76 | E | A | -2.7561 | |
| 77 | D | A | -2.7577 | |
| 78 | F | A | -1.4022 | |
| 79 | I | A | -1.6824 | |
| 80 | D | A | -2.4066 | |
| 81 | P | A | -1.9476 | |
| 82 | E | A | -2.3559 | |
| 83 | T | A | -1.4277 | |
| 84 | E | A | -1.3601 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.4356 | |
| 90 | L | A | 0.0000 | |
| 91 | V | A | 0.0000 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.3830 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.1584 | |
| 99 | G | A | -0.8826 | |
| 100 | E | A | -1.7134 | |
| 101 | L | A | -0.7727 | |
| 102 | G | A | -1.0334 | |
| 103 | K | A | -1.7682 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4919 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.0479 | |
| 108 | H | A | -1.5826 | |
| 109 | P | A | -1.5336 | |
| 110 | N | A | -2.2584 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -0.8036 | |
| 114 | L | A | -0.6211 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.1375 | |
| 117 | V | A | -0.7786 | |
| 118 | D | A | -2.3674 | |
| 119 | N | A | -2.2683 | |
| 120 | P | A | -1.2488 | |
| 121 | T | A | -0.7572 | |
| 122 | A | A | -0.3811 | |
| 123 | P | A | -0.0719 | |
| 124 | Q | A | -0.5134 | |
| 125 | H | A | -0.7015 | |
| 126 | G | A | -1.3818 | |
| 127 | T | A | -1.0766 | |
| 128 | S | A | -1.0372 | |
| 129 | N | A | -1.7334 | |
| 130 | N | A | -1.2632 | |
| 131 | T | A | -1.2023 | |
| 132 | V | A | -0.9086 | |
| 133 | N | A | -1.5681 | |
| 134 | L | A | -0.8034 | |
| 135 | S | A | -0.5595 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.4549 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | -0.5204 | |
| 140 | R | A | 0.0000 | |
| 141 | K | A | -0.5475 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | L | A | 0.0119 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | -0.1824 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.5529 | |
| 155 | Y | A | -0.2016 | |
| 156 | T | A | -0.5313 | |
| 157 | A | A | -0.8830 | |
| 158 | K | A | -1.4661 | |
| 159 | A | A | -0.8258 | |
| 160 | A | A | -0.4787 | |
| 161 | P | A | -0.2304 | |
| 162 | A | A | -0.0984 | |
| 163 | P | A | -0.2940 | |
| 164 | G | A | -0.2588 | |
| 165 | L | A | 0.5751 | |
| 166 | P | A | 0.0251 | |
| 167 | P | A | -0.2053 | |
| 168 | G | A | -0.0668 | |
| 169 | A | A | 0.6418 | |
| 170 | V | A | 1.5024 | |
| 171 | P | A | 0.4112 | |
| 172 | P | A | -0.0893 | |
| 173 | T | A | -0.4972 | |
| 174 | T | A | -0.4261 | |
| 175 | T | A | -0.2449 | |
| 176 | V | A | -0.0592 | |
| 177 | S | A | -0.1958 | |
| 178 | T | A | -0.1765 | |
| 179 | T | A | -0.3558 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.8700 | |
| 182 | H | A | -1.0146 | |
| 183 | G | A | -0.6946 | |
| 184 | D | A | -0.6675 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2025 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2018 | |
| 190 | F | A | 0.0313 | |
| 191 | G | A | -0.2295 | |
| 192 | A | A | -0.2886 | |
| 193 | K | A | -0.6165 | |
| 194 | D | A | -0.8602 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.3783 | |
| 197 | A | A | -0.7583 | |
| 198 | L | A | -0.8550 | |
| 199 | E | A | -1.6720 | |
| 200 | P | A | -1.9919 | |
| 201 | R | A | -2.9168 | |
| 202 | K | A | -3.4198 | |
| 203 | N | A | -2.3331 | |
| 204 | N | A | -1.5657 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | E | A | -2.2461 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.6874 | |
| 211 | N | A | -1.7836 | |
| 212 | T | A | -0.8528 | |
| 213 | T | A | -0.5373 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.1204 | |
| 217 | L | A | 0.0000 | |
| 218 | D | A | -0.9706 | |
| 219 | L | A | -1.2637 | |
| 220 | D | A | -2.5067 | |
| 221 | G | A | -1.8478 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.5418 | |
| 224 | A | A | -1.5948 | |
| 225 | E | A | -1.4765 | |
| 226 | P | A | -0.9690 | |
| 227 | T | A | -0.6005 | |
| 228 | G | A | -0.9723 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.5454 | |
| 231 | M | A | -0.4031 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.5469 | |
| 234 | Y | A | -0.2666 | |
| 235 | D | A | -1.0487 | |
| 236 | E | A | -1.3178 | |
| 237 | K | A | -1.3808 | |
| 238 | T | A | -0.6700 | |
| 239 | S | A | -0.9287 | |
| 240 | S | A | -1.4408 | |
| 241 | K | A | -2.3129 | |
| 242 | D | A | -2.2623 | |
| 243 | V | A | -0.9156 | |
| 244 | K | A | -1.7501 | |
| 245 | N | A | -1.1057 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | -0.3971 | |
| 249 | D | A | -1.1773 | |
| 250 | G | A | -1.1567 | |
| 251 | P | A | -1.6057 | |
| 252 | D | A | -2.4091 | |
| 253 | K | A | -2.7043 | |
| 254 | R | A | -2.2659 | |
| 255 | P | A | -1.8150 | |
| 256 | P | A | -1.8790 | |
| 257 | P | A | -1.1750 | |
| 258 | D | A | -2.1967 | |
| 259 | A | A | -1.4349 | |
| 260 | P | A | -1.0552 | |
| 261 | P | A | -0.9788 | |
| 262 | P | A | -0.8908 | |
| 263 | S | A | -0.0846 | |
| 264 | P | A | 0.5336 | |
| 265 | L | A | 1.9000 | |
| 266 | Y | A | 1.0911 | |
| 267 | V | A | 1.1130 | |
| 268 | K | A | -0.8437 | |
| 269 | P | A | -0.2192 | |
| 270 | P | A | -0.5596 | |
| 271 | P | A | -0.3869 | |
| 272 | S | A | -0.3298 | |
| 273 | S | A | 0.0428 | |
| 274 | P | A | 0.3608 | |
| 275 | Y | A | 0.9720 | |
| 276 | A | A | 0.6303 | |
| 277 | V | A | 1.4212 | |
| 278 | R | A | -0.0019 | |
| 279 | P | A | -0.3261 | |
| 280 | S | A | -0.9432 | |
| 281 | T | A | -0.4065 | |
| 282 | N | A | -0.6691 | |
| 283 | Y | A | 0.8118 | |
| 284 | F | A | 0.4035 | |
| 285 | T | A | -0.1970 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.4945 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | 0.0000 | |
| 291 | E | A | -2.0224 | |
| 292 | I | A | -1.1057 | |
| 293 | T | A | -1.3689 | |
| 294 | E | A | -1.9081 | |
| 295 | A | A | -1.1994 | |
| 296 | D | A | -1.6716 | |
| 297 | L | A | -1.1191 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0963 | |
| 301 | K | A | -1.4074 | |
| 302 | P | A | -0.9677 | |
| 303 | K | A | -0.6648 | |
| 304 | F | A | -0.5171 | |
| 305 | F | A | -1.0407 | |
| 306 | E | A | -2.4556 | |
| 307 | K | A | -2.7760 | |
| 308 | A | A | 0.0000 | |
| 309 | A | A | -0.8557 | |
| 310 | G | A | -1.2682 | |
| 311 | K | A | -1.3681 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | Y | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8641 | |
| 319 | N | A | -0.9937 | |
| 320 | R | A | -1.0533 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | A | A | -1.2847 | |
| 333 | I | A | -1.2141 | |
| 334 | E | A | -2.3419 | |
| 335 | K | A | -2.6358 | |
| 336 | I | A | -1.2607 | |
| 337 | E | A | -1.7388 | |
| 338 | T | A | -0.1186 | |
| 339 | L | A | 1.5549 | |
| 340 | L | A | 1.7108 | |
| 341 | S | A | 0.7940 | |
| 342 | T | A | -0.0680 | |
| 343 | P | A | -0.7039 | |
| 344 | K | A | -2.2800 | |
| 345 | E | A | -2.5541 | |
| 346 | N | A | -1.4813 | |
| 347 | V | A | 0.5414 | |
| 348 | Y | A | 0.9763 | |
| 349 | D | A | 0.0901 | |
| 350 | P | A | 0.1273 | |
| 351 | S | A | 0.0318 | |
| 352 | Y | A | 0.3595 | |
| 353 | Y | A | 0.2305 | |
| 354 | K | A | -1.3102 | |
| 355 | T | A | -1.5062 | |
| 356 | S | A | -1.4984 | |
| 357 | E | A | -1.6125 | |
| 358 | R | A | -1.3199 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.4815 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.1675 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.5985 | |
| 365 | I | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.5303 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -1.1896 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.9740 | |
| 376 | L | A | -0.5974 | |
| 377 | T | A | -0.6318 | |
| 378 | P | A | -0.9713 | |
| 379 | E | A | -1.7895 | |
| 380 | V | A | 0.0000 | |
| 381 | L | A | -0.6780 | |
| 382 | A | A | -1.0838 | |
| 383 | L | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -1.6561 | |
| 386 | R | A | -1.5635 | |
| 387 | I | A | -0.7637 | |
| 388 | D | A | -0.8997 | |
| 389 | P | A | -0.9381 | |
| 390 | S | A | -1.2056 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.3091 | |
| 394 | D | A | -1.9373 | |
| 395 | A | A | -1.5999 | |
| 396 | E | A | -2.4578 | |
| 397 | L | A | -1.8235 | |
| 398 | P | A | -1.6436 | |
| 399 | E | A | -1.9711 | |
| 400 | I | A | -0.7484 | |
| 401 | P | A | -0.5168 | |
| 402 | P | A | -0.6091 | |
| 403 | V | A | 0.5820 | |
| 404 | E | A | -1.6064 | |
| 405 | R | A | -1.6226 | |
| 406 | P | A | -1.3672 | |
| 407 | D | A | -1.5574 | |
| 408 | P | A | -0.7778 | |
| 409 | L | A | -0.4449 | |
| 410 | A | A | -0.6345 | |
| 411 | G | A | -0.7250 | |
| 412 | L | A | -0.6285 | |
| 413 | K | A | -1.9326 | |
| 414 | F | A | -1.3153 | |
| 415 | H | A | -1.6116 | |
| 416 | E | A | -2.5661 | |
| 417 | I | A | -2.0495 | |
| 418 | D | A | -2.9195 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.9386 | |
| 421 | D | A | -2.6945 | |
| 422 | K | A | -2.5438 | |
| 423 | L | A | -1.4432 | |
| 424 | S | A | -2.0848 | |
| 425 | R | A | -2.5879 | |
| 426 | D | A | -2.8173 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.6047 | |
| 429 | K | A | -3.5381 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.4326 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.9127 | |
| 435 | E | A | -1.8825 | |
| 436 | Y | A | -1.0026 | |
| 437 | L | A | -0.5247 | |
| 438 | N | A | -1.8931 | |
| 439 | R | A | -2.1476 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine