Project name: 86d13d30156232

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYNMNWVRQAPGKGLEWVSYISSSSSTIYYADSVKGRFTISRDNAKNSLSLQMNSLRDEDTAVYYCARAYYYGMDVWGQGTTVTVSS; L: DIQMTQSPSSVSASVGDRVTITCRASQGISGWLAWYQQKPGKAPKFLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPPTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:38)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:39)

• Minimal score value: -3.6502
• Maximal score value: 1.8912
• Average score: -0.5303
• Total score value: -118.7953

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0231
2	V	H	-1.0410
3	Q	H	-1.0930
4	L	H	0.0000
5	V	H	1.0080
6	E	H	0.0000
7	S	H	-0.3896
8	G	H	-0.8289
9	G	H	-0.2908
11	G	H	0.2967
12	L	H	1.1876
13	V	H	-0.2492
14	Q	H	-1.6169
15	P	H	-2.1277
16	G	H	-1.7109
17	G	H	-1.2015
18	S	H	-0.9787
19	L	H	-0.6753
20	R	H	-1.5333
21	L	H	0.0000
22	S	H	-0.3724
23	C	H	0.0000
24	A	H	-0.1868
25	A	H	0.0000
26	S	H	-0.8126
27	G	H	-1.2027
28	F	H	-0.4975
29	T	H	-0.2502
30	F	H	0.0000
35	S	H	-0.8708
36	S	H	-0.3339
37	Y	H	0.0184
38	N	H	-0.1802
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.7760
45	A	H	-1.1884
46	P	H	-0.9695
47	G	H	-1.4559
48	K	H	-2.2788
49	G	H	-1.4542
50	L	H	0.0000
51	E	H	-0.9747
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	Y	H	0.7220
56	I	H	0.0000
57	S	H	-0.1051
58	S	H	-0.5809
59	S	H	-0.5477
62	S	H	-0.4006
63	S	H	-0.1711
64	T	H	0.3121
65	I	H	1.0793
66	Y	H	1.0123
67	Y	H	-0.1768
68	A	H	-1.0308
69	D	H	-2.3518
70	S	H	-1.6935
71	V	H	0.0000
72	K	H	-2.3437
74	G	H	-1.6369
75	R	H	-1.3497
76	F	H	0.0000
77	T	H	-0.5170
78	I	H	0.0000
79	S	H	-0.3080
80	R	H	-1.1526
81	D	H	-1.6993
82	N	H	-1.7222
83	A	H	-1.4265
84	K	H	-2.3534
85	N	H	-1.8636
86	S	H	-1.1684
87	L	H	0.0000
88	S	H	-0.6327
89	L	H	0.0000
90	Q	H	-0.9019
91	M	H	0.0000
92	N	H	-1.2759
93	S	H	-1.3164
94	L	H	0.0000
95	R	H	-3.4227
96	D	H	-3.6502
97	E	H	-3.2056
98	D	H	0.0000
99	T	H	-1.1846
100	A	H	0.0000
101	V	H	0.2244
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	A	H	0.5786
108	Y	H	1.0779
109	Y	H	1.8912
113	Y	H	1.6178
114	G	H	0.0000
115	M	H	0.0000
116	D	H	0.1440
117	V	H	-0.1403
118	W	H	-0.3309
119	G	H	0.0000
120	Q	H	-1.3106
121	G	H	-0.5684
122	T	H	-0.1425
123	T	H	0.0399
124	V	H	0.0000
125	T	H	-0.3680
126	V	H	0.0000
127	S	H	-1.0523
128	S	H	-0.7781
1	D	L	-2.0481
2	I	L	0.0000
3	Q	L	-2.2832
4	M	L	0.0000
5	T	L	-1.4184
6	Q	L	-1.0690
7	S	L	-0.7263
8	P	L	-0.6388
9	S	L	-0.8386
10	S	L	-0.9626
11	V	L	-0.4831
12	S	L	-0.6116
13	A	L	0.0000
14	S	L	0.0643
15	V	L	0.9198
16	G	L	-0.3361
17	D	L	-1.1767
18	R	L	-2.0536
19	V	L	0.0000
20	T	L	-0.5919
21	I	L	0.0000
22	T	L	-0.8557
23	C	L	0.0000
24	R	L	-2.8230
25	A	L	0.0000
26	S	L	-2.0406
27	Q	L	-2.1728
28	G	L	-1.4756
29	I	L	0.0000
36	S	L	-0.7132
37	G	L	-0.3034
38	W	L	0.4588
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.8693
46	P	L	-1.2818
47	G	L	-1.7220
48	K	L	-2.6178
49	A	L	-1.5805
50	P	L	0.0000
51	K	L	-1.2706
52	F	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.7175
56	A	L	0.4538
57	A	L	0.0000
65	S	L	-0.2088
66	T	L	0.1009
67	L	L	0.2920
68	Q	L	-0.2498
69	S	L	-0.4073
70	G	L	-0.5732
71	V	L	0.0000
72	P	L	-0.3988
74	S	L	-0.4142
75	R	L	-0.7726
76	F	L	0.0000
77	S	L	-0.3306
78	G	L	-0.2667
79	S	L	-0.6604
80	G	L	-1.0708
83	S	L	-1.0221
84	G	L	-1.2352
85	T	L	-1.7924
86	D	L	-2.1407
87	F	L	0.0000
88	T	L	-0.7544
89	L	L	0.0000
90	T	L	-0.6153
91	I	L	0.0000
92	S	L	-1.2108
93	S	L	-0.9223
94	L	L	0.0000
95	Q	L	-0.6109
96	P	L	-0.5693
97	E	L	-1.6930
98	D	L	0.0000
99	F	L	-0.3967
100	A	L	0.0000
101	T	L	-0.9742
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	A	L	0.6111
108	N	L	-0.0683
109	S	L	0.1551
114	F	L	0.9336
115	P	L	0.0621
116	P	L	0.0000
117	T	L	-0.6595
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-1.2903
121	G	L	-1.0192
122	T	L	0.0000
123	K	L	-1.7936
124	V	L	0.0000
125	E	L	-0.6108
126	I	L	1.0738
127	K	L	-0.7066