Project name: 2510-14.pdb

Chain sequence(s)	H: EVQLVESGGGLVKPGGSLKLSCAASGFTFSSYTMSWVRQTPEKRLEWVATISSTGTYTFYPDSVKGRFTISRDNAKNTLYLQMSSLKSEDTAMYYCTRHYYDSTHPFDYWGQGTTVTVSA; L: DVQMIQSPSSLSASLGERVSLTCRASQDIGSSLNWLQQEPDGTIKRLIYATSSLDSGVPKRFSGSRSGSDYSLTISSLESEDFVDYYCLQYASSPPTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:52)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:54)

• Minimal score value: -2.9945
• Maximal score value: 1.5308
• Average score: -0.5955
• Total score value: -135.1845

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9416
2	V	H	-0.8406
3	Q	H	-0.6414
4	L	H	0.0000
5	V	H	1.1609
6	E	H	0.2259
7	S	H	-0.3757
8	G	H	-0.7459
9	G	H	-0.3010
11	G	H	0.3148
12	L	H	1.1044
13	V	H	-0.2922
14	K	H	-1.7860
15	P	H	-1.8194
16	G	H	-1.5109
17	G	H	-1.2335
18	S	H	-1.0650
19	L	H	-0.6031
20	K	H	-1.3193
21	L	H	0.0000
22	S	H	-0.2501
23	C	H	0.0000
24	A	H	0.0035
25	A	H	0.0000
26	S	H	-0.5734
27	G	H	-1.0730
28	F	H	-0.4530
29	T	H	-0.1872
30	F	H	0.0000
35	S	H	-0.6286
36	S	H	-0.0566
37	Y	H	0.3033
38	T	H	0.2312
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	0.0000
45	T	H	-1.9032
46	P	H	-1.8649
47	E	H	-2.8721
48	K	H	-2.6321
49	R	H	-2.9945
50	L	H	0.0000
51	E	H	-1.0390
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	T	H	0.7289
56	I	H	0.0000
57	S	H	0.5933
58	S	H	0.1150
59	T	H	-0.1330
62	G	H	-0.0193
63	T	H	0.4395
64	Y	H	1.5308
65	T	H	1.3418
66	F	H	1.4671
67	Y	H	-0.2019
68	P	H	-1.3671
69	D	H	-2.3890
70	S	H	-1.7945
71	V	H	0.0000
72	K	H	-2.4137
74	G	H	-1.7352
75	R	H	-1.5720
76	F	H	0.0000
77	T	H	-0.5602
78	I	H	0.0000
79	S	H	-0.2141
80	R	H	-0.8221
81	D	H	-1.2760
82	N	H	-1.4384
83	A	H	-1.2431
84	K	H	-2.1750
85	N	H	-1.5778
86	T	H	-0.8605
87	L	H	0.0000
88	Y	H	-0.3773
89	L	H	0.0000
90	Q	H	-1.0244
91	M	H	0.0000
92	S	H	-0.9833
93	S	H	-1.1546
94	L	H	0.0000
95	K	H	-2.5702
96	S	H	-2.0630
97	E	H	-2.4610
98	D	H	0.0000
99	T	H	-0.7493
100	A	H	0.0000
101	M	H	-0.0900
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	T	H	0.0000
106	R	H	0.0000
107	H	H	0.1337
108	Y	H	0.2305
109	Y	H	0.4177
110	D	H	-1.2120
111	S	H	-0.6591
112	T	H	-0.4476
113	H	H	-0.5908
114	P	H	0.0000
115	F	H	0.0000
116	D	H	0.0724
117	Y	H	0.5777
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.1558
121	G	H	-0.3651
122	T	H	-0.2599
123	T	H	-0.0823
124	V	H	0.0000
125	T	H	-0.1848
126	V	H	0.0000
127	S	H	-0.8164
128	A	H	-0.4922
1	D	L	-2.3156
2	V	L	0.0000
3	Q	L	-1.8974
4	M	L	0.0000
5	I	L	-0.1211
6	Q	L	-0.4727
7	S	L	-0.4625
8	P	L	-0.4189
9	S	L	-0.5988
10	S	L	-0.9086
11	L	L	-0.4803
12	S	L	-0.6802
13	A	L	0.0000
14	S	L	-0.7224
15	L	L	-0.2079
16	G	L	-1.2573
17	E	L	-1.9456
18	R	L	-2.3213
19	V	L	-1.1165
20	S	L	-0.6283
21	L	L	0.0000
22	T	L	-0.6138
23	C	L	0.0000
24	R	L	-2.3622
25	A	L	0.0000
26	S	L	-1.9435
27	Q	L	-2.5921
28	D	L	-2.7259
29	I	L	0.0000
36	G	L	-1.1630
37	S	L	-0.6763
38	S	L	-0.4331
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	L	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	E	L	-1.3739
46	P	L	-1.2951
47	D	L	-2.2048
48	G	L	-1.4969
49	T	L	-1.2093
50	I	L	0.0000
51	K	L	-0.4612
52	R	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.0039
56	A	L	-0.1469
57	T	L	0.0000
65	S	L	-0.4111
66	S	L	-0.0948
67	L	L	-0.2656
68	D	L	-0.5285
69	S	L	-0.4445
70	G	L	-0.7458
71	V	L	-0.6685
72	P	L	-1.0342
74	K	L	-1.8910
75	R	L	-1.5200
76	F	L	0.0000
77	S	L	-0.6883
78	G	L	-0.4402
79	S	L	-0.8105
80	R	L	-1.3966
83	S	L	-1.1359
84	G	L	-1.4129
85	S	L	-1.9321
86	D	L	-1.6690
87	Y	L	0.0000
88	S	L	-0.7993
89	L	L	0.0000
90	T	L	-0.6193
91	I	L	0.0000
92	S	L	-1.6105
93	S	L	-1.6658
94	L	L	0.0000
95	E	L	-1.7643
96	S	L	-1.2004
97	E	L	-2.3024
98	D	L	0.0000
99	F	L	-0.7275
100	V	L	0.0000
101	D	L	-0.9793
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	L	L	0.0000
106	Q	L	0.0000
107	Y	L	-0.1103
108	A	L	-0.5565
109	S	L	-0.7945
114	S	L	-0.4630
115	P	L	-0.7072
116	P	L	-0.5854
117	T	L	-0.7425
118	F	L	-0.4131
119	G	L	0.0000
120	G	L	-1.3025
121	G	L	-0.9890
122	T	L	0.0000
123	K	L	-1.4901
124	L	L	0.0000
125	E	L	-1.0500
126	I	L	0.5335
127	K	L	-0.9554