Project name: 559

Chain sequence(s)	H: EVQLLESGGGLVQPGGSLRLSCTASGYTNRLKCMGWFRQAPGKEREEIASISTGTGNTYYADSVKGRFTISRDKSRNTLYLQMNTLRAEDTAVYYCAADVRPHGTTCHYNSRGQGTQVTVSS
Selected Chain(s)	H
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with H chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:56)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:56)

• Minimal score value: -3.0979
• Maximal score value: 1.1358
• Average score: -0.8756
• Total score value: -106.8172

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9336
2	V	H	-1.4493
3	Q	H	-1.6248
4	L	H	0.0000
5	L	H	0.5969
6	E	H	0.0000
7	S	H	-0.3961
8	G	H	-0.8211
9	G	H	-0.4642
11	G	H	0.1666
12	L	H	1.1358
13	V	H	0.0098
14	Q	H	-1.3266
15	P	H	-1.7270
16	G	H	-1.3221
17	G	H	-0.9174
18	S	H	-0.9816
19	L	H	-0.4148
20	R	H	-1.2213
21	L	H	0.0000
22	S	H	-0.3242
23	C	H	0.0000
24	T	H	-0.4056
25	A	H	0.0000
26	S	H	-0.5377
27	G	H	-0.7716
28	Y	H	-0.2663
29	T	H	-0.5855
30	N	H	-1.4530
35	R	H	-1.2818
36	L	H	-1.0097
37	K	H	-1.7337
38	C	H	-0.8086
39	M	H	0.0000
40	G	H	0.0000
41	W	H	0.0000
42	F	H	-1.1780
43	R	H	0.0000
44	Q	H	-1.5862
45	A	H	-1.4309
46	P	H	-1.0265
47	G	H	-1.4848
48	K	H	-2.2438
49	E	H	-2.9649
50	R	H	-2.2810
51	E	H	-2.0954
52	E	H	-2.2035
53	I	H	0.0000
54	A	H	0.0000
55	S	H	0.0252
56	I	H	0.0000
57	S	H	-0.8319
58	T	H	-1.1527
59	G	H	-1.0361
62	T	H	-0.9492
63	G	H	-1.1441
64	N	H	-1.2084
65	T	H	-0.0336
66	Y	H	0.6971
67	Y	H	-0.4660
68	A	H	-1.4157
69	D	H	-2.2924
70	S	H	-1.8639
71	V	H	0.0000
72	K	H	-2.3565
74	G	H	-1.6712
75	R	H	-1.4601
76	F	H	0.0000
77	T	H	-0.5254
78	I	H	0.0000
79	S	H	-0.9140
80	R	H	-1.9986
81	D	H	-2.5753
82	K	H	-3.0580
83	S	H	-2.4005
84	R	H	-3.0979
85	N	H	-2.6083
86	T	H	0.0000
87	L	H	0.0000
88	Y	H	-0.6179
89	L	H	0.0000
90	Q	H	-0.7796
91	M	H	0.0000
92	N	H	-1.1063
93	T	H	-1.0894
94	L	H	0.0000
95	R	H	-2.1209
96	A	H	-1.6260
97	E	H	-2.1683
98	D	H	0.0000
99	T	H	-0.6616
100	A	H	0.0000
101	V	H	-0.1152
102	Y	H	0.0000
103	Y	H	-0.6471
104	C	H	0.0000
105	A	H	0.0000
106	A	H	0.0000
107	D	H	0.0000
108	V	H	-0.9945
109	R	H	-1.7957
110	P	H	-1.4026
111	H	H	-1.5553
111A	G	H	-1.2161
112A	T	H	-1.0869
112	T	H	-0.7051
113	C	H	-0.7845
114	H	H	-1.2212
115	Y	H	-1.0742
116	N	H	-1.6165
117	S	H	-1.6905
118	R	H	-2.1631
119	G	H	0.0000
120	Q	H	-1.3320
121	G	H	-0.6572
122	T	H	-0.4480
123	Q	H	-0.4900
124	V	H	0.0000
125	T	H	-0.1003
126	V	H	0.0000
127	S	H	-0.4011
128	S	H	-0.4491