| Chain sequence(s) |
A: APKDNTWYTGAKLGWSQYHDTGFIPNNGPTHENQLGAGAFGGYQVNPYVGFEMGYDWLGRMPYKGDNINGAYKAQGVQLTAKLGYPITDDLDIYTRLGGMVWRADTKANVPGGASFKDHDTGVSPVFAGGVEYAITPEIATRLEYQWTNNIGDANTIGTRPDNGLLSLGVSYRFGQGEAAPVVAPAPAPEVQTKHFTLKSDVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVKGIKDVVTQPQA
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:03)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | A | A | -1.4934 | |
| 2 | P | A | -2.0576 | |
| 3 | K | A | -2.6588 | |
| 4 | D | A | -2.4973 | |
| 5 | N | A | -1.8133 | |
| 6 | T | A | -0.4834 | |
| 7 | W | A | 1.5623 | |
| 8 | Y | A | 0.0000 | |
| 9 | T | A | 1.0906 | |
| 10 | G | A | 0.7522 | |
| 11 | A | A | 1.2299 | |
| 12 | K | A | 0.0000 | |
| 13 | L | A | 3.0290 | |
| 14 | G | A | 0.0000 | |
| 15 | W | A | 2.0451 | |
| 16 | S | A | 0.0000 | |
| 17 | Q | A | -0.8248 | |
| 18 | Y | A | 0.0000 | |
| 19 | H | A | -1.9992 | |
| 20 | D | A | -2.5209 | |
| 21 | T | A | -1.3242 | |
| 22 | G | A | -0.7080 | |
| 23 | F | A | 0.2485 | |
| 24 | I | A | 1.5720 | |
| 25 | P | A | 0.4963 | |
| 26 | N | A | -1.1714 | |
| 27 | N | A | -1.9879 | |
| 28 | G | A | -2.2234 | |
| 29 | P | A | -1.5767 | |
| 30 | T | A | -1.6111 | |
| 31 | H | A | -2.2875 | |
| 32 | E | A | -2.2977 | |
| 33 | N | A | -1.7911 | |
| 34 | Q | A | -0.5810 | |
| 35 | L | A | 1.6942 | |
| 36 | G | A | 0.0000 | |
| 37 | A | A | 1.5372 | |
| 38 | G | A | 0.7869 | |
| 39 | A | A | 0.9181 | |
| 40 | F | A | 0.0000 | |
| 41 | G | A | 1.0589 | |
| 42 | G | A | 0.0000 | |
| 43 | Y | A | 1.3799 | |
| 44 | Q | A | 0.4122 | |
| 45 | V | A | 0.2435 | |
| 46 | N | A | -0.7117 | |
| 47 | P | A | 0.0066 | |
| 48 | Y | A | 1.9563 | |
| 49 | V | A | 1.8434 | |
| 50 | G | A | 0.0000 | |
| 51 | F | A | 3.0622 | |
| 52 | E | A | 0.0000 | |
| 53 | M | A | 2.3791 | |
| 54 | G | A | 0.0000 | |
| 55 | Y | A | 1.7789 | |
| 56 | D | A | 0.0000 | |
| 57 | W | A | 0.4948 | |
| 58 | L | A | 0.0000 | |
| 59 | G | A | 0.0000 | |
| 60 | R | A | -2.1074 | |
| 61 | M | A | 0.0000 | |
| 62 | P | A | -1.6984 | |
| 63 | Y | A | 0.0000 | |
| 64 | K | A | -3.0435 | |
| 65 | G | A | -2.7795 | |
| 66 | D | A | -3.1250 | |
| 67 | N | A | -2.7131 | |
| 68 | I | A | -1.8746 | |
| 69 | N | A | -2.4518 | |
| 70 | G | A | -1.4154 | |
| 71 | A | A | 0.0000 | |
| 72 | Y | A | 0.0000 | |
| 73 | K | A | -1.8599 | |
| 74 | A | A | 0.0000 | |
| 75 | Q | A | -0.2813 | |
| 76 | G | A | 0.0000 | |
| 77 | V | A | 2.3428 | |
| 78 | Q | A | 0.0000 | |
| 79 | L | A | 2.8651 | |
| 80 | T | A | 0.0000 | |
| 81 | A | A | 1.9387 | |
| 82 | K | A | 0.0000 | |
| 83 | L | A | 2.1930 | |
| 84 | G | A | 2.1705 | |
| 85 | Y | A | 2.8819 | |
| 86 | P | A | 1.4747 | |
| 87 | I | A | 2.1410 | |
| 88 | T | A | 0.1681 | |
| 89 | D | A | -1.8327 | |
| 90 | D | A | -1.0795 | |
| 91 | L | A | 1.0885 | |
| 92 | D | A | 1.6733 | |
| 93 | I | A | 2.9897 | |
| 94 | Y | A | 0.0000 | |
| 95 | T | A | 1.3279 | |
| 96 | R | A | 0.0000 | |
| 97 | L | A | 1.8658 | |
| 98 | G | A | 1.2085 | |
| 99 | G | A | 1.5939 | |
| 100 | M | A | 0.0000 | |
| 101 | V | A | 2.8078 | |
| 102 | W | A | 0.0000 | |
| 103 | R | A | -0.4505 | |
| 104 | A | A | 0.0000 | |
| 105 | D | A | -2.1904 | |
| 106 | T | A | -1.8569 | |
| 107 | K | A | -2.2354 | |
| 108 | A | A | -1.2278 | |
| 109 | N | A | -1.4928 | |
| 110 | V | A | -0.6531 | |
| 111 | P | A | -1.1698 | |
| 112 | G | A | -0.9734 | |
| 113 | G | A | -0.5342 | |
| 114 | A | A | -0.2163 | |
| 115 | S | A | -0.4102 | |
| 116 | F | A | 0.1465 | |
| 117 | K | A | -2.1887 | |
| 118 | D | A | -2.2811 | |
| 119 | H | A | -2.3426 | |
| 120 | D | A | -1.2754 | |
| 121 | T | A | -0.0918 | |
| 122 | G | A | 0.8561 | |
| 123 | V | A | 2.1780 | |
| 124 | S | A | 0.0000 | |
| 125 | P | A | 0.7893 | |
| 126 | V | A | 0.0000 | |
| 127 | F | A | 1.9452 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 1.1536 | |
| 130 | G | A | 1.3010 | |
| 131 | V | A | 2.4170 | |
| 132 | E | A | 0.0000 | |
| 133 | Y | A | 1.9855 | |
| 134 | A | A | 1.2219 | |
| 135 | I | A | 2.4117 | |
| 136 | T | A | 1.0486 | |
| 137 | P | A | -0.3092 | |
| 138 | E | A | 0.5096 | |
| 139 | I | A | 2.1597 | |
| 140 | A | A | 0.0000 | |
| 141 | T | A | 2.4140 | |
| 142 | R | A | 0.0000 | |
| 143 | L | A | 2.7338 | |
| 144 | E | A | 0.0000 | |
| 145 | Y | A | 2.0099 | |
| 146 | Q | A | 0.0000 | |
| 147 | W | A | 1.0152 | |
| 148 | T | A | 0.0000 | |
| 149 | N | A | -0.8029 | |
| 150 | N | A | -1.9972 | |
| 151 | I | A | 0.0000 | |
| 152 | G | A | 0.0000 | |
| 153 | D | A | -1.5144 | |
| 154 | A | A | -1.0682 | |
| 155 | N | A | -1.5564 | |
| 156 | T | A | -1.3220 | |
| 157 | I | A | 0.0000 | |
| 158 | G | A | -0.4872 | |
| 159 | T | A | 0.0000 | |
| 160 | R | A | -2.3411 | |
| 161 | P | A | 0.0000 | |
| 162 | D | A | -1.6648 | |
| 163 | N | A | 0.0000 | |
| 164 | G | A | 0.0000 | |
| 165 | L | A | 0.0000 | |
| 166 | L | A | 2.3411 | |
| 167 | S | A | 0.0000 | |
| 168 | L | A | 3.2143 | |
| 169 | G | A | 0.0000 | |
| 170 | V | A | 2.9398 | |
| 171 | S | A | 0.0000 | |
| 172 | Y | A | 1.7430 | |
| 173 | R | A | 0.0000 | |
| 174 | F | A | 1.3544 | |
| 175 | G | A | -0.5405 | |
| 176 | Q | A | 0.0000 | |
| 177 | G | A | -1.2078 | |
| 178 | E | A | -2.0728 | |
| 179 | A | A | -0.6364 | |
| 180 | A | A | 0.1557 | |
| 181 | P | A | 0.8792 | |
| 182 | V | A | 2.5298 | |
| 183 | V | A | 2.5402 | |
| 184 | A | A | 1.2883 | |
| 185 | P | A | 0.5176 | |
| 186 | A | A | 0.1222 | |
| 187 | P | A | -0.5867 | |
| 188 | A | A | -0.4089 | |
| 189 | P | A | -1.1358 | |
| 190 | E | A | -1.6511 | |
| 191 | V | A | -0.6077 | |
| 192 | Q | A | -1.6940 | |
| 193 | T | A | -1.5563 | |
| 194 | K | A | -1.9934 | |
| 195 | H | A | -1.8078 | |
| 196 | F | A | -0.5058 | |
| 197 | T | A | -0.5586 | |
| 198 | L | A | -0.6411 | |
| 199 | K | A | -1.7704 | |
| 200 | S | A | 0.0000 | |
| 201 | D | A | -1.6169 | |
| 202 | V | A | -0.9122 | |
| 203 | L | A | 0.0000 | |
| 204 | F | A | 0.0000 | |
| 205 | N | A | -1.1390 | |
| 206 | F | A | 0.0664 | |
| 207 | N | A | -1.5375 | |
| 208 | K | A | -2.3946 | |
| 209 | A | A | -1.7912 | |
| 210 | T | A | -0.9959 | |
| 211 | L | A | -0.8163 | |
| 212 | K | A | -1.4889 | |
| 213 | P | A | -1.3330 | |
| 214 | E | A | -2.1545 | |
| 215 | G | A | 0.0000 | |
| 216 | Q | A | -1.4504 | |
| 217 | A | A | -1.4746 | |
| 218 | A | A | -1.0948 | |
| 219 | L | A | 0.0000 | |
| 220 | D | A | -1.8283 | |
| 221 | Q | A | -1.8459 | |
| 222 | L | A | 0.0000 | |
| 223 | Y | A | -1.2130 | |
| 224 | S | A | -1.4796 | |
| 225 | Q | A | -1.8695 | |
| 226 | L | A | 0.0000 | |
| 227 | S | A | -1.4361 | |
| 228 | N | A | -1.9876 | |
| 229 | L | A | -2.0698 | |
| 230 | D | A | -3.2118 | |
| 231 | P | A | -2.6151 | |
| 232 | K | A | -3.1149 | |
| 233 | D | A | -3.0803 | |
| 234 | G | A | -2.1161 | |
| 235 | S | A | -1.5592 | |
| 236 | V | A | 0.0000 | |
| 237 | V | A | -0.6402 | |
| 238 | V | A | 0.0000 | |
| 239 | L | A | -0.9173 | |
| 240 | G | A | 0.0000 | |
| 241 | Y | A | 0.0000 | |
| 242 | T | A | 0.0000 | |
| 243 | D | A | 0.0000 | |
| 244 | R | A | -1.7337 | |
| 245 | I | A | -0.6178 | |
| 246 | G | A | -0.9756 | |
| 247 | S | A | -1.2240 | |
| 248 | D | A | -2.1269 | |
| 249 | A | A | -0.8104 | |
| 250 | Y | A | -0.1609 | |
| 251 | N | A | 0.0000 | |
| 252 | Q | A | -1.8499 | |
| 253 | G | A | -1.4754 | |
| 254 | L | A | 0.0000 | |
| 255 | S | A | 0.0000 | |
| 256 | E | A | -3.1581 | |
| 257 | R | A | -3.3215 | |
| 258 | R | A | 0.0000 | |
| 259 | A | A | 0.0000 | |
| 260 | Q | A | -2.4773 | |
| 261 | S | A | -1.4472 | |
| 262 | V | A | 0.0000 | |
| 263 | V | A | 0.0000 | |
| 264 | D | A | -1.6442 | |
| 265 | Y | A | -0.9371 | |
| 266 | L | A | 0.0000 | |
| 267 | I | A | -0.5445 | |
| 268 | S | A | -0.7291 | |
| 269 | K | A | -1.0527 | |
| 270 | G | A | -0.7807 | |
| 271 | I | A | 0.0000 | |
| 272 | P | A | -0.9845 | |
| 273 | A | A | -1.1889 | |
| 274 | D | A | -2.0120 | |
| 275 | K | A | -1.8197 | |
| 276 | I | A | 0.0000 | |
| 277 | S | A | -1.1230 | |
| 278 | A | A | -1.8258 | |
| 279 | R | A | -2.6605 | |
| 280 | G | A | -2.2300 | |
| 281 | M | A | -1.1387 | |
| 282 | G | A | 0.0000 | |
| 283 | E | A | -1.8339 | |
| 284 | S | A | -1.2736 | |
| 285 | N | A | -1.1520 | |
| 286 | P | A | -0.7017 | |
| 287 | V | A | 1.0185 | |
| 288 | T | A | -0.1133 | |
| 289 | G | A | -0.9453 | |
| 290 | N | A | -2.0346 | |
| 291 | T | A | -1.2458 | |
| 292 | C | A | 0.0000 | |
| 293 | D | A | -2.9868 | |
| 294 | N | A | -2.7277 | |
| 295 | V | A | -2.2659 | |
| 296 | K | A | -3.1479 | |
| 297 | Q | A | -2.8042 | |
| 298 | R | A | -2.7293 | |
| 299 | A | A | -1.5626 | |
| 300 | A | A | -1.4556 | |
| 301 | L | A | -1.6791 | |
| 302 | I | A | -0.9159 | |
| 303 | D | A | -1.6398 | |
| 304 | C | A | -0.8269 | |
| 305 | L | A | 0.0000 | |
| 306 | A | A | -0.7596 | |
| 307 | P | A | -0.4092 | |
| 308 | D | A | 0.0000 | |
| 309 | R | A | 0.0000 | |
| 310 | R | A | 0.0000 | |
| 311 | V | A | 0.0000 | |
| 312 | E | A | -0.8214 | |
| 313 | I | A | 0.0000 | |
| 314 | E | A | -1.2089 | |
| 315 | V | A | 0.0000 | |
| 316 | K | A | -1.6747 | |
| 317 | G | A | -2.1679 | |
| 318 | I | A | -1.6018 | |
| 319 | K | A | -2.3183 | |
| 320 | D | A | -1.3963 | |
| 321 | V | A | 0.9056 | |
| 322 | V | A | 1.4951 | |
| 323 | T | A | 0.2662 | |
| 324 | Q | A | -0.9223 | |
| 325 | P | A | -1.1991 | |
| 326 | Q | A | -1.6122 | |
| 327 | A | A | -0.7488 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine